CDHB HaematologyPage 1 of 2

Burkitt-type Lymphoma
Hyper-CVAD - cycles 5 and 7
This alternates with MTX Ara C / Height / cm
Weight / kg
BSA / m2
Cycle length: / 21 days / CBC / Day 1 / Limits / Allergies/Hypersensitivities:
Antiemetics
± domperidone 10-20mg PO QID
± Lorazepam 1-2mg PO daily / Agent
Cyclophosphamide days 1-4 Q12H
Vincristine days 4 and 11 (2 doses)
Doxorubicin day 4
Dexamethasone days 1-4 and 11-14
DOSE MODIFIED:NO YESNOYES / Round
20mg
0.2mg
5mg
Cycle no / 5 7 / Date
Destination / Neuts / ≥3 X 109/L
Plts / ≥50X 109/L
Reference:Thomas et al Cancer, 2006106(7) 1569-1580
Day / Date / Time / Agent / Dose / Route / Instructions / Doctor / Nurse / Check / Start / Stop
-1 / Methotrexate 12mg IT / See intrathecal chemotherapy chart
1-4 / Dexamethasone daily for 4 days / 40 / mg / PO / (days 1-4 and 11-14) Prescribe on QMR4/outpatient script
1 / Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T =0 / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5W over 2 hours Q12H
MESNA 600mg/m2 / mg / IV / In 500ml D5W over 24 hrs
Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T +12h / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5Wover 2 hours Q12H
  • Encourage patients to drink at least 3 litres of fluid per day, and to void frequently when receiving cyclophosphamide.
  • Cyclophosphamide and mesna are infused via a Y-site connector
  • Give IV hydration with alkalinisation and allopuinol ( or rasbuicase for high tumour burden) during course 1
  • Hyper CVAD consists of 2 regimes – Hyper CVAD and High dose Methotrexate and Cytarabine Arabinoside. Both regimes are given 21 days apart.8 cycles are usually given.
  • CNS prophylaxis is given with each cycle total of 16 treatments. If CNS disease, IT therapy is given twice weekly until CSF cell count normalised and cytology negative
  • Rituximab is given with the first 4 cycles only.

Patient Category:
Y J A P O 1 3 Z / OSP Group:
1 2 3 4 5 6 7 / Consultant:
NZMC Reg. No: / Special authority:
Rituximab
Burkitt-type Lymphoma
Hyper-CVAD- cycles 5 and 7
This alternates with MTX Ara C / Height / cm
Weight / kg
BSA / m2
Day / Date / Time / Agent / Dose / Route / Instructions / Doctor / Nurse / Check / Start / Stop
2 / Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T =0 / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5W over 2 hours Q12H
MESNA 600mg/m2 / mg / IV / In 1000ml D5W over 24 hrs
Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T +12h / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5W over 2 hours Q12H
3 / Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T =0 / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5W over 2 hours Q12H
MESNA 600mg/m2 / mg / IV / In 1000ml D5W over 24 hrs
Ondansetron / 8 / mg / PO / Give 30-60 minutes prior to chemo
T +12h / Cyclophosphamide 300mg/m2 / mg / IV / In 100ml D5W over 2 hours Q12H
4 / Vincristine 1.4mg/m2 / mg / IV / In 50ml 0.9S free run over 10 mins
0.9% Sodium Chloride / 250 / ml / IV / Flush and fast running saline
Doxorubicin 50mg/m2 / mg / IV / In 500ml 0.9% saline over 24 hrs
Pegylated GCSF / 6 / mg / SC / 24 hours following last dose of cyclophosphamide
8 / Cytarabine 100mg IT / See intrathecal chemotherapy chart
11 / Vincristine 1.4mg/m2 / mg / IV / In 50ml 0.9S free run over 10 mins
0.9% Sodium Chloride / 100 / ml / IV / For flushing
11-14 / Dexamethasone daily for 4 days / 40 / mg / PO / Chart on QMR4 or give OP Script
  • Doxorubicin must be given via a CVAD

Authorised by: Dr S Gibbons, Pharmacist B Harden / August 2013
\\cdhb.local\dfsgeneral\CHC13HomeLink\JennyR1\Jen\Chemo charts\NHL\NHL Burkitt-type lymphoma hyper-CVAD.docx / Review 2015
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