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BSM 456–001 PATHOGENIC MICROBIOLOGY
Fall 2006
SYLLABUS
Mon, Wed, Fri 8 – 8:50 a.m. 232 Parkinson Hall
Instructor: George Pinchuk, M.D., Cand. Sci. Med.
Office: 208 Parkinson Hall
E-mail:
Telephone: (662) 329-7281 (office), (662) 324-5238 (home)
Office hours: Mon, Wed 9-11 a.m.; Mon 1-2 p.m.; Wed 1-5 p.m. (Any other time – by appointment)
WHAT WILL THIS COURSE BE ABOUT?
This senior division-oriented course will concentrate on medical aspects of microbiology. We will discuss everything that has to do with pathogenic microorganisms and with ways these microorganisms cause disease in humans.
WHY TAKE THIS COURSE?
I see this course as an important step in the students’ preparation for their further professional (medical) schooling, or for a career in basic research (graduate school). I hope it will provide the students with the opportunity to broaden their horizons about the human disease and the role microorganisms play in it.
DESIRED STUDENT GOALS AND OUTCOMES
At the end of this course, students are expected to be able to: a) know basic facts and concepts regarding the etiology and pathogenesis of infectious diseases; b) identify - i.e., properly name and accurately describe properties of, approximately, 100 most important infectious agents that cause disease in humans; c) understand basic principles of action and particular applications of antimicrobial therapeutic agents; d) understand the work of the human immune system and the principles of immunization against microorganisms; e) clearly communicate about the applications of microbiology in medicine and pathology.
TEXTBOOK
Murray, P.R., Rosenthal, K.S., and Pfaller, M.A. Medical Microbiology. Mosby-Elsevier, 2005 (5th edition). 963 pp. ISBN 0-323-03303-2. Available at the university bookstore.
PREREQUISITES
BSM 240 with lab; BSB 120 or 322.
ATTENDANCE POLICY
Division policy states that any student who misses more than 30% of the classes (in this case, 20 or more lectures) will receive an F in that course, regardless of their grade at that time and regardless of the validity of their excuses.
MISSED EXAMS AND LATE ASSIGNMENT
Make-up exams will be given if an acceptable excuse is provided. Any illness must be appropriately documented by a medical professional. Known conflicts with exams must be approved prior to the exam date. You will be given an assignment (a written essay) and a deadline to complete it; if you are late, ten percent of your grade for the assignment will be deducted unless you provide an acceptable excuse.
STUDENTS WITH DISABILITIES
Every attempt will be made to accommodate students with disabilities. However, it is the student’s responsibility to notify the instructor of any professionally diagnosed disabilities so the necessary steps can be taken to meet the student’s learning needs.
METHOD OF EVALUATION
Three semester exams, two unannounced pop quizzes, one comprehensive final exam, and an essay. See descriptions below. Exam dates are indicated in the lecture plan (see below). The final grade for the course will be evaluated according to the following principle:
Total number of points………. 500 pts (100%)
Semester exams…………….... 60 pts/exam x 4 = 240 pts
Essay…………………………. 60 pts
Unannounced quizzes………. … 25 pts
Student Presentations……………… 25 pts
Final exam……………………. 150 pts
If your score of points is 90-100% of the total, you will receive an A; 80-89% - a B, 70-79% - a C, 60-69% - a D, 0-59% - an F.
EXAM STRUCTURE AND QUESTION TYPES
There will be two major types of exam questions: one probing your familiarity with terms and facts, and one testing your understanding of concepts. Questions of the first type may appear in a multiple choice or in short answer format; of the second type – usually in short answer format.
ESSAY
You will be required to write a 7-page (typewritten, double spaced) essay on a topic in pathogenic microbiology. I am deeply convinced that independently written essays are a great learning tool. Find some interesting material on the topic that intrigues you, and summarize your understanding of what you found. Essays should be concise, informative, and logical. They should trigger a reader’s interest; “infect” him or her with your enthusiasm about your findings. I will deduct points for sloppy writing or for incorrect understanding (misinterpretation) of your material. A short list of sources is mandatory. I may ask you to bring me a copy of a source that you used (to be sure that you did not plagiarize the material).
STUDENT PRESENTATIONS
We will have three classes entirely dedicated to your presentations. You may present your essay, or any other interesting topic in pathogenic microbiology (please consult with me). Present your material in no more than 20 minutes (followed by 5-10 minute discussion). Use conventional or PowerPoint slides, or the classroom overhead projector (your choice).
EXTRA CREDIT
None will be given. If you are unhappy with your performance, come see me immediately, before it is too late. We will work out ways to help you.
IMPORTANT DATES
Fri August 25 – last day to add and/or register for classes
Wed September 20 – last day to drop a course without receiving a grade
Fri September 22 – last day to apply for a degree to be awarded in December
Wed October 18 – last day to drop a course (will receive WP/WF)
Fri November 10 – last day to withdraw from the University
LECTURE AND EXAM PLAN
Note: topics are tentative. We will cover the chapters in the order indicated, but pace-wise, we may or may not proceed exactly as indicated. “M” stands for the Murray et al. textbook (see section “TEXTBOOK” above); Arabic numbers are chapter numbers.
Date / Topic / ReadingFri Aug 18 / Introduction. The subject and a brief history of pathogenic (medical) microbiology. Bacterial classification. General properties of bacteria (structure, metabolism, genetics) / M 1-5
Mon Aug 21 / Bacterial classification (continued). Viral classification. Fungal and parasitic classification. / M 6-8
Wed Aug 23 / Commensal and pathogenic microbial flora in humans. Mechanisms of bacterial infection. Sterilization, disinfection, antiseptics. Antibacterial agents. / M 9-10, 19, 20
Fri Aug 25 / Immune response. Antimicrobial vaccines. / M 11-15
Mon Aug 28 / Principles of laboratory diagnostics. / M 16-18, 21
Wed Aug 30 / Review / M 1-21
Fri Sep 1 / Exam 1 / M 1-21
Mon Sep 4 / Staphylococcus, Streptococcus, Enterococcus / M 22-24
Wed Sep 6 / Bacillus, Listeria, Erysipelotrix, Corynebacterium, Nocardia / M 25-28
Fri Sep 8 / Mycobacteria / M 29
Mon Sep 11 / Neisseria / M 30
Wed Sep 13 / Enterobacteriaceae, Vibrio, Aeromonas, Campylobacter, Helicobacter / M 31-33
Fri Sep 15 / Pseudomonas, Hemophilus, Bordetella, Brucella, Legionella, Francisella / M 34-38
Mon Sep 18 / Review / M 22-38
Wed Sep 20 / Exam 2 / M 22-38
Fri Sep 22 / Anaerobic, Gram-positive, spore-forming rods. Anaerobic Gram-positive non-spore-forming bacteria / M 40-41
Mon Sep 25 / Anaerobic Gram-negative bacteria. / M 42
Wed Sep 27 / Treponema, Borrelia, Leptospira / M 43
Fri Sep 29 / Mycoplasma and Ureaplasma / M 44
Mon Oct 2 / Rickettsia and Orientia / M 45
Wed Oct 4 / Ehrlichia, Anaplasma, Coxiella / M 46
Fri Oct 6 / Chlamydiaceae / M 47
Mon Oct 9 / Fall Break
Wed Oct 11 / Role of bacteria in disease / M 48
Fri Oct 13 / Review / M 40-48
Mon Oct 16 / Exam 3 / M 40-48
Wed Oct 18 / Mechanisms of viral pathogenesis. Antiviral agents. Laboratory diagnosis of viral diseases / M 49-51
Fri Oct 20 / Papillomaviruses, polyomaviruses, adenoviruses / M 52-53
Mon Oct 23 / Herpesviruses, poxviruses, parvoviruses / M 54-56
Wed Oct 25 / Picornaviruses, coronaviruses, noraviruses / M 57-58
Fri Oct 27 / Paramyxoviruses, orthomyxoviruses / M 59-60
Mon Oct 30 / Rhabdoviruses, filoviruses, bornaviruses, reoviruses / M 61-62
Wed Nov 1 / Review / M 49-62
Fri Nov 3 / Exam 4 / M 49-62
Mon Nov 6 / Togaviruses, flaviviruses, bunyaviruses, arenaviruses, retroviruses / M 63-65
Wed Nov 8 / Hepatitis viruses / M 66
Fri Nov 10 / Unconventional slow viruses, viroids, prions / M 67
Mon Nov 13 / Fungi and antifungal agents. Laboratory diagnostics of fungal diseases. / M 69-71
Wed Nov 15 / Mycoses / M 72-78
Fri Nov 17 / Parasites, antiparasitic agents. Laboratory diagnosis of parasitic diseases / M 79-81
Mon Nov 20 / Protozoa, nematodes, trematodes, cestodes, arthropods / M 82-88
Wed Nov 22 / Student Presentations
Fri Nov 24 / Student Presentations
Mon Nov 27 / Student Presentations
Wed Nov 29 / General Review / All material
Fri Dec 1 / General Review / All material
Mon Dec 4 / General Review / All material
FINAL EXAM: Wednesday, December 6, 8-11 a.m.
ACADEMIC INTEGRITY
In accordance with the University policy and the MUW student honor code, academic dishonesty will not be tolerated and will result in a grade of 0 for the exam or assignment in which the dishonesty occurred. In addition, any student who is a party to academic dishonesty, whether having given or accepted assistance, shall appear before the Academic Standards Board for appropriate action.
Academic dishonesty includes cheating and plagiarism. While cheating is rather self-explanatory, plagiarism is not always understood by students correctly. Please keep in mind that if you copy your essay from some source and then just change a word or two, it’s still plagiarism.
If you have any questions about what constitutes cheating or plagiarism, please do not hesitate to ask me.