Current Titlejack and Deloris Lange Professor of Molecular Physiology

Jan, Yuh-Nung-1

CURRICULUM VITAE

Name:Yuh Nung Jan

Current TitleJack and DeLoris Lange Professor of Molecular Physiology

Investigator, Howard Hughes Medical Institute

Department:Departments of Physiology, Biochemistry and Biophysics

University of California, San Francisco

San Francisco, CA 94143-0725

Office Phone:(415) 476-8747

Email:

Education:

B.Sc. in Physics / 1967 / National Taiwan University, Department of Physics (1963-1967)
M.Sc. in Physics / 1970 / California Institute of Technology, Division of Physics, Mathematics and Astronomy (1968-1970)
Ph.D. in Biophysics and Physics / 1974 / California Institute of Technology, Division of Biology (1970-1974), Dr. Max Delbrück, Thesis Advisor
MILITARY SERVICE (COMPULSORY) / 1967-1968 / Communication and Electronics Officer, Second Lieutenant, Signal Corp, Air Force (Taiwan)

Teaching and Research Appointments:

Postdoctoral Research Fellow1974-1977

Dr. Seymour Benzer (Sponsor)

California Institute of Technology

Postdoctoral Research Fellow1977-1979

Dr. Steve W. Kuffler (Sponsor)

Department of Neurobiology

Harvard Medical School

Assistant Professor of Physiology19791983

University of California, San Francisco

Associate Professor of Physiology and19831985

Biochemistry, University of California,

San Francisco

Instructor, “Neurobiology of Drosophila” 19841987

Cold Spring Harbor Summer Course

Investigator, Howard Hughes Medical Institute1984-present

Professor of Physiology and Biochemistry1985present

University of California, San Francisco

Scholar in residence1989

“Neurobiology” Woods Hole Summer Course

Jack and DeLoris Lange Endowed Chair in1999-present

Molecular Physiology, University of California,

San Francisco

Awards/Honors:

Scottish Rite Schizophrenia Research Program Fellowship19741976

Muscular Dystrophy Association Postdoctoral Fellowship19761978

McKnight Scholar Award19781981

W. Alden Spencer Award and Lectureship, Columbia University1988

38th Faculty Lecturer Award, University of California, San Francisco1995

Elected member, National Academy of Sciences, U.S.A. 1996

Elected member, Academia Sinica (Taiwan)1998

K.S. Cole Award, Biophysical Society 2004

Distinguished Alumni Award, California Institute of Technology2006

SCBA Presidential Award2006

Jan Lab Symposium2006

Elected fellow, American Academy of Arts and Sciences2007

Outstanding Mentorship Award, The Postdoctoral Scholar’s

Association of UCSF 2007

Ralph Gerard Prize, Society for Neuroscience 2009

Javits Neuroscience Investigator Award, NINDS, NIH2010

Edward. M. Scolnick Prize in Neuroscience, Massachusetts Institute2010

of Technology

NARSAD Distinguished Investigator Award2010

Special Lectures/Keynote Lectures:

SCBA 5th International Symposium, Keynote Speaker, Baltimore1993

Karolinska Research Lecture, Nobel Forum, Stockholm, Sweden1997

Harvey Lecture, New York1998

The Stephen W. Kuffler Lecture, Harvard Medical School, Boston1999

Eighth Symposium on Recent Advances in Cellular and Molecular Biology.

Chinese Society of Cell and Molecular Biology, Keynote Lecture, Taiwan2000

SCBA 10th International Symposium, Keynote Speaker, Beijing2004

Keystone Symposia "Cell Polarity and Asymmetric Cell Divisions",

Keynote Speaker, Coeur d'Alene, Idaho2005

University of Utah Neuroscience Snowbird Symposium,

Keynote Speaker, Utah2005

International Symposium on Epithelia Organization and Organ Development,

Keynote speaker, Max Delbrück Center, Berlin, Germany2006

SCBA 11th International Symposium, Keynote Speaker, San Francisco2006

Liu Lecture, University of Pennsylvania School of Medicine, Philadelphia2006

European Science Foundation-EMBO Symposium “Cell Polarity and

Membrane Traffic”, Keynote Speaker, Saint Feliu de Guixols, Spain2009

Membership:

American Society of Cell Biology

Genetics Society of America

Society of Chinese Bioscientists in America

Society for Developmental Biology

Society for Neuroscience

Professional Service:

Editorial Board: Neuron, 1992-1994; Developmental Biology, 1995-2001; Molecular and Cellular Neuroscience, 1995-present; Genes and Development, 1996-present; Development, 1999-2004; Developmental Cell, 2001-present; PNAS, 2008-present

Co-Editor: Current Opinion of Cell Biology, Membrane Permeability 1994, 1997 (with L.Y. Jan); Current Opinion of Neurobiology, Neural Development 1997 (with A. Lumsden)

Reviewer (more than 50 per year) for various journals, mainly Genes and Development, Cell, Nature, Neuron, Development, Developmental Cell, Current Biology, PLoS, Journal of Neurosciene, Nature Neuroscience,Nature Cell Biology, PNAS and Science.

ad hoc reviewer of National Science Foundation, National Institute of Health, International Human Frontier Science Program Organization (Strasbourg), Academia Sinica (Taiwan), Swiss National Science Foundation, The Wellcome Trust (UK), and MRC (UK)

Postdoctoral Fellowship Selection Committee, American Cancer Society, California Chapter
(1994-1996)

Academia Sinica Investigator Selection Committee (2004)

RIKEN Brain Science Institute, Evaluation committee (2007)

Institute of Physics, Academia Sinica Advisory Committee, 2008-present

Co-organizer, Keystone “Stem Cells, Origins, Fates, and Functions” meeting, 2002 (with F. Gage and B. Hogan).

Co-organizer, Janelia Conference, HHMI “Dendrites: Development and Plasticity” meeting, 2008 (with L. Jan And J. Magee)

Mentoring:

More than 10 graduate students and 50 postdocs have trained in my lab. Many went on to have fine careers in science, medicine, biotech, teaching, publishing and law. Please see our lab website:

Invited Lectures and Seminars:

Department of Biology, Princeton University, March 1978

Department of Physiology, Yale University, School of Medicine, May 1978

Department of Biology, University of California, San Diego, August 1978

Department of Neurobiology, Stanford University Medical School, August 1978

Neurobiology Summer Course, Woods Hole, 1978

Department of Physiology, University of California, San Francisco, August 1978

Department of Neurology, Harvard Medical School, January 1979

Cold Spring Harbor Summer Course on “The Synapse”, July 1980

Department of Pharmacology, Tokyo Dental and Medical School, August 1980

Division of Biology, California Institute of Technology, October 1980

Department of Physiology and Anatomy, University of California, Berkeley, May 1982

Department of Biology, Massachusetts Institute of Technology, June 1982

Society for Neuroscience Short Course “Strategies for Studying the roles of peptides in neuronal functions”, Minneapolis, October 1982

Department of Neuroscience, Washington University, St. Louis, January 1983

Cold Spring Harbor Summer Course on “Cellular and Molecular Neurobiology, July 1983

Division of Biology, California Institute of Technology, January 1984

Department of Pharmacology, Tokyo Dental and Medical School, September 1984

University of California, Berkeley, 1986

Department of Neurobiology, Stanford University, April 1986

Department of Biology, Institute of Molecular Biology, UCLA, 1987

Spencer lecture, Columbia University, October 1988

Division of Biology, California Institute of Technology, January 1989

Developmental Biology, University of California, Irvine, January 1989

Department of Biology, Stanford University, January 1989

International Summer School on Molecular Biology of Differentiation, Berlin, July 1989

Woods Hole Neurobiology Course, July 1989

Woods Hole Neurobiology Seminar, July 1989

Department of Cell Biology, Yale University, October 1989

Department of Biophysics, Kyoto University, Kyoto, Japan, March 1990

Distinguished Lecture Series, USC, Dec. 1991

Department of Biology, UC San Diego, Dec. 1991

Department of Biochemistry and Molecular Biology, Harvard University, Dec. 1991

University Lecture, The Rockefeller University, October 1992

Fred Hutchinson Cancer Institute, Seattle, May 1993

Department of Biology, Stanford University, December 1993

Department of Biology, University of Virginia, May 1994

Department of Cell Biology, Harvard Medical School, October 1994

Department of Developmental Biology, Stanford University, March 1995

Department of Molecular Biology, Institut Pasteur, Paris, France, October 1995

Max Planck Institute, Frankfurt, Germany, October 1995

Department of Molecular and Cell Biology, Merck lecture series, UC Berkeley, April 1997

Skirball Institute of Molecular Medicine, NYU Medical Center, April 1997

Cold Spring Harbor “Developmental Neurobiology” course, June 1997

Karolinska Institute “Neuron” Course, Stockholm, Sweden, November 1997

Osaka University Medical School, Osaka, Japan, December 1997

Distinguished Lecture in Cell Biology, Baylor University Medical School, March 1998

Department of Neuroscience, Johns Hopkins University Medical School, March 1998

Neurobiology Seminar, California Institute of Technology, April 1998

University Lecture, University of Texas Southwestern Medical School, May 1998

Department of Cell Biology, Duke University Medical School, May 1998

Neurobiology Seminar, Yale University Medical School, May 1998

EMBL, Heidelberg, Germany, May 1999

Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, January 2000

Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, January 2000

Chiron, Emeryville, CA, April 2000

Department of Biology, Stanford University, October 2000

Cold Spring Harbor, “Developmental Neurobiology” course, June 2001

Laboratory of Molecular Biology, MRC, Cambridge, UK, September 2001

Department of Molecular Biology, Princeton University, December 2002

Cold Spring Harbor, “Developmental Neurobiology” Course, June 2003

Developmental Biology Program, Sloan Kettering Institute, New York, November 2003

Department of Molecular and Cellular Physiology, Stanford University, May 2004

National Institute of Genetics, Mishima, Japan, December 2004

RIKEN Center of Developmental Biology, Kobe, Japan, December 2004

Department of Molecular and Cell Biology, UC Berkeley, Feb 2005

Broad Institute, MIT, February 2005

Cold Spring Harbor Laboratory, February 2005

Distinguished Speaker in the Developmental Biology Program at the University of Toronto, May 2005

Skirball Institute of Molecular Medicine, NYU Medical Center, May 2005

Children’s Hospital, Harvard Medical School, May 2006

Max Planck Institute, Munich, Germany, May 2006

Kyoto University, Kyoto, Japan, June 2006

Department of Neurobiology, Yale University, March 2008

Department of Pathology, Harvard Medical School, March 2009

Perspective in Neuroscience Lecture Series, UC Davis, April 2009

Edward. M. Scolnick Prize in Neuroscience Lecture, Massachusetts Institute of Technology, May 2010

Invited Speaker in Symposium or Workshop:

Neuroscience Research Program “Neurogenetics” Workshop, Boston, November 1977

International Titisee Conference on “Membrane Channels”, Titisee, West Germany, March 1980

XVI International Congress of Entomology Symposium on “Developmental and Molecular Biology of Insects”, Kyoto, Japan, August 1980

Winter Conference on Brain Research Panel “Neuronal Mechanisms of Peptide Action-Intracellular Studies”, Keystone, Colorado, January 1981

Ciba Foundation Symposium 88 “Neurochemical Pharmacology of Insects”, London, England, July 1981

9th Meeting of the International Neurobiology Society “Molecular and Cellular Interactions Underlying Higher Brain Function”, Val de Loire, France, September 1981

66th Annual Meeting of the FASEB, New Orleans, LA, April 1982. Symposium “Coexistence of neuromodulators: biochemical and pharmacological consequences”.

12th Society for Neuroscience Annual Meeting, Minneapolis, MN, November 1982. Symposium on “The Function of Multi Transmitters in Neurons”.

Cold Spring Harbor 48th Symposium on “Molecular Neurobiology” June 1983

International Symposium on Neuropeptides, Montpellier, France, September, 1983

UCLA Symposium on Molecular Neurobiology, Keystone, Colorado, April 1984

9th International Symposium on Neurosecretion, Japan, September 1984

Cajal Conference on Neurobiology, Madrid, Spain, September 1984

“Coexistence of Neuronal Messengers” Symposium, Stockholm, Sweden, June 1985

“Mechanisms of Secretion and Action of Neurotransmitters and Neuromodulators in Central and Peripheral Synapse”, Jerusalem, Israel, October 1985

EMBO Workshop on “Molecular and Developmental Biology of Drosophila”, Crete, June 1986

HHMI meeting on “Developmental Neurobiology”, Miami, Florida, February 1987

Southern California Drosophila Meeting, UCLA, 1987

Gordon Conference, “Developmental Biology” New Hampshire, July 1987

17th Society of Neuroscience Annual Meeting “Molecular Genetic Analysis of Neuronal Development” Symposium, New Orleans, November 1987

1st NIMH Conference on “Molecular Neurobiology, Santa Barbara, California, May 1988

Society of Developmental Biology 47th Symposium, “The Assembly of the Nervous System” Connecticut, June 1988

Winter Conference of Immunologists, “Development of the Nervous System” Symposium, Asilomar, California, January 1989

Society of Cell Biology and Society of Molecular Biology Joint Annual Meeting, Symposium, San Francisco, January 1989

Miami Biotechnology Winter Symposium, “Molecular Neurobiology”, March 1989

EMBO Workshop on Neurogenesis, Simonswald, West Germany, April 1989

Max Planck Society “Drosophila embryogenesis” symposium, Schloss Ringberg, Tegernsee, West Germany, January 1990

International symposium on pharmacology and drug development based on new biology, Tokyo and Kyoto, Japan, March 1990

Cold Spring Harbor 55th Symposium, “The Brain”, May 1990

Gordon Conference, “Biological Regulatory Mechanisms”, New Hampshire, June 1990

SCBA 3rd International Symposium “Molecular Biology”, Hong Kong, June 1990

NIH Zebrafish Workshop, Eugene, Oregon, Sept. 1990

Fundacion Juan March Workshop on Neural Development in Drosophila, El Palmar, Spain, October 1990

HHMI Workshop on Developmental Neurobiology, Bethesda, Maryland, March 1991

Seymour Benzer Symposium, Cal Tech, Oct. 1991

31st Society of Cell Biology Annual Meeting, “Neural Induction” Symposium, Boston, Massachusetts, Dec. 1991

Gordon Conference “Molecular Genetics”, Rhode Island, July 1992

5th International Congress of Cell Biology, “Early Neurogenesis” Symposium, Madrid, Spain, July 1992

Bambury Workshop on “Constructing Organisms”, Cold Spring Harbor, November 1992

SCBA 5th International Symposium, Keynote Speaker, Baltimore, June 1993

12th International Congress of Developmental Biologists, Vienna Austria, August 1993

National Institute of Child Health and Human Development Workshop on “The Neuronal Phenotype” Corsica France, August 1993

Fundacion Juan March/EMBO Workshop on “Cellular Interactions in the Early Development of the Nervous System of Drosophila” Madrid, Spain, April 1994

“Molecular Neurobiology” Symposium. Uppsala, Sweden, August 1994

Gordon Conference “Developmental Biology”, New Hampshire, June 1995

Eighth IIGB Meeting “Evolution and Development”, Capri, Italy, October 1995

Keystone Symposia “Cell Polarity” Lake Tahoe, California, February 1996

HHMI “Neural Development” Workshop, Chevy Chase, Maryland, February 1996

Keystone Symposia “Signaling in Neuronal Development, Differentiation,” Taos, New Mexico, March 1996

“Molecular Biology: The Next Decade” Symposium, Institute of Molecular Biology, Academia Sinica, Taipai, Taiwan, May 1996

55th Society of Developmental Biology Annual Meeting “Localization and Function of Cytoplasmic Determinants” Symposium, Nashville, Tennessee, May 1996

Gordon Conference “Neural Development”, Newport, Rhode Island, June 1996

Eighth Annual Mahajani Symposium on Molecular Medicine, La Jolla, California, September 1996

1st International Symposium on Molecular Control of Organogenesis, Ann Arbor, Michigan, October, 1996

26th Annual Meeting of the Society for Neuroscience, “Cell Cycle Regulation and CNS Development” Symposium, Washington, D.C., November 1996

Howard Hughes Medical Institute Workshop “Germ Line Development,” Chevy Chase, Maryland, December 1996

Cold Spring Harbor 62nd symposium, “Pattern Formation during Development,” May 1997

Gordon Conference “Developmental Biology,” New Hampshire, June 1997

17th International Congress of Biochemistry and Molecular Biology, “Cell Fate Determination in Development” symposium, San Francisco, California, August 1997

4th International Kyoto Life Science Symposium, “Development and Organization of Complex Multicellular Systems,” Kyoto, Japan, November 1997

Keio University International Symposia for Life Science and Medicine, “Neuroscience: Frontier of Neural Development” symposium, Tokyo, Japan, December 1997

Annual Meeting of American Society for Biochemistry and Molecular Biology, “Signaling Molecules in Development” Symposium, Washington, D.C., May 1998

Nobel Symposium “Assembly of the Nervous System”, Stockholm, Sweden, June 1998

EMBO Workshop on “Molecular and Developmental Biology of Drosophila,” Crete, July 1998

Gordon Conference, “Molecular Genetics,” Rhode Island, July 1998

Banbury Workshop on “Stem Cell,” Cold Spring Harbor, NY, February 1999

The 10th IMP Spring Conference on “The Cell Biology of Cell Division,” Vienna, Austria, May 1999

Inauguration Symposium of Shanghai Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China, November 1999

Neuroscience Symposium, Xian, China, November 1999

Keystone Symposia, “Stem Cells, Asymmetric Cell Division and Cell Fate,” Keystone, CO, January 2000.

Eighth Symposium on Recent Advances in Cellular and Molecular Biology. Chinese Society of Cell and Molecular Biology, Keynote Lecture, Kenting, Taiwan, January 2000

Keystone Symposia, “Genetic Bases of Brain Development and Dysfunction,” Taos, New Mexico, March 2000

EMBO Workshop in “Molecular and Developmental Biology of Drosophila”, Crete, June 2000.

“Recent Advances in Biomedical Sciences.” Symposium by new members of Academia Sinica, Academia Sinica, Taipei, Taiwan, July 2000

30th Annual meeting of the Society for Neuroscience, “On Form and Function: Molecular Mechanisms of Synapse Development” Symposium, New Orleans, November 2000

14th International Congress on Developmental Biology, Kyoto, Japan, July 2001

Medical Research Council, King’s College, London, Inaugural conference on “The Developing Brain” at Guy’s Hospital, London, UK, September 2001

Keystone Symposia “Stem Cells, Origins, Fates, and Functions” Keystone, CO, March 2002

Gordon Conference “Molecular and Cellular Neurobiology, “ Hong Kong, June 2002

The 2nd Wu Ta You Science Camp, Taiwan, August 2002

62nd Society of Developmental Biology Annual Meeting “From Neuron to Brain” Symposium, Boston, MA, July 2003

“Cell Biology of the Neuron” Neuron 15th Anniversary Meeting, New Orleans, LA, November 2003

Society for Neuroscience 33rd Annual Meeting “Dendrite Development: Morphogenesis, Targeting and Plasticity” Symposium, New Orleans, LA, November 2003

Keystone Symposia “Stem Cells” Keystone, CO, January 2004

SCBA 10th International Symposium, Keynote Speaker, Beijing, July 2004

Gordon Conference “Neural Development”, Newport, Rhode Island, August 2004

Molecular Biology Society of Japan Symposium, Kobe, Japan, December 2004

Autism Think Tank, Columbia University, New York, February 2005

Keystone Symposia "Cell Polarity and Asymmetric Cell Divisions", Keynote Speaker, Coeur d'Alene, Idaho, March 2005

46th Annual Drosophila Research Conference, Plenary Lecture, San Diego, March 2005

Keystone Symposia "Axonal Connections: Molecular Cues for Development and Regeneration" Breckenridge, CO, April 2005

The 4th Wu Ta You Science Camp, Taiwan, August 2005

15th International Congress on Developmental Biology, Plenary Lecture, Sydney, Australia, September 2005

EMBO Workshop, Ascona, Switzerland, September 2005

University of Utah Neuroscience Snowbird Symposium, Keynote Speaker, Snowbird, Utah, October 2005

UCSD Neuroscience Symposium on the Assembly of Neural Circuits, La Jolla, CA, January 2006

International Symposium on Epithelia Organization and Organ Development. Keynote speaker, Max Delbrück Center, Berlin, Germany, May 2006.

Gordon Conference “Molecular and Cellular Neurobiology,” Hong Kong, June 2006

Osaka-NAIST Joint COE Symposium “Cells to Organisms”, Nara, Japan, June 2006

20th IUBMB International Congress of Biochemistry and Molecular Biology “Neuronal Polarity” Symposium, Kyoto, Japan, June 2006

SCBA 11th International Symposium, Keynote Speaker, San Francisco, July 2006

Santa Cruz Developmental Biology Meeting, Santa Cruz, CA, August 2006

Cold Spring Harbor Meeting “Axon Guidance, Synaptogenesis and Neural Plasticity, ” Cold Spring Harbor Lab, NY September 2006

Society for Neuroscience 36th Annual Meeting “Neuronal Polarity” Symposium, Atlanta, GA, October 2006

UCSF/Karolinska Stem Cell Symposium, UCSF, San Francisco, CA, January 2007

Gordon Conference “Dendrites: Molecules, Structure and Function.” Ventura, CA, March 2007

2007 Asian Science Camp, Taipei, Taiwan, August 2007

Bay Area Neuroscience Gathering, Keynote speaker, UCSF, January 2008

UCSF Cancer Center Symposium “Stem Cells and Cancer”, UCSF, May 2008

17th Biennial Meeting of the International Society for Developmental Neuroscience, Plenary Lecture, Asilomar, CA, June 2008

UCSF Center for Neurobiology and Psychiatry Symposium “Understanding Autism: lessons from genetics and rules of brain development”, UCSF, June 2008

Gordon Conference “Neural Development”, Newport, Rhode Island, August 2008

Janelia Conference, “Behavioral Neurogenetics of Drosophila Larva” meeting, JFRC, HHMI, October 2008

San Francisco-Japan Joint Meeting on Vertebrate Organogenesis, UCSF, November 2008