Cheil Moon

CHEIL MOON

Department of Oral Anatomy and Neurobiology

School of Dentistry

KyungpookNationalUniversity

188-1, 2-Ga, Samdeok-Dong, Jung-Gu, Daegu 700-412

Republic of Korea

(82) 53-660-6861

Date of Birth: October 28th 1963

Nationality:USA Citizen

PROFESSIONAL EXPERIENCE:

Dec. 1994 - Mar. 1999 Dept. of Neuroscience, JohnsHopkinsUniversity.

Post-doctoral fellow

Apr. 1999 - Jun. 2004Dept. of Neuroscience, JohnsHopkinsUniversity.

Research Associate

Jun. 2004– Aug. 2005Dept. of Neuroscience, JohnsHopkinsUniversity.

Instructor

Aug. 2004 – presentDept. of Oral anatomy & Neurobiology, KyungpookNationalUniversity.

Assistant Professor

Aug. 2004 – presentDept. of Neuroscience, JohnsHopkinsUniversity.

Visiting Professor

EDUCATION:

1994 Dept. of Biology, ImperialCollege - London, U.K.

Ph.D. in Neurobiology

Thesis: Two-electrode voltage clamp study of endogenous and expressed receptor characteristics in Xenopus oocytes.

1990 Centre for Biotechnology, ImperialCollege - London, U.K.

DIC and M.Sc. in Biotechnology

Thesis: Proteolytic nicking and kinetics studies of Arthrobacter D-xylose isomerase.

1989 Dept. of Biochemistry, YonseiUniversity - Seoul, R.O.Korea

B.Sc. in Biochemistry

AWARDS:

1992 - 1993Oversea Research Students Awards. Ministry of Education, Great Britain.

1994 - 1996Post-doctoral Fellowships Grant. NIH (c/o Dr.G.V.Ronnett)

1996 - 1999National Research Service Award. NIDCD. (5F32DC000243-03)

Project title: Role of Olfactory particulate guanylyl cyclase.

GRANTS:

1999 - 2001Small Research Grant. NIDCD. (5R03DC003224-02)

Project title: Guanylyl cyclase activating protein in olfaction.

2006 - 2010Research Grant, NIH(in submission).

Project title: Activity-dependentsurvival in the olfactory receptor neurons.

TEACHING:

Undergraduate Practical Demonstrator, ImperialCollege, London (1992-1993):

Membrane potential measurement of Xenopus oocytes.

Undergraduate Tutorial Course, ImperialCollege, London (1992-1993):

3rd Year Animal Physiology

Membrane potential of cells

Undergraduate Tutorial Course, ImperialCollege, London (1992-1994):

3rd Year Cell Signaling

Protein kinases/phosphatases, and their roles for neuronal functions.

Undergraduate Research Mentorship, JohnsHopkinsUniversity, Baltimore.

Jaberi P.2nd –4th Year (1995-1997), Neuroscience.

present : School of Medicine, University of Maryland.

Kwak N.2nd Year (1997-1998), Neuroscience.

present : School of Medicine, JohnsHopkinsUniversity.

Quintones M.2nd-4th Year (1997-1999), Neuroscience.

present : School of Medicine, UMDNJ-NewJerseyMedicalSchool.

Kim E.1st –3rd Year (1999-2002), Biomedical Engineering.

present : School of Medicine, University of Maryland.

Mammen A.2nd –4th Year (1999-2003), Biology

present : MedicalCollege of Georgia.

LiuB.3rd Year (2004-2005), Biology

Lecture, KyungpookNationalUniversity, Daegu (2005-present):

Post-graduate Course

Aging of oral tissues.

PRESENTATIONS:

  • April, 1992.Nottingham, U.K.Poster Presentation

Brain Research Association, 9th National Meeting

  • May, 1993.Seoul, R.O.KoreaSlide Presentation

Korean Society for Neuroscience, 2nd International Symposium of the Korean Society for Neuroscience

  • Nov,1995.San Diego, CAPoster Presentation

Society for Neuroscience, 25th Annual Meeting

  • Nov,1996.WashingtonD.C.Poster Presentation

Society for Neuroscience, 26th Annual Meeting

  • July, 1997.San Diego, CAPoster Presentation

International Symposium on Olfaction and Taste 12th and AChemS Meeting 19th

  • Oct,1997.New Orleans, LAPoster Presentation

Society for Neuroscience, 27th Annual Meeting

  • Nov,1998.Los Angeles, CAPoster Presentation

Society for Neuroscience, 28th Annual Meeting

  • Oct,1999.Miami, FLPoster Presentation

Society for Neuroscience, 29th Annual Meeting

  • April, 2000.Sarasota, FLSlide Presentation

AChemS Meeting 22nd

  • Nov, 2001.San Diego, CAPoster Presentation

Society for Neuroscience, 31st Annual Meeting

  • April, 2002.Sarasota, FLPoster Presentation

AChemS Meeting 24th

  • Nov, 2003.New Orleans, LAPoster Presentation

Society for Neuroscience, 33rd Annual Meeting

  • Nov, 2004.San Diego, CAPoster Presentation

Society for Neuroscience, 34th Annual Meeting

  • Oct, 2005.Daegu, KoreaSlide Presentation

KyungpookUniversity-OsakaUniversity International Symposium

INVITED TALKS:

  • Jan, 2001.Uniformed ServiceUniversity of Health Service, School of Medicine, Bethesda, MD

“Post-natal development of olfactory receptor neurons”

  • Apr, 2002.University of Louisville, School of Medicine, Louisville, KY

“The roles of LIF in post-natal development of olfactory receptor neurons”

  • Dec, 2002.Uniformed ServiceUniversity of Health Service, School of Medicine, Bethesda, MD

“Post-natal neurodevelopment in the olfactory system”

  • Oct, 2004.University of West Virginia, Integrated Centers in Neuroscience, Morgantown, WV

“Odorant stimulation promotes survival of olfactory receptor neurons via Erk activation”

  • Nov, 2004.KyungpookNationalUniversity, School of Medicine, Daegu, Korea

“Electrophysiology of Olfaction”

  • Feb, 2005.KyungpookNationalUniversity, School of Dentistry, Daegu, Korea

“Activity-dependent olfactory neuronal survival”

  • Mar, 2005.MonellChemicalSensesCenter, Philadelphia, PA

“Nose Story: Activity-dependent cell survival of olfactory receptor neurons”

  • Sep, 2005.CatholicUniversity, Seoul, Korea

“Activity-dependent neuronal survival of olfactory receptor neurons”

PROFESSIONAL MEMBERSHIPS:

Baltimore Yonsei Life Scientist Association (President in 2004)

Korean Society of Biochemistry

Korean Scientists and Engineers Association in U.K.

Korean Scientists and Engineers Association in USA

Society for Neuroscience

PUBLICATIONS:

Book chapter

  1. Fraser, S.P., Moon, C. and Djamgoz, M.B.A. Electrophysiology of Xenopus oocytes: an expression system in molecular neurobiology. In 'Electrophysiology: A Practical Approach' (D.I. Wallis, Ed.). OxfordUniversity Press, Oxford. 1993.
  2. Djamgoz, M.B.A., Fraser, S.P. and Moon. C. Modulation of ionotropic receptors for amino acid neurotransmitters by protein kinase activators and inhibitors: application of the Xenopus oocyte expression system. In 'Current Trends in Neuroscience-Proceeding of Inaugural International Symposium of the Korean Society for Neuroscience: Learning, Memory and Neuronal plasticity' (Y.Suh, Ed.). Seoul. 1994.
  3. Ronnett, G.V and Moon, C. Molecular neurobiology of olfactory transduction. In ‘Handbook of Olfaction and Gustation’ 2nd Edition (R.L. Doty, Ed.). Maecel Dekker, Inc., New York. 2003. 71-86.
  4. Simpson, P.J., Suh, K.S., Moon, C. and Ronnett, G.V. Smell. In ‘Encyclopedia of the Neurological Sciences’ (M. Aminoff and R.B. Daroff, Eds.). Academic Press, San Diego, CA. 2003. 310-314.
Article
  1. Moon, C., Fraser, S.P., Barrett, P., Morgan, P.J. and Djamgoz, M.B.A. Functional expression of 2-amino-4-phosphonobutyrate receptors in Xenopus laevis oocytes by injection of poly (A)+ RNA from quail brain. FEBS Lett. 1994. 348, 99-101.
  2. Fraser, S.P., Barrett, P., Moon, C., Morgan, P.J. and Djamgoz, M.B.A. AlF4--induced eletrophysiological response and melatonin receptor expression in Xenopus oocytes. Molecular Neuropharmacology. 1994. 3, 175-187.
  3. Moon, C., Fraser, S.P. and Djamgoz, M.B.A. G-protein activation, intracellular Ca2+ mobilization and phosphorylation studies of membrane currents induced by AlF4- in Xenopus oocytes. Cell. Signalling. 1997. 9, 497-504.
  4. Moon, C., Jaberi, P., Otto-Bruc, A., Baehr, W., Palczewski, K. and Ronnett, G.V. Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J. Neuroscience, 1998. 18, 3195-3205.
  5. Moon, C., Sung, Y., Reddy, R. and Ronnett G.V. Odorants induce phosphorylation of the cAMP response element binding protein in olfactory receptor neurons. Proc.Natl.Acad.Sci.USA. 1999. 96, 14605-14610.
  6. Moon, C., Djamgoz, M.B.A. and Fraser, S.P. Protein kinase and phosphatase modulation of quail brain GABAA receptor and non-NMDAs receptor co-expressed in Xenopus oocytes. Cell. Signalling.2000. 12, 105-112.
  7. Ronnett, G.V. and Moon, C. G proteins and olfactory transduction. Ann. Rev. Physiol., 2002. 64, 189-222.
  8. Sung, Y.*, Moon, C.*, Yoo, J., Pevsner, J., and Ronnett, G.V. plunc, a member of the secretory gland protein family is up-regulated in nasal respiratory epithelium after olfactory bulbectomy. J. Biol. Chem., 2002. 277. 12762-12769. *Equal contribution.
  9. Simpson, P.J., Miller, I., Moon, C., Hanlon, A., Liebl, D., Parada, L., and Ronnett, G.V. Atrial nautriuretic peptide type C (CNP) induces a cell switch in neurotrophin-primed olfactory receptor neuronal precursors. J. Neuroscience, 2002. 22, 5536-5551.
  10. Moon, C.*, Yoo, J.*, Matarazzo, V.,Sung, Y., Kim, E., and Ronnett, G.V.Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3activation. Proc.Natl.Acad.Sci.USA, 2002. 99. 9015-20. *Equal contribution.
  11. Moon, C.*, Moon, C.*, Kang, W.-S., Jeong, D.-C., and Jin, J.-Y. Distribution of adenoviral vector in brain after intravenous administration. J. Korean Med. Sci., 2003. 18. 108-111. *Equal contribution.
  12. Chen, J., Yi, R., Moon, C., Nagata, E. and Ronnett, G.V. Heme oxygenase-1 and heme oxygenase-2 have distinct roles in proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively. J.Neurochem., 2003. 85. 1247-1261.
  13. Boehning, D., Moon, C., Sharma, S., Hurt, K.J., Hester, L.D., Ronnett, G.V., Shungar, D. and Snyder, S.H. Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2. Neuron, 2003. 40. 129-137.
  14. Simpson, P.J., Wang, E., Moon, C., Cohen, D., Liebl, D., and Ronnett, G.V. NT-3 signaling maintains maturational homeostasis within neuronal populations in the olfactory epithelium. Mol. Cell. Neurosci., 2003. 24. 858-874
  15. Pearse, D.B., Shimoda, L.A., Verin, A.D., Bogatcheva, N., Moon, C., Ronnett, G.V., Welsh, L.A. and Becker, P.M. Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide. Endothelium, 2003. 10. 309-17.
  16. Chen, J., Tu, Y., Moon, C., Matarazzo, V., Palmer, A.M., and Ronnett, G.V. The localization of neuronal nitric oxide synthase determines its role in neuronal precursor proliferation and synaptic maintenance. Developmental Biology, 2004. 269. 165-182.
  17. Mammen, A., Simpson, P.J., Nighorn, A., Imanishi, Y., Palczewski, K., Ronnett, G.V., and Moon, C.* Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem. Biophys. Res. Comm., 2004. 322. 1131-1139. *Corresponding author.
  18. Kim, E., Simpson, P.J., Park, D., Lui, B.Q., Ronnett, G.V., and Moon, C.* Leukemia inhibitory factor is a proliferative factor for olfactory receptor neurons. Neuroreport, 2005. 16. 25-8. *Corresponding author.
  19. Paik, S., Kwak, M., Ahn, D., Kim, Y., Kim, D., Moon, C., Moritani, M., Yoshida, A., and Bae, Y. Ultrastructure of jaw muscle spindle afferents within the rat trigeminal mesencephalic nucleus. Neuroreport, 2005. 16. 1561-1564.
  20. Moon, C., Simpson, P. J.,Tu, Y., Cho, H., and Ronnett, G. V. Regulation of cGMP levels in olfactory receptor neurons in vitro. J.Neurochem., 2005. 95. 200-209.

Abstracts

  1. Moon, C., Fraser, S.P., Barrett, P., Morgan, P.J. and Djamgoz, M.B.A. G-protein activation in oocytes of Xenopus leavis and its inhibition by melatonin receptors. Neurosci. Lett. 1992. Suppl. 42, S21.
  2. Moon, C. and Ronnett, G.V. Characterization of the odorant-induced cyclic GMP response in rat olfactory cilia. Abstracts Society for Neuroscience. 1995. 21, 130 (1/3).
  3. Moon, C., Jaberi, P. and Ronnett, G.V. Characterization of GCAP in rat olfactory tissues. Abstracts Society for Neuroscience. 1996. 22, 650 (1/3).
  4. Moon, C., Jaberi, P., Sung, Y. and Ronnett, G.V. Olfactory specific receptor guanylyl cyclase as a modulator of cAMP level in the olfactory system. Chemical Sense, 1997. 22, 752.
  5. Sung. Y., Moon, C. and Ronnett, G.V. Expression of particulate guanylyl cyclases in the olfactory neuroepithelium. Abstracts Society for Neuroscience. 1997. 23, 736 (1/2).
  6. Moon, C., Williams-Hogarth, L., Cai, X., Sung, Y. and Ronnett, G.V. Immunohistochemical localization of signal transduction proteins in the vomeronasal organ (VNO). Abstracts Society for Neuroscience.1998. 24. 2100 (2/2).
  7. Moon, C., Yoo, J., Sung, Y. and Ronnett, G.V. Odorant-stimulated gene expression in rat olfactory receptor neurons. Abstracts Society for Neuroscience.1999. 25.
  8. Moon, C., Barber, R.D. and Ronnett, G.V. Odorant stimulation of CREB phosphorylation in a clonal olfactory receptor neuron cell line. Chemical Sense, 2000. 25.
  9. Moon, C., Kim, E. and Ronnett, G.V. Leukemia inhibitory factor: a negative regulator of olfactory receptor neuronal maturation.Abstracts Society for Neuroscience.2001. 27.
  10. Wang, E., Simpson P.J., Moon, C., Samanta-Roy, D. and Ronnett, G.V.NT-3 increases the survival of mature ORNs and reduces the proliferation and maturation of immature neurons.Chemical Sense, 2002. 27
  11. Kim, E-K, Miller, I., Landree, L.E., Tihan, T., Moran, T.H., Moon, C., Kuhajda, F.P. and Ronnett, G.V. Expression and regulation of fatty acid synthase within hypothalamus. Abstracts Society for Neuroscience.2002. 28.
  12. Kim, E-K, Miller, I., Aja, S., Landree, L.E., Moon, C., Kuhajda, F.P. Moran, T.H., and Ronnett, G.V. Fatty acid synthase inhibition reduces food intake via hypothalamic AMP-activatedprotein kinase. Abstracts Society for Neuroscience.2003. 29.
  13. Moon, C. and Ronnett, G.V. Odorant stimulation promotes survival of olfactory sensory neurons via Erk1/2 activation. Abstracts Society for Neuroscience.2004.30.
  14. Moon, C. Leukemia inhibitory factor inhibits neuronal terminal differentiation through STAT3 activation. Current topics on frontier Biodentistry. 2005.

Names of Reference:

1) Dr. Ronnett, G.V.

Professor

Department of Neuroscience

JohnsHopkinsUniversity

School of Medicine / 725 North Wolfe Street

Baltimore, MD21205 / USA

(TEL) 1 - 410 - 614 - 6482

(FAX) 1 - 410 - 614 - 6249

(E-mail)

2) Dr. Djamgoz, M.B.A.

Professor

Department of Biology

Imperial College of Science, Technology and Medicine

Imperial College Road

London, SW7 2AZ / United Kingdom

(TEL) 44-171-594-5441

(FAX) 44-171-584-2056

(E-mail)

3) Dr. Bae, Y

Professor

Department of Oral Anatomy and Neurobiology

School of Dentistry

KyungpookNationalUniversity

188-1, 2-Ga, Samdeok-Dong, Jung-Gu, Daegu 700-412

Republic of Korea

(TEL) 82-53-660-6860

(E-mail)

4) Dr. Palczewski, K.

Professor

Department of Ophthalmology

University of Washington

1959 N.E.Pacific Street, HSB, Box 356485

Seattle, WA98195 / USA

(TEL) 1-206-543-9074

(E-mail)

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