Disease Profile of 400 Institutionalized Mentally Retarded Patients in Kuwait

Disease profile of 400 institutionalized mentally retarded patients in Kuwait

·  T. I. Farag11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,22P. O. Box 31145, Suleibikhat 90802, Kuwait,

·  S. A. Al-Awadi11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  M. H. El-Badramary11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  M. A. Aref11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  B. Kasrawi11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  D. S. Krishna Murthy11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  M. Y. El-Khalifa11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  G. Yadav11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  M. J. Marafie11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  L. Bastaki11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  R. A. Wahba11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  F. M. Mohammed11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  S. Abul Hassan11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  A. A. Redha11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  M. A. Redha11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  H. Al-Aboud11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  S. Al-Hijji11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  D. Al-Dighashem11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  N. Al-Hashash11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  L. Al-Jeryan11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  H. Al-Khorafi11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait,

·  E. A. Qurban11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait and

·  I. Al-Sulaiman11Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait

·  1Kuwait Medical Genetics Centre, Maternity Hospital Liaison Genetic Clinic, Institute for Mentally Retarded, Psychological Medicine Hospital, Kuwait

2P. O. Box 31145, Suleibikhat 90802, Kuwait

Clin Genet 1993: 44: 329–334. © Munksgaard, 1993

In this preliminary report we summarize the results of a 4-year multidisciplinary systematic, etiological clinicogenetic survey of 400 institutionalized mentally retarded patients in Kuwait. All had an intelligence quotient below 50. A constitutional disorder, as the direct cause of the mental retardation, was found in 203 patients (50.75%)): a chromosomal abnormality in 37 (9.25%), Mendelian disorders in 137 (34.25%), MCA/MR in 22 (5.55%) and CNS malformations in 7 cases (1.75%). In 157 patients (39.35%) a pre-, peri or postnatal cause was ascertained. No etiological diagnosis was detected in 40 patients (10%). A detailed analysis of the "disease profile" is given and compared with the results of previous diagnostic genetic surveys among different institutionalized mentally retarded populations in Western and developing countries