1.Name and Full Correspondence Address Prof. Parames C. Sil

Curriculum vitae

1.Name and full correspondence addressProf. Parames C. Sil

Division of Molecular Medicine,

Bose Institute,

P-1/12, C.I.T. Scheme VII M,

Kolkata-700054, W.B.

2.Email(s) and contact number(s),

,

03325693243

3.InstitutionBose Institute

4.Date of Birth28/12/1959

5.Gender Male

6.CategoryGeneral

7.Whether differently abled No

Educational Qualification

______

DegreeInstitution Field(s) Year Class/Rank______

B. Sc CalcuttaUniversity Chemistry (Hons) 1981 1st / Third

M. Sc CalcuttaUniversity Physical Chemistry (Spl) 1983 1st / Third

Organic, Inorganic (Physical chemistry)

Ph. D. Calcutta University Chemistry 1990

Ph.D thesis title, Guide’s Name, Institute/Organization/University, Year of Award.

Thesis Title: Studies on basic trypsin-subtilisin inhibitor from marine turtle eggwhite

Guide’s name: Prof. Nirmal K. Sinha

Institute/University: Bose Institute/Calcutta University

Year of Award: 1990

Professional Experience

Sl. No. / Position held / Name of the Institute / From / To / Pay Scale (Rs)
1. / Project Coordinator, Institute Research Program Project IV / Bose Institute, Kolkata, India / September 01, 2014 / Present / Honorary
2. / Head, Division of Molecular Medicine / Bose Institute, Kolkata, India / January 16, 2014 / January 15, 2016 / Honorary
2. / Senior Professor / Bose Institute, Kolkata, India / December 22, 2010 / Present / 39,400-67,000
G.P. 10,000
3. / Professor / Bose Institute, Kolkata, India / December 22, 2005 / December 21, 2010 / 39,400-67,000
G.P. 8,900
4. / Reader / Bose Institute, Kolkata, India / July 10, 2000 / December 21, 2005 / 12,300-18,300

Professional recognition/ Award/ Prize/ Certificate/ Fellowship received:

Fellow of the West Bengal Academy of Science & Technology (WAST)

Membership of Learned Societies

The Indian Science Congress Association(Life Member)

Indian Society of Cell Biology(Life Member)

Indian Society of Biological Sciences(Life Member)

DNA Society of India(Life Member)

Ad hoc Reviewer

Projects: CSIR, DST-SERB, WBDBT

Journals: Reviewer of more than 170 journals

Associate Editor: Toxicology Reports, Reactive Oxygen Species

Regional Editor: Current Diabetes Reviews

Research interest

Through the last decades, our research was focused on several major areas of organ pathophysiology. Unravelling the mechanism(s) of drugs, environmental pollutants and nanostructure induced cell injury and death in multiple vital target organs and exploration of the antitoxic/antioxidant potentials of natural and man-made antioxidants in the prevention and/or amelioration of the organ dysfunction was our major contribution in this field. We made many breakthroughs while studying on natural bioactive compounds like arjunolic acid, taurine, mangiferin, etc. Specifically, we hold a pioneer position in studying the broad spectrum activity of arjunolic acid (Recently Sigma Aldrich Co has launched this product and cited a number of the publications of this study) and that of the non-essential amino acid, taurine. Detail studies on the mechanism of the protective actions of these molecules clearly suggest their excellent hepatoprotective, cardioprotective and renoprotective activities without any detectable side effects and could provide a new promising solution to very serious and potential pathophysiological situations. Along with these achievements, our contribution in the field of diabetic pathophysiology is highly appreciable. We proposed detailed mechanism of the protective action of natural antioxidants (arjunalic acid, taurine, D-saccharic acid 1,4-lactone and mangiferin) on the detrimental effects of oxidative stress in diabetic pathophysiology and its associated complications. This study might help researcher to design potential therapeutics against diabetes in future and relief common people from the burden of expensive commercially available drugs. We have also contributed an excellent quality of research on the environmentally exposed nanostructure-induced organ pathophysiology and its reversal. Applying detail mechanistic approach, we showed that nano copper particles could induce liver and kidney dysfunctions and cellular damage Moreover, we are also working on the preparation of mesoporous silica nanoparticles (MSNs) and intend to devise a targeted anti-cancer therapy by loading those MSNs with potent anticancer natural bioactive compounds and believe that these findings will help the researchers further to assess the worse impact of these nano materials and also help to find suitable remedies. Our research has been highly recognized in the scientific community worldwide as evidenced from the H-index (50), i-10-index (114) and citations (5,821) of our publications (135) in the journals of high international repute (Google Scholar Citation Report).

Publications

Published papers: 135

Published Book Chapter: 9

Citations: 5821

H-index: 50

i-10-index: 114

List of Publications:

1.Bhattacharyya S, Banerjee S, Guha C, Ghosh S, Sil PC (2017). A 35 kDa Phyllanthus niruri protein suppresses indomethacin mediated hepatic impairments: Its role in Hsp70, HO-1, JNKs and Ca 2+ dependent inflammatory pathways. Food and Chemical Toxicology, 102, 76-92.

2.Ghosh S, Sarkar A, Bhattacharyya S, Sil PC(2016) Silymarin protects mouse liver and kidney from thioacetamide induced toxicity by scavenging reactive oxygen species and activating PI3K-Akt pathway. Frontiers in Pharmacology, 2016;7.

3.Chowdhury S, Ghosh S, Rashid K, Sil PC (2016) Deciphering the role of ferulic acid against streptozotocin-induced cellular stress in the cardiac tissue of diabetic rats. Food and Chemical Toxicology, 97, 187-198.

4.Sarkar A, Ghosh S, Chowdhury S, Pandey B, Sil, PC (2016) Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 1860(10), 2065-2075.

5.Sadhukhan P, Saha S, Sinha K, Brahmachari G, Sil PC (2016) Selective Pro-Apoptotic Activity of Novel 3, 3′-(Aryl/Alkyl-Methylene) Bis (2-Hydroxynaphthalene-1, 4-Dione) Derivatives on Human Cancer Cells via the Induction Reactive Oxygen Species. PLoS ONE, 11(7), e0158694.

6.Chowdhury S, Sinha K, Banerjee S, Sil PC (2016) Taurine protects cisplatin induced cardiotoxicity by modulating inflammatory and endoplasmic reticulum stress responses. BioFactors42 (6), 647-664.

7.Saha S, Sadhukhan P, Sil PC (2016) Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential. BioFactors42 (5), 459-474.

8.Saha S, Rashid K, Sadhukhan P, Agarwal N, Sil PC (2016) Attenuative role of mangiferin in oxidative stress mediated liver dysfunction in arsenic intoxicated murines. BioFactors42 (5), 515-532.

9.Saha S, Sadhukhan P, Sinha K, Agarwal N, Sil PC (2016) Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways. Biochem Biophys Rep 5:313–327.

10.Rashid K, Sil PC(2015) Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats.Toxicol Appl Pharmacol282:297–310.

11.Pal S, Ghosh M, Ghosh S, Bhattacharyya S, Sil PC (2015) Atorvastatin induced hepatic oxidative stress and apoptotic damage via MAPKs, mitochondria and ER dependent pathways.Food Chem Toxicol83:36-47.

12.Sinha K, Sadhukhan P, Saha S, Pal PB, Sil PC (2015) Morin protects gastric mucosa from nonsteroidal anti-inflammatory drug, indomethacin induced inflammatory damage and apoptosis by modulating NF-κB pathway.Biochim. Biophys. Acta [General Subjects]1850:769-783.

13.Sadhukhan P, Saha S, Sil PC (2015) Targeting Oxidative Stress: A Novel Approach in Mitigating Cancer. Biochem Anal Biochem 4 (236):2161-1009.1000236.

14.Rashid K, Sil PC (2015) Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress mediated mitochondria and endoplasmic reticulum dependent apoptotic death. Biochim. Biophys. Acta [Molecular Basis of Disease]1852:70-82.

15.Ghosh S, Banjerjee S, Sil PC (2015)The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol83:111-124.

16.Das J, Sarkar A,Sil PC (2015)Hexavalent chromium induces apoptosis in Human Liver (HepG2) cells via redox imbalance. Toxicol Rep2:600-608.

17.Pal S, Sarkar A, Pal PB,Sil PC(2015)Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways. Biochimie112:20-34.

18.Ghosh S, Bhattacharyya S, Rashid K,Sil PC(2015)Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and MAPKs mediated stress response pathways. Toxicol Rep2:365–376.

19.Bhattacharyya S, Sinha K, Sil PC (2014) Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress. Curr Drug Metab15:719-742.

20.Pal PB, Sinha K, Sil PC (2014) Mangiferin attenuates diabetic nephropathy by inhibiting oxidative stress mediated signaling cascade, TNFα related and mitochondrial dependent apoptotic pathways in streptozotocin-induced diabetic rats. PLoS ONE9(9):e107220.

21.Saha S, Sadhukhan P, Sil PC (2014) Genistein: A phytoestrogen with multifaceted therapeutic properties. Mini-Rev Medicinal Chem14:920-940.

22.Ghosh M, Pal S, Sil PC(2014) Taurine attenuates nano copper induced oxidative hepatic damage via mitochondria dependent and NF-B/TNF-mediatedpathway. Toxicol Res 3:474–486.

23.Bhattacharyya S, Ghosh S, Sil PC (2014) Amelioration of Aspirin Induced Oxidative Impairment and Apoptotic Cell Death by a Novel Antioxidant Protein Molecule Isolated from the Herb Phyllanthus niruri.PLoS ONE9(2):e89026.

24.Sarkar A, Sil PC (2014) Iron oxide nanoparticles mediated cytotoxicity via PI3K/AKT pathway:Role of quercetin. Food Chem Toxicol71:106-115.

25.Sinha K,Pal PB,Sil PC (2014) Cadmium (Cd2+) exposure differentially elicits both cell proliferation and cell death related responses in SK-RC-45. Toxicol In Vitro 28:307-318.

26.Sarkar A, Ghosh M, Sil PC (2014) Nanotoxicity: Oxidative stress mediated toxicity of metal and metal oxide nanoparticles. J Nanosci Nanotech 14:730-743.

27.Rashid K, Sinha K, Sil PC (2013) An update on oxidative stress-mediated organ pathophysiology.Food Chem Toxicol62:584-600.

28.Sinha K, Das J, Pal PB, Sil PC (2013) Oxidative stress: the mitochondrial dependent and independent pathways of apoptosis. Arch Toxicol 87(7):1157-1180.

29.BhattacharyaS, GachhuiR, Sil PC (2013) Effect of Kombucha, a fermented black tea in attenuating oxidative stress mediated tissue damage in alloxan induced diabetic rats. Food Chem Toxicol60:328-340.

30.Manna P, Das J, Sil PC(2013) Role of sulfur containing amino acids as an adjuvant therapy in the prevention of diabetes and its associated complications. Curr Diabetes Rev9(3):237-248.

31.Bhattacharyya S, Pal PB, Sil PC(2013) A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food Chem Toxicol56:119-130.

32.Ghosh J, Sil PC (2013) Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine. Biochimie 95(6):1098-1109.

33.BhattacharyaS, GachhuiR, Sil PC (2013) The prophylactic role of D-saccharic acid-1,4-lactone against hyperglycemia-induced hepatic apoptosis via inhibition of both extrinsic and intrinsic pathways in diabetic rats. Food Func4(2):283-296.

34.Pal PB, Sinha K, Sil PC (2013) Mangiferin, a natural xanthone, protects murine liver in Pb(II) induced hepatic damage and cell death via MAP kinase, NF-<kappa>B and mitochondria dependent pathways. PLoS ONE8(2):e56894.

35.BhattacharyS, Manna P, GachhuiR, Sil PC (2013) D-saccharic acid 1,4-lactone protects diabetic rat kidney by ameliorating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via NF-<kappa>B and PKC signaling. Toxicol Appl Pharmacol 267(1):16-29.

36.Rashid K, Das J, Sil PC (2013) Taurine ameliorate alloxan induced oxidative stress and intrinsic apoptotic pathway in the hepatic tissue of diabetic rats. Food Chem Toxicol51(1):317-329.

37.Manna P, Ghosh M, Ghosh J,Das J, Sil PC(2012) Contribution of nano-copper particles to in vivo liver dysfunction and cellular damage:Role of IκBα/NF-κB, MAPKs and mitochondrial signal. Nanotoxicology 6(1):1-21.

38.Bhattacharyya S, Ghosh J, Sil PC (2012) Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine. Free Radic Res 46(10):1296-1307.

39.Das J, SilPC (2012) Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. Amino Acids 43(4):1509-1523.

40.Pal S, Ahir M, Sil PC (2012) Doxorubicin-induced neurotoxicity is attenuated by a 43-kD protein from the leaves of Cajanus indicus L. via NF-κB and mitochondria dependent pathways. Free Radic Res 46(6):785-798.

41.Roy A, Sil PC (2012) Tertiary butyl hydroperoxide induced oxidative damage in mice erythrocytes: Protection by taurine. Pathophysiology19(2):137-148.

42.Pal S, Sil PC (2012)A 43 kD protein from the leaves of the herb Cajanus indicus L. modulates doxorubicin induced nephrotoxicity via MAPKs and both mitochondria dependentand independent pathways. Biochimie 94:1356-1367.

43.Ghosh M, Das J, Sil PC(2012) D(+) galactosamine induced oxidative and nitrosative stress-mediated renal damage in rats via NF-B and inducible nitric oxide synthase (iNOS) pathways is ameliorated by a ployphenol xanthone, mangiferin. Free Radic Res46(2):116-132.

44.Das J, Vasan V, Sil PC(2012) Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improvesinsulin-mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis. Toxicol Appl Pharmacol 258:296–308.

45.Pal PB, Pal S, Manna P, Sil PC (2012)Traditional extract of Pithecellobium dulce fruits protects mice against CCl 4 induced renal oxidative impairments and necrotic cell death. Pathophysiology19(2):101-114.

46.Pal PB, Pal S, Das J, Sil PC (2012) Modulation of mercury-induced mitochondria-dependent apoptosis by glycine in hepatocytes. Amino Acids42:1669–1683.

47.Roy A, Sil PC (2012) Taurine protects murine hepatocytes against oxidative stress-induced apoptosis by tert-butyl hydroperoxide via PI3K/Akt and mitochondrial-dependent pathways. Food Chem 131:1086-1096.

48.Manna P, Sil PC(2012) Arjunolic acid: benefi cial role in type 1 diabetes and its associated organpathophysiology.Free Radic Res46(7):815-830.

49.Das J, Ghosh J, Roy A, Sil PC (2012) Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFB pathways. Toxicol Appl Pharmacol260:35–47.

50.Manna P, Sil PC(2012) Impaired redox signaling and mitochondrial uncoupling contributes vascular inflammation and cardiac dysfunction in type 1 diabetes: Protective role of arjunolic acid. Biochimie 94:786-797.

51.Das J, Ghosh J, Manna P, Sil PC(2012) Taurineprotects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis Amino Acids42:1839–1855.

52.Rashid K, Bhattacharya S, Sil PC (2012) Protective role of D-saccharic acid-1,4-lactone in alloxan induced oxidative stress in the spleen tissue of diabetic rats is mediated by suppressing mitochondria dependent apoptotic pathway. Free Radic Res46(3):240–252.

53.Das J, Roy A, Sil PC (2012) Mechanism of the protective action of taurine in toxin and drug induced organ pathophysiology and diabetic complications: a review. Food Func3(12):1251–1264.

54.Ghosh J, Das J, Manna P, Sil PC(2011) The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53 mediated cardiac apoptosis. Biomaterials 32(21):4857-4866.

55.BhattacharyaS, Manna P, GachhuiR, Sil PC (2011) D-saccharic acid-1,4-lactone ameliorates alloxan-induced Diabetes mellitus and oxidative stress in rats through inhibiting pancreatic beta-cells from apoptosis via mitochondrial dependent pathway.Toxicol Appl Pharmacol 257:272-283.

56.Sarkar A, Manna P, Das J, Sil PC (2011) Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways. Toxicology 290:208-217.

57.Sarkar K, Sil PC (2011) Cajanus indicus leaf protein: Beneficial role in experimental organ pathophysiology. A review. Pathophysiology18(4):295-303.

58.Datta P, Mukhopadhyay AP, Manna P, Tiekink ER, Sil PC, Sinha C (2011) Structure, photophysics, electrochemistry, DFT calculation, and in-vitro antioxidant activity of coumarin Schiff base complexes of Group 6 metal carbonyls.J Inorg Biochem105(4):577-588.

59.Das J, Ghosh J, Manna P, Sil PC (2011)Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK.Biochem Pharmacol 81(7):891-909.

60.Pal S, Pal PB, Das J,Sil PC (2011) Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. Toxicology 283(2-3):129-139.

61.Ghosh M, Manna P, Sil PC (2011)Protective role of a coumarin derived schiff base scaffold against TBHP induced oxidative impairment and cell death via MAPKs, NFκB and mitochondria dependent pathways. Free Radic Res 45(5): 620-637.

62.BhattacharyaS, GachhuiR, Sil PC (2011) Hepatoprotective properties of Kombucha tea against TBHP-induced oxidative stress via suppression of mitochondria dependent apoptosis. Pathophysiology18(3):221-234.

63.Manna P, Bhattacharyya S,Das J, Ghosh J, Sil PC (2011) Phytomedicinal Role of Pithecellobium dulce against CCl4-mediated Hepatic Oxidative Impairments and Necrotic Cell Death.Evid-Based Compl Altern MedArticle ID 832805, 17 pages,doi: 10.1155/2010/neq065.

64.BhattacharyaS, ChatterjeeS, Manna P, Das J, Ghosh J, GachhuiR, Sil PC (2011) Prophylactic role of D-saccharic acid-1,4-lactone in tertiary butyl hydroperoxide induced cytotoxicity and cell death of murine hepatocytes via mitochondria dependent pathways. J Biochem Mol Toxicol25:341-354.

65.BhattacharyaS, Manna P, GachhuiR, Sil PC (2011) Protective effect of Kombucha tea against tertiary butyl hydroperoxide induced cytotoxicity and cell death in murine hepatocytes. Indian J Exp Biol 49(7):511-524.

66.Ghosh J, Das J, Manna P, Sil PC(2010) Hepatotoxicity of di-(2-ethylhexyl)phthalate is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization, and ERK/NF-κB pathway activation. Free Radic Biol Med49:1779-1791.

67.Ghosh J, Das J, Manna P, Sil PC(2010) Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chem 123:1062-1073.

68.Das J, Ghosh J, Manna P, Sil PC (2010) Protective Role of Taurine against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis via the Inhibition of PKC-JNK Pathway. PLoS ONE5:e12602.

69.Sarkar MK, Sil PC(2010) Prevention of tertiary butyl hydroperoxide induced oxidative impairment and cell death by a novel antioxidant protein molecule isolated from the herb, Phyllanthus niruri.Toxicol In Vitro 24:1711–1719.

70.Manna P, Das J, Ghosh J, Sil PC(2010) Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent Prophylactic role of arjunolic acid. Free Radic Biol Med 48:1465–1484.

71.Manna P, Ghosh J, Das J, Sil PC(2010) Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: Protective role of arjunolic acid. Toxicol Appl Pharmacol 244:114-129.

72.Ghosh J, Das J, Manna P, Sil PC(2010) Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection.Free Radic Biol Med 48:535-553.

73.Das J, Ghosh J, Manna P, Sil PC.(2010) Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 269(1):24-34.

74.Ghosh J, Das J, Manna P, Sil PC(2010) Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: Therapeutic potential of arjunolic acid.Toxicology 268:8-18.

75.Das J, Ghosh J, Manna P, Sil PC(2010) Acetaminophen induced acute liver failure via oxidative stress and JNK activation: Protective role of taurine by the suppression of cytochrome P450 2E1.Free Radic Res 44(3):340-355.

76.Manna P, Sinha M, Sil PC(2009) Prophylactic role of arjunolic acid in response to streptozotocin mediated diabetic renal injury: Activation of polyol pathway and oxidative stress responsive signaling cascades. Chem Biol Interact 181:297-308.

77.Sinha M, Manna P, Sil PC(2009) Induction of necrosis in cadmium-induced hepatic oxidative stress and its prevention by the prophylactic properties of taurine.J Trace Elem Med Biol 23(4):300-313.

78.Roy A, Manna P, Sil PC (2009) Prophylactic role of taurine on arsenic mediated oxidative renal dysfunction via MAPKs/NF-kappaB and mitochondria dependent pathways.Free Radic Res 43:995-1007.

79.Ghosh J, Das J, Manna P, Sil PC(2009) Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kappaB, p38 and JNK MAPK pathway.Toxicol Appl Pharmacol 240:73-87 [Cover page].

80.Das J, Ghosh J, Manna P, Sinha M, Sil PC(2009) Arsenic-induced oxidative cerebral disorders: protection by taurine.Drug Chem Toxicol 32(2):93-102.