Margaret Rosenfeld, MD, MPH
Page 15
March 2009
Margaret Rosenfeld, M.D., M.P.H.
Curriculum Vitae
PERSONAL DATA:
Born: 2/2/61, Berkeley, CA
Married: Daniel S. Weld
Children: Adam, Galen and Leah Weld
CONTACT INFORMATION:
Division of Pulmonary Medicine, A5937
Seattle Children’s Hospital
4800 Sandpoint Way NE, Seattle, WA 98105
(206) 987-5644
EDUCATION
l983 B.S., Molecular Biophysics and Biochemistry, Yale University,
New Haven, CT. Magna cum laude, Distinction in the Major
l988 M.D., Harvard Medical School, Boston, MA
1995 M.P.H., Department of Epidemiology, University of Washington
School of Public Health, Seattle, WA
POSTGRADUATE TRAINING
l988-91 Internship/Residency in Pediatrics, University of Washington School of Medicine/Children's Hospital and Medical Center, Seattle, WA
l992-95 Fellowship, Pediatric Pulmonology, University of Washington
School of Medicine, Seattle, WA
FACULTY POSITIONS HELD
1995-1998 Acting Instructor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
1999-2000 Acting Assistant Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
2000-2005 Assistant Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
2005- Associate Professor, Department of Pediatrics, University of
Washington School of Medicine, Seattle, WA
HOSPITAL POSITIONS HELD
1995- Attending Physician, Children’s Hospital and Regional Medical Center
2000- Medical Director, Pulmonary Function Laboratory, CHRMC
2003- Co-Director, Fellows’ College
2007- Medical Director, Pediatric Clinical Research Center, and Associate Director, Center for Clinical and Translational Research, Seattle Children’s Hospital Research Institute
HONORS
1992-98 Leroy Matthews Physician Scientist Award, Cystic Fibrosis Foundation
1993 Physician Scientist Fellowship Award, Glaxo Corporation
BOARD CERTIFICATION
l993, 2000 Diplomate, General Pediatrics, American Board of Pediatrics (expired as of 1/31/2006)
1998, 2005 Diplomate, Pediatric Pulmonology, American Board of Pediatrics
LICENSURE
l988- State of Washington, # 00027801
PROFESSIONAL ORGANIZATIONS
American Academy of Pediatrics
American Thoracic Society
Society for Pediatric Research
Western Society for Pediatric Research
Association for Patient Oriented Research
Association of Pediatric Program Directors
TEACHING RESPONSIBILITIES
Courses:
1991- Housestaff noon conference didactic sessions on chronic cough, obstructive sleep apnea, and common airway disorders (each given annually)
1992- Visiting lecturer, NURS 517 (Pediatric Nurse Practitioner graduate course), University of Washington School of Nursing (annually)
1995- Attending rounds didactic sessions to resident ward team on various relevant topics in pediatric pulmonary medicine (cystic fibrosis, pulmonary physiology, asthma, bronchiolitis)
1995-2002 Visiting lecturer, Core Pediatrics Clerkship,
University of Washington School of Medicine (~ 6 times annually)
2002- 2007 Lecturer, Core Pediatrics Clerkship, ethics session (9 times annually)
2004- Lecturer, HuBio 512 course to 1st year medical students (lectures on cystic fibrosis)
2007 Lecturer and panel discussant, UW Educational Outreach 88597-Intro to Clinical Trials
Trainees:
1997-1999 Graduate thesis preceptor for Toby Lewis, M.D., M.P.H., former fellow, Division of Pulmonary Medicine. Advised her in design, conduct and analysis of her study assessing outcomes associated with urban vs. rural residence among cystic fibrosis patients in the U.S. CF Foundation National Registry. Dr. Lewis is currently an Assistant Professor in the Division of Pulmonary Medicine, Department of Pediatrics, University of Michigan School of Medicine.
2000 Research mentor for Victoria Cartwright, MD, former fellow in Division of Rheumatology, “A Randomized, Controlled Trial of Pain Management Methods for Intraarticular Steriod Injections in Patients with Juvenile Rheumatoid Arthritis.” Dr. Cartwright is currently on faculty in the Department of Pediatrics at Madigan Army Medical Center in Tacoma, WA.
2001 Research mentor to Chris Goss, MD, MSc, now Assistant Professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine. Assisted him in preparation of his successful grant applications to the Cystic Fibrosis Foundation for a LeRoy Matthews Physician Scientist Award and to the NIH for a K23 award. His proposals assess the quality of life in cystic fibrosis patients with end-stage lung disease.
2001- Research mentor to Jason Debley, MD, Assistant Professor, Division of Pulmonary Medicine. Assisted him in preparing three successful grant applications and currently serve as one of his mentors on his NIH K23 career development award assessing predictors of asthma among wheezy infants utilizing infant pulmonary function tests.
2002- 2004 Advisor to Doris Uh, Pharm.D., postdoctoral fellow, Department of Pharmaceutics. Mentored her in investigation of pharmacokinetics of inhaled antibiotics and supervising her role as consulting clinical pharmacist in the Division of Pediatric Pulmonary Medicine.
2003 Research mentor to Martha McKinney, MD, MPH, former fellow, Division of Pulmonary Medicine. Assisted her in her preparing her thesis in fulfillment of the Masters in Public Health degree, assessing the prevalence of smoking among Canadian asthmatics. Sat on her thesis committee. Dr. McKinney is currently an Assistant Professor, Department of Paediatrics, Queen's University, Kingston, Ontario.
2006- Research Mentor to Maida Chen, Acting Assistant Professor, Division of Pulmonary Medicine, on her submitted grant application to University of Washington. Alcohol and Drug Abuse Institute, ”Sleep in Fetal Alcohol Spectrum Disorders,” and for her planned application for an NIH K12 career development award, “Sleep Disordered Breathing in Special Needs Pediatric Populations.”
2007-08 Biology project advisor to Paramita Saha, doctoral candidate in Biostatistics
2007- Member, Scholarship Oversight Committee of Don “DB” Sanders, fellow in Pulmonary Medicine
2008- Primary Mentor to Maida Chen, MD, Assistant Professor of Pediatrics, Division of Pulmonary Medicine, through Seattle Children’s Hospital Research Institute Center for Clinical and Translational Research Mentored Scholar Program
EDITORIAL RESPONSIBILITIES
Regular reviewer for American Journal of Respiratory and Critical Care Medicine, Pediatric Pulmonology, Journal of Pediatrics, Annals of Epidemiology, Thorax, European Respiratory Journal, Pediatric Infectious Diseases, Journal of Antimicrobial Chemotherapy, Journal of Cystic Fibrosis, Chest, JAMA
2006 Guest Editor, Proceedings of the American Thoracic Society, “Imaging Endpoints in Cystic Fibrosis”
SPECIAL NATIONAL RESPONSIBILITIES
1999-2000 Participant in development of Pulmonology subspecialty examination, American Board of Pediatrics
1999 Correspondent Reviewer, NIDDKM K01 grant application
2002-2003 Member, Nominating Committee, Pediatric Assembly, American Thoracic Society
2002-2004 Member, American Thoracic Society Health Care Policy Committee
2002-2004 Member, Cystic Fibrosis Foundation Therapeutics Development Network Protocol Review Committee
2003 Manuscript judge, 2003 Uniformed Services Scientific Award Competition
2003-2004 Member, Writing Committee, “The Clinical Utility of Newborn Screening for Cystic Fibrosis” report published in Morbidity and Mortality Weekly Reports in 2004
2003-2007 Member, American Thoracic Society Pediatric Assembly Planning Committee
2005-2006 Chair, U.S. Cystic Fibrosis Foundation task force On Updating Spirometry Reference Equations for the CFF National Patient Registry
2005-2007 Member, American Thoracic Society Pediatric Assembly Program Committee
2006 Co-Chair, U.S. Cystic Fibrosis Foundation workshop on Defining a Pulmonary Exacerbation, held Sept 17-18, 2006, Bethesda, MD
2007 Faculty Member, Cystic Fibrosis Foundation Learning and Leadership Collaborative V
2003- Member, Cystic Fibrosis Foundation National Patient Registry Committee
2004- Member, Cystic Fibrosis Foundation Therapeutics Development Network Publication and Presentations Committee
2005- Vice-Chair, EPIC (Early Pseudomonas Infection Control) Steering Committee
2007- Co-Chair, Cystic Fibrosis Foundation Therapeutics Development Network Working Group on Outcome Measures in Young Children with CF
2008- Chair, American Thoracic Society Working Group on Infant / Preschool Lung Function
2008- WA State representative to the Cystic Fibrosis Foundation Special Interest Group on CF Newborn Screening
SPECIAL LOCAL RESPONSIBILITIES
1997-2000 Subspecialty Teaching Ad Hoc Subcommittee of the Residency Committee, Children’s Hospital and Regional Medical Center
1997- Residency Program Liaison, Division of Pulmonary Medicine, Children’s Hospital and Regional Medical Center
2002, 2005 Reviewer, Cystic Fibrosis Critical Elements of Care Community Provider Guidelines, Center for Children with Special Needs and Chronic Health Conditions, CHRMC
1998- Member, Scientific Advisory Committee to the Clinical Research Center, UW and CHRMC.
2000-2003 Member, UW Clinical Research Training Grant K-30 Steering Committee – Training Grant Program Track
2001-2002 Member, Newborn Screening Advisory Committee to Washington State Board of Health regarding additional universal newborn screening tests.
2001- Member, CHRMC Pharmacy and Therapeutics Committee
2000- Member, Medical Advisory Board, World Bike for Breath
2003- Member, Faculty Council on Academic Affairs, UW School of Medicine
2004- Member, Education Committee, University of Washington School of Medicine General Clinical Research Center
2005-2006 Member, Institutional Resident/Fellow Advisory Committee (IR/FAC), University of Washington School of Medicine
2006 Member, CHRMC Strategic Plan Task Force on Education
2006 Leader, Workgroup on Family Support Services for Symposium on Creating Institutional Change for Work-Life Balance in Pediatric Careers, CHRMC, October 11, 2006
2007 Member, Seattle Children’s Hospital Research Institute Center for Health Services and Behavioral Research Strategic Planning Committee
2007 Member, Seattle Children’s Hospital Research Institute Center for Clinical and Translational Research Strategic Planning Committee
2007- Member, University of Washington Department of Pediatrics Recognition Committee
2007- Member, Steering Committee, Seattle Children’s Hospital Research Institute Center for Clinical and Translational Research
2008- Member, Leadership Committee, Institute for Translational Health Sciences (ITHS)
RESEARCH FUNDING
ACTIVE
OBSERV04K0 (Rosenfeld – PI) 4/1/04 – 3/31/09
3.0 calendar mo.
Cystic Fibrosis Foundation $384,782
EPIC Observational Study
A large, multicenter, prospective, descriptive study of the risk factors for and outcomes associated with initial acquisition of Pseudomonas aeruginosa as well as outcomes associated with therapy among CF patients 1 to 12 years of age. No overlap.
1 U54 FF019480 (Knowles – PI) 8/4/04 – 7/31/09
.60 calendar mo.
NIH (NCRR) (Subcontract from University of $382,893
North Carolina at Chapel Hill) (Rosenfeld – Site PI)
Genetic Disorders of Mucociliary Clearance
Four-center prospective, longitudinal study to define the onset and progression of lung disease in a cohort of patients with primary ciliary dyskinesia (PCD) using standardized procedures. No overlap.
UL1RR025014-01 (Disis – PI) 6/1/08 – 5/31/09
2.4 calendar mo.
University of Washington (UW), Institute of $1,560,594
Translational Health Science
Institutional Clinical and Translational Health Science Award CTSA
Dr. Rosenfeld is the Medical Director of the Pediatric Clinical Research Center, overseeing programs and infrastructure to conduct clinical research in the Pediatric Clinical Research Center located at Seattle Children’s Hospital. No overlap.
ISIS07K1 (Rosenfeld – PI) 10/1/07 – 9/30/12
0.0 calendar mo.
Cystic Fibrosis Foundation $350,639
Infant Study of Inhaled Saline
A large multicenter randomized controlled trial of inhale 7% hypertonic saline in infants with cystic fibrosis. This is a jointly funded project with NIH U01 092931.
U01 HL 092931 (Rosenfeld – PI) 9/15/08 – 7/31/12
2.4 calendar mo.
NIH/NHLBI $405,335
Infant Study of Inhaled Saline
A large multicenter randomized controlled trial of inhale 7% hypertonic saline in infants with cystic fibrosis. This is a jointly funded project with CFF ISIS07K0.
CFF EPIC09K0 (Rosenfeld – PI) 4/1/09 – 3/31/12
2.4 calendar mo.
Cystic Fibrosis Foundation Therapeutics Inc $764,187
EPIC Observational Study
The objectives of this study are to prospectively assess the risk factors for early age at acquisition of Pseudomonas aeruginosa (Pa) and clinical outcomes associated with Pa acquisition, in order to determine improved early prevention and treatment strategies.
ITHS Pilot Project 4/1/09-3/31/10
0 calendar mo
Institute for Translational Health Sciences $10,000
Parent Report of Respiratory and Gastrointestinal Signs in Infants and Young Children with Cystic Fibrosis: A Feasibility Study
Pilot study to develop a patient-centered outcome measure for clinical trials in young children with CF.
OVERLAP: CFF ISIS07K0 and NIH U01 HL092931 jointly fund the same project. Dr. Rosenfeld’s effort for the entire project is paid under NIH U01 HL092931.
PENDING:
(Knowles – PI) 8/1/09-7/31/14
.6 Calendar mo.
NIH (NCRR) (Subcontract from University of $129,739
North Carolina at Chapel Hill) (Rosenfeld – Site PI)
Genetic Disorders of Mucociliary Clearance
Multicenter prospective, longitudinal study to define the onset and progression of lung disease in a cohort of patients with primary ciliary dyskinesia (PCD) using standardized procedures.
Role: Site PI
Completed
1. K23 RR15529 (PI, Margaret Rosenfeld). Source: NCRR, NIH. Dates: 5/01/2000– 11/30/2005. Annual Direct Costs: $96,333. Percent Effort: 75%. Title: Mentored Patient Oriented Research Career Development Award
2. HR 597004 (PI: Margaret Rosenfeld). Source: Research Endowment Fund, Childrens Hospital and Regional Medical Center. Dates: 1/01/2002– 3/31/2004. Annual Direct Costs: $24,780. Percent Effort: 0%. Title: A pilot study of sputum induction as a non-invasive means to measure serial airway antibiotic concentration in cystic fibrosis.
3. Cystic Fibrosis Foundation, Leroy Matthew Physician Scientist Award (Bonnie Ramsey, MD PI, 1992-95 for my fellowship funding; M. Rosenfeld, PI, 1996-98). Dates: 1992-1998. 1997-98 direct costs: $65,250.
4. Pari Respiratory Equipment, for Study of Efficacy of Cleaning Methods for Small-Volume Nebulizers (M. Rosenfeld, PI). Date: 1997. Direct costs: $1,847.
5. PathoGenesis Corp., Safety Study of Aerosolized Tobramycin in Young Children with Cystic Fibrosis (M. Rosenfeld, PI). Dates: 4/98 – 10/98. Total direct costs: $90,591.
6. PathoGenesis Corp. and Cystic Fibrosis Foundation. A Pilot Study of the Deposition of Inhaled Tobramycin in Young Children with Cystic Fibrosis (M. Rosenfeld, PI). Dates: 4/99-5/00. Total award: $81,968.
7. ROSENF03AO (Rosenfeld – PI). Dates: 2/1/03 – 1/31/08. Funding source: Cystic Fibrosis Foundation Therapeutics, Inc. Direct Costs: $910,024. Title: Evaluation of pulmonary function from raised lung volumes as outcome measures for clinical trails in infants with cystic fibrosis.
8. ISIS07K1P (Rosenfeld – PI). Dates: 10/1/107 – 9/30/08. Source: Cystic Fibrosis Foundation Therapeutics, Inc. Direct costs:$112,745. Title: A Pilot Study to Evaluate Inhaled 7% Hypertonic Saline in CF Infants
BIBLIOGRAPHY
Manuscripts in Refereed Journals
1. Rosenfeld M, Ramsey B. Evolution of airway microbiology in the infant with cystic fibrosis: role of pseudomonal and non-pseudomonal pathogens. Semin Respir Infect 1992;7(3):158-67.
2. Rosenfeld M, Cohen M, Ramsey B. Aerosolized antibiotics for bacterial lower airway infections: principles, efficacy and pitfalls. Clinical Pulmonary Medicine 1997;4(2):101-12. (Also appeared in Infectious Diseases in Clinical Practice 1998:7;66-79)
3. Rosenfeld M, Davis R, Fitzsimmons S, Pepe M, Ramsey B. The gender gap in cystic fibrosis mortality. American Journal of Epidemiology 1997;145(9):794-803.
4. Rosenfeld M, Emerson J, Astley S, Joy P, Williams-Warren J, Standaert T, Yim DL, Crist D, Thykkuttathil J, Torrence M, FitzSimmons S, Ramsey B. Home nebulizer usage among patients with cystic fibrosis. Journal of Pediatrics 1998;132:125-31.