CURRICULUM VITAE
Personal data
Name : Gianluigi Forloni
Date and place of birth: May 15,1956 in Rho (Mi), Italy
Citizenship: Italian
Residence: Piazza San Vittore , 7, 20017 Rho (Mi)
Education
1976 Diploma in Industrial Chemistry, Rho (Mi)
1985 Degree in Biological Sciences, University of Milan
Research Experience
1977-1980 Technician fellow, Laboratory of Neuropharmacology of the Cholinergic System, Mario Negri Institute of Pharmacological Research, Milan.
1980-1985 Senior technician, Laboratory of Neuropharmacology of the Cholinergic System, Mario Negri Institute
1986-1988 Postdoctoral fellow, Department of Psychiatry and Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, U.S.A.
1988-1992 Research assistant,Laboratory of Geriatric Neuropsychiatry Mario Negri Institute
1992 -1995 Head of the Unit of Neurobiology of Alzheimer, Mario Negri Institute.
1996 - present Head of the Laboratory of Biology of Neurodegenerative Disorders, Mario Negri Institute.
2002- present Head of the Department of Neuroscience, Mario Negri Institute.
Area of research:
Biological and genetic bases of Alzheimer’s disease (AD), Prion-related encephalopathies (PRE) and Parkinson's disease (PD). Studies on pathogenesis and possible therapeutic approaches based on the role of protein aggregation in the neurodegenerative diseases and mechanisms of neuronal death using in vitro and in vivo models. Identification of biological markers of disease.
Membership :
American Society of Neuroscience, 1987-
Italian Association Research on Brain Aging, 1989- (1999- member of Directive Council, 2003- President)
New York Accademy of Science, 1992-96
Italian Society of Neuroscience, 2000-
European Academy of Science, 2004-
International Society to Advance Alzheimer Research and Treatment (ISTAART) 2008-
Brain Mapping and Therapeutics 2014-
Scientific Committees Membership
Scientific Committee of Dementia section (SINDEM) of Italian Society of Neurology
Scientific Committee of the Trial Stamina appointed by Italian Ministry of Health
Scientific Committee "Associazione per la Ricerca sulle Demenze", Association for the Research on the Dementia
Editorial Board:
Biochemical Journal 2000-2007
Brain Aging 2003-2010
Journal Epigenetics of Neurodegenerative Diseases
Open Geriatric Medicine Journal
Open Longevity Science
PlosOne (Academic Editor)
International Journal of Molecular Epidemiology
Dr. Forloni has served as a member of several committees of the European Community for the examination of the projects in the Neuroscience field. He is now member of the Coordinating Group of the European Consortium “IMI-PharmaCog”. He has been in charge of an elective course on genetic of neurodegenerative disorders at the Medical School of the University of Milan, he was invited for lectures and seminars in numerous Universities and Research Centers. Dr. Forloni is the author of more than 250 peer-review scientific articles and about 30 reviews or book chapters, H index=54 (google scholar).
Bibliography
Articles
1979
1. Consolo S., Forloni G., Garattini S., Ladinsky H., Tirelli A.S.
Differential effects of the isomers of fenfluramine and norfenfluramine on rat striatal acetylcholine content.
J. Pharm. Pharmacol. 31: 706 (1979)
1980
2. Consolo S., Ladinsky H., Forloni G., Tirelli A.S., Garattini S.
Comparison of the effects of the stereoisomers of fenfluramine on the acetylcholine content in rat striatum, hippocampus an nucleus accumbens.
J. Pharm. Pharmacol. 32: 201-203 (1980)
3. Ladinsky H., Consolo S., Tirelli A.S., Forloni G.
Evidence for noradrenergic mediation of the oxotremorine-induced increase in acetylcholine content in rat hippocampus.
Brain Res. 187: 494-498 (1980)
1981
4. Ladinsky H., Consolo S., Forloni G., Tirelli A.S.
Studies on the indirect feedback inhibition of cholinergic neurons triggered by oxotremorine in striatum.
Brain Res. 225: 217-223 (1981)
1982
5. Consolo S., Ladinsky H., Forloni G., Grombi P.
Modulation of the hippocampal alpha-adrenoceptor population by lesion of the serotonergic raphe-hippocampal pathway in rats.
Life Sci. 30: 1113-1120 (1982)
1983
6. Forloni G., Consolo S., Grombi P., Wang J.X., Mennini T., Ladinsky H.
Modifications in recognition sites for neurotransmitters in rat hippocampus by kainic acid lesion.
Brain Res. 274: 165-170 (1983)
7. Consolo S., Forloni G., Fisone G., Sieklucka M., Ladinsky H.
Mediation by the corticostriatal input of the in vivo increase in rat striatal acetylcholine content induced by 2-chloroadenosine.
Biochem. Pharmacol. 32: 2993-2996 (1983)
1984
8. Garattini S., Forloni G., Tirelli A.S., Ladinsky H., Consolo S.
Neurochemical effects of minaprine, a novel psychotropic drug on thecentral cholinergic system of the rat.
Psychopharmacology (Berl.) 82: 210-214 (1984)
9. Consolo S., Wang J.X., Fusi R., Vinci R., Forloni G., Ladinsky H.
In vitro and in vivo evidence for the existence of presynaptic muscarinic cholinergic receptors in the rat hippocampus.
Brain Res. 309: 147-151 (1984)
1985
10. Consolo S., Wang J.X., Forloni G., Mocchetti I., Racagni G., Ladinsky H.
Studies on the up regulation of alpha-adrenoceptors on rat hippocampal perikarya by chemical lesion of the median raphe nucleus.
Life Sci. 37: 449-460 (1985)
11. Wang J.X., Consolo S., Vinci R., Forloni G., Ladinsky H.
Characterization of the alpha adrenergic receptor population in hippocampus up regulated by serotonergic raphe deafferentiation.
Life Sci. 36: 255-270 (1985)
12. Kolasa K., Consolo S., Forloni G., Garattini S., Ladinsky H.
Blockade of the diazepam-induced increase in rat striatal acetylcholine content by the specific benzodiazepine antagonists ethyl-beta-carboline-3-carboxylate and Ro 15-1788.
Brain Res. 336: 342-345 (1985)
1986
13. Consolo S., Sieklucka M., Fiorentini F., Forloni G., Ladinsky H.
Frontal decortication and adaptive changes in striatal cholinergic neurons in the rat.
Brain Res. 363: 128-134 (1986)
14. Forloni G., Fisone G., Consolo S., Ladinsky H.
Qualitative differences in the effects of adenosine analogs on the cholinergic systems of rat striatum and hippocampus.
Naunyn Schmiedebergs Arch. Pharmacol. 334: 86-91 (1986)
15. Forloni G., Fisone G., Guaitani A., Ladinsky H., Consolo S.
Role of the hippocampus in the sex-dependent regulation of eating
behavior: Studies with kainic acid.
Physiol. Behav. 38: 321- 326 (1986)
1987
16. Forloni G., Bidzinski A., Fusi R., Ladinsky H., Consolo S.
Striatal cholinergic function reflects differences in D-2 dopaminergic receptor activation.
Life Sci. 41: 1717-1723 (1987)
17. Forloni G.L, Graznna, R. Blakely R., and Coyle J.T.
Co-localization of N-acetyl-aspartyl-glutamate in cholinergic, noradrenergic and serotonergic neurons
Synapse, 1, 455-460 (1987)
18. Saltarelli M.D., Forloni G., Oster-Granite M.L., Gearhart J.D., Coyle J.T.
Neurochemical characterization of embryonic brain development in trisomy 19 (Ts19) mice: Implications of selective deficits observed for abnormal neural development in aneuploidy.
Dev. Genet. 8: 267-279 (1987)
1988
19. Guarda A., Robinson M., Ory-Lavollee L., Forloni G.,Blakely R. and Coyle J.T.
Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissue: findings with anovel liquid phase radioimmunoassay
Molec.Brain Research 3: 223-232 (1988)
20. Consolo S., Forloni G., Ladinsky H. and Palazzi E.
Frontal decortication enhances opiate catalepsy in rats.
Brain Res. 449: 97-103 (1988)
21. Bendotti C., Forloni G., Morgan R., Reeves R., Oster-Granite M.,Gerheart J. and Coyle J.T. Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid and lesioned mice
Proc.Nat.Acad.Sci (USA) 85: 3628-3632 (1988)
22. Tsai, G.,Forloni G., Robinson, M.B., Stauch, B.L. and Coyle, J.T.
Calcium-dependent evoked release of [3H]N-acetylaspartylglutamate from the optic pathway
J. Neurochem. 51: 1956-195 (1988)
1989
23. Stauch L.B., Robinson M.B., Forloni G., Tsai G. and Coyle J.T.
The effects of N-Acetylated Alpha-Linked Acidic Dipeptidase (NAALADase) inhibitors on [3H]NAAG catabolism in vivo
Neurosci Lett.100: 90-95 (1989)
24. Forloni G., Blake K, Hohmann C.H. and Coyle J.T.
The postnatal expression of acetylcholinesterase in somatostatin-positive cells of mouse hippocampus
Dev. Brain Research 48: 73-85 (1989)
1990
25. Frondoza C., Logan S., Forloni G. and Coyle, J.T.
Production and characterization of monoclonal antibodies to N-acetyl-aspartyl-glutamate
J.Histochem Cytochem.38, 493-502 (1990)
26. Forloni G., Hohmann C., Coyle J.T.
Developmental expression of somatostatin in mouse brain. I. Immunocy-tochemical studies.
Dev. Brain Res. 53: 6-25 (1990)
27. Bendotti C., Hohmann C., Forloni G., Reeves R.H., Coyle J.T., Oster-Granite M.L.
Developmental expression of somatostatin in mouse brain. II. In situ hybridization.
Dev. Brain Res. 53: 26-39 (1990)
29. Consolo S., Bertorelli R., Forloni G., Butcher L.L.
Cholinergic neurons of the pontomesencephalic tegmentum release acetylcholine in the basal nuclear complex of freely moving rats.
Neuroscience 37: 717-723 (1990)
30. Cella S.G., Locatelli V., Mennini T., Zanini A., Bendotti C., Forloni G., Fumagalli G., Arce V., De Gennaro C.V., Wehrenberg W.B., Muller E.E.
Deprivation of growth hormone-releasing hormone early in the rat's neonatal life permanently affects the somatotropic function.
Endocrinology 127: 1625-1634 (1990)
31. Bendotti C., Servadio A., Forloni G., Angeretti N., Samanin R.
Increased tryptophan hydroxylase mRNA in raphe serotonergic neurons spared by 5,7-dihydroxytryptamine.
Mol. Brain Res. 8: 343-348 (1990)
32. Forloni G., Angeretti N., Amoroso D., Addis A., Consolo S.
Decrease in [3H]hemicholinium binding to high-affinity choline uptake sites in deafferented striatum: Restoration by oxiracetam.
Brain Res. 530: 156-160 (1990)
33. Rosina A., Morara S., Provini L., Forloni G.
Modulation of cerebellar CGRP binding sites induced by climbing fibre
activation.
NeuroReport 1: 215-217 (1990)
1991
34. Vezzani A., Forloni G., Serafini R., Rizzi M., Samanin R.
Neurodegenerative effects induced by chronic infusion of quinolinic acid in rat striatum and hippocampus. Europ.J. Neurosci. 3: 40-46 (1991)
35. Manfridi A., Forloni G., Vezzani A., Fodritto F., De Simoni M.G.
Functional and histological consequences of quinolinic and kainic acid-induced seizures on hippocampal somatostatin neurons.
Neuroscience 41: 127-135 (1991)
36. Bertorelli R., Forloni G., Consolo S.
Modulation of cortical in vivo acetylcholine release by the basal nuclear complex: Role of pontomesencephalic tegmental area. Brain Res. 563: 353-356 (1991)
37. Spagnoli A., Lucca U., Menasce G., Bandera L., Cizza G., Forloni G., Tettamanti M., Frattura L., Tiraboschi P., Comelli M., Senin U., et al.
Long-term acetyl-L-carnitine treatment in Alzheimer's disease.
Neurology 41: 1726-1732 (1991)
1992
38 Forloni G., Angeretti N., Rizzi M., Vezzani A.
Chronic infusion of quinolinic acid in rat striatum: Effects on discrete neuronal populations.
J. Neurol. Sci. 108: 129-136 (1992)
39. Forloni G., Angeretti N.
Decreased [3H]hemicholinium binding to high-affinity choline uptake sites in aged rat brain Brain Res. 570: 354-357 (1992)
40. Han S.Y., Sweeney J.E., Bachman E.S., Schweiger E.J., Forloni G., Coyle J.T., Davis B.M., Joullie` M.M. Chemical and pharmacological characterization of galanthamine, an acetylcholinesterase inhibitor, and its derivatives. A potential
application in Alzheimer's disease?.
Europ. J.Med.Chem. 27: 673-687 (1992)
41. Giorgi S., Forloni G., Amoroso D., Consolo S. Expression of GAL mRNA in rat hypothalamus: Effect of frontal deafferentation and colchicine treatment.
Mol. Brain Res. 14: 277-281 (1992)
42. Provini, L., Morara, S., Rosina, A. and Forloni, G., Expression of CGRP binding sites in the developing rat cerebellum, Ann. N. Y. Acad. Sci., 657:423-425 (1992).
43 Rosina, A., Morara, S., Provini, L. and Forloni, G., Activation of olivocerebellar fibers induces an increase in CGRP cerebellar binding sites, Ann. N. Y. Acad. Sci., 657: 432-434 (1992)
44. Forloni G., Demicheli F., Giorgi S., Bendotti C., Angeretti N. Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: Modulation by interleukin-1. Mol. Brain Res. 16: 128-134 (1992)
45. Manfridi A., Forloni G., Arrigoni-Martelli E., Mancia M. Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl-l-carnitine and NGF.
Int. J. Dev. Neurosci. 10: 321-329 (1992)
1993
46. Masseroli M., Bollea A., Bendotti C., Forloni G. In situ hybridization histochemistry quantification: Automatic count on single cell in digital image.
J. Neurosci. Methods 47: 93-103 (1993).
47. Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O.,Tagliavini F.
Neurotoxicity of a prion protein fragment. Nature 362: 543-546 (1993).
48. Forloni G., Chiesa R., Smiroldo S., Verga L., Salmona M., Tagliavini F., Angeretti N.
Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.
NeuroReport 4: 523-526 (1993)
49. Ammassari-Teule M., Amoroso D., Forloni G., Rossi-Arnaud C., Consolo S.
Mechanical deafferentation of basal forebrain-cortical pathways and neurotoxic lesions of the nucleus basalis magnocellularis: Comparative effect on spatial learning and acetylcholine release in vivo.
Behav. Brain Res. 54: 145-152 (1993)
50. Forloni G., Del Bo R., Angeretti N., Smiroldo S., Gabellini N., Vantini G.
Nerve growth factor does not influence the expression of beta amyloid precursor protein mRNA in rat brain: In vivo and in vitro studies.
Brain Res. 620: 292-296 (1993)
51. Selvaggini C., De Gioia L., Cantu' L., Ghibaudi E., Diomede L., Passerini F.,
Forloni G., Bugiani O., Tagliavini F., Salmona M.
Molecular characteristics of a protease-resistant, amyloidogenic and
neurotoxic peptide homologous to residues 106-126 of the prion protein.
Bioch. Biophy. Res. Comm. 194: 1380-1386 (1993)
52. Tagliavini F., Prelli F., Verga L., Giaccone G., Sarma R., Gorevic P., Ghetti B., Passerini F., Ghibaudi E., Forloni G., Salmona M.,Bugiani O. and Frangione, B.
Synthetic peptides homologous to prion protein residues 106-147 form
amyloid-like fibrils in vitro.
Proc. Natl. Acad. Sci. (USA) 90: 9678- 9682 (1993)
53. Masseroli, M., Messori, A. Ponti, M., Bendotti C., Forloni G.
Automatic quantitatiive evaluation of autoradiographic band films by computerized image analysis
LIfe Sciences 53: 331- 336 (1993)
54. Masseroli M., Bollea A., Forloni G. Quantitative morphology and shape classification of neurons by computerized image analysis.
Comput. Meth. Progr. Biomed. 41: 89- 99 (1993)
1994
55. Forloni G., Angeretti N., Smiroldo S.
Neuroprotective activity of acetyl-L-carnitine: studies in vitro.
J. Neurosci. Res. 37: 92-96 (1994)
56. De Gioia L.Selvaggini C, Ghibaudi E., Diomede L., Forloni G., Bugiani O., Tagliavini F., Salmona M.
Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
J. Biol. Chem. 269: 7859-7862 (1994)
57. Forloni, G., Del Bo, R., Angeretti, N. Smiroldo, Chiesa, R., Doni R. Ghibaudi E. Salmona, M., Porro, M., Verga, L. Giaccone, G. Bugiani, O., Tagliavini, F.
A neurotoxic prion protein fragment induces rat astroglial proliferation in vitro.
Eur. J. Neurosci. 6:1415-1422 (1994)
58. Lucca, U., Tettemanti, M., Forloni, G. and Spagnoli A.
Nonsteroidal anti-inflammatory drug use in Alzheimer's disease and elderly population.
Biol. Psychiatry 36: 854- 856 (1994)
1995
69 Del Bo R., Angeretti, N., Lucca E. De Simoni M.G. and Forloni, G.
Reciprocal control of inflammatory cytokines and amyloid production in cultures
Neurosci lett. 188: 70-74 (1995)
60. De Simoni, M.G., Del Bo R., De Luigi A., Simard, S. and Forloni, G.