Department of Post Graduate Studies in Shalya Tantra

FROM :

JANET ESTHER

Preliminary M.S.(Ayu) Scholar

Department of Post Graduate Studies in Shalya Tantra,

S.D.M College of Ayurveda and Hospital,

HASSAN- 573201.

To,

THE REGISTRAR

Rajiv Gandhi University Of Health Sciences Karnataka,

BANGALORE.

Through,

The Principal and Head of the Department of Shalya Tantra,

S.D.M College of Ayurveda and Hospital,

HASSAN – 573201.

Subject : “Submission of completed proforma for registration of subject for

Dissertation”.

Respected Sir ,

I request you to kindly register the below mentioned subject against my name for the submission of the Dissertation to Rajiv Gandhi University of Health Sciences Karnataka, Bangalore for partial fulfillment of M.S (Ayurveda).

Title of Dissertation:

“ ROLE OF TAGARADI COMPOUND IN THE MANAGEMENT OF PRE –OPERATIVE ANXIETY.”

Here with I am enclosing a completed proforma of synopsis for registration of the subject for Dissertation.

Thanking You,

Place : Hassan Yours faithfully,

Date : 05/11/2007 (Janet Esther)

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES

BANGALORE, KARNATAKA

ANNEXURE- II

COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT DISSERTATION

1. NAME OF THE CANDIDATE : JANET ESTHER

AND ADDRESSPRELIMINARY M.S ( AYU ) SCHOLAR

(IN BLOCK LETTERS) DEPARTMENT OF POST GRADUATE

STUDIES IN SHALYA TANTRA S.D.M.COLLEGE OF AYURVEDA AND

HOSPITAL , P.O. BOX NO. 164

HASSAN -573201

PERMANENT ADDRESS : D/O SUGANDHARAJU

H NO 377, SHANTHA NILAYA

KOTILINGA NAGAR

HUBLI – 580024

2. NAME OF THE INSTITUTE : S.D.M COLLEGE OF AYURVEDA AND

HOSPITAL, HASSAN- 573201.

3. COURSE OF STUDY IN : M.S (AYURVEDA) SHALYA TANTRA

SUBJECT

4. DATE OF ADMISSION TO : 2nd JUNE 2007

THE COURSE

5. TITLE OF THE DISSERTATION : “ROLE OF TAGARADI COMPOUND IN

THE MANAGAMENT OF PRE- OPERATIVE ANXIETY”.

6.BRIEF RESUME OF THE STUDY

6.1 Need for the study :

Surgical patients have a high incidence of Anxiety . Even with the modern advancement of instruments and procedures the fear of the procedures has not come down. Even for minor surgical procedures the patients become more anxious towards the operating room, the diseased condition, the surgical procedures and its outcome. Relief of this Anxiety is accomplished by pharmacological i.e., administration of drugs and Non Pharmacological i.e., Psychotherapy measures. In some cases Psychotherapy may be insufficient to allay these symptoms. Hence it is customary and traditional to administer Anxiolytic medication. Use of medicines to relieve Pre-Operative Anxiety can be considered as one of the Yukti Vyapashraya Chikitsa

In Ayurveda no drugs are mentioned for the management of Pre-Operative anxiety.Therefore Ayurvedic Surgeons use Modern Anxiolytic Medications . Hence there is a need to find out an effective medicine for Pre-Operative Anxiety from Ayurvedic Materia Medica .Hence here a study is designed to “Evaluate the Role of Tagaradi Compound as Pre-Operative Anxiolytic Drug.

Drugs which are taken in this study which includes Tagara (Vallerina wallichi) , Kushmanda (Benincasa hispida) , Ashvagandha (Withania somnifera) and Karpoora (Cinnamonum camphora) are having sedative and Anxiolytic property”.

6.2 Review of Literature :

1. In Charaka Samhita Vimana Sthana Chittodvega is mentioned 1

2. In Bhavaprakasha detail properties of the drugs taken for the study is mentioned. 2A

3. In K.M.Nadkarni’s Indian Materia Medica also details of the drugs is available. 2B

4. In Priyavrat Sharma’s Dravya Guna Vignana also the properties of the drugs is explained. 2C

5. Psycho-therapy and pharmaco-therapy is mentioned in Essentials of Psychiatry by Dr M.S.Bhatia. 3

6. Pre-operative Medication is explained in the book “ Drugs and Equipments in anaesthetic Practice” 4

7. The properties of the drugs is mentioned in Trease And Evans Pharmacognossy By William Charles Evans5

8. Diagnosis is made on the basis of the symptoms mentioned in

a) ICD-10, World Health Organisation,Geneva6a

b) Kaplan and Sadock’s Synopsis of Psychiatry 6b

c) Diagnostic and Statistical manual of Mental Disorders 6c

d) Shorter Oxford Text Book of Psychiatry 6d

Previous Research Works :

1.Dr Mukkawar G J (1980) – Anaesthesia and the role of certain Ayurvedic drugs credited to have Anaesthetic property. Jamnagar University

2.Dr Dixit ashok (1980) – Studies on role of Parasika Yavani as a Pre-Anaesthetic agent.

B.H.U

3.Dr Gulati .P.K (1985) – Role of Jatamansi in Anaesthesia . B.H.U

4.DrPandey Kuldeep Kumar (1990) – Evolution of Ashwagandha as Pre-Anaesthetic Medication B.H.U

5.Dr Sahajeev .Sharma (1991) – Studies on alchoholic extract of Ashwagandha as Pre-anaesthetic medication. B.H.U

6.Dr Dutt Anil (1993) – Comparitive clinical study of Brahmi and Ashwagandha as Pre-anaesthetic medication . B.H.U

7.Dr Mishra.S.K (1997) – Role of Vacha as Pre-medicament in Sangyaharana.

B.H.U

8.Dr Shilpa Sarekar (2000) – Evaluation of Jambu Pallava Kwatha as an Anti emetic Pre medication in Anaesthetic practice. Udupi

9.Dr Kakoda Mastan Rao (2003) – Evaluation of Sarpagandha effect as Pre-operative medication Hassan

10.Dr Bhat Manjunath (2003) – Evaluation of Jambu Pallava Kwatha as an Anti emetic Pre medication in Anaesthetic practice. Udupi

6.3 Objectives of Study :

1.To evaluate the effect of Tagaradi compound as a of Pre-operative Anxiolytic medication.

2.To compare the efficacies of Sarpagandha Churna and Tagaradi Compound as Pre-Operative Anxiolytic medications.

7 .MATERIALS AND METHODS :

7.1 Source of data :

Patients who are posted for elective surgery from S.D.M College of Ayurveda and Hospital, Hassan will be selected.

7.2 Methods of collection ofdata : It is a controlled clinical study

The selected patients will be randomly divided in to two groups , each group consisting of 15 patients of either sex.

Control Group In this group patients will be given Sarpagandha root powder in capsule form i.e., 500 mg twice daily for 2 days prior to surgery.

Treated Group :In this group the patients will be given Tagaradi Compound in capsule form i.e., 500 mg twice daily for 2 days prior to surgery.

Ingredients of Tagaradi Compound.

Tagara churna : 8 Parts
Kushmanda beeja churna : 4 Parts
Ashwagandha Churna : 4 Parts
Karpura Churna : 2 Parts

Method of preparation :

The above mentioned drugs are collected in dry forms. The are powdered and mixed in the Proportion of 8:4:4:2 respectively for Tagara,Kushmanda,Ashwagandha,Karpoora. Then the capsules of 500 mg is prepared and stored in an air tight container.

Diagnostic Criteria :

Diagnosis will be made on the basis of symptoms of Anxiety such as ,

Tension , worry.
Autonomic arousal symptoms.
Symptoms involving chest and abdomen.
Symptoms involving mental state.
General symptoms.

Inclusion Criteria :

Age group between 20 – 50 years.
Patients undergoing elective surgeries in Inguinal,Scrotal and Anorectal procedures under Anaesthesia .

Exclusion Criteria :

Patients suffering from severe systemic diseases such as Bronchial asthma , Cardiac diseases , Renal Failure etc.
Patients who have previously undergone any surgical procedure.
Patients having uncontrolled Hypertention.
Patients on Anti-depressant and Anti-psychotic drugs.

Assessment Criteria :

Objective parameters :

Blood Pressure
Pulse Rate
Rate of Respiration
Oxygen concentration

Subjective parameters :

Tension, Worry
Autonomic Arousal Symptoms
Symptoms involving Chest and Abdomen
Symptoms involving Mental State
General Symptoms
Symptoms of Tension
Other non specific symptoms.

For assessment “ Hamilton Anxiety Rating Scale ” will be considered.

7.3 Has Ethical clearance obtained from your institution : YES

8.List of Referances :

1. Charaka Samhita , Vidyotini Hindi Commentary By Pandit Kashinath Pandey and Dr Gorakhnath Chaturvedi , Chaukambha Bharati Academy Publications , 2001 Reprint , Vimana Sthana 6th Chapter 5th Shloka Page Number 717

2. A)Bhavaprakasha of Bhavamishra Volume 1, Translated By Prof K.R.Srikantha Murthy , Chawkambha Krishnadas Academy Publications , 2004 Reprint

a) Tagara – Karpuradi Varga , Pg No 210

b) Ashwagandha - Guduchyadi Varga , Pg No 257

c)Kushmanda – Shakavarga Pg No 387

d)Karpura- Karpuradi Varga ,Pg No 205.

B) Dr K.M.Nadkarni’s Indian Materia Medica, Revised and Edited By A.K.Nadkarni, Volume 1, Published By Popular Prakashan Private Limited , 3rd Edition ,1995 Reprint

a) Tagara – Pg No 1260

b)Ashwagandha – Pg No 1292

c)Kushmanda – Pg No 185

d)Karpura – Pg No 250

C)Dravyaguna Vignana By Priyavrat Sharma, 16th Edition , 1995 Reprint , Chawkambha Vishwabharati Publishers , Volume 2

a) Tagara – Pg No 64

b) Ashwagandha – Pg No 763

c) Kushmanda – Pg No 14

d) Karpura – Pg No 198

3.Essentials of Psychiatry by Dr M.S.Bhatia,C.B.S Publishers and Distributers, 5th Edition , 2006 Print, Section 13.8

4.Drugs and Equipments in Anaesthetic Practice 4th Edition , 2003 Reprint , Published By B.I.Churchill Livingstone Private Limited , Chapter 1, Pg No 3

5. Trease And Evans Pharmacognossy By William Charles Evans , 15th Edition , 2005 Print , Harcourt Publications.

a)Valleriana wallichii Pg No 35,76,318

b)Withania somnifera Pg No 82,88,313,418,480

c)Cinnamonum camphora Pg No 42,65,84,256,274,475

6 a) ICD 10 World Health Organisation Geneva, Mental and Behavioural Disorders , Pg 339 , Vol I , 10th Revision 2003 Print , A.I.T.B.S Publishers and Distributers, Delhi

b) Kaplan and Sadocks Concise Text Book of Clinical Psychiatry By Benjamin.J.Sadock and Virginia.A.Sadock Derived from Kaplan and sadocks synopsis of Psychiatry, Pg No 240, 9th Edition , 2004 Print , Jaypee Brothers Medical Publishers .

c) Diagnostic and Statistical Manual of Mental Disorders ,DSM IV TM 4th Edition ,

Anxitey Disorders Pg.No 395, Jaypee Brothers Medical Publications (P) Ltd.

d) Shorter Oxford Text Book of Psychiatry ,By Michael Gelder, Richard Mayou, and Philip Cowen, Anxiety and Obsessive Compulsive Disorders , Pg No 218, 4th Edition , 2002 Reprint.

9. Signature of the candidate :

10.Remarks of the Guide :

11.Name and Designation of :

( In Block Letters )

11.1 Guide : DR PRASANNA .N. RAO

M.S (Ayu), PhD.

PROFESSOR ,DEPARMENT OF

P.G. STUDEIES IN SHALYA TANTRA,

S.D.M COLLEGE OF AYURVEDA AND

HOSPITAL , HASSAN.

11.2 Signature :

11.3 Co- Guide : DR.avinash patak

M.S (Ayu).

ASST.PROFESSOR, DEPARTMENT OF

P.G STUDIES IN SHALYA TANTRA

S.D.M COLLEGE OF AYURVEDA AND

HOSPITAL, KUTHPADY, UDUPI.

DR. PRAVESH MISHRA

M.S (AYU)

LECTURER, DEPARTMENT OF

P.G STUDIES IN SHALYA TANTRA S.D.M COLLEGE OF AYURVEDA AND

HOSPITAL , HASSAN.

11.4 Signature :

11.5 Head of the Department : Dr P HEMANTHA KUMAR

MS (AYURVEDA ) IMS, BHU,PhD

PROFESSOR AND HOD, DEPARTMENT OF P.G.STUDIES IN SHALYA TANTRA

SDM COLLEGE OF AYURVEDA AND

HOSPITAL, HASSAN

11.6 Signature :

12.

12.1 Remarks of the chairman :

And the Principal

12.2 Signature :