Supplementary Table 1 Maximum obtained non-parametric multipoint LOD scores ≥1.0 with corresponding Zlr scores and singlepoint LOD scores, with spt results from flanking markers in italics. Also listed are the corresponding genome-wide significance values (p-values) and the significant LOD scores are in bold. A) Linkage results of the full set of 109 families, B) the 63 APOE ε4 positive families and C) the 46 APOE ε4 negative families.

A.

Multipoint Analysis / Singlepoint Analysis
Chr. / Peak Marker / Max LOD (p-value) / Max Zlr / Markers / LOD (p-value) / cM1
2 / close to D2S118 / 1.00 (0.94) / 2.15 / D2S364
D2S118
D2S117 / 0.07 (1)
0.84 (1)
0.29 (1) / 187.67
190.98
194.64
7 / close to
D7S630 / 1.08 (0.91) / 2.23 / D7S2485
D7S630
D7S2409 / 0.30 (1)
0.94 (1)
0.68 (1) / 98.28
100.51
102.82
11 / D11S4080 / 1.08 (0.91) / 2.23 / D11S4163
D11S4080
D11S904 / 0.34 (1)
0.64 (1)
0.33 (1) / 41.80
42.42
43.64
13 / close to
D13S1256 / 1.00 (0.94) / 2.14 / D13S779
D13S1256
D13S158 / 0.05 (1)
0.03 (1)
0.11 (1) / 95.76
97.91
98.96
19 / close to
D19S900 / 5.05 (0.015) / 4.82 / D19S420
D19S900
D19S913 / 2.21 (0.3)
1.98 (0.5)
1.62 (na) / 68.94
69.91
70.342

B.

Multipoint Analysis / Singlepoint Analysis
Chr. / Peak Marker / Max LOD (p-value) / Max Zlr / Markers / LOD (p-value) / cM1
3 / D3S1308 / 1.30 (0.78) / 2.44 / D3S1593
D3S1308
D3S1279 / 0.44 (1)
1.52 (0.8)
0.61 (1) / 152.31
157.07
160.19
7 / D7S507 / 1.58 (0.54) / 2.70 / D7S557
D7S507
D7S2495 / 0.08 (1)
0.37 (1)
0.43 (1) / 28.752
31.51
33.21
14
1414 / close to
D14S985 / 1.16 (0.84) / 2.31 / D14S1426
D14S985
D14S293 / 0.08 (1)
0.74 (1)
0.08 (1) / 114.86
118.33
121.72
18 / close to
D18S869 / 1.20 (0.81) / 2.35 / D18S453
D18S869
D18S1107 / 1.69 (0.73)
0.63 (1)
0.08 (1) / 39.73
44.15
45.83
19 / close to
D19S903 / 5.31 (0.0011) / 4.95 / D19S217
D19S903
D19S559 / 2.28 (0.28)
2.86 (na)
4.43 (0.0027) / 70.53
70.92
71.40


C.

Multipoint Analysis / Singlepoint Analysis
Chr. / Peak Marker / Max LOD (p-value) / Max Zlr / Markers / LOD (p-value) / cM1
7 / close to
D7S630 / 0.95 (0.89) / 2.10 / D7S2485
D7S630
D7S2409 / 0
0.87 (1)
0.53 (1) / 98.28
101.68
102.82
19 / D19S246 / 1.06 (0.86) / 2.21 / D19S867
D19S246
DG19S265 / 0.44 (1)
0.09 (1)
0.21 (1) / 82.03
83.37
87.42

1marker location in Kosambi cM according to deCODE genetic map, 2markers not present in deCODE genetic map and thus the genetic location is estimated, na=not analysed