Genus / Control / Intervention / ΔΔPrevalence§
Year-1 Prevalence / ΔPrevalence p-value* / Year-1 Prevalence / ΔPrevalence p-value*
Peptoniphilus / 92.21% / 0.3204 / 46.84% / <0.0001 / -40.41%
Anaerococcus / 92.21% / 1.0000 / 74.68% / 0.0601 / -11.39%
Unclassified Clostridiales / 84.42% / 0.2275 / 48.10% / <0.0001 / -35.31%
Prevotella / 90.91% / 0.4830 / 51.90% / <0.0001 / -34.21%
Finegoldia / 79.22% / 0.6576 / 48.10% / <0.0001 / -30.31%
Murdochiella / 66.23% / 0.0492 / 15.19% / <0.0001 / -43.94%
Porphyromonas / 80.52% / 0.3972 / 29.11% / <0.0001 / -43.10%
Corynebacterium / 92.21% / 0.0039 / 97.47% / <0.0001 / 13.46%
Unclassified Clostridiales Family XI / 71.43% / 0.6975 / 25.32% / <0.0001 / -43.07%
Dialister / 61.04% / 0.2780 / 16.46% / <0.0001 / -30.18%
Negativicoccus / 45.45% / 0.3726 / 10.13% / <0.0001 / -28.95%
Peptostreptococcus / 41.56% / 0.6576 / 16.46% / 0.0004 / -30.41%
Mobiluncus / 40.26% / 0.2918 / 10.13% / 0.0002 / -13.69%
Gardnerella / 44.16% / 1.0000 / 40.51% / 0.2391 / 7.56%
Lactobacillus / 41.56% / 0.3726 / 44.30% / 0.4015 / 1.07%
Staphylococcus / 62.34% / 0.0007 / 87.34% / <0.0001 / 36.08%
Saccharofermentans / 27.27% / 0.3565 / 12.66% / 0.0716 / -4.83%
Streptococcus / 44.16% / 0.0832 / 35.44% / 0.2761 / 1.00%
Actinomyces / 35.06% / 0.8588 / 10.13% / 0.0269 / -12.69%
Veillonella / 33.77% / 1.0000 / 20.25% / 1.0000 / 2.53%
Peptococcus / 18.18% / 0.0403 / 8.86% / 0.0281 / 5.42%
Olsenella / 24.68% / 0.8588 / 6.33% / 0.0008 / -16.42%
Arcanobacterium / 19.48% / 0.1028 / 5.06% / 0.0022 / -2.27%
Howardella / 23.38% / 0.8289 / 6.33% / 0.0832 / -3.76%
Parvimonas / 16.88% / 0.3972 / 15.19% / 0.6403 / 7.73%
Atopobium / 23.38% / 0.4177 / 13.92% / 0.8101 / -6.46%
Sneathia / 19.48% / 0.5519 / 11.39% / 0.4948 / -7.66%
Sutterella / 19.48% / 0.6576 / 2.53% / 0.0010 / -15.26%
Moryella / 14.29% / 0.4421 / 5.06% / 0.3204 / 0.10%
Peptostreptococcaceae Family / 5.19% / 0.0339 / 1.27% / 0.0186 / 0.26%
Treponema / 10.39% / 0.6202 / 5.06% / 0.0516 / -6.26%
Fusobacterium / 22.08% / 0.0191 / 13.92% / 0.6576 / -14.22%
Pyramidobacter / 9.09% / 0.1986 / 3.80% / 0.3204 / 2.73%
Facklamia / 22.08% / 0.3745 / 26.58% / 0.0053 / 9.96%
Anaerosphaera / 11.69% / 0.6404 / 8.86% / 0.3490 / -5.06%
Kocuria / 25.97% / 0.0734 / 45.57% / <0.0001 / 22.46%
Megasphaera / 14.29% / 0.7981 / 12.66% / 0.5962 / 1.23%
Micrococcus / 28.57% / 0.0096 / 39.24% / 0.0003 / 8.40%
Gemella / 19.48% / 0.2539 / 16.46% / 0.0704 / 2.37%
Ralstonia / 20.78% / 0.6404 / 2.53% / 0.5670 / -3.90%
Eubacterium / 14.29% / 1.0000 / 2.53% / 0.6576 / -1.27%
Eremococcus / 25.97% / 0.0014 / 39.24% / <0.0001 / 12.20%
Propionibacterium / 24.68% / 0.0244 / 30.38% / 0.0001 / 7.20%
Acinetobacter / 20.78% / 0.0734 / 30.38% / <0.0001 / 16.19%
Brevibacterium / 19.48% / 0.0107 / 43.04% / <0.0001 / 23.69%
Jeotgalicoccus / 19.48% / 0.0012 / 18.99% / 0.0022 / -1.69%
Dietzia / 16.88% / 0.5962 / 24.05% / 0.0039 / 13.79%
Pseudomonas / 14.29% / 0.0316 / 24.05% / 0.0059 / 8.60%
Brachybacterium / 14.29% / 0.0033 / 20.25% / 0.0040 / 4.73%
Janibacter / 14.29% / 0.0199 / 15.19% / 0.0516 / -1.59%
Salinicoccus / 12.99% / 0.0832 / 17.72% / 0.0316 / 4.87%
Helcococcus / 11.69% / 0.1326 / 29.11% / <0.0001 / 20.12%
Nesterenkonia / 11.69% / 0.2508 / 22.78% / 0.0002 / 16.32%
Paracoccus / 11.69% / 0.0573 / 20.25% / 0.0003 / 9.93%
Granulicatella / 11.69% / 0.0573 / 12.66% / 0.0832 / -0.20%
Sphingomonas / 9.09% / 0.7835 / 15.19% / 0.0704 / 7.56%
Ornithinimicrobium / 9.09% / 0.3204 / 13.92% / 0.4421 / 2.43%
Nosocomiicoccus / 9.09% / 0.0073 / 12.66% / 0.0059 / 2.30%
Haematobacter / 7.79% / 0.0583 / 16.46% / 0.0704 / 4.90%
Nocardioides / 7.79% / 0.1028 / 16.46% / 0.0192 / 8.73%
Methylobacterium / 7.79% / 0.4177 / 12.66% / 0.0059 / 8.80%
Weissella / 7.79% / 0.3204 / 7.59% / 0.4177 / 1.17%
Haemophilus / 7.79% / 0.1028 / 7.59% / 0.3204 / -1.40%
Moraxella / 7.79% / 0.1028 / 6.33% / 0.1028 / -0.13%
Gallicola / 7.79% / 0.4830 / 5.06% / 0.4177 / -0.07%
Delftia / 7.79% / 0.4830 / 3.80% / 0.6576 / -3.93%
Bulleidia / 7.79% / 1.0000 / 1.27% / 0.0583 / -6.33%
Solobacterium / 7.79% / 0.5306 / 1.27% / 0.5670 / -3.86%
Rothia / 6.49% / 0.1028 / 16.46% / 0.0192 / 8.73%
Comamonas / 6.49% / 0.4177 / 6.33% / 0.3204 / 2.47%
Stenotrophomonas / 6.49% / 0.1814 / 6.33% / 0.0244 / 2.43%
Marmoricola / 6.49% / 0.3204 / 5.06% / 0.0448 / -0.13%
Bifidobacterium / 5.19% / 0.4177 / 17.72% / 0.0022 / 17.79%
Bacillus / 5.19% / 1.0000 / 11.39% / 0.1326 / 6.26%
Bradyrhizobium / 5.19% / 0.0448 / 11.39% / 0.3691 / 1.13%
Brevundimonas / 5.19% / 1.0000 / 10.13% / 0.0958 / 8.86%
Sphaerobacter / 5.19% / 0.1814 / 7.59% / 0.5305 / -1.36%
Mycoplasma / 5.19% / 0.7080 / 5.06% / 0.7080 / -0.03%
Rhizobium / 5.19% / 0.1814 / 5.06% / 0.0448 / 1.17%
Leuconostoc / 5.19% / 0.1814 / 1.27% / 0.3204 / -2.63%
Roseomonas / 3.90% / 0.3204 / 13.92% / 0.0033 / 11.33%
Psychrobacter / 3.90% / 0.3204 / 11.39% / 0.0040 / 7.53%
Aerococcus / 3.90% / 0.4177 / 8.86% / 0.3204 / 6.39%
Flavobacterium / 3.90% / 0.0832 / 7.59% / 0.1028 / 3.70%
Sphingobacterium / 3.90% / 1.0000 / 6.33% / 0.0244 / 3.73%
Macrococcus / 3.90% / 0.5671 / 6.33% / 0.1028 / 1.17%
Zimmermannella / 3.90% / 0.3204 / 5.06% / 0.0832 / 1.20%
Luteimonas / 3.90% / 0.3204 / 5.06% / 0.0448 / 2.47%
Succinivibrio / 3.90% / 0.0832 / 5.06% / 0.0448 / 1.17%
Barnesiella / 3.90% / 0.1326 / 3.80% / 0.3204 / 2.70%
Novosphingobium / 3.90% / 0.3204 / 3.80% / 0.3204 / -0.07%
Massilia / 3.90% / 0.0832 / 3.80% / 0.3204 / -1.36%
Dolosigranulum / 3.90% / 0.0832 / 2.53% / 1.0000 / -3.90%
Propioniferax / 3.90% / 0.0832 / 2.53% / 0.5670 / -2.63%
Lactococcus / 3.90% / 0.0832 / 2.53% / 0.5670 / -2.63%
Propionimicrobium / 3.90% / 0.3204 / 1.27% / 0.1814 / 0.13%
Syntrophococcus / 3.90% / 0.3204 / 1.27% / 0.1814 / -6.39%
Sphingobium / 3.90% / 0.3204 / 1.27% / 0.3204 / -1.33%
Kingella / 3.90% / 0.0832 / 1.27% / 0.3204 / -2.63%
Slackia / 3.90% / 0.6576 / 0.00% / 0.1586 / -3.83%
Simonsiella / 3.90% / 0.0832 / 0.00% / N/A / -3.90%
Escherichia Shigella / 2.60% / 0.0958 / 6.33% / 0.4830 / 9.03%
Aeromonas / 2.60% / 0.5671 / 6.33% / 0.2594 / 2.50%
Neisseria / 2.60% / 0.0832 / 6.33% / 0.1028 / 1.20%
Leptotrichia / 2.60% / 0.1586 / 6.33% / 0.0244 / 3.73%
Blautia / 2.60% / 1.0000 / 5.06% / 0.1814 / 3.80%
Tetrasphaera / 2.60% / 0.5671 / 3.80% / 0.1586 / 1.23%
Gordonia / 2.60% / 0.3204 / 3.80% / 0.3204 / 1.23%
Flavisolibacter / 2.60% / 0.5671 / 3.80% / 0.0832 / 2.50%
Exiguobacterium / 2.60% / 0.1586 / 3.80% / 0.3204 / -0.07%
Pedobacter / 2.60% / 0.1586 / 3.80% / 0.0832 / 1.20%
Ruminococcus / 2.60% / 1.0000 / 3.80% / 0.0832 / 1.20%
Abiotrophia / 2.60% / 0.3204 / 2.53% / 0.1586 / -0.03%
Adhaeribacter / 2.60% / 0.1586 / 2.53% / 0.5670 / -1.33%
Streptomyces / 2.60% / 1.0000 / 2.53% / 0.1586 / -0.07%
Sediminibacterium / 2.60% / 0.1586 / 2.53% / 0.1586 / -0.07%
Singulisphaera / 2.60% / 0.1586 / 2.53% / 0.1586 / -0.07%
Mesorhizobium / 2.60% / 0.5671 / 1.27% / 0.3204 / -0.03%
Ureaplasma / 2.60% / 0.1586 / 1.27% / 0.1586 / -2.60%
Naxibacter / 2.60% / 0.1586 / 1.27% / 0.3204 / -1.33%
Pantoea / 2.60% / 0.1586 / 1.27% / 0.3204 / -1.33%
Klebsiella / 2.60% / 0.5671 / 0.00% / 0.0832 / -5.10%
Succiniclasticum / 2.60% / 0.6576 / 0.00% / N/A / 1.30%
Tessaracoccus / 2.60% / 0.5671 / 0.00% / N/A / -1.30%
Sanguibacter / 2.60% / 0.1586 / 0.00% / N/A / -2.60%
Mucilaginibacter / 2.60% / 0.1586 / 0.00% / N/A / -2.60%
Aquitalea / 2.60% / 0.1586 / 0.00% / N/A / -2.60%
Vogesella / 2.60% / 0.1586 / 0.00% / N/A / -2.60%
Opitutus / 2.60% / 0.1586 / 0.00% / N/A / -2.60%
Dermabacter / 1.30% / 0.5671 / 11.39% / 0.0339 / 10.16%
Hymenobacter / 1.30% / 0.1814 / 7.59% / 0.0134 / 11.49%
Arthrobacter / 1.30% / 1.0000 / 7.59% / 0.0583 / 6.33%
Deinococcus / 1.30% / 0.3204 / 6.33% / 0.0244 / 5.03%
Mobilicoccus / 1.30% / 0.1586 / 5.06% / 0.0448 / 7.66%
Enhydrobacter / 1.30% / 1.0000 / 5.06% / 0.1814 / 3.80%
Clostridium XI / 1.30% / 1.0000 / 5.06% / 0.0448 / 5.06%
Wautersiella / 1.30% / 0.3204 / 5.06% / 0.1814 / 2.50%
Lachnospiracea_incertae_sedis / 1.30% / 0.3204 / 5.06% / 0.1814 / 2.50%
Bacteroides / 1.30% / 1.0000 / 3.80% / 0.0832 / 3.80%
Phenylobacterium / 1.30% / 1.0000 / 3.80% / 0.0832 / 3.80%
Dorea / 1.30% / 0.1586 / 3.80% / 0.0832 / 3.80%
Spirosoma / 1.30% / 0.1586 / 3.80% / 0.0832 / 1.23%
Gemmatimonas / 1.30% / 0.3204 / 3.80% / 0.0832 / 2.50%
Planococcus / 1.30% / 0.3204 / 3.80% / 0.0832 / 2.50%
Clostridium XlVa / 1.30% / 0.3204 / 3.80% / 0.0832 / 2.50%
Hallella / 1.30% / 1.0000 / 2.53% / 1.0000 / 0.00%
Amaricoccus / 1.30% / 1.0000 / 2.53% / 0.5670 / 1.27%
Actinomycetospora / 1.30% / 1.0000 / 2.53% / 0.1586 / 2.53%
Anaerostipes / 1.30% / 1.0000 / 2.53% / 0.1586 / 2.53%
Phascolarctobacterium / 1.30% / N/A / 2.53% / 0.1586 / 2.53%
Erysipelotrichaceae_incertae_sedis / 1.30% / N/A / 2.53% / 0.1586 / 2.53%
Clostridium sensu stricto / 1.30% / 0.1586 / 2.53% / 0.1586 / -0.03%
Conexibacter / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Ferruginibacter / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Pontibacter / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Gemmata / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Rheinheimera / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Clostridium XVIII / 1.30% / 0.3204 / 2.53% / 0.1586 / 1.23%
Collinsella / 1.30% / 0.3204 / 1.27% / 0.5670 / 0.03%
Microlunatus / 1.30% / 1.0000 / 1.27% / 0.3204 / 1.27%
Rubellimicrobium / 1.30% / 1.0000 / 1.27% / 0.3204 / 1.27%
Hydrogenophaga / 1.30% / 0.3204 / 1.27% / 1.0000 / -1.30%
Ilumatobacter / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Turicella / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Leifsonia / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Zhihengliuella / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Saccharopolyspora / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Solirubrobacter / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Paraprevotella / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Truepera / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Skermanella / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Vampirovibrio / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Cellvibrio / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Xanthomonas / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Oceanobacillus / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Jeotgalibacillus / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Atopostipes / 1.30% / 0.3204 / 1.27% / 0.3204 / -0.03%
Jonquetella / 1.30% / 0.1814 / 0.00% / 0.1586 / 1.36%
Enterobacter / 1.30% / 1.0000 / 0.00% / 0.0832 / -3.80%
Varibaculum / 1.30% / 1.0000 / 0.00% / 0.3204 / -1.27%
Catonella / 1.30% / 0.3204 / 0.00% / 0.1586 / -3.83%
Planobacterium / 1.30% / 1.0000 / 0.00% / N/A / 0.00%
Xanthobacter / 1.30% / 1.0000 / 0.00% / N/A / 0.00%
Desulfovibrio / 1.30% / 1.0000 / 0.00% / N/A / 0.00%
Tepidimicrobium / 1.30% / 1.0000 / 0.00% / N/A / 0.00%
Jonesia / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Micromonospora / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Rugosimonospora / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Amycolatopsis / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Gordonibacter / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Euzebya / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Flectobacillus / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Olivibacter / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Zavarzinella / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Pseudolabrys / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Rhodopila / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Blastomonas / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Aquabacterium / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Polaromonas / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Geobacter / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Anaeromyxobacter / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Serratia / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Dyella / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Synergistes / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Verrucomicrobium / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Tumebacillus / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Marinococcus / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Mogibacterium / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Pseudoramibacter / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Oribacterium / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Misuokella / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Schwartzia / 1.30% / 0.3204 / 0.00% / N/A / -1.30%
Devosia / 0.00% / 0.3204 / 8.86% / 0.0330 / 8.89%
Aurantimonas / 0.00% / N/A / 7.59% / 0.0134 / 7.59%
Microbacterium / 0.00% / 0.3204 / 6.33% / 0.2594 / 5.10%
Kineococcus / 0.00% / 0.3204 / 6.33% / 0.0244 / 7.63%
Roseburia / 0.00% / N/A / 6.33% / 0.1028 / 5.06%
Microvirga / 0.00% / N/A / 6.33% / 0.1814 / 6.33%
Bosea / 0.00% / 0.3204 / 5.06% / 0.3204 / 6.36%
Planomicrobium / 0.00% / 0.3204 / 5.06% / 0.0448 / 6.36%
Piscicoccus / 0.00% / N/A / 5.06% / 0.0832 / 3.80%
Kytococcus / 0.00% / N/A / 5.06% / 0.0448 / 5.06%
Agrococcus / 0.00% / N/A / 5.06% / 0.0448 / 5.06%
Friedmanniella / 0.00% / 0.3204 / 3.80% / 0.0832 / 5.10%
Alloiococcus / 0.00% / 0.3204 / 3.80% / 0.0832 / 5.10%
Rhodococcus / 0.00% / N/A / 3.80% / 0.3204 / 2.53%
Curtobacterium / 0.00% / N/A / 3.80% / 0.0832 / 3.80%
Mycobacterium / 0.00% / N/A / 3.80% / 0.0832 / 3.80%
Aeromicrobium / 0.00% / N/A / 3.80% / 0.0832 / 3.80%
Pannonibacter / 0.00% / N/A / 3.80% / 0.5670 / 3.80%
Parabacteroides / 0.00% / 0.3204 / 2.53% / 0.1586 / 3.83%
Gemmiger / 0.00% / 0.3204 / 2.53% / 0.1586 / 3.83%
Catenibacterium / 0.00% / 0.3204 / 2.53% / 0.1586 / 3.83%
Pelomonas / 0.00% / N/A / 2.53% / 0.5670 / 1.27%
Iamia / 0.00% / N/A / 2.53% / 0.1586 / 2.53%
Phycicoccus / 0.00% / N/A / 2.53% / 0.1586 / 2.53%
Terrabacter / 0.00% / N/A / 2.53% / 0.1586 / 2.53%
Citricoccus / 0.00% / N/A / 2.53% / 0.1586 / 2.53%