BASIC NEUROSCIENCE

2° YEAR STUDENTS

UNIVERSITY OF SPLIT SCHOOL OF MEDICINE

All data are valid for the academic year 2015/2016

PROFESSORS AND ASSOCIATES

•Prof. dr. sc. Zoran Đogaš, MD, PhD; full professor; Head of Department

e-mail: , tel. 557-905

Individual consultation: THURSDAY 14,00 - 15,00

•Prof. dr. sc. Ivica Grković, MD, PhD; full professor

e-mail: , tel. 557-803

Individual consultation: WEDNESDAY 13,00 - 14,00

•Prof. dr. sc. Maja Valić, MD, PhD; Head of laboratory

e-mail: , tel. 557-860

Individual consultation: THURSDAY 14,00 - 15,00

• Doc. dr. sc. Renata Pecotić, MD,PhD; Head of educational department

e-mail: , tel. 557-857

Individual consultation: THURSDAY 14,00 - 15,00

• Ivana PavlinacDodig, MD, PhD; research fellow

e-mail: , tel. 557-862

Individual consultation: THURSDAY 14,00 - 15,00

•Maja RogićVidaković, PhD; research fellow; Head of Laboratory for Human and Experimental Neurophysiology (LAHEN)

e-mail: , tel. 557-876

Individual consultation: THURSDAY 14,00 - 15,00

Neuroscience is one of the basic medical sciences studying morphology and function of a healthy nervous system, with an emphasis on the mechanisms responsible for achieving its role as a central organism control and management system. This course will introduce students to and enable them to approach problems in this area using scientific methods. The aim of the Basic neuroscience course is to teach a student how to use the acquired knowledge on physics, chemistry, biochemistry, biology, anatomy, histology and physiology in acquiring knowledge on the normal function of the nervous system to the extent necessary for further successful studying.

The Basic neuroscience course lectures will be held during the 4th semester with a total duration of115 hours.

Neuroscience is tested in the form of written exam that consists of 100 multiple answer questions with only one answer being correct. Each correct answer carries one point.

Topics to be covered through lectures, seminars and practical lessons, including an indication of the prescribed literature, will be announced on the beginning of the course. Attendance of all forms of instruction is MANDATORY (except the attendance of individual consultations), and all students are obligated to study the prescribed material IN ADVANCE for seminars and practical lessons, using the main textbook and/or the additional literature.

 The course Basic neuroscience is consisted of:

•LECTURES • SEMINARS • PRACTICAL LABORATORY WORK • INDIVIDUAL TEACHING CONSULTATIONS

CURICCULUM

The course content is divided into six units:

A Neuroanatomy

LECTURES

Research methods of the CNS structure and the structure of gray and white matter of the spinal cord

seminarES

The structure of gray and white matter of the spinal cord, brainstem and cerebellum, diencephalon and telencephalon

PRACTICAL WORK

Review of the CNS structures

Appearance and distribution of gray and white matter of the spinal cord and brainstem

Clinical-anatomic syndromes of the spinal cord

B Basics of neuron electrophysiology

LECTURES

Neuron is a basic structural-functional unit of CNS

The biophysical basics of excitability

seminarS

The cell membrane, ion channels, passive and active neuron properties

PRACTICAL WORK

Computational models of the membrane resting potential and the action potential

Computational models of the postsynaptic potential

C Intercellular signaling

LECTURES

Signaling mechanisms, signaling molecules and their receptors

seminarS

Structure and function of the synapse and the cellular basis of behavior (neuron sequences, pathways, circles, networks, systems)

Neurotransmitters, neuropeptides and their receptors

PRACTICAL WORK

Signalization, Web site

D Sensory system

LECTURES

Principles of sensory systems organization, types of stimuli and sensory receptors

Olfaction and gustation – chemical senses

Physiology of the eye and phototransduction

seminarS

Pain, heat and cold – anterolateral sensory system

Touch, pressure, and kinesthesia - the dorsal column system

Ear - organ of hearing and balance

Auditory and vestibular system

Organization of the retina, primary visual pathway and primary visual cortex

Perception of colours, shapes, depth and movement; and the organization of the associative visual fields of the cerebral cortex

PRACTICAL WORK

Physiology of sensation

E Motor system

LECTURES

General structure of the motor systems

Role of the motor cortex in voluntary movements

SEMINARES

Spinal motor mechanisms and reflexes

Role of the descending pathways from the brainstem in maintaining posture and muscle tone; spinal shock

Motor functions of the cerebellum

Motor functions of the basal ganglia

The hypothalamus controls the endocrine and the autonomic nervous system

F General brain functions

LECTURES

Development of the CNS and processes of development reorganization and plasticity

Stages of wakefulness and sleep; Sleep Medicine

Physiology of intracranial pressure and cerebral circulation

The structure of neurotransmitter systems and reticular formation

SEMINARS

General brain function: ascending activating system, EEG, alertness levels and levels of consciousness

Neurobiology of biological rhythms and motivational states

Neurobiology of emotion and sexuality

Neurobiology of attention and association functions of the prefrontal and posterior parietal cortex

Anatomy and psychology of learning and memory

Cellular mechanisms of learning and memory

• LECTURES:

Lecture program for the academic year 2015/2016

LectureTopic Hours Lecturer

P-1Introductory lecture1Đogaš

P-2 Neuron is a basic

structural-functional unit of the CNS2Đogaš

P-3CNS research methods2Grković

Development of the CNS and

processes of development

reorganization and plasticity

P-4Peripheral nervous system and 1Grković

the spinal cord

P-5Diencephalon and telenchephalon2Grković

P-6Biophysical basics of excitability2Đogaš

P-7Neurotransmitters in health 2Đogaš

and disease

P-8General brain function and sleep2Đogaš

P-9Serotonin (web)2Valić

P-10Controlofbreathingduring

wakefulness and during sleep(web)1Pecotić

P-11General organization of the sensory 1Đogaš

systems (Ch 15, 18)

P-12Physiology of the eye and

phototransduction

General structure of

the motor systems2Đogaš

P-13Clinical importance and basic research2Valić/Pecotić

TOTAL:22 hours

• SEMINARS:

Seminar program for the academic year 2015/2016

SeminarSubjectHours Lecturer

TNZ-A

S1The structure of gray and white matter

of the spinal cord (Ch 9)(2 hours) PavlinacDodig

S2The structure of gray and white matter

of the brainstem and cerebellum (Ch 10, 11, 12, 14)(2 hours) PavlinacDodig

S3The structure of gray and white matter

of the diencephalon (Ch 13)(2 hours) PavlinacDodig

S4Telencephalon(Ch 13)(2 hours) PavlinacDodig

S5Cell membrane, ion channels,(2 hours) Đogaš/Valić

passive and active neuron properties (Ch 6)

S6Structure and function of the synapse and (3 hours) Đogaš/Pecotićthe cellular basis of behavior (neuron sequences,

pathways, circles, networks, systems) (Ch 7)

S7Neurotransmitters, neuropeptides and their receptor (Ch 8)(3 hours)Valić/Pecotić

S8Electrophysiology of neurons and types of potential (Ch 6-8) (2 hours)Valić/Pecotić

S9General brain functions; EEG, evoked potentials(2 hours) Đogaš

S10Stages of wakefulness and alertness; sleep(2 hours) Đogaš/Pecotić

S11Clinical seminar(2 hours) Valić/Pecotić

S12Pain, heat and cold – anterolateral sensory system (2 hours) Valić

Touch, pressure, and kinesthesia - the dorsal

column system (Ch15)

S13Ear - organ of hearing and balance(2 hours) Pecotić

Auditory and vestibular system (Ch 17)

S14Organization of the retina, primary visual pathway (2 hours) Valić

and primary visual cortex (Ch 16)

S15Perception of colors, shapes, depth and movement; (1 hour) Valić

and the organization of associative visual fields (part Ch26)

S16Sensory system(2 hours) Pecotić

S17Role of motor cortex in voluntary movements(2 hours) Valić/Pecotić

Eye movement and eye gaze direction system (Ch 19, 14, p242-50)

S18Neuroanatomy and neurophysiology of

eloquent brainareas (motor, speech, language) (2 hours) RogićVidaković

S19Spinal motor mechanisms and reflexes (Ch 9) (1 sat)Pecotić

S20Role of the descending pathways from the (1 sat) Valić

brainstem in maintaining posture and muscle tone;

spinal shock (Ch9)

S21Motor functions of the cerebellum and(2 hours)Pecotić

the basal ganglia (Ch 20, 21)

S22Organization and structure functions (1 sat)Valić

of the limbic system(Ch 25)

S23Neurobiology of emotion and sexuality(2 hours) PavlinacDodig

S24Neurobiology of attention and associative functions (2 hours) Đogaš

of the prefrontal and posterior parietal cortex

S25Anatomy and psychology of learning and memory(2 hours) PavlinacDodig

S26Cellular mechanisms of learning and memory(2 hours) Đogaš

S27General brain function(2 hours) Đogaš

TOTAL:52 hours

The prescribed material must be studied in advance.

The materials are chapters of the textbook by

  • Allan Siegel and Hreday N. Sapru: Essential Neuroscience, 2nd/3rd Edition.

The text for exercise is an Interactive Tutorial by John Huguenard and David A. McCormick: Electrophysiology of the Neuron, Windows Version

All absences and minuses have to be compensated through a colloquium at least 2 days before the exam.

Students not taking the exam in the first examination period, to compensate their absences and minuses, have to take a colloquium in a 10 days period after the end of the Basic neuroscience course.

• PRACTICAL LESSONS:

Program of the practical laboratory work for the academic year 2015/2016

PracticalHoursTitle Chapter

Venue Lecturer

V12Review of the CNS structures

PAKIPD/RP

V22Appearance and distribution

of gray and white matter of the spinal cord

IT.IPD/RP

V32Appearance and distribution

of gray and white matter of the brainstem

IT.RP/IPD

V42Clinical-anatomic syndromes of

the spinal cord (CD-ROM)RP/IPD

Neuron electrophysiology

V53Resting potential

IT.Valić/Pecotić

Neuron electrophysiology

V63Action potential

IT.Valić/Pecotić

Neuron electrophysiology

V73Synaptic potential

IT.Valić/Pecotić

Neuron electrophysiology

V83SignalizationIT.Pecotić/Valić

PowerLab

V92EEG and evoked potential S L Pecotić/Valić/IPD

*V104SleepLab

PolysomnographySLZĐ/RP/MV/IPD

*V113SleepLab

Polysomnography reportSL ZĐ/RP/MV/IPD

V123PowerLabL

Physiology of sensationZĐ/RP/MV/IPD

V131Transcranial magnetic stimulation (TMS) LAHEN RogićVidaković

Motor evoked potentials (MEP)

Mapping eloquent brain functions (speech)

V142PowerLabL

Muscle and electromyography RP/MV/IPD

V153PowerLab

Reflexes and reaction timeLIPD

*V163PowerLab

Animal neurophysiological research in vivo LRP/MV/IPD

TOTAL:41 hours

Practical lessons marked with a star * (V10, V11i V16) are organized in multiple groups.

PAK - dissection hall;

I.T. - IT classroom (BSB building; 2ndfloor, 4th floor, 5th floor)

L - Neuroscience laboratory, 5th floor

LAHEN- Laboratory for Human and Experimental Neurophysiology- Department of Neuroscience, 5th floor (lab 26)

SL - Sleep medicine centre (Sleep Lab)

TEXTBOOK AND INSTRUCTIONAL MATERIALS

OBLIGATORY TEXTBOOK AND PRACTICUM FOR PRACTICAL LESSONS

  • Siegel, A. and Sapru, H.: ESSENTIAL NEUROSCIENCE, Wolters Kluwer / Lippincott Williams & Wilkins
  • John Huguenard and David A. McCormick: Electrophysiology of the Neuron, Windows Version, A Companion to Neurobiology by Gordon Shepard

ADDITIONAL LITERATURE

  • Purves et al Neuroscience 5th edition published by Sinauer Associates
  • Kandel, E.R., Schwartz, J.H. and Jessel, T.M.: Principles of Neural Science, 4th edition, McGraw-Hill; New York, SAD, 2000.
  • Zigmond, MJ et all.: Fundamental Neuroscience, Academic Press; San Diego, SAD, 1999.
  • Guyton, A.C. and Hall: MEDICAL PHYSIOLOGY, 11th edition. 2006.

Basic Neuroscience 1st exam period will be held on Monday, April 11, 2016.

Department of neuroscience

School of medicine

University of Split

21 000 Split, Šoltanska 2

phone 021/ 557-858

fax. 021/ 557-955