CAT Proposal FormP09052 - Molecular Imaging System Upgrade
I. ADMINISTRATIVE INFORMATION
CEIS Program:__As appropriate______
Project Title:Development of a novel 3-D optical molecular imaging system prototype and calibration methods
CEIS Project Number:
(if continuing project)
Company11 NameCarestream Health Inc.
Company 1 Size:Large
(small < 100 people, large ≥ 100 people)
Company 1 Contact:Mark Morita
(for project Economic Impact matters,)
Phone and E-mail585-627-6311,
Postal Address150 Verona Street, MC 01135, Rochester, NY 14609
Company 11 Contact:Gilbert D. Feke, Ph.D.
(for project technical matters, if different from above)
Phone and E-mail203-786-5638,
Postal Address4 Science Park West, New Haven CT 06511
Company 2 NameQioptiq Imaging Solutions Inc.
Company 2 Size:Small?
(small < 100 people, large ≥ 100 people)
Company 2 Contact:Bob Zinter
(for project Economic Impact matters,)
Phone and E-mail585-223-2370 x150,
Postal Address78 Schuyler Baldwin Drive, Rochester, NY 14450
Company 2 Contact:Linda Antos
(for project technical matters, if different from above)
Phone and E-mail585-223-2370 x148,
Postal Address78 Schuyler Baldwin Drive, Rochester, NY14450
PI Name:Maria Helguera, Ph.D.
PI Phone and E-mail585-475-7053,
Postal AddressRIT, Center for Imaging Science
54 Lomb Memorial Drive, Rochester, NY14623
Co-Investigators Names:Richard Doolittle, Ph.D, Daniel Phillips, Ph.D.
Account Administrator:TBD
Phone and E-mailTBD
Fax:TBD
Matching Corporate Account Number: TBD
(if continuing CEIS project)
II. PROJECT DESCRIPTION
a.Project Title
Development of a novel 3-D optical molecular imaging system prototype and calibration method.
b.Project Abstract
A currently available 2-D high-resolution, optical molecular imaging system will be modified by the addition of a structured illumination source to investigate the feasibility of providing depth resolution along the optical axis. The modification includes additional optics as well as control and signal processing software. The objective of this effort is to evaluate the possibility of providing low-cost, non-invasive, functional imaging in three dimensions. In addition to the proposed system modifications, a calibration device will also be developed to test the capabilities of the system in terms of range and resolution.
c.Project Duration
It is anticipated that the modifications and calibration development can be carried out in parallel over a roughly six month period that includes testing and validation phases. If validation efforts prove successful, it is possible that another three months would be spent in more exhaustive evaluation as well as development of more sophisticated calibration devices.
d.Science and Technology
Problem:
Carestream Health, Inc., has a need for a research prototype of a clinical system capable of performing depth-resolved optical molecular imaging of a stationary human hand, specifically fluorescence imaging.
Carestream Health, Inc., and Qioptiq Imaging Solutions, Inc. of Rochester, NY have a desire to explore the application of Qioptiq’s “structured illumination” solution for depth-resolution (commercially vended under the name Optigrid) to the problem, as well as the integration of structured illumination technology into Carestream Health, Inc.’s molecular imaging system platform (commercially vended under the name KODAK In Vivo Imaging System F).
Carestream Health, Inc.’s existing imaging platform is currently not capable of single-wavelength depth-resolved optical molecular imaging of stationary subjects. Approaches involving structured illumination have been demonstrated by others to solve the problem (for example, see US Patent Appl. No. 2006/0184043 by Tromberg et al., applied to a mouse), so the application of structured illumination to the problem is what Carestream Health, Inc., needs to research.
The initial demonstration of the working research prototype needs to include depth discrimination between fluorescence signals originating from the front of the hand vs. the back of the hand, with special attention paid to the major joint structures at metacarpophalangeal and interphalangeal articulations, whereby the fluorescence signals have the same wavelength (i.e., so that discrimination by color is not available). Such a demonstration would likely involve application of small pieces of commercially available fluorescent plastic sheets to volunteer hands. If possible, a follow-up demonstration should include depth discrimination of the interior of fluorescently-labeled joints of a phantom (i.e., model) hand, whereby the phantom hand shall be developed by RIT.
Hence, the problem is two-fold – modification of Carestream’s imaging platform to provide this capability and development of suitable calibration device to assess the efficacy relative to the stated goal of depth-resolved imaging of a stationary human hand by the modified system.
Objectives:
Engage a multidisciplinary team to:
-Implement and test the envisioned prototype system
-Develop a suitable calibration device and quantitative assessment methodology
-Investigate the methods necessary to develop a suitable anthropomorphic test device based on the anatomy of a human hand
Methodology:
The three objectives can be carried out essentially in parallel and be utilized in an interactive fashion to validate established or suggested development milestones. For example, investigation of human hand anatomy scattering properties could be used to establish parameters of a calibration device that could be utilized to assess preliminary operation of the optical components and light source of the prototype system.
-Implementation and testing of prototype system
The Qioptiq structured illumination system will be integrated with the current KODAK F series system light source. Optical components necessary to provide depth-resolved imaging will be integrated as well. Control electronics, embedded software and application software to be run on a PC platform will be developed. The modified system will be tested in terms of basic functionality.
-Calibration device and testing methodology
A simple geometric test object will be developed that incorporates fluorescent target material(s) at specified depths suitable to assess range, resolution and sensitivity of the desired prototype as well as being representative of features associated with the material properties and spatial organization of a human hand, both of normal and a defined set of pathological circumstances.
-Investigation of methods necessary to produce an anthropomorphic calibration device based on the properties of a human hand
Based on known properties of the anatomy and material composition of the human hand in normal and a defined set of pathological circumstances (e.g., rheumatoid arthritis, osteoarthritis) as well as the desired imaging capabilities of the prototype imaging system, methods of fabrication will be investigated. The methods will be assessed for feasibility, accuracy, repeatability, and flexibility. It is expected that prototype testing of candidate methods and materials will be evaluated and executed using standardized equipment as well as the prototype system as it becomes available.
As sponsors, both Carestream Health, Inc., and Qioptiq will participate in at most one to two hour biweekly design and project reviews. Qioptiq shall provide advice for implementation of structured illumination technology, as well as materials including a standard grid as used for defining the structured illumination pattern, a paddle for interfacing the grid to the actuation mechanism, the actuation mechanism, and the control electronics. Carestream Health, Inc., shall provide advice for integration of structured illumination technology into Carestream Health, Inc.’s existing imaging platform and procedures to achieve the demonstrations, as well as materials including the critical components of the existing imaging platform, additional materials necessary to integrate the materials provided by Qioptiq into the existing imaging platform (where available), and funds for purchase and manufacture of parts (when necessary).
Alternatives:
Modification of the KODAK F series system represents a rather unique task, although alternative illumination sources and optical systems are certainly feasiblealternatives, whether or not they would result in a more expeditious effort. Other, more customized optical solutions may provide more optimal results but would probably lengthen development time and add additional variables in terms of assessing the functionality of the system.
In terms of calibration devices, it is possible that other calibration devices and methods associated with other imaging and calibration methods may already exist or may be easily modified to suit this particular application. If so, that would allow additional allocation of efforts for other aspects of the project.
Based on the known properties and spatial composition of the human hand, it might be possible to utilize currently available physical hand models or even a suitably fixed cadaver hand to provide the necessary testing and validation of the proposed system.
Deliverables:
- Operational prototype consisting of modified KODAK F molecular imaging system including software, full documentation, testing and validation results.
- Characterized calibration device, devices or system including software, algorithms, full documentation and test results.
- Documentation consisting of report, notes, preliminary prototypes regarding construction methodology for producing, testing and validating an anthropomorphic hand model to evaluate depth-resolvable molecular imaging capabilities of modified KODAK F molecular imaging system.
- Technology Transfer
The principal investigator will be in regular contact with RIT collaborators and have the right to retain all materials as a result of the effort of study participants. All investigators will maintain dated lab notebooks and maintain electronic information in the form of reports, simulations, data, analyses and the like in a version controlled electronic repository with access-controlled internet availability to designated individuals. Periodic project progress reviews will be conducted that will include reports in both electronic and printed form. Relevant intellectual property policies of all participants and their sponsoring institutions and employers will be negotiated, detailed and agreed upon prior to the beginning of study efforts.
III. PROJECT DELIVERABLES (One or two-sentence descriptions.)
Project Deliverable No. 1Modified imaging system and supporting documentation.
Due Date for Deliverable No. 1May 30, 2009
Project Deliverable No. 2Calibration device(s), system and supporting documentation.
Due Date for Deliverable No. 2May 30, 2009
Project Deliverable No. 3Results of method necessary to produce anthropomorphic hand model for system testing and supporting documentation and artifacts.
Due Date for Deliverable No. 3May 30, 2009
IV. NYS ECONOMIC IMPACT (Proposal ranking will be strongly dependent on a credible estimate of the potential jobs and revenues caused by the proposed projects. PIs are expected to collaborate with their industrial sponsors in preparing the Economic Impact portion of their proposals. CEIS personnel may directly contact designated company contacts in order to enhance Economic Impact estimates.) See Economic Impact Guidelines for additional information.
New Jobs / Increased / Capital
Quantitative Estimate by Year / Admin. / Professional / Manufact. / Retained Jobs / Revenues / Cost Savings / Funds Acq'd / Improv's
2007 – 2008
2008 – 2009
2009 – 2010
2010 - 2011
*Potential added revenue, savings, financing, and capital expenditures ($) each year. (Not cumulative)
** Net potential jobs, added or saved (#) each year. (Not cumulative.)
***NOTE: Each project’s economic impact is calculated five years from the project’s end date. Based on the Research and Development life cycle, the first year of the project is expected to return cost savings. As the development process continues further economic impact is expected with regards to revenues, jobs, etc.
a.Rationale/derivation of estimate:
b.Source of estimate (PI or Company; Company is preferred):
c.Describe the cause and effect relationship between your proposed research and potential economic impact:
d.How is your research incorporated in your corporate sponsor’s business plans?
V.DOCUMENTATION OF COMMITMENT: Documentation of company commitment is supportive, but not essential at this time. CEIS must receive evidence of company funding in order to release the CEIS award funding. If evidence is not received within four months of the proposal submission deadline, CEIS may rescind the award.
VI.UPDATED CEIS PROFILE or CURRICULUM VITAE You may download your CEIS Profile from , mark it up and send it to CEIS c/o Heather Tipaldos, P.O.Box 270194, Rochester, NY 14627-0194
María Helguera
Professional Preparation.
1999Ph.D. Imaging Science, Rochester Institute of Technology
1989M.S. Electrical Engineering, University of Rochester
1984B.S. Physics, National Autonomous University of Mexico (UNAM)
Appointments.
04/05–Present Assistant Professor, Rochester Institute of Technology, Rochester, NY
Head of the Biomedical and Materials Multimodal Imaging Lab. Research areas: ultrasound tissue characterization, NDE of materials, medical image processing.
04/02 – 04/05 Visiting Assistant Professor, CIS, Rochester Institute of Technology
04/00–04/02 Electronic Curriculum Developer, CIS, Rochester Institute of Technology, Rochester, NY.
05/99-04/00 Adjunct Professor, CIS, Rochester Institute of Technology, Rochester, NY
09/95-05/99 Research Assistant, CIS, Rochester Institute of Technology, Rochester, NY
04/91-05/95 Professor/Researcher, Centro Nacional de Investigación y Desarrollo Tecnológico, CENIDET, Cuernavaca, Morelos, México
Head of the Electronics Department
Member of the National Researcher System, Mexico.
09/88-09/90 Research Assistant, Electrical Engineering Department, University of Rochester, Rochester, NY.
05/80-05/84 Academic Technician, Institute of Astronomy, National Autnomous University of Mexico, Mexico, DF.
03/79-05/80 Teaching Assistant, Department of Mathematics, College of Science, National Autonomous University of Mexico.
Publications –current and most relevant (*indicates undergraduate author, ** indicates high school author)
1. Helguera, M., Arney, J., Tallapally, N., Zollo, D.**, “Non-Contact Ultrasound Characterization of Paper Substrates”, 9th. European NDT conference Proceedings, Berlin, September 2006
2. Helguera, M. “Medical Imaging and what lies ahead”, Advanced Imaging, September 2006.
3. Baum, K. G., Schmidt, E. **, Rafferty, K.*, D.H. Feiglin, A. Krol, Helguera, M, “Preliminary Study of PET/MRI Image Fusion Schemes for Enhanced Breast Cancer Diagnosis”, 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference..
4. Baum, K. G., Helguera, M., Schmidt, E. **, Rafferty, K. *, Krol, A. ,“Evaluation of Genetic Algorithm-Generated Multivariate Color Tables for Visualization of Multimodal Fused Data Sets”, submitted to 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference.
5. Baum, K. G., Helguera, M., Krol, A. ,“A New Application for Displaying and Fusing Multimodal Data Sets” , 2007 SPIE Symposium on Biomedical Optics.
6. Baum, K. G., Helguera, M., “Distributed Wrapper for SimSet Monte-Carlo PET/SPECT Simulator”, Journal of Digital Imaging, June 2007
7. Baum, K.G., Helguera, M., Krol, A., “Development of a Tool for Multimodality Fusion Visualization and Dynamic Range Adjustment”, Journal of Digital Imaging, November 2007.
8. Baum, K. G., McNamara, K.**, Helguera, M., “Design of a Multiple Component Geometric Breast Phantom,” Medical Imaging, Proceedings of SPIE, Vol. 6913, 69134H, 2008
Collaborators and Other Affiliations:
Collaborators:In addition to those noted in publication list above, Dr. Joel Kastner, CIS, RIT, co-Editor “Imaging in the Physical Sciences”, Dr. Andrzej Krol, SUNY Upstate Medical, Dr. Axel Wismuller, Radiology/Bioengineering, University of Rochester, Dr. Benjamín Varela, ME, RIT, Dr. José Taméz Peña, VirtualScopics.
Student Supervision: Karl Baum (PhD, 2008), Michelle Brennan (MS, 2007), Robert Rose (MS, 2007), Stephanie Shubert (BS, MS NSF Graduate Research Fellow), Raymundo Vázquez-Lugo (MS, 2008), David Fetzer (BS, 2004), Jeffrey Meade (BS, 2005).
Richard Doolittle
Gilbert Feke
Linda Antos
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CAT Proposal FormP09052 - Molecular Imaging System Upgrade
Daniel B. Phillips
Education:
B.S. State University of New York at Buffalo, New York, May 1979, Electrical Engineering
M.S. University of Rochester, Rochester, New York, May 1994, Electrical Engineering
Ph.D. University of Rochester, Rochester, New York, June 1998, Electrical Engineering
Appointments:
Rochester Institute of Technology, Rochester, New York
2000 to 2001 Visiting Assistant Professor, Department of Electrical Engineering.
2001 to 2006 Assistant Professor, Department of Electrical Engineering.
2006 to present Associate Professor, Department of Electrical Engineering
University of Rochester, Rochester, New York
1992 to 1994 Teaching Assistant, Department of Electrical Engineering.
1994 to 1998 Research Assistant, Department of Electrical Engineering.
1998 to 1999 Visiting Research Associate, Department of Electrical Engineering.
1999 to 2000 Scientist and Assistant Professor, Department of Electrical Engineering.
2000 to present Adjunct Professor, Department of Electrical Engineering.
Employment:
Yale School of Medicine, New Haven, Connecticut, 1990 – 1992 Systems Engineer, Anesthesiology
Hewlett Packard, Glastonbury, Connecticut, 1989 – 1990 Customer Engineer – Medical Products Group
Summation Inc., Kirkland, Washington, 1987 – 1989 Applications Engineer – Automated Test Equipment
John Fluke Manufacturing company, Paramus, New Jersey, 1985 – 1987 Field Systems Engineer
Saint Francis Hospital and Medical Center, Hartford, Connecticut, 1982 – 1985 Staff Engineer
Sierra Research Corporation, Buffalo, New York, 1981 – 1982 Automated Test Equipment Programmer
Neurosensory Laboratory, SUNYAB, Buffalo, New York, 1979 - 1981 Research Assistant
Department of Neurobiology, SUNYAB, Buffalo, New York, 1979 Electronic Technician
Bio:
Daniel B. Phillips received the Bachelor of Science in Electrical Engineering from the State University of New York in 1979. He was employed in both the test engineering and biomedical engineering fields in industry and academia from 1979 until 1992. He returned to pursue a graduate course of study in Electrical Engineering at the University of Rochester in 1992 and received his Ph.D. in Electrical Engineering with an emphasis in biomedical ultrasound in 1998. He was employed as a scientist and engineer in the Ultrasound Research Laboratory of Professor Robert C. Waag at the University of Rochester from 1998 until 2000. He accepted an offer to teach in the Department of Electrical Engineering at the Rochester Institute of Technology in 2000 and entered a tenure track position that culminated in his achieving tenure in 2006 and being promoted to Associate Professor. His research interests lie in the application of embedded systems and signal processing to address challenges in biomedical instrumentation and assistive device development.
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Project DescriptionP09052Molecular Imaging System Upgrade
BUDGET (using separate downloadable Excel file)
21 January 2019Page 1 of 5