CURRICULUM VITAE- PABLO GONZÁLEZ MUÑOZ

Birth date:03/06/1979

Citizenship:Chilean and French

Contact:Department of Microbiology and Immunology, Albert Einstein College of Medicine, NY, USA.f: 1-718-6781073

e-mail:, ,

Languages:English, French and Spanishspoken and writtenfluidly

Education and Training

1999-2004Biochemist, Pontificia Universidad Católica de Chile.

2005-2006MSc, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile.

2006-2008PhD. inMolecular Genetics and Microbiology, Pontificia Universidad Católica de Chile.

2008-2010Post-doctoral CONICYT fellow at the Pontificia Universidad Católica de Chile.

2010-PresentPost-doctoral Howard Hughes Medical Institute fellow at the Albert Einstein College of Medicine, NY, USA.

Internships:

May 2010-May 2011Dr. William Jacobs, HHMI, Howard Hughes Medical Institute, Department of Immunology and Microbiology, Albert Einstein College of Medicine, Yeshiva University, NY, USA.

January 2009Dr. Stanley Nathenson, Department of Molecular Biology, Albert Einstein College of Medicine, Yeshiva University, NY, USA. Crystallization of Respiratory Syncytial Virus proteins for structural determination.

October 2007-March 2008.Dr. William Jacobs, HHMI, Howard Hughes Medical Institute Mycobacterium MicrobiologyLaboratory, Department of Immunology and Microbiology, Albert Einstein College of Medicine, Yeshiva University, NY, USA.

Awards and Fellowships:

October 20082-year CONICYT Post-doctoral Fellowship.

October 2009Award granted to the best Doctoral Thesis at the Faculty of Biological Sciences, Pontificia Universidad Católica de Chile.

September 2008Hermann Niemeyer Medal delivered by the Chilean Society of Biochemistry and Molecular Biology to the most distinguished Ph.D. student within Biological Sciences doctorate programs in Chile.

September 2008Award to the best oral presentation on scientific research, delivered by the Chilean Society of Cellular Biology.

2007CONICYT fellowship for international internships: 6 month internship performed at the laboratory of Dr. William Jacobs, Albert Einstein College of Medicine, NY, USA (October 2007-March 2008).

03/05-10/08CONICYT doctorate Fellowship.

March 2003Honor Fellowship, award delivered by the Pontificia Universidad Católica de Chile for academic excellence.

ISI Publications (last 7 years):

  1. Paras Jain, Tsungda Hsu, Masayoshi Arai, Karolin Biermann, Pablo Gonzalez, David S. Thaler, Michelle H. Larsen and William R. Jacobs Jr. Construction of Precise Deletion Antibiotic-Sensitive Mycobacterium Tuberculosis Mutant Strains Using Genetically Engineered Mycobacteriophages. Submitted toPLoS Genetics, January 2013.
  2. Natalia Cheshenko, Janie B. Trepanier, Martha Stefanidou, Pablo Gonzalez, William Jacobs and Betsy C. Herold. HSV Activates Akt to Trigger Calcium Release and Promote Viral Entry: Novel Candidate Target for Treatment and Suppression. FASEB J.Resubmitted, January 2013.
  3. Pablo F. Céspedes*, Pablo A. González* and Alexis M. Kalergis. Human metapneumovirus keeps dendritic cells from priming antigen-specific naive T cells. Accepted for publication in Immunology, January 2012. *equal contribution.
  4. Lay MK, González PA, León MA, Céspedes P, Bueno SM, Riedel CA, Kalergis AM. Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response. Microbes Infect. 2012 Dec 12. PMID: 23246463
  5. González PA, Carreño LJ, Bueno SM, Riedel CA, Kalergis AM. Understanding respiratory syncytial virus infection to improve treatment and immunity. Curr Mol Med. 2012 Nov 15.
  6. Cortés C, Eugenin E, Aliaga E, Carreño LJ, Bueno SB, Gonzalez P, Gayol S, Naranjo D, Noches V, Marassi MP, Rosenthal D, Jadue C, Ibarra P, Keitel C, Wohllk N, Court F, Kalergis AM, Riedel CA. Hypothyroidism in the adult rat causes an increment of BDNFin the brain, neuronal and astrocyte apoptosis, gliosis and deterioration of the postsynaptic density.Thyroid. 2012 May 16.
  7. González PA, Bueno SM, Carreño LJ, Riedel CA, Kalergis AM. Respiratory syncytial virus infection and Immunity. Rev Med Virol. 2012 Jul;22(4):230-44.
  8. Bueno SM*, González PA*, Riedel CA, Carreño LJ, Vásquez AE, Kalergis AM. Local cytokine response upon respiratory syncytial virus infection. Immunol Lett. 2011 May;136(2):122-9. *Equal contribution.
  9. Carreño LJ, González PA, Bueno SM, Riedel CA, Kalergis AM. Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity.Immunotherapy. 2011 Apr;3(4 Suppl):6-11.
  10. Carvajal CA, Stehr CB, González PA, Riquelme EM, Montero T, Santos MJ, Kalergis AM, Fardella CE. A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes Familial Hyperaldosteronism type I. J Endocrinol Invest. 2010 Jul 13.
  11. Carreño LJ, Riquelme EM, González PA, Espagnolle N, Riedel CA, Valitutti S, Kalergis AM. T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC.Proc Natl Acad Sci USA. 2010 Jan 5;107(1):210-5. Epub 2009 Dec 14.
  12. Herrada AA, Contreras FJ, Marini NP, Amador CA, González PA, Cortés CM, Riedel CA, Carvajal CA, Figueroa F, Michea LF, Fardella CE, Kalergis AM.Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity. J Immunol. 2009 Nov 30.
  13. P.A. González, S.M. Bueno, C.A. Riedel and A.M. Kalergis. Impairment of T Cell Immunity by the Respiratory Syncytial Virus, Current Medicinal Chemistry, 2009;16(34):4609-25.
  14. Riquelme E, Carreño LJ, González PA, Kalergis AM. The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity, Eur J Immunol.2009;16(34):4609-25.
  15. González HE, Leiva A, Tobar H, Böhmwald K, Tapia G, Torres J, Mosso LM, Bueno SM, Gonzalez P, Kalergis AM, Riedel CA. Altered chemokine receptor expression in papillary thyroid cancer, Thyroid. 2009 Sep;19(9):957-65.
  16. Bueno SM, González PA, Kalergis AM, Use of genetically modified bacteria to modulate adaptive immunity,Curr Gene Ther. 2009 Jun;9(3):171-84.
  17. Susan M. Bueno, Pablo A. González, Kelly M. Cautivo, Jorge E. Mora, Eduardo D. Leiva, Hugo E. Tobar,Glenn J. Fennelly, Eliseo A. Eugenin, William R. Jacobs, Jr., Claudia A. Riedel, and Alexis M. Kalergis. Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG. Proc Natl Acad Sci USA:2008 Dec 30;105(52):20822-7. Epub 2008 Dec 15.
  18. Pablo A. Gonzalez, Carolina E. Prado, Eduardo D. Leiva, Leandro J Carreño, Susan M. Bueno, Claudia A. Riedel and Alexis M. Kalergis. Respiratory Syncytial Virus impairs T cell activation by preventing synapse assembly with Dendritic cells. Proc Natl Acad Sci USA: 2008 2008 Sep 30;105(39):14999-5004.
  19. Alexis M. Kalergis, Mirentxu I. Iruretagoyena, Magaly J. Barrientos, Pablo A. González, Eduardo D. Leiva, Andres A. Herrada, Miguel A. Gutiérrez, Claudia A. Riedel, Susan M. Bueno and Sergio H. Jacobelli, Modulation of NF-ΚB activity can influence the susceptibility to systemic lupus erythematosus. Immunology, 2008, Sep;128(1 Suppl):e306-14.
  20. Opazo MC, Gianini A, Pancetti F, Azkcona G, Alarcón L, Lizana R, Noches V, Gonzalez PA, Porto M, Mora S, Rosenthal D, Eugenin E, Naranjo D, Bueno SM, Kalergis AM, Riedel CA. Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring. Endocrinology 2008 Oct;149(10):5097-106.
  21. Susan M. Bueno, Pablo A. Gonzalez, Rodrigo Pacheco, Eduardo D. Leiva, Kelly M. Cautivo, Hugo E. Tobar, Jorge E. Mora, Carolina E. Prado, Juan P. Zúñiga, Jorge Jiménez, Claudia A. Riedel, Alexis M. Kalergis. Host immunity during RSV pathogenesis. International Immunopharmacology, 2008 Oct;8(10):1320-9.
  22. Bueno SM, González PA, Carreño LJ, Tobar JA, Mora GC, Pereda CJ, Salazar-Onfray F, Kalergis AM. The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific. Immunology, 2008 Aug;124(4):522-33.
  23. Susan M. Bueno, Pablo A. González and Alexis M. Kalergis. T cell immunity evasion by virulent Salmonella enterica. Immunology Letters, 2007, Jul 31;111(1):14-20.
  24. Pablo A. González, Leandro J. Carreño, Claudio A. Figueroa and Alexis M. Kalergis. Modulation of immunological synapse by membrane-bound and soluble ligands. Cytokine Growth Factor Rev, 2007, Feb-Apr;18(1-2):19-31.
  25. Tobar J.A., Carreño L.J., Bueno S.M., Gonzalez P.A., Mora J.E., Quezada S.A. and Kalergis A.M. Virulent Salmonella enterica serovar Typhimurium evades adaptive immunity by preventing dendritic cells from activating T cells. Infection and Immunity, 2006 Nov;74(11):6438-48.
  26. Leandro Carreño, Pablo González y Alexis Kalergis. Modulation of T cell function by TCR/pMHC binding kinetics. Immunobiology, 2006;211(1-2):47-64.

Participation at Conferences

  1. XXIV Annual Reunion of the Cellular Biology Society of Chile, Pucón-Chile, November 1-5, 2010. Human Metapneumovirus Impairs T Cell Activation by Dendritic Cells. González, Pablo; Céspedes Pablo; Mora, Jorge; Cortés, Claudia; Bueno, Susan; Riedel, Claudia; Kalergis, Alexis.
  2. The Endocrine Society 2010, June 19-22, 2010. A novel unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes Familial Hyperaldosteronism type I. CA Carvajal, CB Stehr, PA Gonzalez, EM Riquelme, TD Montero, MJ Santos, AM Kalergis, and CE Fardella.
  3. 9th Latin American Congress of Immunology, Viña del Mar, Chile, November 3-7th 2009, XII Chilean Society of Immunology Congress, LVII Argentinean Society of Immunology Satellite Scientific Meeting. Impaired T Cell Activation and Synapse Assembly with Dendritic Cells by The Respiratory Syncytial Virus (RSV). Pablo A. González, Carolina E. Prado, Eduardo D. Leiva, Leandro J Carreño, Susan M. Bueno, and Alexis M. Kalergis.

4.XXII Annual Reunion of the Cellular Biology Society of Chile, Pucón-Chile October 5-9, 2008. Respiratory Syncytial Virus Impairs T Cell Activation by Preventing Synapse Assembly with Dendritic Cells. Pablo A. González, Carolina E. Prado, Eduardo D. Leiva, Leandro J Carreño, Susan M. Bueno, and Alexis M. Kalergis.

5.XXXI Annual Reunion of the Biochemistry and Molecular Biology Society of Chile, Chillán-Chile September 23-29, 2008. Respiratory Syncytial Virus inhibits T cell activation by blocking Immunological synapse with Dendritic cells. Pablo González, Carolina Prado, Eduardo Leiva, Leandro Carreño, Susan Bueno, Claudia Riedel y Alexis Kalergis.

6.XIII International Immunology Congress, August 21-25, 2007, Río de Janeiro, Brasil.

7.ANEB Congress (Asociación Nacional de Estudiantes de Bioquímicos) August 1-3, 2007, Pontificia Universidad Católica de Chile, Santiago-Chile. “Flow Citometry, Theory and Applications”. Pablo Gonzalez.

8.Southern Symposium on Dendritic Cells, Instituto de Higiene, Montevideo, Uruguay, 26-29 de March 2007.

  1. Spring Immunology Symposium. October 16th, 2006, Santiago-Chile. Modulation of T cell activation by the TCR/pMHC interaction half-life and antigen density on APCs. Pablo González, oral presentation.
  2. Southern Symposium on Dendritic Cells, from basic science to clinic applications. January 5-7, 2005, Santiago-Chile.T cell activation can be modulated by the TCR/pMHC interaction half-life.Pablo González, oral presentation.

11.II Vaccine Course for the new Millennium, August 8-10, 2005, Estadio Italiano, Las Condes-Santiago-Chile.

12.II Jornadas de Bioempresarios en Sudamérica, Encuentro de Bioempresarios, 18-19 de Noviembre de 2004, Punta del Este–Uruguay.

  1. XII International Congress of Immunology and IV annual Congress of FOCIS, 18-23 July 2004, Montreal-Canada. Optimal TCR:pMHC dwell time for T cell activation depends on antigen density. Alexis M. Kalergis, Pablo González, Edith Palmieri and Stanley G. Nathenson.
  2. VIII ImmunologyCongress, X Latin-American Group of PrimaryImmunodeficiencies Reunion (LAGID), Chilean Immunology Society, April 22-24, 2004, Santiago-Chile. Vaccination with immature dendritic cells to prevent the development of autoimmunity in animal models. Iruretagoyena M., Sepúlveda S., Tobar J.A., González P. y Kalergis A.M.
  3. First World Biotechnology Global Forum, March 2-5, 2004, Concepción-Chile.
  4. XXV Chilean Microbiology Congress, November 6-8, 2003, Antofagasta-Chile. Salmonella Typhimurium interference with dendritic cell function as an evasion mechanism against T cell mediated immunity. Tobar J.A., Jakovljevic T., González P., Sanhueza A. y Kalergis A.M.
  5. XVII Annual Reunion of the Chilean Cellular Biology Society, October 9-13, 2003, Pucón-Chile. Dendritic cell Fcγ receptors increase bacterial antigen processing and presentation to T cells. Tobar J.A., Jakovljevic T., González P., Sanhueza A. y Kalergis A.M.

Memberships

  1. Member of the International Society for Dendritic Cells and Vaccine Science,
  2. Member of the New York Academy of Sciences,

Teaching

Undergraduate PUC

  1. 2009-2012Immunology (Bio389c, invited speaker).
  2. 2006Immunology (Bio145c invited speaker).

Graduate PUC

  1. 2010-2011 Advanced Microbiology (Bio4404, invited speaker).
  2. 2009 Advanced Microbiology (Bio447, invited speaker).

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