June 10, 2005
CURRICULUM VITAE
Name: Samuel M. Moskowitz, M.D.
Professional Address: Children’s Hospital and Regional Medical Center (CHRMC)
Division of Pulmonary Medicine, 3D-4
4800 Sand Point Way NE
Seattle, WA 98105
Education
1982-1986 A.B. Princeton University, Princeton, NJ
Summa cum laude in Biology
Certificate in American Studies
1988-1994 M.D. Harvard Medical School, Boston, MA
Magna cum laude in a Special Field (Molecular Genetics)
Postgraduate Training
Internships and Residencies
1994-1995 Intern in Pediatrics, University of Washington School of Medicine (UWSOM) and CHRMC, Seattle, WA
1995-1997 Senior Resident in Pediatrics, UWSOM and CHRMC, Seattle
Fellowships
1997-2001 Senior Fellow in Pulmonary Medicine, Department of Pediatrics, UWSOM and CHRMC, Seattle
Academic Appointments
1986-1988 Biology Teacher (Introductory and Advanced Placement Courses)
Oakwood High School, North Hollywood, CA
1994-2001 Academic Staff, Department of Pediatrics, UWSOM, Seattle
2001-present Acting Assistant Professor, Department of Pediatrics, UWSOM, Seattle
Hospital Appointments
1997-2000 Medical Staff (Critical Care Float), CHRMC, Seattle
2000-present Attending Physician, Pulmonary Medicine, CHRMC, Seattle
2001-present Attending Physician, Pediatric Pulmonology, UWSOM, Seattle
Honors
1986 Senior Book Prize in Biology, Princeton University
1986 Sigma Xi Associate
1992-1994 Howard Hughes Medical Institute, Medical Student Research Fellow Award for Return to Medical Studies
1994 Leon Reznick Memorial Prize for Research, Harvard Medical School
1997-1998 Sponsored Clinical Fellowship, Dept. of Pediatrics, CHRMC, Seattle
Professional Organizations
1988-present Massachusetts Medical Society
1990-present American Society of Human Genetics
1991-present American Association for the Advancement of Science
1994-present American Academy of Pediatrics (Fellow, 1999)
1997-present American Thoracic Society
1999-present American Society for Microbiology
Teaching Responsibilities
1993-1994 Tutor, Introduction to Clinical Medicine, Harvard Medical School 1995-1997 Co-Creator, Pediatric Housestaff Survival Guide, CHRMC
1997-present Teaching of medical students on general pediatrics rotations and review of pediatric pulmonary case scenarios, Pediatrics 665, UWSOM
1997-present Teaching of medical students on pediatric pulmonary elective,
Pediatrics 684, UWSOM
1997-present Section Author (Cystic Fibrosis), Pediatric Housestaff Manual,
CHRMC
1999, 2001 Seminar co-leader for session on cystic fibrosis, Genetics 531, UWSOM
2001-present Lectures on croup, bronchiolitis and bronchopulmonary dysplasia at
pediatric housestaff noon conference, CHRMC
2004 Independent research supervisor for two undergraduate students,
Pediatrics 499, UWSOM
Special Local Responsibilities
1995, 1997, 2004 Intern Selection Committee, Department of Pediatrics, UWSOM
1996-1998 Grand Rounds Steering Committee, Dept of Pediatrics, UWSOM
1998-present Creator and editor, Standard Orders for Cystic Fibrosis Admissions,
CHRMC
2000-2001 Medical Monitor, Cystic Fibrosis Therapeutics Development
Network, CF-TDN Coordinating Center, Seattle, WA
Special National Responsibilities
2002-present Patient Advocacy and Education Committee, Cystic Fibrosis Therapeutic Development Network, CF Foundation
2003 Manuscript Judge, Ogden Bruton Award, Uniformed Services Scientific Awards Competition
2001-present Reviewer, Journal of Antimicrobial Chemotherapy
Research Funding
1986 Neurological Sciences Institute (Portland, OR), Student Research Fellowship
1989 National Tay-Sachs and Allied Diseases Association, Student Research Fellowship
1990-1992 Howard Hughes Medical Institute, Medical Student Research Fellowship
1998-2001 Howard Hughes Medical Institute, Postdoctoral Research Fellowship for Physicians
1999-2001 Cystic Fibrosis Foundation, Seattle CF-RDP Pilot and Feasibility Project Award, Co-Investigator
2001-2004 Cystic Fibrosis Foundation, Pilot and Feasibility Project Award
2001-2002 Marian E. Smith Junior Faculty Research Award, UWSOM
2001-2003 Child Health Research Center, UW Department of Pediatrics, New Investigator Award
2001-2003 Poncin Research Award, UWSOM
2001-2006 National Heart Lung and Blood Institute, Mentored Clinical Scientist Development Award (K08)
2002-2004 Interdepartmental Research Endowment Award, CHRMC
2003-2005 Cystic Fibrosis Foundation, Clinical Research Grant (Co-Investigator)
Bibliography
Manuscripts in Refereed Journals
1. Paw BH, Moskowitz SM, Uhrhammer N, Wright N, Kaback MM, Neufeld EF (1990) Juvenile GM2 gangliosidosis caused by substitution of histidine for arginine at position 499 or 504 of the a-subunit of b-hexosaminidase. J Biol Chem 265: 9452-9457.
2. Stoltzfus LJ, Sosa-Pineda B, Moskowitz SM, Menon KP, Dlott B, Hooper L, Teplow DB, Shull RM, Neufeld EF (1992) Cloning and characterization of cDNA encoding canine a-L-iduronidase; mRNA deficiency in mucopolysaccharidosis I dog. J Biol Chem 267: 6570-6575.
3. Moskowitz SM, Tieu PT, Neufeld EF (1993) A deletion/insertion mutation in the IDUA gene in a Libyan Jewish patient with Hurler syndrome (mucopolysaccharidosis IH). Hum Mutat 2: 71-73.
4. Bach G, Moskowitz SM, Tieu PT, Matynia A, Neufeld EF (1993) Molecular analysis of Hurler syndrome in Druze and Muslim Arab patients in Israel: multiple allelic mutations of the IDUA gene in a small geographic area. Am J Hum Genet: 53: 330-338.
5. Moskowitz SM, Tieu PT, Neufeld EF (1993) Mutation in Scheie syndrome (MPS IS): a G—>A transition creates new splice site in intron 5 of one IDUA allele. Hum Mutat 2: 141-144.
6. Moskowitz SM, Ernst RK, Miller SI (2004) PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol 186: 575-579.
Abstracts and Other Presentations
1. Moskowitz SM, Dlott B, Chuang PD, Neufeld EF (1992) Cloning and expression of cDNA encoding the human lysosomal enzyme, a-L-iduronidase. FASEB J 6:A77.
2. Moskowitz SM, Menon KP, Tieu PT, Neufeld EF (1992) Architecture of the gene encoding a-L-iduronidase and some mutations underlying human and canine MPS I. Am J Hum Genet 51:A53.
3. Moskowitz SM, Ernst RK, Miller SI (1999) The pmrA/B locus regulates resistance to the cationic antimicrobial peptides polymyxin B and C18G in Pseudomonas aeruginosa. Pediatr Pulmonol Supplement 19: A339.
4. Moskowitz SM, Ernst RK, Miller SI (2000) Resistance to cationic antimicrobial peptides cause by mutation of pmrA/B, an environmental sensing system that regulates outer membrane structure in Pseudomonas aeruginosa. Pediatr Pulmonol Supplement 20: A297.
5. Moskowitz SM, Burns JL, Nguyen CD, Høiby N, Ernst RK, Miller SI (2000) Polymyxin resistance and lipid A structure of Pseudomonas aeruginosa isolated from colistin-treated and colistin-naîve cystic fibrosis patients. Pediatr Pulmonol Supplement 20: A348.
6. Moskowitz SM, Ernst RK, Miller SI (2001) Antimicrobial peptide resistance and regulation of lipid A structure in Pseudomonas aeruginosa. Poster presented at 3rd Gordon Research Conference on Antimicrobial Peptides, Ventura, CA, March 18th-22nd, 2001.
7. Moskowitz SM, Ernst RK, Miller SI (2002) Antimicrobial peptide resistance and regulation of lipid A structure in Pseudomonas aeruginosa. Invited talk at “Pseudomonas 2002 at ASM”, Salt Lake City, May 17th, 2002.
8. Moskowitz SM, Foster J, Emerson JC, Gibson RL, McNamara S, Burns JL (2003) Discordance of antibiotic regimens based on biofilm and conventional susceptibilities of Pseudomonas aeruginosa from cystic fibrosis patients. Pediatr Res 53 (4): in press.
9. Moskowitz SM, Foster J, Emerson JC, Gibson RL, McNamara S, Burns JL (2003) Discordance of conventional and biofilm antibiotic susceptibilities of Pseudomonas aeruginosa isolated from cystic fibrosis airways. AJRCCM 167 (7): A322.
10. Moskowitz SM, Foster J, Emerson J, Gibson RL, McNamara S, Burns JL (2003) Development of a Numerical Algorithm to Select Antibiotic Regimens Based on Biofilm Susceptibilities of CF P. aeruginosa Isolates. Pediatr Pulmonol Supplement 25: A335.
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