Curriculum Vitae
Yi-Chung Lee M.D., Ph.D.
李宜中
Current Position: Attending physician
Department of Neurology
Taipei Veterans General Hospital
Associate Professor
Department of Neurology
National Yang-Ming University School of Medicine
Address: Department of Neurology,
Taipei Veterans General Hospital,
201, Sec. 2, Shih-Pai Road,
Taipei, Taiwan (ROC) 112
TEL: 886-2-28712121-3790
FAX: 886-4-28757579
E-mail:
Medical Education:
1989-1996 M.D. National Yang-Ming University School of Medicine
1995-1996 Internship at Taipei Veterans General Hospital
2003.10-2004.3 Research Volunteer, Pulmonary Division, Harvard Medical School affiliated Brigham and Women’s Hospital
2004.9-2008.5 Ph.D. program, Institute of Clinical medicine, National Yang-Ming University
Neurology Training Program:
1998.7-1999.1 Residency in Neurology, Chung-Hsiao Municipal Hospital, Taipei, Taiwan
1999.1-2002.6 Residency in Neurology, Taipei Veterans General Hospital, Taiwan
2002.7-2004.3 Fellowship in Neurology, Taipei Veterans General Hospital, Taiwan
Position:
2004.3-2004.6 Attending Physician, Department of Neurologogy, Taipei Veteran General Hospital, Taiwan
2004.6-2008.11 Attending Physician, Section of Neurology, Department of Internal Medicine, Taichung Veterans General Hospital
2008.8-2012.8 Asistant Professor, Department of Neurology, National Yang-Ming University School of Medicine
2008.11-now Attending Physician, Department of Neurology, Taipei Veterans General Hospital
2012.8-now Associate Professor, Department of Neurology, National Yang-Ming University School of Medicine
Qualified Neurologist in Taiwan in 2001:
Taiwan Board of Neurology
Present Membership of Society:
Taiwan Neurological Society since 1998
Taiwan Society of Clinical Neurophysiology since 2002
American Academy of Neurology since 2003
Taiwan Headache Society since 2005
Taiwan Human Genetics Society since 2009
Taiwan Proteomics Society since 2009
Taiwan Dementia Society since 2009
BMJ board of international fellow since 2013
Reviewer
Journal of Neurology, Neurosurgery & Psychiatry since 2008
Acta Neurologica Taiwanica since 2011
Expermental and molecular medicine since 2012
Gene since 2012
Molecular Neurobiology since 2013
Journal of the Neurological Sciences since 2014
Endocrine Practice since 2014
PLoS One since 2014
Journal of Neurogenetics since 2015
Experimental and Therapeutic Medicine since 2015
Theranostics since 2015
Acting Editor
Acta Neurologica Taiwanica since 2011
Publications:
1. Lee YC, Yen DJ*, Lirng JF, Yiu CH. Epileptic seizures in a patient by immersing his right hand into hot water. Seizure 2000;9:605-607.
2. Kao CD, Lee YC, Chen JT, Guo WY, Liao KK*. Spinal cord infarct presenting as Brown-Séquard plus syndrome: a case report. Acta Neurol Taiwan 2000; 9:145-150.
3. Yu HY, Chen JT, Lee YC, Guo YC, Kao CD, Shan DE, Liao KK*. Single-pulse transcranial magnetic stimulation reset the rhythm of essential tremor but not heart beat. Chinese Medical Journal (Taipei) 2001; 64:271-276.
4. Lee YC, Wei YH, Lirng JF, Lee HC, Tso DJ, Lin KP, Wu ZA, Liu HC*. Wernicke,s encephalopathy in a patient with multiple symmetrical lipomatosisand the A8344G mutation of mitochondrial DNA. Eur Neurol 2002; 47(2): 126-128.
5. Lin KN, Wang PN, Liu CY, Chen WT, Lee YC, Liu HC*. Cutoff scores of the cognitive abilities screening instrument, Chinese version in screening of dementia. Dement Geriatr Cogn Disord 2002;14(4):176-82
6. Lee YC, Liu RS, Liao YC, Sun CM, Wang BS, Wang PN, Liu HC*. Statistical parametric mapping of brain SPECT perfusion abnormalities in AD patients. Eur Neurol 2003;49:142-145.
7. Lee YC, Chen JT, Liao KK, Wu ZA, Soong BW*. Prolonged cortical relay time of long latency reflex and central motor conduction in patients with spinocerebellar ataxia type 6. Clin Neurophysiol 2003;114:458-462.
8. Liao YC, Liu RS, Lee YC, Sun CM, Liu CY, Wang PS, Wang PN, Liu HC*. Selective hypoperfusion of anterior cingulated gyrus in depressed AD patients: a brain SPECT findig by statistical parametric mapping. Dement Geriatr Cogn Disord 2003;16:238-244.
9. Kao CD, Chen JT, Lee YC, Shan DE, Lin YY, Chen R, Chung PST, Wu ZA, Liao KK*. Using EMG machine to study movement rhythm variation. J Chin Med Assoc 2003;66:587-592.
10. Chen JT, Lin YY, Lee YC, Wu ZA, Soong BW, Liao KK*. Prolonged central motor conduction time of lower limb muscle in spinocerebellar ataxia 6. J Clin Neurosci 2003;11:381-383.
11. Liu YT, Lee YC, Liu HC*. Isolated oculomotor nerve palsy due to head injury. J Chin Med Assoc 2004;67:149-151.
12. Lee YC, Soong BW, Lin KP*, Lee HY, Wu ZA, Kao KP. Myelin protein zero gene mutations in type 1 Charcot-Marie-Tooth disease patients in Taiwan. J Neurol Sci 2004;219:95-100.
13. Lee YC, Liu RS, Liao YC, Wang PN, Lin KN, Liu HC*. Longitudinal cerebral perfusion decrease in mild Alzheimer’s disease revealed by SPECT with statistical parametric mapping method. Eur Neurol 2004;52:42-49.
14. Lee YC, Soong BS, Liu YT, Lin KP*, Kao KP, Wu ZA. Median nerve motor conduction velocity is concordant with myelin protein zero gene mutation. J Neurol 2005;252:151-155.
15. Cheng SH, Chang MH, Soong BS, Chen CW, Lee YC*. Spastic paraparesis as a manifestation of metabolic vitamin B12 deficiency: a case report. J Neurol 2005;252:1125-1126. (corresponding author)
16. Liao YC, Liu RS, Teng EL, Lee YC, Wang PN, Lin KN, Chung CP, Liu HC*. Cognitive reserve: a SPECT study of 132 AD patients with an education range of 0-19 years. Dement Geriatr Cogn Disord 2005;20(1):8-14.
17. Chen CW, Chiang HC, Chen PL, Hsieh PF*, Lee YC, Chang MH. General paresis with reversible mesial temporal T2-weighted hyperintensity on magnetic resonance image: a case report. Acta Neurol Taiwan 2005;14:208-212.
18. Chang MH*, Liu LH, Lee YC, Wei SJ, Chiang HL, Hsieh PF. Comparison of sensitivity of transcarpal median motor conduction velocity and conventional conduction techniques in electrodiagnosis of carpal tunnel syndrome. Clin Neurophysiol 2006;117:984-91.
19. Lee YC, Yang AH, Liu HC, Wong WJ, Lu YC, Chang MH, Soong BW*. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy due to two novel mutations in the NOTCH3 gene. J Neurol Sci 2006;246:111-5. (NSC93-2314-B-010-054, NSC94-2321-B-010-008)
20. Lee YC, Lu YC, Chang MH, Soong BW*. Common mitochondrial DNA and POLG1 mutations are rare in the Chinese patients with adult-onset ataxia on Taiwan. J Neurol Sci 2007;254:65-8. (NSC93-2314-B-010-054, NSC94-2321-B-010-008)
21. Tseng JS, Lee YC, Pan HC, Chang MH*. Motor neuron disease-like syndrome secondary to trapped fourth ventricle and obstruction of cerebrospinal fluid pathway. Clin Neurol Neurosurg 2007;109:383-7.
22. Hsieh PF*, Tsan YT, Hung DZ, Hsu CL, Lee YC, Chang MH. Bromism caused mix-formulated analgesic injectables. Hum Exp Toxicol 2007;26:971-3.
23. Lee YC, Yu CTR, Lin KP, Chang MH, Hsu SL, Liu YF, Lu YC, Soong BW*. MPZ mutation G123S characterization; evidence for a complex pathogenesis in CMT disease. Neurology 2008;70:273-7. (NSC94- 2321-B-010-008, NSC95-2321-B-010-003)
24. Liu YT, Lee YC, Yang CC, Chen ML, Lin KP*. Transthyretin Ala97Ser in Chinese-Taiwanese patients with familial amyloid polyneuropathy: genetic studies and phenotype expression. J Neurol Sci 2008;267:91-9.
25. Lee WJ, Chang LB, Lee YC*. Incidental Findings on Brain MRI in general population. N Engl J Med 2008;358:853-4.
26. Chang MH*, Liu LH, Lee YC, Hsieh PF. Alteration of proximal conduction velocity at distal nerve injury in carpal tunnel syndrome: demyelinating versus axonal change. J Clin Neurophysiol 2008;25:161-6.
27. Hsieh PF*, Lee YC, Chang MH. Unilateral carotid and vertebral artery dissections and contralateral subarachnoid hemorrhage in a postpartum patient. Acta Neurol Taiwan 2008;17:94-8.
28. Lee YC*, Chang MH, Lin KP. Charcot-Marie-Tooth disease. Acta Neurol Taiwan 2008;17:203-13.
29. Chang MH*, Lee YC, Hsieh PF. The role of forearm mixed nerve conduction study in the evaluation of proximal conduction slowing in carpal tunnel syndrome. Clin Neurophysiol 2008;119:2800-3.
30. Chang MH*, Lee YC, Hsieh PF. The real role of forearm mixed nerve conduction velocity in the assessment of proximal forearm conduction slowing in carpal tunnel syndrome. J Clin Neurophysiol 2008;25:373-7.
31. Lee YC, Liu CS, Chang MH, Lin KP, Fuh JL, Lu YC, Liu YF, Soong BW*. Population-specific spectrum of NOTCH3 mutations, MRI features, and founder effect of CADASIL in Chinese. J Neurol 2009;256:249-55. (NSC 96-2314-B-075A-009 and NSC96-2314-B-010-036-MY3)
32. Lee YC, Liu CS, Wu HM, Wang PS, Chang MH, Soong BW*. The “hot cross bun” sign in the patients with spinocerebellar ataxia. Eur J Neurol 2009;16:513-6. (NSC 96-2314-B-075A-009 and NSC96-2314-B-010-036-MY3)
33. Lee YC, Yang AH, Soong BW*. The remarkably variable expressivity of CADASIL: report of a minimally symptomatic gentleman at an advanced age. J Neurol 2009;256:1026-7. (NSC 96-2314-B-075A-009 and NSC96-2314-B-010-036-MY3).
34. Lee SW, Lee BJ, Lee YC, Hou TC*. Myasthenia gravis in a patient with a first presentation of acute hypercapnic respiratory failure. J Emerg Crit Care Med 2009;20:49-50.
35. Chang MH*, Hung WL, Liao YC, Lee YC, Hsieh PF. Eye of the tiger-like MRI in parkinsonian variant of multiple system atrophy. J Neural Transm 2009;116:861-6.
36. Lee YC, Liu YT, Lin KP*. Familial transthyretin-related amyloid polyneuropathy in a Malaysian patient of ethnic Chinese descent. (Correspondence) Neurology Asia 2009;14:43.
37. Morris Z, Whiteley WN, Longstreth WT Jr, Weber F, Lee YC, Tsushima Y, Alphs H, Ladd SC, Warlow C, Wardlaw JM, Al-Shahi Salman R*. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2009 17;339:b3016.
38. Chang MH*, Liao YC, Lee YC, Hsieh PF, Liu LH. Electrodiagnosis of carpal tunnel syndrome: which transcarpal conduction technique is best? J Clin Neurophysiol 2009 26;366-71.
39. Chi NF, Lee YC, Lu YC, Wu HM, Soong BW*. Transmissible spongiform encephalopathies with P102L mutation of PRNP manifesting different phenotypes: clinical, neuroimaging, and electrophysiological studies in Chinese kindred in Taiwan. J Neurol 2010;257:191-7.
40. Su SL, Jou SH, Cheng WL, Lin TT, Li JY, Huang CC, Lee YC, Soong BW, Liu CS*. Mitochondrial DNA damage in spinal and bulbar muscular atrophy patients and carriers. Clin Chim Acta 2010;411:626-30.
41. Chen CH, Wu ML, Lee YC, Layne MD, Yet SF*. Intronic CarG box regulates cysteine-rich protein 2 expression in the adult but not in developing vasculature. Arterioscler Thromb Vasc Biol 2010;30:835-42.
42. Lee YC, Lin KP, Chang MH, Liao YC, Tsai CP, Liao KK, Soong BW*. Cellular characterization of MPZ mutations presenting with diverse clinical phenotypes. J Neurol 2010;257:1661-8.
43. Lee YC, Lee TC, Lin KP, Lin MW, Chang MH, Soong BW*. Clinical characterization and genetic analysis of a possible novel type of dominant intermediate Charcot-Marie-Tooth disease. Neuromuscul Disord 2010;20:534-9.
44. Hung WL, Hsieh PF*, Lee YC, Chang MH. Occipital lobe seizures related to marked elevation of hemoglobin A1C: Report of two cases. Seizure 2010;19:359-62.
45. Lo YC, Lin KP, Lin CY, Kao CD, Chen JT, Lai KL, Lin YY, Lee YC, Liao KK*. Fatigue as the only clinical manifestation of colchicine induced myopathy. Acta Neurol Taiwan 2010;19:180-4.
46. Lee YC, Soong BW*, Wong WJ. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Chin J Stroke 2010;5:573-8.
47. Lin KP, Lo YC, Lin CY, Chen JT, Lin YY, Lee YC, Liao KK*. Fatigue in colchicine myopathy: a study of transcranial magnetic stimulation. J Chin Med Assoc 2010;73:623-7.
48. Liu CS*, Soong BW, Lee YC, Chen WL, Kuo CL, Cheng WL, Huang CS, Lin WT. Gluten sensitivity: associated sporadic cerebellar ataxia in Taiwan. Acta Neurol Taiwan 2010;19:263-9.
49. Tsai CP, Soong BW (co-first author), Lin KP, Tu PH, Lin JL, Lee YC*. FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS. Neurobiol Aging 2011;32:553.e13-21.
50. Tang CW, Chang FC, Chern CM, Lee YC, Hu HH, Lee IH. Stenting versus medical treatment for severe symptomatic intracranial stenosis. AJNR Am J Neuroradiol 2011;32:911-6.
51. Lee YC, Liao YC (co-first author), Wang PS, Lee IH, Lin KP, Soong BW. Comparison of cerebellar ataxias: A three-year prospective longitudinal assessment. Mov Disorder 2011;26:2081-7.
52. Lo YC, Liao KK, Lee YC, Soong BW. Gabapentin for complex regional pain syndrome in Machado-Joseph disease: a case report. J Med Case Reports 2011;5:268.
53. Lin KP, Soong BW (co-first author), Yang CC, Huang LW, Chang MH, Lee IH, Antonellis A, Lee YC*. The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan. PLoS One 2011;6(12): e29393.
54. Lin KP, Soong BW, Chang MH, Chen WT, Lin JL, Lee WJ, Lee YC*. Clinical and cellular characterization of two novel MPZ mutations, pI135M and p.Q187PfsX63. Clin Neurol Neurosurg 2012;114:124-9.
55. Lee YC, Liu CS, Lee TY, Lo YC, Lu YC, Soong BW*. SCA31 is rare in the Chinese population on Taiwan. Neurobiol Aging 2012;33:426.e23-4.
56. McLaughlin HM, Sakaguchi R, Giblin W; NIH Intramural Sequencing Center, Wilson TE, Biesecker L, Lupski JR, Talbot K, Vance JM, Züchner S, Lee YC, Kennerson M, Hou YM, Nicholson G, Antonellis A. A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with charcot-marie-tooth disease type 2N (CMT2N) .Hum Mutat 2012;33:244-253.
57. Chen WT, Wang SJ, Fuh JL, KoYC, Lee YC, Hämäläinen MS, LinYY. Visual cortex excitability and plasticity associated with remission from chronic to episodic migraine. Cephalagia. 2012;32:537-543.
58. Huang LW, Lin KP, Chang MH, Liao YC, Liao KK, Soong BW, Lee YC*. Electrophysiological characterization of Charcot-Marie-Tooth disease type 1A in Taiwan. J Chin Med Assoc 2012;75:197-202.
59. Tsai CP, Soong BW (co-first author), Tu PH, Lin KP, Fuh JL, Tsai PC, Lu YC, Lee IH, Lee YC*. A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan. Neurobiol Aging 2012;33:2232e11-8.
60. Lee YC*, Lee MJ, Yu HY, Chen C, Hsu CH, Lin KP, Liao KK, Chang MH, Liao YC, Soong BW*. PRRT2 mutations in paroxysmal kinesigenic dyskinesia with infantile convulsions in a Taiwanese cohort. PLoS One 2012;7:e38543.
61. Su SL, Wang WF, Wu SL, Wu HM, Chang JC, Huang CS, Cheng WL, Soong BW, Lee YC, Li YJ, Kuo SJ, Chen M, Huang CN, Liu CS*. FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease. Clin Chim Acta 2012;414C:225-227.
62. Lee YC, Durr A, Majczenko K (co-first author), Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT, Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M*, Stevanin G*, Soong BW*. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann Neurol 2012;72:859-869.
63. Soong BW, Liao YC, Tu PH, Tsai PC, Lee IH, Chung CP, Lee YC*. A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. J Chin Med Assoc 2013;76:319-324.
64. Soong BW, Huang YH (co-first author), Tsai PC, Huang CC, Pan HC, Lu YC, Chien HJ, Liu TT, Chang MH, Lin KP, Tu PH, Kao LS*, Lee YC*. Exome sequencing identifies GNB4 mutations as a cause of dominant intermediate Charcot-Marie-Tooth disease. Am J Hum Genet 2013;92(3):422-430.