JANET HEMINGWAY CBE, FRS, DSc, PhD, BSc,FRCP (Hon), FMedSci, FRES (Hon), (foreign associate National Academy of Sciences USA), FAAM

CURRICULUM VITAE DETAILS

Date of Birth: 13.06.1957

Current Positions:Director of the Liverpool School of Tropical Medicine 2001 to date

Advocacy, Resources and Mobilisation, Innovative Vector Control Consortium (IVCC) August 2013 to date

Academic qualifications:

1978BSc, First Class, Genetics and Zoology, University of Sheffield

1981PhD on 'The biochemistry and genetics of insecticide resistance in Anopheles'

University of London (London School of Hygiene and Tropical Medicine)

2009 DSc, Medicine, University of Sheffield

2015 DSc, Medicine, University of Warwick

Positions held:

1981-1982 Lecturer in Toxicology, University of California Riverside, USA.

1982-1984 MRC Research Fellow, London School of Hygiene and Tropical Medicine (LSHTM)

1984-1993Royal Society Junior Research Fellow, LSHTM

1986Secondment to CSIRO (Animal Health Division), Brisbane, Australia (for a six month period)

1992-1993 Senior Lecturer, Department of Medical Parasitology, LSHTM (Co- Appointment with the Royal Society Fellowship)

1994–2001Biosciences Director of Research and Professor of Applied Molecular Entomology, University of Wales Cardiff

2005-2013 CEO of Innovative Vector Control Consortium (IVCC)

Official Appointments:

Vice President Royal Society of Tropical Medicine 2005 to 2008

Bill and Melinda Gates Foundation Malaria Strategy Group 2007 to 2010

Google Foundation Emerging Infectious Diseases Strategy Group 2008 to date

Royal Society Committee Member for Dorothy Hodgkin Biological Fellowships, 1995 to 2009.

MRC Special Advisory Panel in infection and immunity 2004 to date.

President Science and Medicine Panel, British Association for the Advancement of Science 2007 to 2009.

Member of the World Health Organization Expert Committee on Insecticides and Insecticide Resistance since 1985.

Academy of Medical Sciences Fellowships Panel 2007 to 2011

Malaria Elimination Group member (USA) 2007 to date.

Panel Advisor AusAid and Global Fund for Pacific Rim Malaria Control Operations 2007 to date

Member of the Advisory Board to the World Bank/WHO Onchocerciasis Control Programme in West Africa 1986 - 1989.

Advisor to the Anti-Malaria Campaign Sri Lanka 1984 to date.

Advisor to the Ministry of Health Cuba 1989 to 2007.

The sole academic member of Joint Industries Pesticide Resistance Action Committee 1990 to 2004.

IOPERM Cotton Crop Resistance Management Steering Group member for cotton crop pest control in China, 1996.

Scientific Advisor and panel member for Aga Khan University, Pakistan since 2003 Chair of this group since 2007.

Keystone Symposia Chairperson and Organising Committee member 2001 - 2007.

EMBL bioinformatics workshops organising committee 2003 - 2007.

Member of the NIH panel on infectious diseases 2000 - 2005

Imperial College London, Post-graduate training oversight group 2004.

BBSRC RothamstedRes Institutional Review Group 2005.

MacArthur Foundation Biology of Disease Vectors Course Organiser and steering committee member 2003 - 2008.

FNIH Oversight panel member for Gates Grand Challenges

Wellcome Trust MAP Advisory committee member

Wellcome Trust Infectious Disease Fellowship panel member 2011 to date

Governor, Royal Liverpool & Broadgreen University Hospitals NHS Trust

Oak Foundation specialist advisor 2011 to 2013

Awards:

Commander of the British Empire (CBE) for services to the Control of Tropical Disease Vectors 2012

Knowledge Leader of the Year 2012, Merseyside

Fellow of the Royal Society 2011

Fellow of American Academy of Microbiology 2011

Foreign associate National Academy of Sciences USA 2010

Honorary Fellow and elected life member Royal Society of Entomology 2010

Honorary Fellow of the Royal College of Physicians 2008

Fellow Academy of Medical Sciences 2006

Welsh Woman of the Year 1999.

Tropical Entomology Medals from Indonesia and Cuba 1997 and 1994.

Merseyside Woman of the Year, (public services) 2003

Welsh Development Agency undergraduate supervisor of the year 1998 and 2001

DTI National Award Winner for Industry-Academe collaboration 1999 (presented in 10 Downing Street)

Invited and Keynote speaker at numerous meetings including The Royal Society (UK) and the National Academy of Sciences (USA).

Editorial Boards:

Insect Biochemistry and Molecular Biology

Salud Publica de Mexico

Proceedings National Academy of Sciences

Institutional and Academic commitments:

After being instrumental in the re-organisation of the University of Cardiff’s Biosciences and Biomedical Departments, resulting in a re-structuring of undergraduate teaching, merger of departments and move from two RAE grade 3As to two Grade 5s I was head-hunted in 2001 to become the head of the world’s oldest Tropical Medicine Institution in Liverpool. This was a challenging role as the Institution is a complex independent Charity with an annual turn-over of approximately £45Million, which indirectly receives its HEFCE income through an affiliation with the University of Liverpool. It provides the infectious disease in- and out-patient cover for the NHS for the North of England (where we provide infectious diseases staff for the major local hospitals and run an in house NHS and private travel clinic), runs extensive post-graduate and specialist undergraduate biological and medical courses, but with the bulk (80%) of the institutions income coming from research (with research covering both medical and veterinary areas).

Since 2001 I have restructured the Institution, turned it around financially, and have raised £35million of capital grants to build new state of the art facilities, which has allowed the Institution to expand substantially. I had sole responsibility for raising the capital funding for the new School building from a variety of sources. This was clearly a major undertaking, but this, alongside the financial controls that have been put in place has put the Institution on a much sounder footing than it has been at any stage during the last 50 years. LSTM’s growth was strategically driven and is part of a coherent plan formally adopted in 2002, with five year reviews, to ensure that the School is recognised as the premier School of Tropical Medicine in the coming decades.

In addition to the staff in Liverpool I also have oversight of one of four Wellcome Trust Tropical Centres with approximately 40 staff based out in Malawi (a joint venture with Liverpool University) and centres in Tanzania and Ecuador. The School has a wholly owned subsidiary company, Well Travelled Clinics, undertaking the private travel medicine work. I was responsible for the successful spin out of this business from within the School and have also spun out the Gates funded IVCC programme into a separate legal entity and attracted a further $50Million of new funding from the Gates Foundation.

In late 2005 I reduced my percentage time as Head of the Institution to 50%, with the full agreement of LSTM’s Board of Trustees and became founding member and CEO of the Bill and Melinda Gates Funded Innovative Vector Control Consortium. This was established as a new Product Development Partnership for stimulating the development of new public health pesticides for malaria and dengue control, with an initial $50million investment. This required engagement of multinational companies, academia and overseas Ministries of Health in Africa and Latin America in large scale projects aimed at transforming the way that malaria, dengue and other vector borne diseases are controlled. The first new products from this venture are now coming to the market.

While running both the Liverpool School and the IVCC I have continued to run an active research group, although I took the decision in 2007 not to directly supervise any further PhD students and to start to wind down my direct role in the research, transferring the activity to three senior post-doctoral staff to take forward. Currently I lead a group of twenty-nine research scientists at post-doctoral and post-graduate level. The group is unique in that it covers the full spectrum of insect vector control from bench to bush. We have cutting edge work on going on the biochemistry and molecular biology of specific enzyme systems associated with xenobiotic resistance through to large scale operational programmes in Mexico and Mozambique putting control theory into practice. Grant holder on current projects in excess of £29 million. Overseas projects currently in Cambodia, Mozambique, Mexico, South Africa, Sri Lanka, Thailand, and USA. Extensive experience of working in tropical regions of Africa, Asia and South America over a 20 year period. In addition I have been a part of the International consortia that have had responsibility for undertaking the Anopheles gambiae and Aedes aegypti mosquito genome sequences and I am currently driving phase 1 of the Culex quinquefasciatus genome programme with the normalised cDNA libraries from a range of pathogen infected mosquitoes being made in my lab. I also act as the lead for LATH for vector M & E on the PMI programme with RTI as the lead organisation.

Current Research Grants (All as PI): Total Value of Current Research Grants approximately £33.4Million. An additional £30Million in capital grants has been raised over the last 5 years in addition to this.

Gates Foundation

Topic:Innovative Vector Control Consortium (re-financing)

Value:US$50,726,000 (£26,000,000)

Topic:Innovative Vector Control Consortium

Value:US$50,726,000 (£26,000,000)

Topic:GIS mapping of drug and insecticide resistance in southern Africa

Value:US$300,000 (£214,200)

Topic:Malaria PhD studentships

Value:£240,000

National Institute of Health, USA

Topic:Resistance management in southern African malaria vectors

Value:US$2,100,000 (£1.5million)

Department for International Health (DFID)

Topic:Control of outdoor biting vectors in Cambodia

Value:£1,300,000

Medical Research Council

Topic:Does insecticide resistance affect disease transmission

Value:£309,000

Topic:Molecular approaches to the control of insect vector borne disease

Value:£65,000

The Wellcome Trust

Topic:Capital development of Centre for Tropical infectious Diseases

Value: £2,000,000

Topic:QTL mapping and field validation of pyrethroid resistance in Anopheles funestus (Sponsor role C. Wondji as senior fellow)

Value: £1,200,000

Topic:Positional cloning of pyrethroid resistance genes from Anopheles gambiae

Value: £486,000

Topic: Characterization of a novel class of Anopheles gambiae glutathione S-transferases genetically linked to the inheritance of DDT resistance.

Value:£196,000

Topic: Insecticide resistance in Anopheles albimanus.

Value: £71,600

Topic: GIS mapping of the movement of insecticide resistance genes through Anopheles populations.

Value: £178,000.

Topic: The affect of insecticide resistance on vectorial capacity.

Value: £170,000

Topic: Metabolic resistance in Anopheles funestus in South Africa. Tropical Development Award.

Value: £88,600.

Topic: Microarray Centre for insect vectors of disease

Value: £150,000

Topic: Population structure of Anopheles albimanus.

Value: £60,359

Topic: Molecular approaches to dengue control through manipulation of Aedes aegypti

Value: £18,000

Topic: Molecular characterisation of glutathione S-transferases in the Anopheles gambiae and An. dirus complexes

Value:£18,000

Topic:Monitoring insecticide resistant Aedes aegypti

Value:£18,000

Topic: Molecular characterisation of insecticide resistance in the Anopheles culicifacies complex

Value: £18,000

Topic: Pyrethroid resistance in Aedes aegypti.

Value: £18,000

European Union

Topic: Species composition and insecticide resistance status of SE Asian vectors

Value: Euro 560,000

Shell

Topic: Resistance in malaria vectors and parasites in Nigeria

Value:£54,000

Outside Interests

Combined with my role of mother of a 23-year-old daughter and the general interests of reading and walking, for the last 20 years I have played competitive squash up to county level. This was curtailed three years ago by snapping my Achilles tendon. I also own, breed and train a small herd of pure bred Arabian horses for showing, cross country jumping and endurance riding.

PUBLICATION LIST (full refereed articles only)

  1. Hemingway, J.1980.Modification of the adult resistance test kit to measure knock-down rates. Trans. Roy. Soc. Trop. Med. Hyg. 74:677 - 679.
  2. Hemingway, J.1982.Genetics of organophosphate and carbamate resistance in Anopheles atroparvus. J. Econ. Ent. 75:1055-1058.
  3. Hemingway, J.1982.The biochemical nature of malathion resistance in Anopheles stephensi from Pakistan. Pest. Biochem. Physiol. 17:149-155.
  4. Hemingway, J. and G. Davidson.1983.Resistance to organophosphate and carbamate insecticides in Anopheles atroparvus. Parassitologia 25:1-8.
  5. Hemingway, J.1983.Biochemical studies on malathion resistance in Anopheles arabiensis from Sudan. Trans. Roy. Soc. Trop. Med. Hyg. 77:477-480.
  6. Hemingway, J.1983.Add on drugs fight insecticide resistance. New Scientist 97:649.
  7. Hemingway, J. and G. P. Georghiou.1983.Studies on the acetylcholinesterase of Anopheles albimanus resistant and susceptible to organophosphate and carbamate insecticides. Pest. Biochem. Physiol. 19:167-171.
  8. Hemingway, J.1983.The genetics of malathion resistance in Anopheles stephensi from Pakistan. Trans. Roy. Soc. Trop. Med. Hyg. 77:106-108.
  9. Hemingway, J., M. Rowland, and K. E. Kissoon.1984.Efficacy of Pirimiphos methyl as a larvicide or adulticide against insecticide resistant and susceptible mosquitoes (Diptera: Culicidae). J. Econ. Ent. 77:868-871.
  10. Hemingway, J.1984.The joint action of malathion and IBP against malathion-resistant and susceptible strains of Anopheles stephensi. Bull. Wld Hlth Org. 62:445-449.
  11. Hemingway, J. and G. P. Georghiou.1984.Baseline esterase levels for anopheline and culicine mosquitoes. Mosq. News 44:33-35.
  12. Hemingway, J. and G. P. Georghiou.1984.Differential suppression of organophosphorus resistance in Culex quinquefasciatus by the synergists IBP, DEF and TPP. Pest. Biochem. Physiol. 21:1-9.
  13. Hemingway, J., C. A. Malcolm, K. E. Kissoon, R. G. Boddington, C. F. Curtis, and N. Hill.1985.The biochemistry of insecticide resistance in Anopheles sacharovi: comparative studies with a range of insecticide susceptible and resistant Anopheles and Culex species. Pest. Biochem. Physiol. 24:68-76.
  14. Hemingway, J.1985.Malathion carboxylesterase enzymes in Anopheles arabiensis from Sudan.Pest. Biochem. Physiol. 23:309-313.
  15. Hemingway, J., C. Smith, K. G. I. Jayawardena, and P. R. J. Herath.1986.Field and laboratory detection of the altered acetylcholinesterase resistance genes which confer organophosphate and carbamate resistance in mosquitoes (Diptera: Culicidae). Bull. Ent. Res. 76:559-565.
  16. Hemingway, J., Y. Rubio, and K. E. Bobrowicz.1986.The use of ELISA demonstrates the absence of Culex organophosphorous-resistance-associated esterases in Anopheles species. Pest. Biochem. Physiol. 25:327-335.
  17. Hemingway, J., K. G. I. Jayawardena, I. Weerasinghe, and P. R. J. Herath.1987.The use of biochemical tests to identify multiple insecticide resistance mechanisms in field-selected populations of Anopheles subpictus Grassi (Diptera: Culicidae). Bull. Ent. Res. 77:57-66.
  18. Herath, P. R. J., J. Hemingway, I. S. Weerasinghe, and K. G. I. Jayawardena.1987.The detection and characterization of malathion resistance in field populations of Anopheles culicifacies B in Sri Lanka. Pest. Biochem. Physiol. 29:157-162.
  19. Rowland, M. and J. Hemingway.1987.Changes in malathion resistance with age in Anopheles stephensi from Pakistan. Pest. Biochem. Physiol. 28:239-247.
  20. Villani, F. and J. Hemingway.1987.The detection and interaction of multiple organophosphorus and carbamate insecticide resistance genes in field populations of Culex pipiens from Italy. Pest. Biochem. Physiol. 27:218-228.
  21. Bonning, B. C., C. A. Malcolm, and J. Hemingway.1988.Purification and characterization of acetylcholinesterase from Culex pipiens. Pest. Science 24:278-280.
  22. Herath, P. R. J., K. G. I. Jayawardena, J. Hemingway, and J. Harris.1988.DDT resistance in Anopheles culicifacies Giles and A. subpictus Grassi (Diptera: Culicidae) from Sri Lanka: a field study on the mechanisms and changes in gene frequency after cessation of DDT spraying. Bull. Ent. Res. 78:717-723.
  23. Amin, A. M. and J. Hemingway.1989.Preliminary investigation of the mechanisms of DDT and pyrethroid resistance in Culex quinquefasciatus Say (Diptera: Culicidae) from Saudi Arabia. Bull. Ent. Res. 79:361-366.
  24. El-Sayed, S., J. Hemingway, and R. P. Lane.1989.Susceptibility baselines for DDT metabolism and related enzyme systems in the sandfly Phlebotomus papatasi (Scopoli) (Diptera: Psychodidae). Bull. Ent. Res. 79:679-684.
  25. Hemingway, J., R. G. Boddington, J. Harris, and S. J. Dunbar.1989.Mechanisms of insecticide resistance in Aedes aegypti (L.) (Diptera: Culicidae) from Puerto Rico. Bull. Ent. Res. 79:123-130.
  26. Hemingway, J.1989.A note on simple biochemical methods for resistance detection and their field application in Sri Lanka. Pest. Sci. 27:281-285.
  27. Hemingway, J., A. Callaghan, and D. C. Kurtak.1989.Temephos resistance in Simulium damnosum Theobald (Diptera: Simulidae): a comparative study between larvae and adults of the forest and savanna strains of this species complex. Bull. Ent. Res. 79:659-669.
  28. Bisset, J. A., M. M. Rodriguez, C. Diaz, E. Ortiz, M. C. Marquetti, and J. Hemingway.1990.The mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus (Diptera: Culicidae) from Cuba. Bull. Ent. Res. 80:245-250.
  29. Hemingway, J., A. Callaghan, and A. M. Amin. 1990.Mechanisms of organophosphate and carbamate resistance in Culex quinquefasciatus from Saudi Arabia. Med. Vet. Entomol. 4:275-282.
  30. Peiris, H. T. R. and J. Hemingway.1990.Mechanisms of insecticide resistance in a temephos selected Culex quinquefasciatus (Diptera: Culicidae) strain from Sri Lanka. Bull. Ent. Res. 80:453-457.
  31. Peiris, H. T. R. and J. Hemingway.1990.Temephos resistance and the associated cross-resistance spectrum in a strain of Culex quinquefasciatus Say (Diptera: Culicidae) from Peliyagoda, Sri Lanka. Bull. Ent. Res. 80:49-55.
  32. Bisset, J. A., M. M. Rodriguez, J. Hemingway, C. Diaz, G. J. Small, and E. Ortiz.1991.Malathion and pyrethroid resistance in Culex quinquefasciatus from Cuba: efficacy of pirimiphos-methyl in the presence of at least three resistance mechanisms. Med. Vet. Entomol. 5:223-228.
  33. Bonning, B. C., J. Hemingway, R. Romi, and G. Majori.1991.Interaction of insecticide resistance genes in field populations of Culex pipiens (Diptera: Culicidae) from Italy in response to changing insecticide selection pressure. Bull. Ent. Res. 81:5-10.
  34. Bonning, B. C. and J. Hemingway.1991.Identification of reduced fitness associated with an insecticide resistance gene in Culex pipiens by microtitre plate assay. Med. Vet. Entomol. 5:377-379.
  35. Bonning, B. C. and J. Hemingway.1991.The efficacy of acetylcholinesteraes in organophosphorus and carbamate resistance in Culex pipiens L. from Italy. Pest. Biochem. Physiol. 40:143-148.
  36. Callaghan, A., C. A. Malcolm, and J. Hemingway.1991.Biochemical-studies of A-carboxylesterase and B-carboxylesterase from organophosphate resistant strains of an Italian Culex pipiens (Diptera, Culicidae). Pest. Biochem. Physiol. 41:198-206.
  37. Hemingway, J.1991.The role of growth regulators and other novel compounds in vector control and resistance management. WHO/CTD/OPR/EC 91.48.
  38. Hemingway, J., A. Callaghan, and D. C. Kurtak.1991.Biochemical characterization of chlorphoxim resistance in adults and larvae of the Simulium damnosum complex (Diptera: Simulidae). Bull. Ent. Res. 81:401-406.
  39. Hemingway, J., J. Miyamoto, and P. R. J. Herath.1991.A possible novel link between organophosphorus and DDT insecticide resistance genes in Anopheles: supporting evidence from fenitrothion metabolism studies. Pest. Biochem. Physiol. 39:49-56.
  40. Hemingway, J.1992.Genetics of insecticide resistance in mosquito vectors of disease. Parasitology Today 8:296-298.
  41. Hemingway, J., G. J. Small, A. Monro, B. V. Sawyer, and H. Kasap.1992.Insecticide resistance gene frequencies in Anopheles sacharovi populations of the Cukurova plain, Adana province, Turkey.