Evaluation of Hepatitis B Vaccine on Antibody Production in Health Care Workers in North

Evaluation of Hepatitis B Vaccine on Antibody Production in Health care workers in North West of Iran, 2012

Karimi Zarchi Ali Akbar (PhD)1, Mehrabi Tavana Ali (PhD)2, Akbari Ali(Msc) 3, Hormoz Sanaiinasab4

1. Corresponding Author: Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, I.R. of Iran

Tel: +989122033898

Fax: +982126127252

Email:

2.Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran,

3. Department of Epidemiology and Biostatistics. Faculty of Health, Baqiatallah University of Medical Sciences, Tehran, I.R. of Iran. Ali

4. Health Education Department, school of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background

Hepatitis B virus (HBV) infection is a problem and between 350 and 400 million persons is estimated to suffer from thisinfectionWorldwide. No epidemiologic studies have been done about the vaccination status and the effect of the Hepavac vaccineamong the Health care workers in North West of Iran.

Objectives

This study aimed to evaluate the efficacy of Hepavac vaccine on antibody levels in different time amongHealth careworkers.

Patients and Methods

The cross-sectional study was performed on Twenty hundred Health careworkers.Data collection was done by interview and by the use of a questionnaire and Body mass index (BMI) was computed from measured height and weight by personnel as weight/height2 (kg/m2). To determine the immunogenicity of the vaccine (Hpavac) HBs-Ab titers were measured in two steps with a given time interval. The data collected were analyzed using SPSSversion 18.0 software. Using descriptive statistics, the chi-square test and Fisher's exact test was used to compare groups and the Odds Ratio for strength of associations.

Results

The age mean of the participants was 36.2 years (SD=7.5).Sixty five percent of them were female and 85 percent of them were married at the time of the study. The body mass index of the 43% of the participant was normal. Mean (Standard deviation) of HBs-Ab in first and second titration were 444 ml/IU (229ml/IU) and 403ml/IU (228ml/IU) respectively. The associations of the HBs-Ab production with gender (P=0.012), as well as the frequency of vaccination(P=0.000) were statistically significant but not associated with BMI, family history of hepatitis, Jaundice, immunoglobulin injected, ethnicity, needle stick, cupping and tattoo.

Conclusion

Received three doses of hepatitis B vaccine can produce safe level of HBs-Ab, but reduced with elapse time and some people were no response to vaccination. It should be suggested that Health care workers must be checked for their immunity against HBV periodically and because of reduce titer rate regarding time passes, they should be completed their vaccination program especially in early of starting their jobs.

Keywords: Hepatitis B virus, HBs- Antibody, Cupping, Needle Stick,Tattoo.