Disease / Brain region / Level of atrophy
Prominent / Not prominent or absent / Not assessed
Corticobasal
degeneration / Frontal lobe / 1, 2, 3, 4, 5, 6, 7 / 10 / 9
Temporal lobe / 5, 6 / 1, 2, 3, 4, 8, 10 / 9
Parietal lobe / 1, 4, 5, 6 / 40, 41, 48 / 9, 10
Insula / 1, 2, 3, 5, 6 / 8 / 4, 9, 10
Striatum / 1, 2, 3, 5, 6, 8 / 10 / 4, 9
Anterior cingulate / 6 / 1, 2, 3, 5, 8 / 4, 9, 10
Corpus callosum‡ / 1, 4 / 6 / 2, 3, 5, 8, 9, 10
Brainstem / 5, 8, 9, 10 / 1, 2, 3, 6 / 4
Progressive
supranuclear palsy / Frontal lobe / 1, 2 / N.D. / 7, 9
Temporal lobe / N.D. / 1, 2 / 7,9
Parietal lobe / N.D. / 1, 2 / 7, 9
Insula / N.D. / 1, 2 / 7, 9
Striatum / 1, 2 / N.D. / 7, 9
Anterior cingulate / N.D. / 1, 2 / 7, 9
Corpus callosum‡ / N.D. / 12 / 2, 7, 9
Brainstem / 1, 7, 9 / 2* / N.D.
Pick’s disease / Frontal lobe / 3, 5, 6, 11 / N.D. / N.D.
Temporal lobe / 3, 5, 6, 11 / N.D. / N.D.
Parietal lobe / N.D. / 3, 5, 6, 11 / N.D.
Insula / 3, 5, 6, 11 / N.D. / N.D.
Striatum / 3, 5, 6, 11 / N.D. / N.D.
Anterior cingulate / 3, 5, 6, 11 / N.D. / N.D.
Corpus callosum† / 6 / N.D. / 3, 5, 11
Brainstem / 3, 5, 6, 11 / N.D.
MAPT-associated FTLD / Frontal lobe / 6, 11, 13, 14, 15, 16 / N.D. / N.D.
Temporal lobe / 6, 11, 13, 14, 15, 16 / N.D. / N.D.
Parietal lobe / 15, 16 / 44, 53, 63, 64 / N.D.
Insula / 6, 11, 13, 14, 15, 16 / N.D. / N.D.
Striatum / 11, 14, 15, 16 / 6, 13 / N.D.
Anterior cingulate / 14 / 6, 11, 13, 15, 16 / N.D.
Corpus callosum / N.D. / 6, 13 / 11, 14, 15, 16
Brainstem / N.D. / 6, 11, 13, 14, 15, 16 / N.D.
Numbers represent references. *Only grey matter loss was assessed in the brainstem of reference 2. ‡Only included in studies that assessed white matter. Patient overlap may have occurred between studies6 and 13, 15 and 16, 1 and 2, 1 and 3. Abbreviations: FTLD, frontotemporal lobar degeneration; N.D., no data.
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