BIOVENTURES INVESTS IN LEADING BIOTECH COMPANY

Johannesburg - Tuesday April 23, 2002

Bioventures, South Africa's first biotechnology (biotech) venture capital fund,

has made its first investment in a company involved in the development of novel

drug delivery systems.

Bioventures is investing R12-million in Shimoda Biotech (Pty) Limited, a leading

South African biotech company. Shimoda specialises in innovative drug delivery

systems that allow for the more efficient delivery of pharmaceutical drugs

within the body, for example by facilitating better absorption. The company is

also involved in identifying novel targets for new drugs and developing the

drugs themselves.

Bioventures, which was launched a year ago, is an R80-million fund jointly

managed by two of the country's most innovative investment groups - Gensec Bank

and Real Africa Holdings. Manager of the fund Dr Heather Sherwin explained that

Bioventures had examined a number of interesting investment opportunities during

the past year. "In assessing opportunities we have to satisfy ourselves and our

investors that the company met our stringent investment criteria. Shimoda,

which is one of South Africa's most exciting biotech companies, certainly does

that and we believe that the company has great potential."

Another of Shimoda's attractions for Bioventures is the fact that its management

team combines world class scientific skills with experienced business management

skills. "In addition," Dr Sherwin said, "Shimoda has strong working

relationships with a number of top scientists in South African universities."

She went on to say that Shimoda has just signed its first licensing agreement

with a US pharmaceutical company. "Shimoda has a substantial product pipeline

and some of its products have near term cash generating abilities. This is

unusual in a young biotech company as the drug development cycle tends to be

long."

Shimoda chief executive Dr Lawrence Penkler (previously head of Innovative

Research at SA Druggists) said that Bioventures was Shimoda's preferred

financing partner as the venture capital fund understood its technology and

business model. "With their industry specific contacts both locally and

internationally, the Bioventures team can really add value. We anticipate that

with Bioventures behind us we will be able to take our business to the next

level."

Shimoda was founded by Greg Gilbert in 1995 and its main laboratories are

situated in the heart of the Knysna forest near PlettenbergBay, a genetically

resource rich area. Seed financing for the company was provided by angel

investors and the JSE-listed Peregrine financial services group.