Supplemental Table 1. IMC-A12 Trough Serum Concentrations During Cycle 1 and Cycle 2

Supplemental Table 1. IMC-A12 trough serum concentrations during cycle 1 and cycle 2

IMC-A12 Dose (mg/kg) / Temsirolimus Dose (mg/m2) / IMC-A12 Serum concentration (g/ml)
Cycle / 1 / 2
Day / 8 / 15 / 22 / 28 / 43 / 56
4 / 8 / N / 3 / 3 / 3 / 3 / 1 / 1
Average / 53 / 102 / 116 / 149 / 196 / 195
SD / 9 / 36 / 29 / 43
Median / 49 / 111 / 111 / 160 / 196 / 195
Low / 46 / 63 / 89 / 102
High / 63 / 133 / 147 / 186
6 / 8 / N / 13 / 13 / 12 / 9 / 4 / 4
Average / 68 / 112 / 168 / 188 / 143 / 155
SD / 33 / 38 / 61 / 63 / 86 / 80
Median / 66 / 114 / 163 / 197 / 124 / 123
Low / 24 / 61 / 84 / 92 / 60 / 101
High / 145 / 181 / 301 / 288 / 263 / 274
6 / 10 / N / 6 / 5 / 6 / 5 / 3 / 3
Average / 65 / 98 / 150 / 214 / 167 / 105
SD / 35 / 43 / 51 / 60 / 77 / 106
Median / 63 / 114 / 129 / 202 / 183 / 197
Low / 0 / 35 / 66 / 72 / 61 / 67
High / 104 / 135 / 188 / 222 / 204 / 277
6 / 15 / N / 14 / 13 / 11 / 10 / 7 / 8
Average / 107 / 143 / 200 / 243 / 265 / 266
SD / 60 / 77 / 100 / 178 / 89 / 88
Median / 104 / 131 / 156 / 180 / 226 / 222
Low / 46 / 63 / 82 / 60 / 183 / 189
High / 241 / 307 / 379 / 544 / 424 / 383