Supplementary tables
RISKs OF CIRCULATORY DISEASES AMONG MAYAK PA WORKERS WITH radiation doses estimated using THE IMPROVED Mayak Worker Dosimerty System 2008
M.B. Moseeva1, T.V. Azizova1, E. Grigorieva1, R. Haylock2
Correspondence should be addressed to Ph.D. Tamara V. Azizova, MD, Southern Urals Biophysics Institute (SUBI),
19 Ozyorskoe shosse, Ozyorsk, Chelyabinsk region, 456780 RF; tel: +7 35130 29373; fax: +7 35130 29953; mail to
Table S0. Characteristics of the study cohort; BMI – body mass index; for details see manuscriptDoses-2005 / MWDS-2008
Cases
(IHDorCVD) / “Healthy” / Cases
(IHDorCVD) / “Healthy”
Number of workers / 8,217 / 10,546 / 8,342 / 10,514
Mean age at the moment of quit from the study, y.o. / 53.3 ± 7.5* / 33.4 ± 11.8 / 53.2 ± 7.5* / 33.4 ± 11.7
Proportion of smokers, % / 57.3 ± 0.5* / 52.7 ± 0.5 / 57.6 ± 0.5* / 53.0 ± 0.5
Proportion of alcohol consumers, % / 77.7 ± 0.5* / 61.4 ± 0.5 / 78.4 ± 0.5* / 61.7 ± 0.5
Proportion of individuals with hypertension, % / 15.4 ± 0.4* / 12.5 ± 0.3 / 15.2 ± 0.4* / 12.3 ± 0.3
Proportion of individuals with BMI greater than the norm, % / 19.1 ± 0.4* / 9.9 ± 0.3 / 19.0 ± 0.4* / 9.7 ± 0.3
Meanabsorbedcumulativedose of external gamma-rays, Gy / 0.78 ± 0.88* / 0.50 ± 0.72 / 0.71 ± 0.81* / 0.49 ± 0.83
Meancumulative absorbedliverdose of internal alpha-radiation, Gy / 0.32 ± 2.20 / 0.47 ± 2.08 / 0.32 ± 1.41 / 0.53 ± 2.55
Period of employment, years / 26.7 ± 13.1* / 9.1 ± 10.1 / 27.4 ± 12.7* / 9.1 ± 9.8
Table S1. IHD and CVDincidence and mortality: analyses of non-radiation factors.[1]
Incidence / Mortality
IHD / CVD / IHD / CVD
RR (95% CI) / Number of cases / RR (95% CI) / Number of cases / RR (95% CI) / Number of deaths / RR (95% CI) / Number of deaths
Relative risk (RR) for females versus males
Males / 1 / 4,416 / 1 / 5,085 / 1 / 2,088 / 1 / 931
Females / 0.597 (0.563, 0.634) / 1,803 / 0.884 (0.838, 0.933) / 2,355 / 0.362 (0.325, 0.402) / 469 / 0.635 (0.561, 0.718) / 451
RRs for various groups for age (relative to [65-70) years), separately for males and females
Males / <20 / — / 0 / — / 0 / — / 0 / — / 0
[20-25) / 0.000 (0.000, 0.001) / 2 / 0.000 (0.000, 0.001) / 1 / 0.004 (0.000, 0.028) / 1 / 0.007 (0.001, 0.071) / 1
[25-30) / 0.001 (0.000, 0.002) / 7 / 0.000 (0.000, 0.001) / 3 / 0.018 (0.008, 0.039) / 8 / 0.003 (0.000, 0.030) / 1
[30-35) / 0.003 (0.002, 0.004) / 24 / 0.001 (0.001, 0.002) / 12 / 0.025 (0.013, 0.047) / 12 / 0.003 (0.000, 0.025) / 1
[35-40) / 0.019 (0.015, 0.024) / 116 / 0.006 (0.004, 0.008) / 47 / 0.035 (0.022, 0.057) / 22 / 0.022 (0.010, 0.049) / 8
[40-45) / 0.108 (0.091, 0.128) / 554 / 0.058 (0.049, 0.069) / 398 / 0.095 (0.071, 0.129) / 68 / 0.015 (0.007, 0.033) / 7
[45-50) / 0.228 (0.194, 0.267) / 868 / 0.137 (0.118, 0.159) / 767 / 0.175 (0.139, 0.220) / 134 / 0.049 (0.031, 0.078) / 24
[50-55) / 0.373 (0.320, 0.434) / 945 / 0.266 (0.232, 0.305) / 1164 / 0.300 (0.249, 0.361) / 241 / 0.118 (0.083, 0.165) / 50
[55-60) / 0.592 (0.511, 0.685) / 847 / 0.484 (0.425, 0.551) / 1341 / 0.459 (0.389, 0.541) / 326 / 0.270 (0.206, 0.353) / 95
[60-65) / 0.737 (0.639, 0.849) / 556 / 0.739 (0.649, 0.840) / 921 / 0.649 (0.560, 0.753) / 372 / 0.541 (0.432, 0.677) / 148
[65-70) / 1 / 337 / 1 / 341 / 1 / 371 / 1 / 176
[70-75) / 0.937 (0.750, 1.169) / 115 / 0.650 (0.488, 0.866) / 60 / 1.314 (1.116, 1.546) / 266 / 1.934 (1.562, 2.394) / 183
[75-80) / 1.214 (0.853, 1.728) / 39 / 1.245 (0.820, 1.890) / 26 / 1.748 (1.435, 2.129) / 159 / 3.172 (2.498, 4.027) / 133
[80-85) / 1.577 (0.647, 3.845) / 5 / 1.068 (0.393, 2.904) / 4 / 2.734 (2.122, 3.523) / 76 / 5.483 (4.112, 7.310) / 69
[85+ / 6.354 (0.878, 45.960) / 1 / — / 0 / 3.394 (2.345, 4.912) / 32 / 8.328 (5.719, 12.130) / 35
Females / <20 / — / 0 / — / 0 / — / 0 / — / 0
[20-25) / — / 0 / — / 0 / — / 0 / — / 0
[25-30) / — / 0 / 0.000 (0.000, 0.002) / 1 / — / 0 / — / 0
[30-35) / 0.001 (0.000, 0.003) / 2 / 0.001 (0.000, 0.002) / 2 / — / 0 / — / 0
[35-40) / 0.005 (0.003, 0.009) / 12 / 0.007 (0.004, 0.011) / 17 / 0.014 (0.002, 0.122) / 1 / — / 0
[40-45) / 0.047 (0.035, 0.063) / 93 / 0.048 (0.036, 0.063) / 105 / 0.028 (0.006, 0.132) / 2 / 0.014 (0.002, 0.116) / 1
[45-50) / 0.153 (0.120, 0.196) / 225 / 0.125 (0.100, 0.156) / 229 / 0.094 (0.038, 0.230) / 7 / 0.014 (0.002, 0.106) / 1
[50-55) / 0.334 (0.268, 0.417) / 333 / 0.336 (0.279, 0.405) / 502 / 0.166 (0.089, 0.311) / 15 / 0.095 (0.042, 0.212) / 8
[55-60) / 0.575 (0.469, 0.704) / 348 / 0.665 (0.560, 0.790) / 688 / 0.266 (0.163, 0.432) / 25 / 0.271 (0.157, 0.469) / 21
[60-65) / 0.852 (0.708, 1.026) / 302 / 0.933 (0.788, 1.105) / 492 / 0.531 (0.371, 0.760) / 51 / 0.437 (0.272, 0.701) / 27
[65-70) / 1 / 231 / 1 / 213 / 1 / 83 / 1 / 54
[70-75) / 1.338 (1.084, 1.651) / 175 / 0.959 (0.729, 1.260) / 74 / 1.781 (1.321, 2.399) / 105 / 2.249 (1.593, 3.176) / 94
[75-80) / 1.665 (1.241, 2.234) / 68 / 1.234 (0.815, 1.868) / 28 / 3.513 (2.573, 4.796) / 107 / 5.843 (4.149, 8.230) / 121
[80-85) / 1.145 (0.603, 2.176) / 10 / 0.429 (0.103, 1.795) / 2 / 5.676 (3.925, 8.209) / 51 / 13.540 (9.368, 19.570) / 79
[85+ / 1.348 (0.493, 3.690) / 4 / 4.111 (0.567, 29.830) / 2 / 7.640 (4.662, 12.520) / 22 / 23.930 (15.650, 36.580) / 45
RR for workers first employed in 1954 or later versus workers first employed before 1954, separately for males and females
Males / 1948-53 / 1 / 2,036 / 1 / 2,069 / 1 / 1,049 / 1 / 531
1954-58 / 0.801 (0.732, 0.875) / 979 / 0.731 (0.672, 0.796) / 1185 / 0.963 (0.843, 1.099) / 446 / 1.027 (0.845, 1.250) / 176
1959-63 / 0.766 (0.695, 0.845) / 878 / 0.642 (0.585, 0.704) / 1133 / 0.964 (0.831, 1.118) / 406 / 1.265 (1.021, 1.567) / 165
1964-68 / 0.718 (0.626, 0.825) / 354 / 0.710 (0.627, 0.805) / 488 / 0.962 (0.776, 1.193) / 143 / 0.934 (0.652, 1.339) / 39
1969-72 / 0.754 (0.618, 0.920) / 169 / 0.668 (0.557, 0.802) / 210 / 0.634 (0.435, 0.922) / 44 / 1.387 (0.833, 2.309) / 20
Females / 1948-53 / 1 / 1,030 / 1 / 1,206 / 1 / 314 / 1 / 267
1954-58 / 0.881 (0.768, 1.011) / 287 / 0.794 (0.703, 0.897) / 374 / 0.870 (0.644, 1.177) / 56 / 0.889 (0.643, 1.227) / 47
1959-63 / 0.843 (0.735, 0.966) / 295 / 0.719 (0.636, 0.814) / 395 / 0.981 (0.739, 1.302) / 71 / 1.325 (1.024, 1.715) / 98
1964-68 / 0.804 (0.654, 0.987) / 119 / 0.831 (0.705, 0.981) / 230 / 0.885 (0.546, 1.435) / 20 / 1.540 (1.015, 2.335) / 27
1969-72 / 0.731 (0.567, 0.944) / 72 / 0.728 (0.602, 0.881) / 150 / 0.553 (0.252, 1.214) / 8 / 1.568 (0.859, 2.862) / 12
RRs for various calendar periods (relative to [2001-2005]), separately for males and females
Males / 1948-1950 / 0.867 (0.455, 1.651) / 10 / 0.031 (0.004, 0.218) / 1 / 0.829 (0.194, 3.538) / 2 / — / 0
1951-1955 / 3.214 (2.562, 4.032) / 168 / 0.751 (0.593, 0.951) / 117 / 0.534 (0.234, 1.216) / 7 / 1.364 (0.304, 6.134) / 2
1956-1960 / 5.452 (4.470, 6.651) / 321 / 1.799 (1.500, 2.158) / 320 / 0.598 (0.337, 1.060) / 16 / 1.124 (0.389, 3.247) / 4
1961-1965 / 1.742 (1.384, 2.191) / 145 / 1.006 (0.823, 1.229) / 194 / 0.631 (0.407, 0.979) / 28 / 0.790 (0.338, 1.847) / 7
1966-1970 / 1.982 (1.630, 2.409) / 297 / 0.708 (0.587, 0.854) / 253 / 0.664 (0.469, 0.939) / 47 / 1.148 (0.663, 1.988) / 17
1971-1975 / 1.838 (1.534, 2.202) / 430 / 0.504 (0.422, 0.602) / 294 / 0.681 (0.513, 0.904) / 75 / 0.855 (0.532, 1.373) / 22
1976-1980 / 1.814 (1.530, 2.150) / 576 / 0.492 (0.418, 0.578) / 398 / 0.930 (0.746, 1.160) / 159 / 1.085 (0.767, 1.535) / 46
1981-1985 / 1.365 (1.156, 1.612) / 551 / 0.576 (0.497, 0.666) / 573 / 0.899 (0.738, 1.096) / 207 / 1.200 (0.909, 1.584) / 84
1986-1990 / 0.928 (0.787, 1.093) / 445 / 0.745 (0.652, 0.852) / 815 / 0.945 (0.793, 1.128) / 279 / 1.014 (0.789, 1.305) / 106
1991-1995 / 0.900 (0.773, 1.049) / 496 / 0.766 (0.674, 0.870) / 807 / 1.124 (0.963, 1.312) / 422 / 1.232 (0.993, 1.528) / 174
1996-2000 / 1.072 (0.935, 1.230) / 557 / 0.955 (0.848, 1.076) / 779 / 1.059 (0.918, 1.222) / 442 / 1.272 (1.052, 1.538) / 237
2001-2005 / 1 / 420 / 1 / 534 / 1 / 404 / 1 / 232
Females / 1948-1950 / 3.494 (0.849, 14.370) / 2 / 0.754 (0.184, 3.097) / 2 / — / 0 / — / 0
1951-1955 / 2.860 (1.527, 5.355) / 12 / 0.579 (0.303, 1.107) / 11 / — / 0 / — / 0
1956-1960 / 6.500 (4.498, 9.394) / 55 / 1.710 (1.200, 2.437) / 62 / — / 0 / — / 0
1961-1965 / 3.091 (2.191, 4.360) / 68 / 0.655 (0.457, 0.937) / 56 / 1.025 (0.225, 4.674) / 2 / — / 0
1966-1970 / 2.365 (1.745, 3.204) / 110 / 0.566 (0.418, 0.768) / 107 / 0.854 (0.272, 2.681) / 4 / 1.030 (0.240, 4.421) / 2
1971-1975 / 1.684 (1.274, 2.228) / 151 / 0.448 (0.340, 0.589) / 160 / 0.383 (0.130, 1.129) / 4 / 0.850 (0.298, 2.426) / 4
1976-1980 / 1.508 (1.167, 1.948) / 225 / 0.361 (0.280, 0.466) / 220 / 0.979 (0.552, 1.737) / 19 / 1.079 (0.559, 2.083) / 12
1981-1985 / 1.405 (1.105, 1.787) / 292 / 0.591 (0.470, 0.744) / 469 / 0.911 (0.576, 1.439) / 31 / 1.571 (1.019, 2.421) / 35
1986-1990 / 0.744 (0.585, 0.946) / 199 / 0.683 (0.546, 0.853) / 512 / 0.893 (0.614, 1.299) / 48 / 0.667 (0.430, 1.034) / 27
1991-1995 / 0.742 (0.595, 0.924) / 224 / 0.751 (0.601, 0.938) / 375 / 1.239 (0.929, 1.651) / 97 / 0.934 (0.688, 1.268) / 67
1996-2000 / 0.858 (0.706, 1.044) / 240 / 0.941 (0.751, 1.179) / 252 / 1.048 (0.812, 1.354) / 117 / 1.092 (0.861, 1.385) / 132
2001-2005 / 1 / 225 / 1 / 129 / 1 / 147 / 1 / 172
RRs for workers at Radiochemical and Plutonium Plants versus Reactors, separately for males and females
Males / Reactors / 1 / 1,128 / 1 / 1,232 / 1 / 538 / 1 / 245
Radiochemical plant / 0.947 (0.879, 1.021) / 1,887 / 1.151 (1.071, 1.237) / 2,172 / 1.057 (0.947, 1.178) / 876 / 1.070 (0.909, 1.261) / 379
Plutonium plant / 0.966 (0.892, 1.047) / 1,401 / 1.102 (1.021, 1.188) / 1,681 / 1.054 (0.939, 1.183) / 674 / 1.071 (0.902, 1.273) / 307
Females / Reactors / 1 / 326 / 1 / 422 / 1 / 105 / 1 / 83
Radiochemical plant / 1.058 (0.928, 1.205) / 820 / 1.245 (1.109, 1.397) / 1,060 / 0.926 (0.729, 1.175) / 208 / 0.925 (0.711, 1.203) / 187
Plutonium plant / 1.184 (1.033, 1.358) / 657 / 1.113 (0.986, 1.257) / 873 / 0.733 (0.568, 0.946) / 156 / 0.940 (0.719, 1.229) / 181
RRs for various groups for age at first employment (relative to <20 years)
<20 / 1 / 1,152 / 1 / 1,595 / 1 / 497 / 1 / 176
[20-25) / 1.163 (1.063, 1.274) / 2,031 / 1.045 (0.964, 1.132) / 2,492 / 1.122 (0.972, 1.295) / 839 / 1.085 (0.867, 1.359) / 389
[25-30) / 1.268 (1.119, 1.437) / 1,104 / 0.952 (0.850, 1.067) / 1,280 / 1.418 (1.169, 1.719) / 482 / 1.418 (1.060, 1.897) / 244
[30-35) / 1.408 (1.175, 1.686) / 675 / 1.004 (0.852, 1.182) / 774 / 1.731 (1.318, 2.274) / 284 / 1.561 (1.055, 2.309) / 160
[35-40) / 1.456 (1.157, 1.831) / 575 / 1.074 (0.867, 1.330) / 599 / 1.727 (1.211, 2.462) / 194 / 2.230 (1.395, 3.565) / 173
[40+ / 1.636 (1.237, 2.164) / 682 / 1.255 (0.956, 1.647) / 700 / 2.916 (1.881, 4.520) / 261 / 2.028 (1.162, 3.538) / 240
RRs for various groups for duration of employment at the main plants of Mayak PA (relative to [5-10) year) , separately for males and females
Males / <1 / 0.894 (0.726, 1.101) / 113 / 0.723 (0.589, 0.888) / 119 / 0.885 (0.718, 1.092) / 121 / 1.075 (0.796, 1.451) / 63
[1-5) / 0.968 (0.857, 1.094) / 549 / 0.879 (0.779, 0.993) / 535 / 0.946 (0.828, 1.080) / 534 / 0.959 (0.783, 1.173) / 239
[5-10) / 1 / 630 / 1 / 635 / 1 / 413 / 1 / 181
[10-20) / 0.977 (0.873, 1.093) / 961 / 0.991 (0.888, 1.105) / 1,014 / 1.046 (0.902, 1.214) / 412 / 1.074 (0.859, 1.343) / 200
[20-30) / 0.972 (0.865, 1.091) / 1,112 / 1.005 (0.899, 1.124) / 1,208 / 0.887 (0.745, 1.057) / 305 / 1.117 (0.858, 1.454) / 134
[30+ / 0.983 (0.869, 1.111) / 1,051 / 1.028 (0.920, 1.149) / 1,574 / 0.597 (0.497, 0.717) / 303 / 0.634 (0.475, 0.847) / 114
Females / <1 / 0.903 (0.679, 1.200) / 63 / 0.636 (0.482, 0.840) / 70 / 1.484 (1.003, 2.196) / 38 / 0.711 (0.413, 1.225) / 18
[1-5) / 0.851 (0.716, 1.011) / 268 / 0.998 (0.850, 1.172) / 337 / 0.943 (0.717, 1.242) / 123 / 1.021 (0.774, 1.347) / 113
[5-10) / 1 / 357 / 1 / 394 / 1 / 111 / 1 / 131
[10-20) / 0.919 (0.788, 1.073) / 469 / 0.974 (0.842, 1.125) / 570 / 0.816 (0.600, 1.109) / 95 / 0.880 (0.659, 1.175) / 109
[20-30) / 0.850 (0.723, 1.000) / 433 / 0.920 (0.793, 1.067) / 621 / 0.915 (0.645, 1.298) / 73 / 0.841 (0.579, 1.221) / 54
[30+ / 0.763 (0.626, 0.930) / 213 / 0.980 (0.825, 1.163) / 363 / 0.717 (0.447, 1.151) / 29 / 0.915 (0.559, 1.499) / 26
RRs for migrants from Ozyorsk versus those who stayed in the city
Ozyorsk residents / — / — / 1 / 1480 / 1 / 814
Migrants / — / — / 0.865 (0.797, 0.939) / 1077 / 0.870 (0.776, 0.975) / 567
unknown / — / — / — / 0 / 0.707 (0.098, 5.121) / 1
RRs for never-smokers versus current or ex-smokers, separately for males and females
Males / never-smokers / 0.839 (0.775, 0.908) / 777 / 0.861 (0.801, 0.925) / 967 / 0.570 (0.504, 0.644) / 319 / 0.781 (0.662, 0.923) / 191
smokers / 1 / 3,584 / 1 / 4,073 / 1 / 1657 / 1 / 695
unknown / 0.698 (0.525, 0.927) / 55 / 0.531 (0.389, 0.723) / 45 / 0.970 (0.793, 1.187) / 112 / 0.931 (0.676, 1.283) / 45
Females / never-smokers / 1 / 1,628 / 1 / 2,137 / 1 / 384 / 1 / 372
smokers / 1.096 (0.882, 1.362) / 93 / 1.159 (0.949, 1.416) / 109 / 2.372 (1.666, 3.376) / 38 / 1.429 (0.923, 2.213) / 25
unknown / 0.777 (0.607, 0.995) / 82 / 0.758 (0.611, 0.941) / 109 / 1.344 (0.972, 1.857) / 47 / 1.319 (0.959, 1.815) / 54
RRs for never-drinkers versus current or ex-drinkers, separately for males and females
Males / never-drinkers / 0.888 (0.734, 1.075) / 115 / 0.885 (0.740, 1.057) / 134 / 0.697 (0.549, 0.884) / 75 / 0.982 (0.720, 1.339) / 47
drinkers / 1 / 4,166 / 1 / 4,815 / 1 / 1,799 / 1 / 808
unknown / 0.827 (0.690, 0.992) / 135 / 0.670 (0.560, 0.802) / 136 / 1.132 (0.970, 1.320) / 214 / 0.906 (0.701, 1.171) / 76
Females / never-drinkers / 1 / 950 / 1 / 1195 / 1 / 280 / 1 / 252
drinkers / 0.998 (0.902, 1.104) / 713 / 0.959 (0.877, 1.050) / 982 / 0.791 (0.634, 0.986) / 127 / 0.870 (0.695, 1.088) / 130
unknown / 0.876 (0.723, 1.063) / 140 / 0.794 (0.669, 0.944) / 178 / 1.183 (0.885, 1.582) / 62 / 1.207 (0.902, 1.614) / 69
RRs for workers with hypertension versus those without hypertension, separately for males and females
Males / without hypertension / 1 / 3,165 / 1 / 3,806 / 1 / 1,438 / 1 / 632
with hypertension / 1.232 (1.137, 1.335) / 843 / 1.097 (1.013, 1.187) / 846 / 1.327 (1.183, 1.490) / 409 / 1.317 (1.113, 1.558) / 202
unknown / 0.898 (0.800, 1.008) / 408 / 0.820 (0.733, 0.918) / 433 / 1.231 (1.059, 1.430) / 241 / 0.927 (0.731, 1.176) / 97
Females / without hypertension / 1 / 1373 / 1 / 1845 / 1 / 310 / 1 / 306
with hypertension / 1.090 (0.936, 1.270) / 219 / 1.059 (0.922, 1.217) / 260 / 1.448 (1.114, 1.884) / 82 / 1.227 (0.928, 1.623) / 69
unknown / 0.952 (0.815, 1.110) / 211 / 0.710 (0.614, 0.822) / 250 / 1.241 (0.948, 1.624) / 77 / 1.376 (1.037, 1.827) / 76
RRs for male workers with increased or decreased body mass index versus normal body mass index
Males / < normal / 1.090 (0.804, 1.479) / 43 / 0.878 (0.659, 1.170) / 50 / 1.320 (0.845, 2.064) / 20 / 1.059 (0.470, 2.386) / 6
normal / 1 / 3,011 / 1 / 3,570 / 1 / 1,218 / 1 / 551
> normal / 1.222 (1.121, 1.333) / 703 / 1.020 (0.938, 1.108) / 754 / 1.286 (1.123, 1.473) / 288 / 1.058 (0.860, 1.302) / 129
unknown / 0.926 (0.845, 1.014) / 659 / 0.810 (0.742, 0.885) / 711 / 1.266 (1.135, 1.411) / 562 / 1.079 (0.914, 1.272) / 245
Females / < normal / 1.305 (0.791, 2.152) / 16 / 0.658 (0.413, 1.050) / 19 / 0.879 (0.278, 2.780) / 3 / 1.090 (0.344, 3.454) / 3
normal / 1 / 926 / 1 / 1276 / 1 / 197 / 1 / 171
> normal / 1.184 (1.056, 1.329) / 535 / 1.077 (0.971, 1.193) / 673 / 1.313 (1.033, 1.669) / 126 / 1.343 (1.050, 1.717) / 137
unknown / 1.003 (0.879, 1.146) / 326 / 0.767 (0.679, 0.868) / 387 / 1.295 (1.029, 1.630) / 143 / 1.423 (1.115, 1.816) / 140
Medical exposure, absorbed lung dose from external gamma-rays
Males / unknown / 0.948 (0.860, 1.045) / 741 / — / — / 1.176 (1.031, 1.341) / 388 / — / —
0-0.05 Gy / 1 / 1,776 / — / — / 1 / 883 / — / —
0.05-0.1 Gy / 1.067 (0.986, 1.154) / 1,194 / — / — / 2.145 (1.877, 2.451) / 416 / — / —
>0.1 Gy / 0.602 (0.549, 0.660) / 705 / — / — / 1.625 (1.407, 1.876) / 401 / — / —
Females / unknown / 0.831 (0.712, 0.971) / 308 / — / — / 1.294 (1.005, 1.666) / 127 / — / —
0-0.05 Gy / 1 / 790 / — / — / 1 / 192 / — / —
0.05-0.1 Gy / 0.867 (0.769, 0.977) / 530 / — / — / 1.368 (1.038, 1.804) / 100 / — / —
>0.1 Gy / 0.676 (0.566, 0.806) / 175 / — / — / 1.944 (1.365, 2.768) / 50 / — / —
Medical exposure, absorbed skull dose from external gamma-rays
Males / unknown / — / — / 0.875 (0.768, 0.996) / 821 / — / — / 1.148 (0.912, 1.445) / 191
0-0.00001 Gy / — / — / 1 / 391 / — / — / 1 / 161
0.00001-0.00005 Gy / — / — / 0.867 (0.766, 0.981) / 898 / — / — / 0.840 (0.657, 1.075) / 132
>0.00005 Gy / — / — / 0.863 (0.771, 0.967) / 2,975 / — / — / 1.514 (1.217, 1.885) / 447
Females / unknown / — / — / 0.723 (0.582, 0.897) / 414 / — / — / 1.190 (0.846, 1.674) / 121
0-0.00001 Gy / — / — / 1 / 143 / — / — / 1 / 57
0.00001-0.00005 Gy / — / — / 0.930 (0.751, 1.152) / 309 / — / — / 0.821 (0.554, 1.217) / 67
>0.00005 Gy / — / — / 0.910 (0.754, 1.099) / 1,489 / — / — / 0.806 (0.571, 1.139) / 206
1
Supplementary tables
RISKs OF CIRCULATORY DISEASES AMONG MAYAK PA WORKERS WITH radiation doses estimated using THE IMPROVED Mayak Worker Dosimerty System 2008
M.B. Moseeva1, T.V. Azizova1, E. Grigorieva1, R. Haylock2
Correspondence should be addressed to Ph.D. Tamara V. Azizova, MD, Southern Urals Biophysics Institute (SUBI),
19 Ozyorskoe shosse, Ozyorsk, Chelyabinsk region, 456780 RF; tel: +7 35130 29373; fax: +7 35130 29953; mail to
Table S2. IHD incidence: analyses by external dose.<0.2 Gy / 0.2-0.5 Gy / 0.5-1.0 Gy / >1.0 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 2,167 / 0.944 (0.868, 1.028) / 1,292 / 1.038 (0.945, 1.140) / 1,066 / 1.222 (1.109, 1.346) / 1,662 / 0.145 (0.082, 0.207)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 2,090 / 0.947 (0.869, 1.033) / 1,235 / 1.025 (0.932, 1.129) / 1,005 / 1.212 (1.097, 1.339) / 1,540 / 0.147 (0.082, 0.212)
Main analysis, 10 y lag / 1 / 1,974 / 0.958 (0.876, 1.047) / 1,158 / 1.000 (0.906, 1.105) / 908 / 1.227 (1.106, 1.362) / 1,382 / 0.160 (0.089, 0.230)
Main analysis, 15 y lag / 1 / 1,909 / 0.891 (0.813, 0.977) / 1,031 / 1.003 (0.907, 1.110) / 861 / 1.213 (1.090, 1.350) / 1,234 / 0.164 (0.091, 0.238)
Main analysis, 20 y lag / 1 / 1,696 / 0.984 (0.894, 1.084) / 951 / 1.046 (0.940, 1.165) / 750 / 1.250 (1.115, 1.403) / 1,012 / 0.155 (0.077, 0.233)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 2407 / 0.940 (0.864, 1.024) / 1,235 / 1.018 (0.927, 1.118) / 1,005 / 1.203 (1.091, 1.325) / 1,540 / 0.141 (0.078, 0.204)
Main analysis, 10 y lag / 1 / 2,739 / 0.939 (0.860, 1.024) / 1,158 / 0.979 (0.888, 1.078) / 908 / 1.195 (1.080, 1.322) / 1,382 / 0.140 (0.074, 0.207)
Main analysis, 15 y lag / 1 / 3,061 / 0.896 (0.819, 0.980) / 1,031 / 1.011 (0.916, 1.116) / 861 / 1.221 (1.100, 1.355) / 1,234 / 0.162 (0.091, 0.234)
Main analysis, 20 y lag / 1 / 3,474 / 0.972 (0.886, 1.067) / 951 / 1.031 (0.930, 1.142) / 750 / 1.225 (1.098, 1.368) / 1,012 / 0.137 (0.064, 0.210)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 2,167 / 0.947 (0.873, 1.026) / 1,292 / 1.065 (0.974, 1.165) / 1,066 / 1.256 (1.145, 1.378) / 1,662 / 0.159 (0.097, 0.220)
Adding to stratification (0 y lag):
Hypertension / 1 / 2,167 / 0.948 (0.867, 1.036) / 1,292 / 1.048 (0.949, 1.156) / 1,066 / 1.207 (1.089, 1.339) / 1,662 / 0.139 (0.075, 0.204)
Body mass index / 1 / 2,167 / 0.933 (0.852, 1.022) / 1,292 / 1.020 (0.923, 1.129) / 1,066 / 1.209 (1.088, 1.344) / 1,662 / 0.154 (0.086, 0.221)
Employment duration / 1 / 2,167 / 0.923 (0.839, 1.015) / 1,292 / 1.060 (0.955, 1.178) / 1,066 / 1.273 (1.141, 1.420) / 1,662 / 0.171 (0.099, 0.243)
Internal liver dosewithout smoking status taken into account / 1 / 2,167 / 0.938 (0.855, 1.029) / 1,292 / 1.012 (0.912, 1.122) / 1,066 / 1.196 (1.071, 1.336) / 1,662 / 0.119 (0.051, 0.187)
Internal liver dosewith smoking status taken into account / 1 / 2,167 / 0.940 (0.857, 1.031) / 1,292 / 1.007 (0.907, 1.117) / 1,066 / 1.189 (1.064, 1.328) / 1,662 / 0.115 (0.048, 0.182)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 400 / 0.789 (0.666, 0.936) / 322 / 0.935 (0.784, 1.116) / 363 / 1.243 (1.032, 1.498) / 364 / 0.165 (0.025, 0.304)
Radiochemical plant / 1 / 473 / 0.873 (0.751, 1.015) / 621 / 0.967 (0.819, 1.142) / 485 / 1.078 (0.915, 1.270) / 1,122 / 0.118 (0.039, 0.197)
Plutonium plant / 1 / 1,294 / 1.107 (0.971, 1.263) / 349 / 1.109 (0.945, 1.303) / 218 / 1.280 (1.070, 1.532) / 176 / 0.192 (0.058, 0.327)
Males (0 y lag) / 1 / 1,299 / 0.997 (0.902, 1.102) / 975 / 1.148 (1.028, 1.282) / 804 / 1.349 (1.205, 1.511) / 1,309 / 0.189 (0.112, 0.266)
Females (0 y lag) / 1 / 868 / 0.837 (0.714, 0.980) / 317 / 0.802 (0.671, 0.959) / 262 / 0.936 (0.775, 1.131) / 353 / 0.027 (-0.075, 0.130)
Attained age (0 y lag):
< 40 / 1 / 53 / 1.483 (0.899, 2.448) / 38 / 1.574 (0.893, 2.775) / 29 / 1.837 (1.008, 3.348) / 41 / 0.547 (-0.111, 1.205)
40 – 49 / 1 / 595 / 0.912 (0.780, 1.067) / 331 / 1.104 (0.932, 1.307) / 303 / 1.217 (1.024, 1.446) / 489 / 0.154 (0.044, 0.265)
50 – 59 / 1 / 893 / 0.945 (0.831, 1.076) / 537 / 0.948 (0.816, 1.100) / 391 / 1.147 (0.985, 1.335) / 645 / 0.081 (-0.005, 0.168)
60 – 69 / 1 / 464 / 0.956 (0.799, 1.143) / 316 / 1.060 (0.870, 1.291) / 270 / 1.337 (1.087, 1.646) / 376 / 0.234 (0.074, 0.393)
70+ / 1 / 162 / 0.534 (0.374, 0.763) / 70 / 0.787 (0.551, 1.123) / 73 / 1.040 (0.704, 1.535) / 111 / 0.286 (-0.041, 0.612)
P = 0.186[2]
Table S3. IHD mortality: analyses by external dose.
<0.2 Gy / 0.2-0.5 Gy / 0.5-1.0 Gy / >1.0 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 1,010 / 0.895 (0.789, 1.016) / 489 / 0.984 (0.855, 1.133) / 414 / 1.047 (0.906, 1.211) / 644 / 0.032 (-0.037, 0.101)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,005 / 0.913 (0.804, 1.036) / 486 / 1.020 (0.886, 1.174) / 417 / 1.064 (0.920, 1.231) / 636 / 0.038 (-0.033, 0.108)
Main analysis, 10 y lag / 1 / 1,004 / 0.923 (0.813, 1.048) / 485 / 0.999 (0.866, 1.151) / 400 / 1.062 (0.917, 1.230) / 626 / 0.038 (-0.033, 0.109)
Main analysis, 15 y lag / 1 / 1,004 / 0.926 (0.814, 1.053) / 466 / 1.022 (0.885, 1.180) / 397 / 1.054 (0.908, 1.222) / 601 / 0.036 (-0.036, 0.108)
Main analysis, 20 y lag / 1 / 985 / 0.935 (0.820, 1.066) / 444 / 1.048 (0.906, 1.213) / 384 / 1.054 (0.906, 1.226) / 564 / 0.039 (-0.035, 0.113)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,018 / 0.916 (0.807, 1.040) / 486 / 1.024 (0.889, 1.178) / 417 / 1.066 (0.922, 1.233) / 636 / 0.038 (-0.032, 0.108)
Main analysis, 10 y lag / 1 / 1,046 / 0.924 (0.814, 1.049) / 485 / 1.000 (0.868, 1.153) / 400 / 1.063 (0.918, 1.230) / 626 / 0.038 (-0.033, 0.109)
Main analysis, 15 y lag / 1 / 1,093 / 0.925 (0.814, 1.051) / 466 / 1.020 (0.885, 1.177) / 397 / 1.049 (0.905, 1.216) / 601 / 0.034 (-0.037, 0.105)
Main analysis, 20 y lag / 1 / 1,165 / 0.921 (0.809, 1.048) / 444 / 1.029 (0.891, 1.189) / 384 / 1.033 (0.890, 1.199) / 564 / 0.034 (-0.039, 0.106)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 1,010 / 0.877 (0.777, 0.990) / 489 / 0.980 (0.857, 1.121) / 414 / 1.045 (0.911, 1.200) / 644 / 0.050 (-0.021, 0.120)
Adding to stratification (0 y lag):
Hypertension / 1 / 1,010 / 0.905 (0.792, 1.033) / 489 / 1.038 (0.895, 1.204) / 414 / 1.075 (0.922, 1.254) / 644 / 0.033 (-0.040, 0.105)
Body mass index / 1 / 1,010 / 0.868 (0.758, 0.993) / 489 / 1.018 (0.875, 1.183) / 414 / 1.105 (0.945, 1.291) / 644 / 0.069 (-0.012, 0.150)
Employment duration / 1 / 1,010 / 0.896 (0.785, 1.023) / 489 / 0.987 (0.852, 1.144) / 414 / 1.073 (0.920, 1.251) / 644 / 0.050 (-0.025, 0.126)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 534 / 0.908 (0.765, 1.078) / 295 / 1.019 (0.843, 1.233) / 257 / 1.112 (0.915, 1.352) / 424 / 0.061 (-0.040, 0.162)
Also adjusting for internal liver dose without smoking status taken into account / 1 / 534 / 0.868 (0.722, 1.044) / 295 / 0.970 (0.789, 1.192) / 257 / 1.241 (1.000, 1.540) / 424 / 0.168 (0.025, 0.311)
Also adjusting for internal liver dose with smoking status taken into account / 1 / 534 / 0.883 (0.734, 1.062) / 295 / 0.973 (0.792, 1.195) / 257 / 1.258 (1.013, 1.561) / 424 / 0.167 (0.024, 0.310)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 242 / 0.763 (0.601, 0.968) / 134 / 0.714 (0.547, 0.933) / 116 / 1.026 (0.781, 1.347) / 151 / 0.024 (-0.120, 0.169)
Radiochemical plant / 1 / 230 / 0.932 (0.746, 1.164) / 214 / 1.120 (0.884, 1.418) / 201 / 1.107 (0.878, 1.397) / 439 / 0.040 (-0.051, 0.131)
Plutonium plant / 1 / 538 / 0.984 (0.802, 1.207) / 141 / 1.149 (0.902, 1.463) / 97 / 0.892 (0.655, 1.216) / 54 / 0.020 (-0.143, 0.183)
Males (0 y lag) / 1 / 778 / 0.889 (0.773, 1.022) / 408 / 0.973 (0.834, 1.136) / 344 / 1.056 (0.901, 1.238) / 558 / 0.033 (-0.041, 0.108)
Females (0 y lag) / 1 / 232 / 0.927 (0.689, 1.248) / 81 / 1.038 (0.739, 1.460) / 70 / 0.992 (0.693, 1.422) / 86 / 0.025 (-0.163, 0.212)
Attained age (0 y lag):
< 40 / 1 / 24 / 0.846 (0.332, 2.155) / 7 / 1.020 (0.368, 2.829) / 6 / 1.173 (0.388, 3.545) / 7 / -0.121 (-0.237, -0.004)
40 – 49 / 1 / 121 / 0.623 (0.393, 0.987) / 31 / 0.744 (0.437, 1.269) / 24 / 0.700 (0.387, 1.264) / 35 / -0.120 (-0.218, -0.021)
50 – 59 / 1 / 264 / 0.799 (0.624, 1.022) / 125 / 0.884 (0.662, 1.180) / 91 / 1.007 (0.738, 1.374) / 127 / -0.072 (-0.183, 0.039)
60 – 69 / 1 / 302 / 0.880 (0.713, 1.087) / 175 / 1.033 (0.822, 1.298) / 161 / 1.113 (0.878, 1.412) / 239 / 0.111 (-0.025, 0.248)
70+ / 1 / 299 / 1.013 (0.811, 1.266) / 151 / 1.011 (0.791, 1.291) / 132 / 1.059 (0.833, 1.346) / 236 / 0.055 (-0.064, 0.174)
P = 0.1612
Table S4. CVD incidence: analyses by external dose.
<0.2 Gy / 0.2-0.5 Gy / 0.5-1.0 Gy / >1.0 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 2,684 / 1.146 (1.061, 1.239) / 1,690 / 1.311 (1.200, 1.432) / 1,222 / 1.717 (1.567, 1.882) / 1,807 / 0.511 (0.408, 0.614)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 2,652 / 1.159 (1.072, 1.254) / 1,652 / 1.307 (1.195, 1.429) / 1,177 / 1.677 (1.528, 1.841) / 1,678 / 0.497 (0.393, 0.601)
Main analysis, 10 y lag / 1 / 2,596 / 1.145 (1.057, 1.241) / 1,552 / 1.285 (1.172, 1.409) / 1,101 / 1.668 (1.515, 1.838) / 1,500 / 0.529 (0.415, 0.642)
Main analysis, 15 y lag / 1 / 2,541 / 1.138 (1.049, 1.235) / 1,450 / 1.286 (1.170, 1.413) / 1,037 / 1.738 (1.574, 1.919) / 1,338 / 0.572 (0.450, 0.695)
Main analysis, 20 y lag / 1 / 2,461 / 1.153 (1.061, 1.253) / 1,353 / 1.230 (1.116, 1.355) / 919 / 1.666 (1.501, 1.848) / 1,075 / 0.504 (0.382, 0.625)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 2,896 / 1.162 (1.075, 1.255) / 1,652 / 1.311 (1.200, 1.432) / 1,177 / 1.682 (1.535, 1.842) / 1,678 / 0.494 (0.393, 0.596)
Main analysis, 10 y lag / 1 / 3,250 / 1.128 (1.043, 1.219) / 1,552 / 1.263 (1.155, 1.382) / 1,101 / 1.633 (1.487, 1.794) / 1,500 / 0.491 (0.386, 0.596)
Main analysis, 15 y lag / 1 / 3,578 / 1.121 (1.035, 1.214) / 1,450 / 1.262 (1.151, 1.383) / 1,037 / 1.714 (1.557, 1.888) / 1,338 / 0.546 (0.431, 0.662)
Main analysis, 20 y lag / 1 / 4,056 / 1.155 (1.066, 1.252) / 1,353 / 1.230 (1.119, 1.351) / 919 / 1.668 (1.509, 1.844) / 1,075 / 0.494 (0.380, 0.609)
,
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 2,684 / 1.124 (1.044, 1.209) / 1,690 / 1.290 (1.185, 1.403) / 1,222 / 1.670 (1.530, 1.822) / 1,807 / 0.481 (0.386, 0.576)
Adding to stratification (0 y lag):
Hypertension / 1 / 2,684 / 1.140 (1.050, 1.237) / 1,690 / 1.291 (1.176, 1.418) / 1,222 / 1.716 (1.557, 1.892) / 1,807 / 0.525 (0.413, 0.636)
Body mass index / 1 / 2,684 / 1.136 (1.045, 1.235) / 1,690 / 1.303 (1.184, 1.433) / 1,222 / 1.716 (1.553, 1.896) / 1,807 / 0.529 (0.415, 0.644)
Employment duration / 1 / 2,684 / 1.123 (1.029, 1.227) / 1,690 / 1.266 (1.146, 1.399) / 1,222 / 1.684 (1.518, 1.869) / 1,807 / 0.508 (0.393, 0.623)
Internalliverdose without smoking status taken into account / 1 / 2,684 / 1.100 (1.010, 1.198) / 1,690 / 1.220 (1.106, 1.346) / 1,222 / 1.529 (1.375, 1.700) / 1,807 / 0.385 (0.280, 0.490)
Internalliverdosewith smoking status taken into account / 1 / 2,684 / 1.098 (1.008, 1.196) / 1,690 / 1.218 (1.104, 1.344) / 1,222 / 1.519 (1.366, 1.689) / 1,807 / 0.384 (0.279, 0.488)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 453 / 1.238 (1.052, 1.455) / 425 / 1.388 (1.163, 1.656) / 402 / 1.667 (1.377, 2.017) / 369 / 0.461 (0.247, 0.675)
Radiochemical plant / 1 / 583 / 1.010 (0.881, 1.157) / 831 / 1.190 (1.022, 1.386) / 572 / 1.653 (1.423, 1.920) / 1,242 / 0.553 (0.395, 0.711)
Plutonium plant / 1 / 1,648 / 1.224 (1.086, 1.379) / 434 / 1.341 (1.152, 1.562) / 248 / 1.671 (1.409, 1.983) / 196 / 0.479 (0.301, 0.658)
Males (0 y lag) / 1 / 1,514 / 1.187 (1.082, 1.303) / 1,262 / 1.323 (1.191, 1.470) / 895 / 1.717 (1.541, 1.914) / 1,388 / 0.470 (0.356, 0.583)
Females (0 y lag) / 1 / 1,170 / 1.052 (0.912, 1.213) / 428 / 1.296 (1.097, 1.530) / 327 / 1.735 (1.460, 2.061) / 419 / 0.641 (0.407, 0.875)
Attained age (0 y lag):
< 40 / 1 / 22 / 1.510 (0.649, 3.512) / 13 / 0.863 (0.302, 2.467) / 7 / 3.126 (1.298, 7.531) / 40 / 1.888 (-0.651, 4.426)
40 – 49 / 1 / 433 / 1.161 (0.969, 1.390) / 259 / 1.253 (1.029, 1.525) / 228 / 1.824 (1.512, 2.202) / 564 / 0.552 (0.349, 0.755)
50 – 59 / 1 / 1,388 / 1.093 (0.985, 1.213) / 871 / 1.289 (1.142, 1.455) / 612 / 1.731 (1.521, 1.969) / 805 / 0.503 (0.355, 0.652)
60 – 69 / 1 / 737 / 1.134 (0.979, 1.315) / 505 / 1.303 (1.099, 1.545) / 351 / 1.455 (1.214, 1.743) / 372 / 0.394 (0.208, 0.581)
70+ / 1 / 104 / 0.560 (0.300, 1.044) / 42 / 0.663 (0.303, 1.453) / 24 / 0.756 (0.354, 1.617) / 26 / 0.004 (-0.471, 0.478)
P = 0.0322
Table S5. CVD mortality: analyses by external dose.
<0.2 Gy / 0.2-0.5 Gy / 0.5-1.0 Gy / >1.0 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 572 / 1.016 (0.853, 1.211) / 276 / 1.066 (0.878, 1.295) / 221 / 1.061 (0.868, 1.298) / 313 / 0.057 (-0.046, 0.161)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 571 / 1.026 (0.861, 1.223) / 277 / 1.066 (0.877, 1.295) / 219 / 1.064 (0.870, 1.301) / 312 / 0.057 (-0.046, 0.161)
Main analysis, 10 y lag / 1 / 572 / 1.019 (0.855, 1.216) / 274 / 1.067 (0.878, 1.297) / 217 / 1.059 (0.865, 1.295) / 309 / 0.064 (-0.042, 0.170)
Main analysis, 15 y lag / 1 / 571 / 1.031 (0.864, 1.231) / 267 / 1.097 (0.902, 1.335) / 216 / 1.076 (0.879, 1.318) / 305 / 0.076 (-0.033, 0.186)
Main analysis, 20 y lag / 1 / 564 / 1.056 (0.884, 1.262) / 260 / 1.140 (0.936, 1.389) / 214 / 1.093 (0.891, 1.342) / 296 / 0.070 (-0.039, 0.179)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 574 / 1.028 (0.862, 1.225) / 277 / 1.067 (0.878, 1.297) / 219 / 1.066 (0.872, 1.304) / 312 / 0.058 (-0.046, 0.162)
Main analysis, 10 y lag / 1 / 582 / 1.018 (0.854, 1.214) / 274 / 1.065 (0.876, 1.294) / 217 / 1.057 (0.864, 1.293) / 309 / 0.064 (-0.042, 0.170)
Main analysis, 15 y lag / 1 / 594 / 1.025 (0.859, 1.223) / 267 / 1.091 (0.897, 1.327) / 216 / 1.070 (0.875, 1.310) / 305 / 0.075 (-0.034, 0.184)
Main analysis, 20 y lag / 1 / 612 / 1.060 (0.888, 1.267) / 260 / 1.141 (0.937, 1.389) / 214 / 1.095 (0.893, 1.344) / 296 / 0.072 (-0.038, 0.181)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 572 / 1.017 (0.863, 1.198) / 276 / 1.097 (0.913, 1.320) / 221 / 1.070 (0.885, 1.293) / 313 / 0.056 (-0.042, 0.155)
Adding to stratification (0 y lag):
Hypertension / 1 / 572 / 1.008 (0.837, 1.213) / 276 / 1.064 (0.864, 1.310) / 221 / 1.064 (0.858, 1.319) / 313 / 0.068 (-0.045, 0.182)
Body mass index / 1 / 572 / 1.095 (0.905, 1.324) / 276 / 1.190 (0.965, 1.468) / 221 / 1.167 (0.937, 1.455) / 313 / 0.076 (-0.041, 0.192)
Employment duration / 1 / 572 / 1.020 (0.849, 1.227) / 276 / 1.080 (0.880, 1.325) / 221 / 1.056 (0.854, 1.307) / 313 / 0.043 (-0.061, 0.147)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 353 / 0.881 (0.692, 1.122) / 152 / 0.963 (0.736, 1.260) / 122 / 0.865 (0.657, 1.139) / 187 / -0.042 (-0.152, 0.068)
Also adjusting for internal liver dose without smoking status taken into account / 1 / 353 / 0.860 (0.661, 1.119) / 152 / 0.949 (0.703, 1.280) / 122 / 0.947 (0.691, 1.297) / 187 / -0.012 (-0.146, 0.123)
Also adjusting for internal liver dose with smoking status taken into account / 1 / 353 / 0.880 (0.677, 1.144) / 152 / 0.946 (0.705, 1.270) / 122 / 0.934 (0.685, 1.273) / 187 / -0.031 (-0.158, 0.095)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 120 / 0.816 (0.578, 1.153) / 70 / 1.000 (0.695, 1.437) / 74 / 1.051 (0.709, 1.559) / 64 / 0.118 (-0.136, 0.371)
Radiochemical plant / 1 / 135 / 1.117 (0.820, 1.521) / 121 / 1.079 (0.770, 1.513) / 96 / 1.102 (0.795, 1.529) / 214 / 0.044 (-0.087, 0.175)
Plutonium plant / 1 / 317 / 1.088 (0.825, 1.435) / 85 / 1.130 (0.810, 1.576) / 51 / 0.983 (0.667, 1.449) / 35 / 0.032 (-0.188, 0.252)
Males (0 y lag) / 1 / 312 / 1.064 (0.861, 1.315) / 201 / 1.178 (0.938, 1.481) / 171 / 1.194 (0.943, 1.512) / 247 / 0.091 (-0.036, 0.217)
Females (0 y lag) / 1 / 260 / 0.933 (0.681, 1.279) / 75 / 0.816 (0.557, 1.195) / 50 / 0.770 (0.520, 1.139) / 66 / -0.026 (-0.211, 0.158)
Attained age (0 y lag):
< 40 / 1 / 6 / 1.348 (0.288, 6.303) / 3 / — / 0 / 1.620 (0.136, 19.380) / 2 / -0.003 (-1.392, 1.387)
40 – 49 / 1 / 19 / 0.568 (0.189, 1.713) / 5 / 0.348 (0.074, 1.631) / 2 / 2.093 (0.658, 6.653) / 7 / 0.389 (-0.915, 1.692)
50 – 59 / 1 / 69 / 1.632 (1.028, 2.590) / 41 / 1.832 (1.063, 3.157) / 26 / 2.542 (1.406, 4.597) / 38 / 0.627 (-0.102, 1.356)
60 – 69 / 1 / 138 / 1.132 (0.839, 1.528) / 103 / 1.160 (0.830, 1.622) / 79 / 0.921 (0.633, 1.338) / 85 / -0.003 (-0.162, 0.156)
70+ / 1 / 340 / 0.781 (0.618, 0.987) / 124 / 0.870 (0.673, 1.125) / 114 / 0.862 (0.669, 1.111) / 181 / 0.029 (-0.095, 0.153)
P = 0.3842
Table S6. IHD incidence: analyses by internal absorbed liver dosewithout smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 1,170 / 1.029 (0.936, 1.130) / 1,163 / 1.202 (1.082, 1.335) / 974 / 1.294 (1.092, 1.533) / 206 / 0.029 (-0.024, 0.081)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,379 / 1.052 (0.959, 1.153) / 1,097 / 1.184 (1.064, 1.317) / 810 / 1.242 (1.032, 1.494) / 162 / 0.033 (-0.031, 0.098)
Main analysis, 10 y lag / 1 / 1,557 / 1.070 (0.975, 1.174) / 987 / 1.225 (1.097, 1.368) / 660 / 1.153 (0.932, 1.426) / 115 / 0.042 (-0.041, 0.126)
Main analysis, 15 y lag / 1 / 1,699 / 1.128 (1.025, 1.242) / 866 / 1.205 (1.067, 1.361) / 475 / 1.186 (0.930, 1.511) / 85 / 0.062 (-0.055, 0.180)
Main analysis, 20 y lag / 1 / 1,741 / 1.156 (1.043, 1.281) / 690 / 1.218 (1.058, 1.403) / 320 / 1.204 (0.901, 1.609) / 56 / 0.075 (-0.094, 0.244)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,444 / 1.054 (0.962, 1.156) / 1,097 / 1.189 (1.069, 1.322) / 810 / 1.248 (1.037, 1.501) / 162 / 0.034 (-0.030, 0.099)
Main analysis, 10 y lag / 1 / 1,751 / 1.079 (0.984, 1.183) / 987 / 1.235 (1.107, 1.379) / 660 / 1.161 (0.939, 1.435) / 115 / 0.045 (-0.040, 0.130)
Main analysis, 15 y lag / 1 / 2,087 / 1.127 (1.025, 1.239) / 866 / 1.201 (1.065, 1.356) / 475 / 1.189 (0.934, 1.514) / 85 / 0.066 (-0.053, 0.185)
Main analysis, 20 y lag / 1 / 2,447 / 1.157 (1.045, 1.282) / 690 / 1.219 (1.059, 1.402) / 320 / 1.217 (0.911, 1.626) / 56 / 0.087 (-0.088, 0.261)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 1,170 / 1.054 (0.963, 1.154) / 1,163 / 1.206 (1.089, 1.334) / 974 / 1.285 (1.090, 1.514) / 206 / 0.022 (-0.027, 0.072)
Adding to stratification (0 y lag):
Hypertension / 1 / 1,170 / 1.031 (0.935, 1.138) / 1,163 / 1.210 (1.084, 1.351) / 974 / 1.341 (1.123, 1.600) / 206 / 0.033 (-0.022, 0.089)
Body mass index / 1 / 1,170 / 1.048 (0.948, 1.160) / 1,163 / 1.235 (1.105, 1.381) / 974 / 1.332 (1.114, 1.593) / 206 / 0.023 (-0.030, 0.077)
Employment duration / 1 / 1,170 / 1.041 (0.942, 1.151) / 1,163 / 1.169 (1.044, 1.308) / 974 / 1.312 (1.092, 1.577) / 206 / 0.024 (-0.032, 0.081)
External dose / 1 / 1,170 / 1.043 (0.939, 1.158) / 1,163 / 1.187 (1.049, 1.342) / 974 / 1.284 (1.047, 1.575) / 206 / -0.001 (-0.047, 0.045)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 124 / 0.897 (0.561, 1.433) / 39 / 1.266 (0.547, 2.932) / 10 / — / 0 / -0.609 (-4.805, 3.587)
Radiochemical plant / 1 / 509 / 1.011 (0.889, 1.150) / 729 / 1.196 (1.040, 1.376) / 648 / 1.206 (0.943, 1.543) / 94 / -0.019 (-0.101, 0.063)
Plutonium plant / 1 / 537 / 1.065 (0.920, 1.233) / 395 / 1.202 (1.019, 1.419) / 316 / 1.390 (1.097, 1.762) / 112 / 0.042 (-0.025, 0.108)
Males (0 y lag) / 1 / 836 / 1.044 (0.936, 1.165) / 801 / 1.178 (1.041, 1.334) / 625 / 1.513 (1.239, 1.847) / 143 / 0.138 (0.012, 0.264)
Females (0 y lag) / 1 / 334 / 0.984 (0.816, 1.185) / 362 / 1.232 (1.011, 1.502) / 349 / 0.928 (0.675, 1.278) / 63 / 0.009 (-0.045, 0.063)
Attained age (0 y lag):
< 40 / 1 / 32 / 1.079 (0.476, 2.449) / 9 / 4.980 (2.296, 10.800) / 15 / 4.358 (1.152, 16.480) / 3 / 3.091 (-1.021, 7.203)
40 – 49 / 1 / 377 / 1.178 (0.987, 1.406) / 264 / 1.286 (1.043, 1.586) / 173 / 1.552 (1.127, 2.137) / 53 / 0.016 (-0.065, 0.096)
50 – 59 / 1 / 470 / 1.046 (0.904, 1.211) / 443 / 1.274 (1.084, 1.497) / 388 / 1.459 (1.124, 1.893) / 84 / 0.076 (-0.021, 0.174)
60 – 69 / 1 / 235 / 0.970 (0.807, 1.166) / 342 / 1.129 (0.923, 1.380) / 298 / 1.219 (0.858, 1.731) / 47 / 0.008 (-0.123, 0.139)
70+ / 1 / 56 / 0.969 (0.652, 1.440) / 105 / 0.968 (0.645, 1.453) / 100 / 1.072 (0.590, 1.950) / 19 / 0.006 (-0.257, 0.269)
P = >0.52
Table S7. IHD incidence: analyses by internal absorbed liver dose with smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 1,137 / 1.041 (0.947, 1.144) / 1,168 / 1.209 (1.088, 1.343) / 997 / 1.288 (1.088, 1.525) / 211 / 0.029 (-0.023, 0.081)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,342 / 1.049 (0.956, 1.152) / 1,098 / 1.194 (1.073, 1.327) / 838 / 1.243 (1.037, 1.490) / 170 / 0.034 (-0.029, 0.097)
Main analysis, 10 y lag / 1 / 1,504 / 1.100 (1.002, 1.207) / 1,010 / 1.224 (1.096, 1.367) / 676 / 1.257 (1.027, 1.540) / 129 / 0.043 (-0.039, 0.124)
Main analysis, 15 y lag / 1 / 1,661 / 1.112 (1.010, 1.223) / 876 / 1.196 (1.061, 1.348) / 500 / 1.159 (0.913, 1.472) / 88 / 0.062 (-0.051, 0.176)
Main analysis, 20 y lag / 1 / 1,698 / 1.160 (1.047, 1.285) / 708 / 1.228 (1.070, 1.410) / 341 / 1.202 (0.908, 1.592) / 60 / 0.073 (-0.089, 0.236)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,407 / 1.053 (0.960, 1.155) / 1,098 / 1.199 (1.078, 1.333) / 838 / 1.250 (1.043, 1.498) / 170 / 0.035 (-0.029, 0.099)
Main analysis, 10 y lag / 1 / 1,698 / 1.109 (1.011, 1.216) / 1,010 / 1.235 (1.106, 1.378) / 676 / 1.266 (1.034, 1.550) / 129 / 0.046 (-0.037, 0.129)
Main analysis, 15 y lag / 1 / 2,049 / 1.112 (1.011, 1.222) / 876 / 1.194 (1.060, 1.345) / 500 / 1.164 (0.917, 1.477) / 88 / 0.067 (-0.049, 0.182)
Main analysis, 20 y lag / 1 / 2,404 / 1.160 (1.049, 1.284) / 708 / 1.227 (1.070, 1.407) / 341 / 1.214 (0.918, 1.607) / 60 / 0.085 (-0.083, 0.252)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 1,137 / 1.067 (0.973, 1.169) / 1,168 / 1.216 (1.099, 1.347) / 997 / 1.286 (1.092, 1.513) / 211 / 0.023 (-0.026, 0.072)
Adding to stratification (0 y lag):
Hypertension / 1 / 1,137 / 1.042 (0.943, 1.151) / 1,168 / 1.217 (1.090, 1.359) / 997 / 1.334 (1.119, 1.590) / 211 / 0.034 (-0.021, 0.089)
Body mass index / 1 / 1,137 / 1.065 (0.962, 1.179) / 1,168 / 1.246 (1.114, 1.394) / 997 / 1.335 (1.117, 1.594) / 211 / 0.024 (-0.029, 0.077)
Employment duration / 1 / 1,137 / 1.059 (0.956, 1.172) / 1,168 / 1.182 (1.056, 1.324) / 997 / 1.312 (1.093, 1.574) / 211 / 0.025 (-0.031, 0.081)
External dose / 1 / 1,137 / 1.053 (0.947, 1.171) / 1,168 / 1.198 (1.059, 1.355) / 997 / 1.297 (1.059, 1.589) / 211 / -0.001 (-0.046, 0.045)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 123 / 0.847 (0.529, 1.356) / 40 / 1.187 (0.513, 2.743) / 10 / — / 0 / -0.460 (-4.721, 3.802)
Radiochemical plant / 1 / 485 / 1.034 (0.908, 1.178) / 735 / 1.206 (1.047, 1.389) / 662 / 1.203 (0.943, 1.535) / 98 / -0.017 (-0.096, 0.061)
Plutonium plant / 1 / 529 / 1.069 (0.922, 1.239) / 393 / 1.217 (1.031, 1.436) / 325 / 1.391 (1.099, 1.762) / 113 / 0.043 (-0.023, 0.110)
Males (0 y lag) / 1 / 804 / 1.059 (0.949, 1.183) / 806 / 1.185 (1.047, 1.343) / 647 / 1.492 (1.224, 1.818) / 148 / 0.129 (0.011, 0.247)
Females (0 y lag) / 1 / 333 / 0.988 (0.820, 1.191) / 362 / 1.241 (1.018, 1.513) / 350 / 0.931 (0.676, 1.281) / 63 / 0.009 (-0.045, 0.063)
Attained age (0 y lag):
< 40 / 1 / 30 / 1.275 (0.572, 2.840) / 10 / 5.387 (2.469, 11.760) / 16 / 4.493 (1.175, 17.170) / 3 / 2.600 (-0.915, 6.115)
40 – 49 / 1 / 362 / 1.220 (1.021, 1.457) / 269 / 1.299 (1.054, 1.602) / 181 / 1.544 (1.125, 2.119) / 55 / 0.017 (-0.063, 0.097)
50 – 59 / 1 / 460 / 1.048 (0.905, 1.213) / 444 / 1.267 (1.077, 1.490) / 394 / 1.451 (1.121, 1.879) / 87 / 0.076 (-0.020, 0.171)
60 – 69 / 1 / 230 / 0.957 (0.795, 1.152) / 339 / 1.125 (0.919, 1.376) / 306 / 1.194 (0.840, 1.696) / 47 / 0.009 (-0.119, 0.137)
70+ / 1 / 55 / 0.986 (0.662, 1.469) / 106 / 0.980 (0.650, 1.475) / 100 / 1.070 (0.588, 1.949) / 19 / 0.006 (-0.256, 0.267)
P = >0.52
Table S8. IHD mortality: analyses by internal absorbed liver dose without smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 124 / 1.819 (1.437, 2.302) / 301 / 2.137 (1.650, 2.768) / 280 / 2.672 (1.880, 3.800) / 73 / 0.336 (0.074, 0.598)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 165 / 1.667 (1.339, 2.077) / 293 / 1.899 (1.487, 2.424) / 259 / 2.175 (1.520, 3.114) / 61 / 0.401 (0.098, 0.704)
Main analysis, 10 y lag / 1 / 216 / 1.541 (1.249, 1.901) / 274 / 1.780 (1.403, 2.258) / 233 / 1.985 (1.379, 2.858) / 53 / 0.409 (0.078, 0.740)
Main analysis, 15 y lag / 1 / 266 / 1.577 (1.286, 1.934) / 260 / 1.769 (1.393, 2.247) / 200 / 1.895 (1.287, 2.788) / 43 / 0.434 (0.058, 0.809)
Main analysis, 20 y lag / 1 / 316 / 1.636 (1.335, 2.003) / 249 / 1.486 (1.154, 1.913) / 149 / 2.110 (1.417, 3.143) / 38 / 0.458 (0.025, 0.891)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 165 / 1.678 (1.347, 2.090) / 293 / 1.910 (1.496, 2.438) / 259 / 2.188 (1.529, 3.132) / 61 / 0.403 (0.100, 0.707)
Main analysis, 10 y lag / 1 / 218 / 1.559 (1.263, 1.923) / 274 / 1.800 (1.419, 2.285) / 233 / 2.009 (1.395, 2.892) / 53 / 0.415 (0.082, 0.748)
Main analysis, 15 y lag / 1 / 275 / 1.575 (1.285, 1.929) / 260 / 1.760 (1.387, 2.234) / 200 / 1.878 (1.277, 2.762) / 43 / 0.428 (0.055, 0.800)
Main analysis, 20 y lag / 1 / 342 / 1.640 (1.340, 2.006) / 249 / 1.489 (1.158, 1.914) / 149 / 2.111 (1.418, 3.141) / 38 / 0.463 (0.029, 0.898)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 124 / 1.879 (1.498, 2.357) / 301 / 2.173 (1.694, 2.788) / 280 / 2.614 (1.863, 3.669) / 73 / 0.299 (0.060, 0.538)
Adding to stratification (0 y lag):
Hypertension / 1 / 124 / 1.883 (1.472, 2.410) / 301 / 2.219 (1.692, 2.911) / 280 / 3.023 (2.086, 4.379) / 73 / 0.450 (0.122, 0.777)
Body mass index / 1 / 124 / 1.879 (1.464, 2.413) / 301 / 2.295 (1.742, 3.023) / 280 / 3.113 (2.137, 4.535) / 73 / 0.496 (0.144, 0.848)
Employment duration / 1 / 124 / 1.838 (1.444, 2.338) / 301 / 2.126 (1.633, 2.767) / 280 / 2.731 (1.900, 3.926) / 73 / 0.371 (0.085, 0.657)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 122 / 1.856 (1.464, 2.354) / 292 / 2.112 (1.624, 2.746) / 259 / 2.513 (1.739, 3.632) / 59 / 0.296 (0.012, 0.580)
Also adjusting for external dose / 1 / 122 / 1.780 (1.381, 2.295) / 292 / 1.946 (1.456, 2.599) / 259 / 2.454 (1.615, 3.729) / 59 / 0.288 (-0.048, 0.625)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 19 / 1.372 (0.642, 2.930) / 16 / 9.524 (3.438, 26.380) / 7 / — / 1 / —
Radiochemical plant / 1 / 58 / 1.319 (0.943, 1.845) / 159 / 1.858 (1.304, 2.645) / 188 / 2.249 (1.390, 3.637) / 39 / 0.325 (-0.013, 0.663)
Plutonium plant / 1 / 47 / 2.728 (1.883, 3.950) / 126 / 2.095 (1.378, 3.187) / 85 / 2.988 (1.743, 5.120) / 33 / 0.315 (-0.080, 0.711)
Males (0 y lag) / 1 / 106 / 1.901 (1.478, 2.446) / 247 / 2.245 (1.700, 2.963) / 226 / 2.785 (1.894, 4.096) / 55 / 0.337 (0.026, 0.648)
Females (0 y lag) / 1 / 18 / 1.273 (0.651, 2.488) / 54 / 1.465 (0.718, 2.991) / 54 / 1.889 (0.777, 4.593) / 18 / 0.334 (-0.153, 0.819)
Attained age (0 y lag):
< 40 / 1 / 1 / — / 0 / — / 2 / — / 0 / —
40 – 49 / 1 / 19 / 2.127 (1.064, 4.253) / 19 / 1.069 (0.332, 3.443) / 5 / 0.995 (0.095, 10.390) / 1 / 0.653 (-1.582, 2.888)
50 – 59 / 1 / 27 / 2.228 (1.376, 3.608) / 61 / 2.952 (1.710, 5.096) / 43 / 7.851 (3.726, 16.540) / 16 / 4.258 (0.802, 7.714)
60 – 69 / 1 / 45 / 1.885 (1.304, 2.725) / 118 / 2.022 (1.354, 3.019) / 112 / 2.096 (1.170, 3.754) / 21 / 0.170 (-0.155, 0.494)
70+ / 1 / 32 / 1.475 (0.952, 2.285) / 103 / 1.821 (1.151, 2.883) / 118 / 2.220 (1.266, 3.893) / 35 / 0.297 (-0.051, 0.646)
P = 0.0252
Table S9. IHD mortality: analyses by internal absorbed liver dosewith smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 125 / 1.665 (1.315, 2.109) / 294 / 2.020 (1.560, 2.615) / 285 / 2.464 (1.736, 3.497) / 74 / 0.328 (0.075, 0.581)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 156 / 1.705 (1.364, 2.130) / 294 / 1.951 (1.523, 2.500) / 263 / 2.350 (1.650, 3.348) / 65 / 0.389 (0.098, 0.681)
Main analysis, 10 y lag / 1 / 208 / 1.547 (1.251, 1.913) / 274 / 1.795 (1.413, 2.281) / 238 / 2.026 (1.413, 2.906) / 56 / 0.400 (0.081, 0.718)
Main analysis, 15 y lag / 1 / 259 / 1.566 (1.275, 1.922) / 261 / 1.727 (1.359, 2.194) / 204 / 1.904 (1.299, 2.790) / 45 / 0.426 (0.065, 0.787)
Main analysis, 20 y lag / 1 / 304 / 1.628 (1.327, 1.996) / 248 / 1.593 (1.242, 2.042) / 161 / 2.041 (1.374, 3.031) / 39 / 0.447 (0.033, 0.859)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 156 / 1.716 (1.373, 2.144) / 294 / 1.963 (1.532, 2.515) / 263 / 2.365 (1.660, 3.369) / 65 / 0.392 (0.100, 0.684)
Main analysis, 10 y lag / 1 / 210 / 1.567 (1.267, 1.938) / 274 / 1.818 (1.431, 2.310) / 238 / 2.052 (1.431, 2.944) / 56 / 0.406 (0.085, 0.726)
Main analysis, 15 y lag / 1 / 268 / 1.562 (1.274, 1.917) / 261 / 1.718 (1.354, 2.181) / 204 / 1.888 (1.289, 2.764) / 45 / 0.420 (0.062, 0.778)
Main analysis, 20 y lag / 1 / 330 / 1.635 (1.335, 2.002) / 248 / 1.597 (1.247, 2.045) / 161 / 2.042 (1.376, 3.030) / 39 / 0.451 (0.037, 0.865)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 125 / 1.738 (1.385, 2.181) / 294 / 2.072 (1.616, 2.657) / 285 / 2.447 (1.747, 3.429) / 74 / 0.298 (0.065, 0.530)
Adding to stratification (0 y lag):
Hypertension / 1 / 125 / 1.725 (1.347, 2.209) / 294 / 2.098 (1.600, 2.750) / 285 / 2.806 (1.940, 4.058) / 74 / 0.438 (0.121, 0.755)
Body mass index / 1 / 125 / 1.726 (1.345, 2.217) / 294 / 2.174 (1.651, 2.863) / 285 / 2.886 (1.984, 4.198) / 74 / 0.484 (0.144, 0.824)
Employment duration / 1 / 125 / 1.665 (1.309, 2.118) / 294 / 1.975 (1.519, 2.567) / 285 / 2.498 (1.742, 3.584) / 74 / 0.362 (0.085, 0.639)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 123 / 1.702 (1.342, 2.159) / 285 / 2.003 (1.542, 2.603) / 264 / 2.310 (1.602, 3.331) / 60 / 0.295 (0.019, 0.572)
Also adjusting for external dose / 1 / 123 / 1.623 (1.260, 2.092) / 285 / 1.799 (1.348, 2.401) / 264 / 2.211 (1.460, 3.348) / 60 / 0.294 (-0.037, 0.625)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 19 / 1.284 (0.602, 2.740) / 16 / 9.119 (3.303, 25.180) / 7 / — / 1 / —
Radiochemical plant / 1 / 58 / 1.188 (0.848, 1.665) / 155 / 1.722 (1.209, 2.454) / 191 / 2.021 (1.254, 3.259) / 40 / 0.314 (-0.009, 0.638)
Plutonium plant / 1 / 48 / 2.507 (1.734, 3.623) / 123 / 2.004 (1.322, 3.037) / 87 / 2.806 (1.640, 4.800) / 33 / 0.311 (-0.077, 0.698)
Males (0 y lag) / 1 / 107 / 1.722 (1.338, 2.216) / 240 / 2.112 (1.601, 2.786) / 231 / 2.540 (1.731, 3.726) / 56 / 0.324 (0.027, 0.620)
Females (0 y lag) / 1 / 18 / 1.272 (0.651, 2.487) / 54 / 1.462 (0.716, 2.986) / 54 / 1.886 (0.776, 4.587) / 18 / 0.333 (-0.152, 0.819)
Attained age (0 y lag):
< 40 / 1 / 1 / — / 0 / — / 2 / — / 0 / —
40 – 49 / 1 / 19 / 1.922 (0.954, 3.875) / 18 / 1.240 (0.412, 3.733) / 6 / 0.908 (0.088, 9.339) / 1 / 0.564 (-1.464, 2.592)
50 – 59 / 1 / 27 / 2.078 (1.281, 3.372) / 60 / 2.808 (1.626, 4.847) / 44 / 7.074 (3.362, 14.890) / 16 / 3.986 (0.722, 7.249)
60 – 69 / 1 / 47 / 1.656 (1.149, 2.385) / 114 / 1.826 (1.229, 2.712) / 113 / 1.908 (1.076, 3.383) / 22 / 0.165 (-0.146, 0.476)
70+ / 1 / 31 / 1.469 (0.942, 2.290) / 102 / 1.848 (1.161, 2.942) / 120 / 2.161 (1.226, 3.809) / 35 / 0.289 (-0.049, 0.628)
P = 0.0092
Table S10. CVD incidence: analyses by internal absorbed liver dosewithout smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 1,553 / 1.192 (1.099, 1.293) / 1,566 / 1.446 (1.318, 1.587) / 1,126 / 1.766 (1.504, 2.075) / 221 / 0.334 (0.204, 0.464)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,842 / 1.207 (1.115, 1.306) / 1,472 / 1.433 (1.303, 1.575) / 922 / 1.784 (1.500, 2.122) / 177 / 0.403 (0.241, 0.564)
Main analysis, 10 y lag / 1 / 2,104 / 1.271 (1.174, 1.375) / 1,328 / 1.455 (1.316, 1.609) / 710 / 1.863 (1.532, 2.266) / 131 / 0.500 (0.292, 0.709)
Main analysis, 15 y lag / 1 / 2,395 / 1.289 (1.188, 1.399) / 1,116 / 1.328 (1.186, 1.488) / 481 / 1.831 (1.453, 2.309) / 89 / 0.650 (0.361, 0.938)
Main analysis, 20 y lag / 1 / 2,557 / 1.267 (1.158, 1.388) / 823 / 1.353 (1.181, 1.551) / 301 / 1.718 (1.250, 2.360) / 47 / 0.961 (0.506, 1.417)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,895 / 1.212 (1.120, 1.312) / 1,472 / 1.439 (1.309, 1.581) / 922 / 1.789 (1.504, 2.127) / 177 / 0.406 (0.245, 0.568)
Main analysis, 10 y lag / 1 / 2,297 / 1.276 (1.180, 1.381) / 1,328 / 1.460 (1.321, 1.613) / 710 / 1.874 (1.542, 2.279) / 131 / 0.511 (0.301, 0.722)
Main analysis, 15 y lag / 1 / 2,780 / 1.303 (1.201, 1.413) / 1,116 / 1.344 (1.200, 1.505) / 481 / 1.854 (1.471, 2.336) / 89 / 0.694 (0.398, 0.990)
Main analysis, 20 y lag / 1 / 3,295 / 1.276 (1.167, 1.396) / 823 / 1.359 (1.187, 1.557) / 301 / 1.733 (1.262, 2.379) / 47 / 1.006 (0.546, 1.466)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 1,553 / 1.169 (1.082, 1.264) / 1,566 / 1.415 (1.294, 1.547) / 1,126 / 1.659 (1.420, 1.938) / 221 / 0.275 (0.161, 0.388)
Adding to stratification (0 y lag):
Hypertension / 1 / 1,553 / 1.202 (1.103, 1.309) / 1,566 / 1.459 (1.323, 1.609) / 1,126 / 1.876 (1.585, 2.220) / 221 / 0.384 (0.234, 0.534)
Body mass index / 1 / 1,553 / 1.238 (1.134, 1.351) / 1,566 / 1.489 (1.348, 1.645) / 1,126 / 1.865 (1.572, 2.213) / 221 / 0.385 (0.234, 0.535)
Employment duration / 1 / 1,553 / 1.212 (1.108, 1.326) / 1,566 / 1.531 (1.384, 1.694) / 1,126 / 1.733 (1.453, 2.067) / 221 / 0.347 (0.202, 0.492)
External dose / 1 / 1,553 / 1.174 (1.072, 1.286) / 1,566 / 1.283 (1.151, 1.431) / 1,126 / 1.562 (1.283, 1.901) / 221 / 0.221 (0.072, 0.370)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 152 / 0.893 (0.579, 1.379) / 41 / 1.041 (0.466, 2.328) / 12 / — / 0 / —
Radiochemical plant / 1 / 667 / 1.285 (1.149, 1.436) / 977 / 1.527 (1.348, 1.731) / 724 / 1.837 (1.438, 2.347) / 84 / 0.695 (0.394, 0.996)
Plutonium plant / 1 / 734 / 1.112 (0.979, 1.264) / 548 / 1.398 (1.209, 1.616) / 390 / 1.722 (1.388, 2.136) / 137 / 0.194 (0.073, 0.315)
Males (0 y lag) / 1 / 987 / 1.172 (1.065, 1.291) / 1,083 / 1.404 (1.256, 1.570) / 745 / 1.863 (1.534, 2.263) / 145 / 0.609 (0.378, 0.841)
Females (0 y lag) / 1 / 566 / 1.244 (1.067, 1.449) / 483 / 1.547 (1.305, 1.833) / 381 / 1.608 (1.208, 2.139) / 76 / 0.126 (0.011, 0.241)
Attained age (0 y lag):
< 40 / 1 / 16 / 1.397 (0.549, 3.560) / 9 / 4.036 (1.514, 10.760) / 10 / 2.973 (0.607, 14.570) / 2 / 1.149 (-1.140, 3.438)
40 – 49 / 1 / 294 / 1.611 (1.337, 1.940) / 296 / 1.934 (1.571, 2.381) / 227 / 2.599 (1.936, 3.488) / 70 / 0.305 (0.107, 0.503)
50 – 59 / 1 / 830 / 1.142 (1.023, 1.275) / 764 / 1.435 (1.263, 1.631) / 550 / 1.538 (1.211, 1.952) / 92 / 0.356 (0.162, 0.551)
60 – 69 / 1 / 386 / 1.064 (0.915, 1.237) / 460 / 1.250 (1.053, 1.484) / 314 / 1.752 (1.258, 2.439) / 54 / 0.402 (0.042, 0.763)
70+ / 1 / 27 / 1.696 (0.712, 4.039) / 37 / 1.215 (0.521, 2.837) / 25 / 0.030 (0.002, 0.480) / 3 / -0.442 (-1.448, 0.564)
P > 0.500 2
Table S11. CVD incidence: analyses by internal absorbed liver dosewith smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases / RR (95% CI) / No. of cases
Main analysis, 0 y lag / 1 / 1,521 / 1.185 (1.092, 1.286) / 1,563 / 1.440 (1.312, 1.581) / 1,153 / 1.762 (1.503, 2.066) / 229 / 0.331 (0.204, 0.457)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,807 / 1.188 (1.097, 1.287) / 1,463 / 1.434 (1.305, 1.576) / 962 / 1.721 (1.450, 2.043) / 181 / 0.399 (0.242, 0.556)
Main analysis, 10 y lag / 1 / 2,049 / 1.268 (1.171, 1.372) / 1,350 / 1.452 (1.314, 1.604) / 736 / 1.837 (1.516, 2.225) / 138 / 0.495 (0.293, 0.698)
Main analysis, 15 y lag / 1 / 2,342 / 1.280 (1.180, 1.389) / 1,142 / 1.304 (1.166, 1.459) / 501 / 1.818 (1.453, 2.274) / 96 / 0.644 (0.366, 0.922)
Main analysis, 20 y lag / 1 / 2,486 / 1.302 (1.191, 1.424) / 866 / 1.375 (1.203, 1.571) / 320 / 1.876 (1.402, 2.511) / 56 / 0.933 (0.499, 1.366)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 1,860 / 1.192 (1.101, 1.291) / 1,463 / 1.440 (1.311, 1.582) / 962 / 1.725 (1.453, 2.048) / 181 / 0.402 (0.245, 0.560)
Main analysis, 10 y lag / 1 / 2,242 / 1.274 (1.177, 1.379) / 1,350 / 1.458 (1.320, 1.610) / 736 / 1.849 (1.527, 2.239) / 138 / 0.507 (0.303, 0.710)
Main analysis, 15 y lag / 1 / 2,727 / 1.293 (1.193, 1.402) / 1,142 / 1.321 (1.181, 1.477) / 501 / 1.840 (1.472, 2.301) / 96 / 0.687 (0.402, 0.973)
Main analysis, 20 y lag / 1 / 3,224 / 1.312 (1.201, 1.433) / 866 / 1.382 (1.210, 1.577) / 320 / 1.891 (1.414, 2.527) / 56 / 0.978 (0.540, 1.417)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 1,521 / 1.165 (1.077, 1.260) / 1,563 / 1.413 (1.292, 1.545) / 1,153 / 1.668 (1.431, 1.945) / 229 / 0.276 (0.165, 0.387)
Adding to stratification (0 y lag):
Hypertension / 1 / 1,521 / 1.194 (1.095, 1.301) / 1,563 / 1.451 (1.315, 1.601) / 1,153 / 1.869 (1.582, 2.207) / 229 / 0.379 (0.233, 0.525)
Body mass index / 1 / 1,521 / 1.230 (1.126, 1.343) / 1,563 / 1.481 (1.340, 1.637) / 1,153 / 1.848 (1.561, 2.188) / 229 / 0.377 (0.232, 0.523)
Employment duration / 1 / 1,521 / 1.207 (1.103, 1.321) / 1,563 / 1.529 (1.382, 1.692) / 1,153 / 1.720 (1.445, 2.048) / 229 / 0.341 (0.201, 0.481)
External dose / 1 / 1,521 / 1.163 (1.061, 1.275) / 1,563 / 1.280 (1.147, 1.427) / 1,153 / 1.536 (1.265, 1.864) / 229 / 0.216 (0.073, 0.360)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 151 / 0.875 (0.568, 1.347) / 42 / 1.005 (0.451, 2.239) / 12 / — / 0 / —
Radiochemical plant / 1 / 643 / 1.292 (1.155, 1.446) / 977 / 1.522 (1.342, 1.726) / 742 / 1.848 (1.455, 2.348) / 90 / 0.658 (0.373, 0.943)
Plutoniumplant / 1 / 727 / 1.090 (0.959, 1.239) / 544 / 1.402 (1.213, 1.621) / 399 / 1.712 (1.382, 2.122) / 139 / 0.196 (0.076, 0.316)
Males (0 y lag) / 1 / 956 / 1.168 (1.060, 1.287) / 1,082 / 1.399 (1.251, 1.564) / 771 / 1.830 (1.511, 2.216) / 151 / 0.578 (0.360, 0.797)
Females (0 y lag) / 1 / 565 / 1.229 (1.055, 1.432) / 481 / 1.541 (1.300, 1.825) / 382 / 1.645 (1.239, 2.183) / 78 / 0.126 (0.011, 0.241)
Attained age (0 y lag):
< 40 / 1 / 15 / 1.437 (0.553, 3.735) / 9 / 4.366 (1.623, 11.740) / 11 / 2.916 (0.586, 14.500) / 2 / 1.080 (-1.033, 3.193)
40 – 49 / 1 / 286 / 1.538 (1.273, 1.858) / 285 / 1.946 (1.581, 2.395) / 241 / 2.614 (1.957, 3.491) / 75 / 0.305 (0.113, 0.497)
50 – 59 / 1 / 814 / 1.146 (1.026, 1.280) / 770 / 1.425 (1.253, 1.621) / 557 / 1.548 (1.223, 1.959) / 95 / 0.348 (0.159, 0.538)
60 – 69 / 1 / 379 / 1.072 (0.921, 1.247) / 462 / 1.228 (1.034, 1.460) / 319 / 1.683 (1.209, 2.343) / 54 / 0.406 (0.049, 0.763)
70+ / 1 / 27 / 1.523 (0.642, 3.615) / 37 / 1.233 (0.526, 2.893) / 25 / 0.030 (0.002, 0.479) / 3 / -0.442 (-1.445, 0.561)
P > 0.500 2
Table S12. CVD mortality: analyses by internal absorbed liver dosewithout smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 76 / 1.065 (0.765, 1.484) / 135 / 1.457 (1.038, 2.045) / 177 / 1.257 (0.759, 2.083) / 30 / 0.135 (-0.147, 0.416)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 90 / 1.136 (0.826, 1.563) / 132 / 1.606 (1.154, 2.234) / 172 / 1.207 (0.704, 2.067) / 24 / 0.160 (-0.157, 0.478)
Main analysis, 10 y lag / 1 / 107 / 1.292 (0.952, 1.755) / 136 / 1.647 (1.193, 2.275) / 154 / 1.182 (0.676, 2.067) / 21 / 0.150 (-0.193, 0.493)
Main analysis, 15 y lag / 1 / 137 / 1.212 (0.907, 1.620) / 130 / 1.438 (1.048, 1.973) / 128 / 1.198 (0.690, 2.081) / 21 / 0.157 (-0.231, 0.545)
Main analysis, 20 y lag / 1 / 172 / 0.987 (0.741, 1.316) / 117 / 1.189 (0.865, 1.636) / 106 / 1.219 (0.698, 2.130) / 19 / 0.175 (-0.280, 0.631)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 90 / 1.140 (0.829, 1.568) / 132 / 1.611 (1.158, 2.242) / 172 / 1.211 (0.707, 2.074) / 24 / 0.161 (-0.157, 0.479)
Main analysis, 10 y lag / 1 / 107 / 1.304 (0.960, 1.772) / 136 / 1.661 (1.202, 2.295) / 154 / 1.192 (0.682, 2.084) / 21 / 0.152 (-0.192, 0.496)
Main analysis, 15 y lag / 1 / 139 / 1.208 (0.904, 1.614) / 130 / 1.437 (1.048, 1.970) / 128 / 1.192 (0.687, 2.070) / 21 / 0.157 (-0.231, 0.544)
Main analysis, 20 y lag / 1 / 176 / 1.001 (0.751, 1.334) / 117 / 1.206 (0.877, 1.658) / 106 / 1.232 (0.706, 2.152) / 19 / 0.181 (-0.278, 0.640)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 76 / 1.069 (0.784, 1.457) / 135 / 1.462 (1.060, 2.017) / 177 / 1.044 (0.638, 1.709) / 30 / -0.027 (-0.174, 0.120)
Adding to stratification (0 y lag):
Hypertension / 1 / 76 / 1.086 (0.765, 1.541) / 135 / 1.536 (1.073, 2.198) / 177 / 1.109 (0.643, 1.910) / 30 / 0.053 (-0.205, 0.310)
Body mass index / 1 / 76 / 1.027 (0.717, 1.472) / 135 / 1.622 (1.118, 2.353) / 177 / 1.300 (0.756, 2.236) / 30 / 0.083 (-0.174, 0.340)
Employment duration / 1 / 76 / 1.117 (0.786, 1.588) / 135 / 1.508 (1.051, 2.164) / 177 / 1.326 (0.775, 2.270) / 30 / 0.157 (-0.154, 0.468)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 74 / 1.052 (0.753, 1.469) / 127 / 1.428 (1.012, 2.017) / 162 / 1.210 (0.713, 2.053) / 24 / 0.155 (-0.169, 0.479)
Also adjusting for external dose / 1 / 74 / 1.144 (0.793, 1.651) / 127 / 1.593 (1.081, 2.348) / 162 / 1.469 (0.793, 2.718) / 24 / 0.039 (-0.269, 0.346)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 10 / 0.998 (0.290, 3.435) / 7 / — / 1 / — / 0 / —
Radiochemical plant / 1 / 25 / 1.375 (0.812, 2.331) / 75 / 2.104 (1.228, 3.604) / 110 / 1.845 (0.871, 3.910) / 15 / 0.122 (-0.266, 0.508)
Plutonium plant / 1 / 41 / 0.939 (0.586, 1.506) / 53 / 1.097 (0.686, 1.755) / 66 / 0.950 (0.468, 1.930) / 15 / 0.144 (-0.263, 0.551)
Males (0 y lag) / 1 / 47 / 1.120 (0.750, 1.673) / 82 / 1.740 (1.156, 2.619) / 119 / 1.273 (0.675, 2.400) / 19 / 0.037 (-0.259, 0.333)
Females (0 y lag) / 1 / 29 / 0.912 (0.504, 1.650) / 53 / 0.987 (0.536, 1.817) / 58 / 1.141 (0.490, 2.655) / 11 / 0.245 (-0.280, 0.770)
Attained age (0 y lag):
< 40 / 1 / 1 / — / 0 / — / 0 / — / 0 / —
40 – 49 / 1 / 1 / — / 3 / — / 1 / — / 0 / —
50 – 59 / 1 / 10 / 1.392 (0.560, 3.464) / 11 / 4.030 (1.606, 10.120) / 19 / 4.389 (0.958, 20.110) / 3 / 7.077 (-2.732, 16.890)
60 – 69 / 1 / 18 / 1.627 (0.872, 3.038) / 39 / 2.972 (1.576, 5.606) / 60 / 2.810 (1.051, 7.514) / 7 / 1.324 (-0.173, 2.821)
70+ / 1 / 47 / 0.778 (0.526, 1.152) / 83 / 0.904 (0.596, 1.371) / 97 / 0.700 (0.386, 1.272) / 20 / 0.063 (-0.214, 0.340)
P = 0.2172
Table S13. CVD mortality: analyses by internal absorbed liver dosewith smoking status taken into account.
<0.025 Gy / 0.025-0.1 Gy / 0.1-0.5 Gy / >0.5 Gy / ERR/Gy (95% CI)
RR / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths / RR (95% CI) / No. of deaths
Main analysis, 0 y lag / 1 / 71 / 1.127 (0.803, 1.583) / 137 / 1.548 (1.093, 2.192) / 180 / 1.307 (0.785, 2.176) / 30 / 0.122 (-0.147, 0.390)
Main analyses, in which the first x years following the start of radiation work were omitted when lagging doses by x years:
Main analysis, 5 y lag / 1 / 87 / 1.139 (0.825, 1.573) / 131 / 1.639 (1.174, 2.289) / 175 / 1.272 (0.748, 2.165) / 25 / 0.146 (-0.157, 0.448)
Main analysis, 10 y lag / 1 / 104 / 1.266 (0.930, 1.723) / 135 / 1.657 (1.199, 2.289) / 158 / 1.162 (0.664, 2.031) / 21 / 0.137 (-0.190, 0.464)
Main analysis, 15 y lag / 1 / 135 / 1.153 (0.860, 1.547) / 125 / 1.479 (1.079, 2.027) / 135 / 1.149 (0.662, 1.996) / 21 / 0.143 (-0.225, 0.512)
Main analysis, 20 y lag / 1 / 167 / 1.024 (0.767, 1.366) / 118 / 1.243 (0.905, 1.708) / 110 / 1.136 (0.649, 1.988) / 19 / 0.158 (-0.273, 0.589)
Main analyses, in which the first x years following the start of radiation work were assigned to a “zero dose” category when lagging doses by x years:
Main analysis, 5 y lag / 1 / 87 / 1.143 (0.828, 1.579) / 131 / 1.645 (1.178, 2.297) / 175 / 1.277 (0.750, 2.173) / 25 / 0.146 (-0.157, 0.449)
Main analysis, 10 y lag / 1 / 104 / 1.280 (0.940, 1.742) / 135 / 1.673 (1.211, 2.312) / 158 / 1.173 (0.670, 2.051) / 21 / 0.139 (-0.189, 0.466)
Main analysis, 15 y lag / 1 / 137 / 1.149 (0.857, 1.542) / 125 / 1.478 (1.079, 2.024) / 135 / 1.144 (0.659, 1.986) / 21 / 0.143 (-0.225, 0.512)
Main analysis, 20 y lag / 1 / 171 / 1.039 (0.779, 1.386) / 118 / 1.262 (0.919, 1.733) / 110 / 1.150 (0.657, 2.012) / 19 / 0.164 (-0.271, 0.599)
Main analysis but unadjusted for smoking and alcohol consumption, 0 y lag / 1 / 71 / 1.142 (0.833, 1.567) / 137 / 1.561 (1.124, 2.167) / 180 / 1.100 (0.669, 1.807) / 30 / -0.027 (-0.166, 0.111)
Adding to stratification (0 y lag):
Hypertension / 1 / 71 / 1.137 (0.792, 1.631) / 137 / 1.626 (1.124, 2.352) / 180 / 1.136 (0.654, 1.973) / 30 / 0.043 (-0.201, 0.288)
Body mass index / 1 / 71 / 1.076 (0.744, 1.555) / 137 / 1.715 (1.172, 2.508) / 180 / 1.352 (0.782, 2.336) / 30 / 0.071 (-0.171, 0.313)
Employment duration / 1 / 71 / 1.191 (0.830, 1.710) / 137 / 1.618 (1.116, 2.346) / 180 / 1.414 (0.824, 2.425) / 30 / 0.145 (-0.153, 0.443)
Restricting follow-up to Ozyorsk (0 y lag) / 1 / 69 / 1.122 (0.796, 1.580) / 129 / 1.529 (1.074, 2.176) / 165 / 1.247 (0.731, 2.127) / 24 / 0.141 (-0.170, 0.452)
Also adjusting for external dose / 1 / 69 / 1.227 (0.844, 1.785) / 129 / 1.719 (1.157, 2.554) / 165 / 1.470 (0.792, 2.727) / 24 / 0.031 (-0.264, 0.325)
Analyses (0 y lag) restricted to workers at:
Reactors / 1 / 9 / 1.381 (0.417, 4.570) / 8 / — / 1 / — / 0 / —
Radiochemical plant / 1 / 24 / 1.336 (0.778, 2.292) / 73 / 2.145 (1.238, 3.716) / 112 / 1.922 (0.911, 4.057) / 16 / 0.112 (-0.255, 0.479)
Plutonium plant / 1 / 38 / 1.044 (0.646, 1.687) / 56 / 1.156 (0.715, 1.870) / 67 / 0.929 (0.448, 1.927) / 14 / 0.129 (-0.262, 0.520)
Males (0 y lag) / 1 / 51 / 1.232 (0.844, 1.798) / 99 / 1.799 (1.215, 2.663) / 133 / 1.356 (0.744, 2.473) / 21 / 0.087 (-0.222, 0.396)
Females (0 y lag) / 1 / 30 / 0.951 (0.531, 1.702) / 55 / 1.055 (0.579, 1.922) / 62 / 1.134 (0.491, 2.620) / 11 / 0.215 (-0.267, 0.696)
Attained age (0 y lag):
< 40 / 1 / 1 / — / 0 / — / 0 / — / 0 / —
40 – 49 / 1 / 1 / — / 2 / — / 1 / — / 0 / —
50 – 59 / 1 / 9 / 1.668 (0.662, 4.205) / 12 / 4.632 (1.789, 11.990) / 20 / 3.017 (0.528, 17.250) / 2 / 6.976 (-2.763, 16.720)
60 – 69 / 1 / 18 / 1.432 (0.760, 2.698) / 36 / 3.006 (1.592, 5.676) / 63 / 2.765 (1.034, 7.397) / 7 / 1.235 (-0.183, 2.653)
70+ / 1 / 43 / 0.869 (0.582, 1.298) / 87 / 0.955 (0.623, 1.464) / 96 / 0.778 (0.429, 1.410) / 21 / 0.061 (-0.208, 0.331)
P = 0.2222
1
[1] In these analyses, adjustment was made for gender, attained age, calendar period, period of first employment, plant (plus, for the mortality analysis, place of residence in the year in question), unless the factor(s) under investigation were included in this list, in which case no adjustment was made for them.
[2] Test for a log-linear trend in the ERR/Gy with attained age.