Supplementary Materials For s2

Supplementary materials for

A novel transdermal drug delivery system based on self-adhesive Janus nanofibrous film with high breathability and monodirectional water-penetration

Yongli Shi1, Yue Li1, Jianming Wu2, Weiguo Wang2, Anjie Dong1,

Jianhua Zhang1,3*

1School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

2 Yingtan People's hospital, Yingtan, 335000, China

3Tianjin Key Laboratory of Membrane Science and Desalination Technology, Tianjin University, Tianjin 300072, PR China

*Corresponding author: Jianhua Zhang

E-mail address: ; Tel.: +862 227 402 364; Fax: +862 227 890 710.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

Figure S1. Morphology of HPSA nanofibers with different amount of PVP; (a) HPSA without Azone and PVP; (b) HPSA with 5% Azone and 10% PVP; (c) HPSA with 5% Azone and 30% PVP; (d) HPSA with 5% Azone and 50% PVP; (e) PVP.

To improve the electrospinnability of HPSA, PVP was added into HPSA solutions. The morphologies of HPSA nanofibers with different amount of PVP were shown in Figure S1. It could be seen the PVP content in HPSA could exert a powerful impact on the morphology of HPSA nanofibers. The better morphology of HPSA nanofibers can be achieved by using higher content of PVP.

HPSA casting film, Thickness = 55 μm

HPSA fibrous film with 5% Azone and 10% PVP, Thickness = 53 μm

HPSA fibrous film with 5% Azone and 30% PVP, Thickness = 49 μm

HPSA fibrous film with 5% Azone and 50% PVP, Thickness = 57 μm

Figure S2. 180° peal strength of HPSA casting film and HPSA electrospinning fibrous film with different amount of PVP

To apply in transdermal patches, HPSA electrospinning film should have certain adhesive strength. The 180° peal strength of HPSA casting film and HPSA electrospinning fibrous film with different amount of PVP (25 × 200 mm) were measured by Testometric AX M350-10KN Materials Testing Machine (Testometric Company, Germany) at a peel rate of 300 mm/min at 25 °C, and results were shown in Figure S2. The 180° peal strength of HPSA casting film with thickness of 55 μm was about 11 N/ 25mm. Apparently, the PVP content in HPSA fibrous films could exert a strong influence on their adhesive properties. The increase of the content of PVP fibrous films decreased the adhesive properties. Under similar condition, the 180° peal strengths of HPSA fibrous film with 10%, 30% and 50% PVP were about 6.6, 3.0 and 1.6 N/ 25mm, respectively.

Figure S3. DSC thermograms of HPSA, HPSA with 10% PVP and PVP