CHEM 4670/5900Dr. Sushama A. Dandekar SPRING, 2017
Lecture: MWF 1:00 - 1:50 a.m. ENV, Rm 115
OFFICE:Chemistry, Rm 307D,
PHONE:(940) 369-7090 or (940) 565-2713 (Chemistry Dept. Office)
E-MAIL:
OFFICE HOURS:M, W 10:00 – 10:50a.m.
TEXTBOOK:Required: “Introduction to Medicinal Chemistry”, 5th Ed., by
Graham L. Patrick (Oxford)
DISABILITIES:
The Chemistry Department believes in reasonably accommodating individuals with disabilities and complies with the university policy established under section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act (1990) to provide for equal access and opportunity. Please communicate with me as to your specific needs so that appropriate arrangements can be made through the department and/or the office of Disability Accommodation (ODA, Room 318A, Union, 565-4323).
ATTENDANCE:
Regular attendance at lectures is required and expected. However, if you are unable to attend due to reasons beyond your control, you must inform me as soon as possible. If you are absent from three or more classes without an excuse, you may be dropped from the class.
ASSIGNMENTS, EXAMS:
You are responsible for learning and understanding the material covered in the course whether or not you attend class. You are also responsible for reading the text-book: some questions on assignments and exams may pertain to material in the text that was not discussed explicitly in class.
Several assignments will be given, typically related to the topic under discussion in lecture. These are worth 20% of your semester grade.
Twounit-exams will be given during the semester. The lower of the two exam scores will be worth 10% of your semester grade, while the higher score will be worth 20% of your semester grade.
Tentative dates for the exams:
Exam 1: February 20th
Exam 2: March 27th
TheFinal Exam is comprehensive, covering material from the entire semester.
Date and time: as per the university’s final exam schedule
PROJECT:
One of the objectives of this course is to make you better aware of the chemical world around you and also hone your self-study skills along the way. One of the ways of accomplishing this objective is to read supplementary material (books, magazines, journals, etc.), comprehend it and then present it in an organized way. You are to sign up for a topic: (suggested topics will be discussed in class) during the first week of classes. The final project grade is a composite of grades obtained for the components described below. Since the term project is primarily a team project (for CHEM 4670 students), it is important to have an effective means of working collaboratively team members: PBworks is a very useful wiki tool for this purpose. For CHEM 5900 students, you will be working on the project by yourself, but it will still be helpful for you to use PBworks, so that I can provide feedback as your paper progresses. You must request access to PBworks during the first week of classes.
Paper: (35 %)
Research the topic, then write a review paper (20 pages minimum). Feel free to discuss with me any aspects of the material you are not clear about.
Papers must be typed (at least 1.5-spaced, preferably fontsize 12) and include complete bibliographic information at the end of the paper. Your narrative must contain numbered citations as relevant – these numbered citations must be described in complete detail in the bibliography.
You must use at least ten sources (other than your textbook!), of which at least five must be from peer-reviewed publications (journals, textbooks, monographs, etc.).
Be sure to include figures, tables, reaction schemes, etc., within the main body of the paper to clarify/illustrate the material presented. (i.e, do not place them at the very end of your paper!)
Figures, tables, structures, equations, reaction schemes, references, etc., must be numbered and accordingly referred to in the text.
Each Figure/Table/Scheme must have a number, a title and a reference.
Use the ACS style guide for formatting your paper in accordance with currently accepted norms: if you have questions, ASK !!
Deadlines:Outline:January 30th, 2017
Rough Draft 1:February 10th, 2017
Rough Draft 2: March 3rd, 2017
Final Paper:Any time before March 31st, 2017
Each of these must also be submitted online via the Turnitin tab in the Term Project Rough Draft folder
ALSO:
Your final paper must be uploaded to the Discussions tab on Blackboard.
Seminar: (Begin April 3rd) (35 %)
Prepare your research material for a seminar-style presentation (~ 15 minutes): a power-point presentation would be appropriate and professional. Some information may be suitably presented in poster form if you wish, while molecular models (prepared in advance) may be useful for clarifying some structural concepts. Your presentation will be followed by approximately 5 minutes of open discussion.
NOTE: You must be present for ALL the presentations! Non-attendance
during presentations is subject to penalty.
Follow-up Questions: (20 %)
At the end of the presentation, each student (in the audience) will have an opportunity to ask additional questions, in writing, regarding the topic presented. Go through the questions, and provide answers (typed) to ANY FIVE of these questions within one week of your presentation. You must also provide relevant references for these answers. This documentmust be uploaded to the Discussions forum on Blackboard.
Overall Project Experience: (10 %)
After you have completed all of the above-mentioned items, reflect on the overall project experience: new skills you acquired, glimpses into areas of chemistry that you may have previously been unaware of, better understanding of certain subtle concepts, etc. Also identify what, if anything, you would do differently the next time you have to do a project of this nature. Articulate and organize these thoughts into a 1-2-page summary.
ASSIGNMENTS:
A variety of assignments will be given throughout the semester. This may involve generating “test bank” questions to help prepare for exams, as well as problem-solving and library research regarding further exploration of topics discussed in class.
A valuable self-assigned exercise would be to answer end-of-chapter questions: these are designed to help you grasp some of the subtler details of the concepts presented in the chapter.
GRADING:
Your semester grade will be determined as follows:
Term Project20 % of final grade
Assignments20 % of final grade
Unit Exams30 % of final grade
Final Exam30 % of final grade
A grading curve may be used, at my discretion, to achieve a fair distribution of grades. Course Grades will be determined in the following way:
90-100%A
78-89%B
68-77%C
54-67%D
I am looking forward to a wonderful and rewarding semester with you !
☺
Tentative Schedule
Week / Week of: / Topic / Special Notes1 / Jan 16 / Introduction to the course
Ch 1: Drugs and Drug Targets / Term Project Topics: Sign-Up for Term Projects:
PBWorks: Request access (wiki tool for creating term paper)
2 / Jan 23 / Ch 2: Proteins
Ch 3: Enzymes / Term Project: Outline Due:
Jan 30
3 / Jan 30 / Ch 4: Receptors
Ch 5: Signal transduction: Brief overview
4 / Feb 6 / Ch 6: Nucleic Acids
Ch 7: Enzymes as drug targets / Term Project: Rough Draft 1 Due:
Feb 10
5 / Feb 13 / Ch 8: Receptors as drug Targets
Ch 9: Nucleic Acids as Drug Targets / Exam 1 : Feb 20
6 / Feb 20 / Ch 10: Miscellaneous Drug targets
Ch 11: Pharmacokinetics and related topics
7 / Feb 27 / Ch 11: Pharmacokinetics and related topics
Ch 19: Antibacterial agents / Term Project: Rough Draft 2 Due:
March 3
8 / Mar 6 / Ch 19: Antibacterial agents
Ch 12: Drug Discovery: Finding a lead
9 / Mar 13 / Spring Break: No classes
10 / Mar 20 / Ch 12: Drug Discovery: Finding a lead
Ch 13,14: Selected topics
11 / Mar 27 / Ch 15: Getting the drug to market / Exam 2: Mar 28
Term Paper:
Final Paper Due:
Mar 31
12 / April 3 / BeginTerm Project Presentations
13 / April 10 / Term Project Presentations
14 / April 17 / Term Project Presentations
Ch 15: Getting the drug to market
15 / April 24 / Selected topics
16 / May 1 / Selected topics
17 / May 8 / Final Exams / As per University Schedule
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