Table 1. Demographics of study groups

TB cases / Age / Sex / MT
(Mean ±SD) / M/F / (Mean ±SD)
PTB (n=15) / 32.06±12.03 / 3/12 / 16.53±9.07
EC (n=43) / 29.41±10.69 / 19/25 / 7.80±8.00*

*P=0.001 using student’s t test

Table 2. Recovery rate of TB patients post chemotherapy

Disease parameters
(positive for sign/tested) / 0 months / 6 months / 12 months / 24 months
#Signs and symptoms / 15/15 / 6/15 / 4/15 / 2/15
Fever / 15/15 / 1/15 / 2/15 / 0/15
*ESR / 14/15 / 14 /15 / 14/15 / 11/15
Lung lesions / 15/15 / 10/15 / 6/15 / 2/15

# includes cough, night sweats and weight loss shown in Table S2

*ESR>30mm/hr


Table 3. Radiological recovery in relation to extent of pulmonary disease at intake

TB cases (N) / Fast / intermediate / Slow
PMN (1) / 0 / 0 / 1
PMD (8) / 1 / 4 / 3
PMD-HLN (4) / 4 / 0 / 0
PMD-PE (1) / 0 / 0 / 1
PAD –HLN-PE (1) / 0 / 0 / 1
Total / 5 / 4 / 6

Table 4. Summary of cytokine clustering in relation to rate of radiological recovery

Serial no / TB ID / Extent of Disease / Radiological recovery / IL2 IL4 / IL2 IL4 IL10 / IL2 IL4 IL10 IFNγ
1 / TB268 / PMD-HLN / FAST / C1 / C1 / C1
6 / TB282 / PMD-HLN / FAST / C1 / C3 / C3
7 / TB283 / PMD-HLN / FAST / C1 / C3 / C3
8 / TB285 / PMD-HLN / FAST / C1 / C3 / C3
9 / TB290 / PMD / FAST / C1 / C3 / C3
2 / TB270 / PMD / INT / C1 / C1 / C1
4 / TB272 / PMD / INT / C1 / C3 / C3
5 / TB273 / PMD / INT / C1 / C1 / C1
3 / TB271 / PMD / INT / C2 / C2 / C2
10 / TB291 / PMD / SLOW / C2 / C2 / C2
11 / TB298 / PAD-HLN-PE / SLOW / C2 / C2 / C2
12 / TB299 / PMD / SLOW / C2 / C1 / C1
13 / TB300 / PMD-PE / SLOW / C2 / C2 / C1
14 / TB301 / PMN / SLOW / C2 / C2 / C1
15 / TB302 / PMD / SLOW / C2 / C2 / C2

Suppl.Table S1. Detailed characteristics of pulmonary tuberculosis patients

Lab. ID / Age / Sex / Severity of Disease / Extra-Pulmonary site / Duration of Rx / ATT / AFB (grading) / MT(mm)
TB268 / 45 / F / PMD / HLN / 18 days / R/E/P / ++ / 22
TB270 / 59 / F / PMD / 6days / R/E/P / ++ / 28
TB271 / 32 / F / PMD / 6days / R/E/P / ++ / 0
TB272 / 30 / F / PMD / 7days / R/E/P / ++ / 0
TB273 / 25 / F / PMD / 2 days / R/E/P / ++ / 0
TB282 / 18 / F / PMD / HLN / 6 days / R/E/P / ++ / 22
TB283 / 40 / F / PMD / HLN / 10 days / R/E/P / ++ / 18
TB285 / 18 / F / PMD / HLN / 4 days / R/E/P / ++ / 25
TB290 / 20 / F / PMD / 2 days / R/E/P / ++ / 17
TB291 / 45 / M / PMD / 4 days / R/E/P / ++ / 16
TB298 / 18 / F / PAD / HLN+Pl.eff / 14days / R/E/P/S / ++ / 20
TB299 / 40 / F / PMD / 9days / R/E/P / ++ / 18
TB300 / 30 / M / PMD / Pl.eff / 24days / R/E/P / ++ / 22
TB301 / 35 / F / PMN / 4days / R/E/P / ++ / 20
TB302 / 26 / M / PMD / 4days / R/E/P / ++ / 20

HLN: Hilar Lymphnode, Pl.eff: Pleural Effusion, R: Rifampicin, E: Ethambutol, P: Pyrazinamide, S: Streptomycin.

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Suppl. Table S2: Detail follow- up of clinical symptoms, signs, radiological and hematological (ESR) recovery

Lab. ID / FU
month / Pulmonary severity / EP / Cough / Chest Pain / Night sweats / Weight Loss / Fever / ESR / Calcified / Localized / Diffused / LN / PE / Time
of
Recovery / Recovery
TB268 / 0 / PMD / HLN / y / y / y / y / y / 30 / y / y / n / y / n
TB268A / 6 / n / n / n / n / n / 33 / y / n / n / n / n / 6 / Fast
TB268B / 12 / n / n / n / n / n / 37 / n / n / n / n / n
TB268C / 24 / n / n / n / n / n / 35 / n / n / n / n / n
TB270 / 0 / PMD / y / y / y / y / y / 103 / n / y / y / n / n
TB270A / 6 / n / n / n / n / n / 60 / n / n / y / n / n
TB270B / 12 / n / n / n / n / n / 40 / y / n / n / n / n / 12 / Intermediate
TB270C / 24 / n / n / n / n / n / 30 / n / n / n / n / n
TB271 / 0 / PMD / y / y / y / n / y / 35 / n / y / n / n / n
TB271A / 6 / n / n / n / n / n / 30 / n / y / n / n / n
TB271B / 12 / n / n / n / n / n / 29 / n / n / n / n / n / 12 / Intermediate
TB271C / 24 / n / n / n / n / n / 25 / n / n / n / n / n
TB272 / 0 / PMD / y / y / y / y / y / 123 / n / n / y / n / n
TB272A / 6 / n / n / n / n / n / 110 / n / y / n / n / n
TB272B / 12 / n / n / n / n / n / 100 / n / n / n / n / n / 12 / Intermediate
TB272C / 24 / n / n / n / n / n / 38 / n / n / n / n / n
TB273 / 0 / PMD / y / y / y / y / y / 140 / n / n / y / n / n
TB273A / 6 / y / y / n / y / n / 89 / n / n / y / n / n
TB273B / 12 / n / n / n / n / y / 60 / n / n / n / n / n / 12 / Intermediate
TB273C / 24 / y / n / n / n / n / 35 / n / n / n / n / n
TB282 / 0 / PMD / HLN / y / y / y / y / y / 60 / n / y / n / y / n
TB282A / 6 / y / n / n / n / n / 45 / n / n / n / n / n / 6 / Fast
Lab. ID / FU
month / Pulmonary severity / EP / Cough / Chest Pain / Night sweats / Weight Loss / Fever / ESR / Calcified / Localized / Diffused / LN / PE / Time
of
Recovery / Recovery
TB282B / 12 / y / n / n / n / n / 35 / n / n / n / n / n
TB282C / 24 / n / n / n / n / n / 30 / n / n / n / n / n
TB283 / 0 / PMD / HLN / y / y / y / y / y / 100 / n / n / y / y / n
TB283A / 6 / n / n / n / n / n / 55 / y / n / n / n / n / 6 / Fast
TB283B / 12 / n / n / n / n / n / 45 / n / n / n / n / n
TB283C / 24 / n / n / n / n / n / 20 / n / n / n / n / n
TB285 / 0 / PMD / HLN / y / y / y / y / y / 60 / n / n / y / y / n
TB285A / 6 / n / y / n / n / y / 50 / n / n / n / n / n / 6 / Fast
TB285B / 12 / n / n / n / n / y / 40 / n / n / n / n / n
TB285C / 24 / y / n / n / n / n / 35 / n / n / n / n / n
TB290 / 0 / PMD / y / y / y / y / y / 29 / n / n / n / n / n
TB290A / 6 / n / n / n / n / n / 20 / n / n / n / n / n / 6 / Fast
TB290B / 12 / n / n / n / n / n / 55 / n / n / n / n / n
TB290C / 24 / n / n / n / n / n / 29 / y / n / n / n / n
TB291 / 0 / PMD / y / y / y / y / y / 100 / n / n / y / n / n
TB291A / 6 / n / n / n / n / n / 32 / n / y / n / n / n
TB291B / 12 / n / n / n / n / n / 100 / n / y / n / n / n
TB291C / 24 / n / n / n / n / n / 45 / n / y / n / n / n / 24 / slow
TB298 / 0 / PAD / HLN / y / y / y / y / y / 110 / y / n / y / y / n
TB298A / 6 / PE / y / n / n / n / n / 50 / n / n / n / n / y
TB298B / 12 / n / n / n / n / n / 40 / n / n / y / n / n
TB298C / 24 / n / n / n / n / n / 55 / n / n / n / n / n / 24 / Slow
TB299 / 0 / PMD / y / y / y / y / y / 50 / n / y / n / n / n
TB299A / 6 / n / n / n / n / n / 80 / n / y / n / n / n
TB299B / 12 / n / n / n / n / n / 70 / n / y / n / n / n
Lab. ID / FU
month / Pulmonary severity / EP / Cough / Chest Pain / Night sweats / Weight Loss / Fever / ESR / Calcified / Localized / Diffused / LN / PE / Time
of
Recovery / Recovery
TB299C / 24 / n / n / n / n / n / 30 / n / n / n / n / n / 24 / slow
TB300 / 0 / PMD / PE / y / y / y / y / y / 50 / n / n / y / n / y
TB300A / 6 / y / n / n / n / n / 45 / n / y / n / n / n
TB300B / 12 / n / n / n / n / n / 39 / n / n / y / n / n
TB300C / 24 / n / n / n / n / n / 35 / n / n / n / n / n / 24 / slow
TB301 / 0 / PMN / y / y / y / y / y / 65 / n / y / n / n / n
TB301A / 6 / n / n / n / n / n / 40 / n / y / n / n / n
TB301B / 12 / y / n / n / n / n / 60 / n / y / n / n / n
TB301C / 24 / n / n / n / n / n / 50 / n / n / n / n / n / 24 / slow
TB302 / 0 / PMD / y / y / y / y / y / 100 / n / y / n / n / n
TB302A / 6 / y / n / n / n / n / 38 / n / y / n / n / n
TB302B / 12 / n / n / n / n / n / 39 / n / y / n / n / n
TB302C / 24 / n / n / n / n / n / 25 / n / n / n / n / n / 24 / slow

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