Supplementary material

Description of the neuropsychological tests

-Hooper Organization Visual Test (HOVT): this test consists of 30 fragmented and disorganized drawings which the subject must mentally associate and recognize. The examiner has to register the number of correct answers (1 point) and nearlycorrect answers (0.5 points). The maximum score is 30 points.

-Facial Recognition Test (FRT): this test consists of 22 prints with 7 photographs of unknown faces in each one; one of the photographs is considered the stimuli and the others are the possible answers. The stimuli appear at the top of the print and the others at the bottom (two rows of three photographs). The subject must match the model with other identical photographin the first six items. In the following 16 items, the subject must match the model with photographs with the same face taken from a different angle of view and/or illumination. Each correct answer scores with 1 point. The maximum score is 54 points.

-Judgement Line Orientation Test (JLOT): this test consists of 30 prints with a model of 11 numbered identical lines displayed in a semicircular fashion at the bottom of the print with different orientations. At the top of the print there are two other lines which have the reference orientation for the subject. The examiner registers the correct answers (the recognition of the orientation of the two tested lines).

Supplemental figure I

Example of an “SAH with impairment” patient (patient number 2). (A) CT scan slices showing the extension of the SAH in the interhemispheric fissure and the right Sylvian fissure; (B) Digital angiography showing an inferiorly oriented anterior communicating artery aneurysm and a postoperative CT scan showing the artefact produced by the coils used for the treatment; (C) Pattern of brain activity in the contrast patient activity > healthy controls activity; greater activity is in the MNS regions during execution and observation conditions (areas in red represent higher activity in the patient than in the control group in the conjunction analysis).

Supplementary tables

Supplementary table I.Clinical features of the patients included in the study. “SAH with impairment” patients are highlighted.
Patient / Age / Gender / Location of the lesion / Hunt-Hess/WFNS / Fisher / Bleeding distribution / Follow-up (months) / Treatment
1 / 42 / Male / Negative angiography / 4/4 / 2 / Interpeduncular cistern. / 61,93 / -
2 / 44 / Female / Anterior communicating artery / 2/1 / 3 / Interhemispheric.
Both Sylvian fissures (larger on the right one). / 49,10 / Coiling
3 / 32 / Female / Negative angiography / 2/2 / 3 / Basal cisterns / 27,17 / -
4 / 33 / Male / Carotídeo bifurcación izquierda / 1/1 / 2 / Basal cisterns.
Right parietal convexity. / 30,20 / Coiling
5 / 49 / Male / Anterior communicating artery / 4/5 / 3 / Basal cisterns. Interhemispheric.
Right Sylvian fissure. / 22,67 / Clipping
6 / 39 / Male / Anterior communicating artery / 2/1 / 3 / Basal cisterns.
Right Sylvian fissure. / 34,67 / Stent+Coiling
7 / 50 / Female / Right posterior communicating artery / 1/1 / 2 / Basal cisterns. / 65,00 / Coiling
8 / 44 / Female / Left posterior communicating artery / 2/1 / 2 / Basal cisterns.
Left Sylvian fissure. / 17,60 / Coiling
9 / 43 / Female / Left middle cerebral artery / 1/1 / 3 / Basal cisterns.
Both Sylvian fissures (larger on the left one) / 39,87 / Coiling
10 / 42 / Female / Negative angiography / 4/4 / 3 / Right Sylvian fissure.
Convexity. / 11,80 / -
11 / 23 / Male / Negative angiography / 1/1 / 3 / Left parietal convexity. / 64,13 / -
12 / 35 / Male / Anterior Communicating Artery / 1/1 / 2 / Interhemispheric.
Both Sylvian fissures. / 41,90 / Clipping
WFNS: World Federation Neurological Societies SAH grading scale
Supplementary table II. Neuropsychological data from the visuo-spatial and visuo-perceptive evaluation. “SAH with impairment” patients are highlighted.
Patient / JLOT / HVOT / FRT
Score / Meaning / Score / Meaning / Score / Meaning
1 / 18,00 / MODERATE DEFICIT / 26,50 / LOW RISK OF IMPAIRMENT / 25,00 / NORMAL
2 / 12,00 / SEVERE DEFICIT / 18,00 / HIGH RISK OF IMPAIRMENT / 15,00 / SEVERE DEFICIT
3 / 26,00 / NORMAL / 28,00 / VERY LOW RISK OF IMPAIRMENT / 22,00 / NORMAL
4 / 23,00 / NORMAL / 30,00 / VERY LOW RISK OF IMPAIRMENT / 22,00 / NORMAL
5 / 17,00 / MODERATE DEFICIT / 24,00 / VERY LOW RISK OF IMPAIRMENT / 16,00 / SEVERE DEFICIT
6 / 29,00 / NORMAL / 25,00 / VERY LOW RISK OF IMPAIRMENT / 21,00 / NORMAL
7 / 22,00 / NORMAL / 22,00 / LOW RISK OF IMPAIRMENT / 21,00 / NORMAL
8 / 14,00 / SEVERE DEFICIT / 19,50 / MODERATE RISK OF IMPAIRMENT / 21,00 / NORMAL
9 / 25,00 / NORMAL / 28,00 / VERY LOW RISK OF IMPAIRMENT / 23,00 / NORMAL
10 / 21,00 / NORMAL / 28,00 / VERY LOW RISK OF IMPAIRMENT / 22,00 / NORMAL
11 / 26,00 / NORMAL / 29,00 / VERY LOW RISK OF IMPAIRMENT / 23,00 / NORMAL
12 / 27,00 / NORMAL / 28,00 / PROBABILIDAD MUY BAJA DAÑO / 24,00 / NORMAL
JLOT:judgement line orientation test.
HVOT: Hooper organization visual test.
FRT:facial recognition test.
Supplementary table III. Activation peaks with their locations for simple T contrasts in each group of patients (FWE<0.05 at cluster level; k=10 voxels).
Anatomical region / BA / Peak MNI coordinates / t -value / z - value / Num. Voxels
X / Y / Z
“SAH with impairment”
EXECUTION
Left Postcentral Gyrus / 1, 2, 3 / -38 / -30 / 58 / 13,02 / 65535,00 / 6763
Left Precentral Gyrus / 4 / -38 / -22 / 56 / 12,88 / 65535,00
Left Postcentral Gyrus / 1, 2, 3 / -52 / -28 / 44 / 11,40 / 65535,00
Left Medial Frontal Gyrus / 6 / -6 / 56 / 24 / 5,65 / 5,55 / 582
Left Superior Frontal Gyrus / -6 / 48 / 36 / 4,50 / 4,45
Right Cerebellum / - / 20 / -62 / -24 / 5,64 / 5,54 / 848
Right Cerebellum / 24 / -58 / -30 / 5,59 / 5,50
Right Inferior Parietal Lobule / 40 / 42 / -48 / 52 / 4,96 / 4,89 / 847
56 / -34 / 46 / 4,80 / 4,73
42 / -42 / 58 / 4,71 / 4,65
Left Inferior Frontal Gyrus / 44 / -56 / 16 / 0 / 4,69 / 4,63 / 77
OBSERVATION
Left Superior Frontal Gyrus / 6 / -6 / -18 / 72 / 5,61 / 5,51 / 1644
Left Superior Frontal Gyrus / -16 / -14 / 70 / 5,10 / 5,03
Right Medial Frontal Gyrus / 8 / -18 / 72 / 4,70 / 4,64
Left Postcentral Gyrus / 1, 2, 3 / -34 / -38 / 62 / 4,62 / 4,56 / 523
Left Postcentral Gyrus / 1, 2, 3 / -46 / -36 / 50 / 4,42 / 4,37
Right Middle Frontal Gyrus / 6 / 34 / 46 / -8 / 4,46 / 4,41 / 412
“SAH without impairment”
EXECUTION
Left Postcentral Gyrus / 1, 2, 3 / -42 / -22 / 48 / 12,39 / 65535,00 / 2635
Left Inferior Parietal Lobule / 40 / -46 / -46 / 56 / 4,93 / 4,90
Right Cerebellum / - / 22 / -58 / -32 / 4,42 / 4,39 / 107
OBSERVATION
Left Postcentral Gyrus / 1, 2, 3 / -38 / -30 / 56 / 3.79 / 3.78 / 76
Right Middle Occipital Gyrus / 18, 19 / 46 / -68 / -8 / 3.47 / 3.46 / 26