College of Chemistry and Chemical Engineering, Xiamen University

Curriculum Vitae

Shoufa Han, Professor

Department of Chemical Biology

College of Chemistry and Chemical Engineering, Xiamen University

Spouse: Yaqin Zhu

Children: Fangzheng Han, Fangping Han, and Fangzhou Han

Professional Positions

• 2006-present; Professor, Department of Chemical Biology, Xiamen University, China
• 2008-2009, Group leader, Molecular Cloning Laboratories, South San Francisco, CA
• 2003-2006; Postdoctoral fellow/Research associate, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA

Education

• University of Toledo, OH, Ph.D.(2003) Chemistry
• Institute of Chemistry, Chinese Academy of Science, M.S. (1999) Polymer Chemistry
• Beijing University, B. S. (1996, Chemistry)

Publications

1.Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}.

Organic and Biomolecular Chemistry. 2009, 7(10), 2040-2045

Su R, Li L, Chen X, Han J, Han S*

2.Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates

Bioorganic and Medicinal Chemistry Letter,2009, 19(7):1903-1907

Fang W, Cai Y, Chen X, Su R, Chen T, Xia N, Li L, Yang Q, Han J*, Han S*

3.Homomultimeric complexes of CD22 in B cells revealed byprotein-glycan cross-linking

Nature Chemical Biology, 1, 93-97, 2005

Shoufa Han, Brian E. Collins, Per Bengtson, and James C. Paulson,

4.Sialoside analog arrays for rapid identification of high affinity siglec ligands,

Journal of the American Chemical Society, 130 (21), 6680–6681, 2008

Ola Blixt, Shoufa Han, Liang Liao, Ying Zeng, Julia Hoffmann, James C. Paulson;

5.Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells,

Journal of the American Chemical Society, 2008, 130 (14), pp 4578–4579

Mary O’Reilly, Brian E. Collins, Shoufa Han, Liang Liao, Cory Rillahan, Pavel I. Kitov,David R. Bundle and James C. Paulson;

6.On-Virus Construction of Polyvalent Glycan Ligands for Cell-Surface Receptors; Journal of the American Chemical Society, 2008, 4578 - 4579

Eiton Kaltgrad, Mary O'Reilly, Liang Liao, Shoufa Han, James C. Paulson, M. G. Finn

7.Synthesis of 9-substituted sialic acids as probes for CD22-ligand interactions on B cells Frontiers in Modern Carbohydrate Chemistry, 2006, 2-16Shoufa Han, Brian E. Collins and James C. Paulson

8.High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells

Journal of Immunology, 2006, 177: 2994-3003

Brian E. Collins, Ola Blixt, Shoufa Han, Bao Duong, Hongyi Li, Jay K. Nathan, Nicolai Bovin, and James C. Paulson

9.Probing the role of the hyper-reactive histidine residue of arginase

Archives of Biochemistry and Biophysics, 2005, 444(1), 15-26.

Colleluori, Diana M.; Reczkowski, Robert S.; Emig, Compher, Kevin; Han, S; Viola, Ronald E.; Christianson, David W.; Ash, David E.

10.Splicing unnatural amino acids into proteins: a model study

Protein and Peptide Letters, 2004, 11 (2), 107-114

Shoufa Han and Ronald E. Viola

11.Inhibitor coordination interaction in the binuclear maganese cluster of arginase,

Biochemistry,2004, 8987-8999

Evis Cama, Stephanie Pethe, Jean-Lue Boucher, Shoufa Han, David E. Ash, Ronald E. Viola, Daniel Mansuy, and David W. Christianson

12.Activation of carbonic anhydrase II by active-site incorporation of histidine anologs,

Archives of Biochemistry and Biophysics, 2004, 42(2), 283-289

Illeana Elder, Shoufa Han, Chingkuan Tu, heather Steele, Philip J. Laipis, Ronald E. Viola, and David N. Silverman,

13.A facile synthesis of a difluoromethylene analog of -aspartyl phosphate for inhibition of L-aspartate--semialdehyde dehydrogenase

Synlett, 2003, Vol6, 845-846

Shoufa Han, Roger A. Moore, and Ronald E. Viola

14.Synthesis and evaluation of alternative substrates for arginase

Bioorganic Chemistry, 2002, vol30, 81-94

Shoufa Han, Roger A. Moore, and Ronald E. Viola

15.A apectrophotometric assay of arginase

Analytical Biochemistry, 295(1), 117-119, 2001

Shoufa Han and Ronald E. Viola

16.Nonlinear optical polymer filmes based on sol-gel derived silsesquioxanes with pendant chromophoric subunits embedded in size-matched pores

Journal of Sol-Gel Science and Technology, 18 (2) 137-144, 2000

Shoufa Han, Ze Li, Shengxiang Ji, Daorong Dai, Rongben Zhang, Chuanfeng Zhu, and Chen Wang

17.Synthesis of a noval self-assembling NLO polymer film,

Chinese Journal of Polymer Science, 20, 417-422, 1999

Shou-fa Han, Dao-rong Dai, Ze Li, Gang Wu, Rong-ben Zhang

18.Controlled Free radical Double Ring Opening Polymerization of 8,9-benzo-2-methylene-1,4,6-trioxaspiro [4,4] nonane,

Materials Letters, 31, 137-139, 1997

Xinru Jia, Minqian Li, Shoufa Han, Ce Wang, and Yen Wei,

Patents

• High Affinity Siglec Ligands

James Paulson, Brian Collins, Shoufa Han

US patent, Pending, International Filing Date: 2006-10-11

• Enzymatic Sialylation of Intravenous Immunoglobulin G

Shoufa Han, Jiahuai Han

Chinese Patent, pending, Filling data: 2007-6-1

• poly{styrene-co-[styrene-alt-(maleic acid, sodium salt)]} as potent anti-HIV microbicides

Shoufa Han, Jiahuai Han, Chen Xiaoping

(Chinese Patent, Filling data: 2008-6-6)

• Poly{styrene-co-[styrene-alt-(D-mannopyranosyl-a-O-ethylamidomaleic acid)]}as dual contraceptive anti-HIV microbicides

Shoufa Han, Jiahuai Han, Su Rongmin

Chinese Patent, Filling data: 2008-6-6

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