Curriculum vitae
Khalil Pourkhalili
Associate Professor of medical physiology, Bushehr University of Medical Sciences
Personal Information
Name: Khalil
Family name:Pourkhalili
Date of birth: August 12, 1975
Place of birth: Tonekabon, Iran
Marital status: Married with two children
Office Address
Department of Physiology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
P.O. Box: 7514633341
Phone: +98773330657
Fax: +98773330657
e-mail:
Education:
2003- 2008 PhD in Medical Physiology, Tarbiat Modarres University, Tehran, Iran.
Title of thesis: Investigation on the effects of normobaric hyperoxiapretreatment on
ischemia-reperfusion injury in normal and acute diabetic isolated rat heart.
2000-2003 M.Sc. in Medical Physiology,Shiraz University of Medical Sciences,Shiraz, Iran.
Title of Thesis:Effects of vanadyl sulfate on reproductive efficiency of normal and
streptozotocin-induced diabetic adult male rats.
1993-1997 B.Sc. in Nursing at Mashhad University of Medical Sciences, Mashhad,Iran
Academic positions
Assistant Professor of medical physiology, Bushehr University of Medical Sciences, 2009-2016.
Associate Professor of medical physiology, Bushehr University of Medical Sciences, October 2016.
Employment to date
Lecturer in medical physiology especially cardiovascular physiology for students of medicine, from 2004 to date.
Member of Medical School Research Association, from 2010 to date.
Head of the Department of Physiology, from 2009 to August 2016.
Research Interest:
Ischemic preconditioning
Remote ischemic preconditioning
Ischemia-reperfusion injury and cardioprotection from IR injury
Skeletal muscle preconditioning and exercise performance in athletes
Cardiovascular toxicity of scorpions and snakes venoms on the anesthetized and isolated heart
Technical abilities:
Working with isolated (Langendorff perfused) and in vivo rat and rabbit hearts
Induction of global and local ischemia in rat and rabbit hearts
Assessment of ventricular function during ischemia and reperfusion
Assessment of ventricular arrhythmias during ischemia and reperfusion
Assessment of ventricular infarct size after ischemia and reperfusion by TTC staining
Assessment of cardiac myocyte apoptosis by TUNEL method
Working with PowerLab data acquisition system
Awards
3th rank researcher, School of medicine, Bushehr University of Medical Sciences, 2012.
Dissertation supervised
1. Effects of the nandrolone decanoate on ischemic preconditioning (IPC) phenomena inmale rats heart,2011,By: Ebrahim Avarand, Islamic Azad University, Department of Biology,Kazeroon, Iran.
2. Investigation of the effects of remote ischemic preconditioning (RIPC) on maximal exercise performance and pulmonary function, 2013, By: Esmat Karamean, Islamic Azad University, Department of Exercise Physiology,Jahrom, Iran.
3. Effect of nandrolone decanoate on exercise induced analgesia and role of endogenous opioids, 2014, By: Mehdi Mohebi, Shahid Chamran University, Faculty of Sciences, Department of Biology, Ahvaz, Iran.
4. Investigation of the delayed effects of remote ischemic preconditioning (RIPC) on maximal exercise performance and pulmonary function, 2015, By: Mahnaz Momeni, Islamic Azad University, Department of Exercise Physiology,Jahrom, Iran.
5. Evaluating the alpha-1 adrenergic receptor blockade in prevention of Hemiscorpius lepturus venom induced renal toxicity. 2017, By: Samad Ansari, Medical student, Bushehr University of Medical Sciences.
Participation in:
2003 The 16th Iranian Congress of physiology and Pharmacology. Tehran, Iran.
2004 The 2nd FAONS symposium and 3rd Iranian Neuroscience Congress. Tehran, Iran.
2005 The 1st international symposium on molecular technology. Tehran, Iran.
2006 Workshop on "Application of Recombinant Technology in Medicine" Tehran,
Iran.
2007 The 18th Iranian Congress of Physiology and Pharmacology, Mashhad, Iran.
2007 The 1stadvanced Iranianworkshop of heart electrophysiology and animal ischemic
heart models, Gorgan, Iran.
2008 The Baltic Summer School (Basic and clinical aspects of cardiac arrhythmia’s).
17Aug- 6 Dec,University of Copenhagen, Denmark.
2009 Workshop on “Molecular neuroscience methods”. 7-8 Nov. 2009. Physiology
Department, TarbiatModaresUniversity, Tehran, Iran.
2009 The 19th Iranian Congress of Physiology and Pharmacology, Tehran, Iran.
2011 The 20th Iranian Congress of Physiology and Pharmacology, Hamedan, Iran.
2013 The 21th international Iranian Congress of Physiology and Pharmacology, Tabriz, Iran
2015 The 22thIranianCongress of Physiology and Pharmacology, Kashan, Iran.
2016 2nd International Congress of Nephrology and Urology, Tehran, Iran.
Accepted abstracts:
1st South Asian Conference of Physiological Societies & 11th Biennial Conference of Pakistan Physiological Society, 10 – 12 Nov, 2008. In vivo hyperoxic preconditioning reduces reperfusion arrhythmias in the isolated rat hearts.
36th international congress of physiological sciences, 27 Jul- 1 Aug 2009, Kyoto, Japan. Ischemia and reperfusion induced arrhythmias: role of hyperoxic preconditioning.
19th congress of physiology and pharmacology, 3-6th November 2009, Shaeed Beheshti University of Medical Sciences, Tehran, Iran. Ischemia and reperfusion induced arrhythmias: role of normobaric hyperoxic preconditioning.
20th congress of physiology and pharmacology, 10-14th October 2011, Hamedan University of medical Sciences, Hamedan, Iran. Anabolic androgenic steroid nandrolone decanoate could not impair cardioprotective effects of ischemic preconditioning in isolated rats heart.
.
21th congress of physiology and pharmacology, 23-27th August 2013, TabrizUniversity of Medical Sciences, Tabriz, Iran. Remote ischemic preconditioning improves exercise performance parameters and pulmonary function tests in trained subjects.
22th IranianCongress of Physiology and Pharmacology. 7-11th Sept 2015. KashanUniversity of Medical Sciences, Kashan, Iran. The effects of delayed remote ischemic preconditioning on maximal oxygen uptake (VO2max) and lactate release in trained and untrained subjects.
2nd International Congress of Nephrology and Urology, 1-4 August 2016, Tehran, Iran. Assessing kidney function following ischemia-reperfusion using 99mTc-DMSA renal scan and functional parameters: role of remote ischemic preconditioning
Membership:
Iranian Society of Physiology and Pharmacology
Publications
1. Pourkhalili K, Hajizadeh S, Tiraihi T, Akbari Z, Esmailidehaj M, Bigdeli MR, Khoshbaten A. Ischemia and reperfusion-induced arrhythmias: role of hyperoxic preconditioning. J Cardiovasc Med. 2009 Aug 10(8):635-42.
2. Esmaili M.D. Baharvand B. Rasoulian B. Foadaddini M. Asgari A. Noroozzadeh A. Poorkhalili K. Wahhab Aghai H. Khoshbaten A. Delayed protective effects of hyperoxia against cardiac arrhythmias and infarction in anesthetized rats. J Surg Res. 2009 Jan151(1): 55-61.
3. Baharvand B, Esmaili Dehaj M, Foadaddini M, Rasoulian B, Poorkhalili K, Wahhab Aghai H, Khoshbaten A. Delayed Cardioprotective Effects of Hyperoxia Preconditioning Prolonged by Intermittent Exposure. J Surg Res. 2010 May 1;160(1):53-9.
4. Bigdeli MR, Hajizadeh S, Froozandeh M, Heidarianpour A, Rasoulian B, Asgari AR, Pourkhalili K, Khoshbaten A. Normobaric hyperoxia induces ischemic tolerance and upregulation of glutamate transporters in the rat brain and serum TNF-alpha level. Exp Neurol. 2008 Aug;212(2):298-306.
5. Pourkhalili K, Hajizadeh S, Khoshbaten A, Tiraihi T. Evaluation of the effects of normobaric hyperoxia pretreatment on ischemia-reperfusion injury in a regional ischemia model using isolated rat heart. Physiol Pharmacol. 2008 12 (2), 91 – 100. (Article in Persian).
6. Pourkhalili K, Hajizadeh S, Khoshbaten A, Tiraihi T, Esmaeeli Dahaj M, Bigdeli M.R.Role of hyperoxic preconditioning in protection of cardiac tissue and arrhythmias following ischemia-reperfusion injury. Kowsar medical journal. 2008 13(3), 211-222. (Article in Persian).
7. Heidarianpour A, Hajizadeh S, Khoshbaten A, Niaki AG, Bigdili MR, Pourkhalili K. Effects of chronic exercise on endothelial dysfunction and insulin signaling of cutaneous microvascular in streptozotocin-induced diabetic rats. Eur J Cardiovasc Prev Rehabil. 2007 Des; 14(6): 746-52.
8. Gholamreza Bayat, Sohrab Hajizadeh, Mohammad Javan, Fatemeh Safari, Mahdi Goodarzvand, Saeed Shokri, Khalil Pourkhalili, Firoozeh Alavian. The effect of exercisetraining and chronic administration of nandrolone decanoate on expression of sarcolemmal ATP- sensitive K+ channels in rat heart. Feyz, Journal of Kashan University of Medical sciences, 2012 May; 16(2): 102-111. (Article in Persian).
9. Samad Akbarzadeh, Parviz Bazzi, Adel Daneshi, Iraj Nabipour, Khalil Pourkhalili,Gholamhossein Mohebbi, Kohzad Sartavi, Mohammadreza Abdi, Mostafa Mirzaei andAfshar Bargahi. Anti-diabetic effect of Otostegia persica extract ondiabetic rats. Journal of Medicinal Plants Research.2012 April; 6(16): 3176-3180.
10. Mansour Esmaili-Dehaj, Bahram Rasulian, Mohammad Ebrahim Rezvani, Bahram Delfan, Mohammad Hossein Mosaddeghmehrjardi, Khalil Pourkhalili. The anti-infarct, antistuning and antiarrhythmic effects of Oleuropein in isolated rat heart. EXCLI Journal 2012 April; 11:150-162.
11. Oxytocin protects cardiomyocytes from apoptosis induced byischemia–reperfusion in rat heart: Role of mitochondrial ATP-dependentpotassium channel and permeability transition pore. Ali Mohammad Alizadeh , Mahdieh Faghihi, Vahid Khori, Hamid Sohanaki, Khalil Pourkhalili,FahimehMohammadghasemi, Maryam Mohsenikia. Peptides 2012 March; 36: 71–77.
12. Khalil Pourkhalili*,Sohrab Hajizadeh, Zahra Akbari, Mansour Esmaili Dehaj,Samad Akbarzadeh, Alimohammad Alizadeh. Hyperoxic preconditioning fails to confer additional protection against ischemia-reperfusion injury in acute diabetic rat heart. EXCLI Journal 2012 June;11:263-273.
13. Mazloom R, Hajizadeh S, Semnanian S, Pourkhalili K, Bayat G, Alavian F et al . The Effects of Preconditioning with Normobaric Hyperoxia on Tissue Damage, Mechanical Performance and Arrhythmias Induced by Ischemia-Reperfusion in Isolated Heart of Morphine Dependent Rat. Etiadpajohi Journal 2012; 6(21): 65-80. (Article in Persian).
14. Zahra Akbari, Ebrahim Avarand, Mehrdad Shariati, Samad Akbarzadeh,Mansour Esmaili-Dehaj, Gholamreaza Bayat, Khalil Pourkhalili*. Effects of anabolic steroid nandrolone decanoate
on ischemic preconditioning in isolated heart ofsedentary rats. ISMJ 2014; 17(5): 798-814.(Article in Persian).
15. Mehdi Mohebi, Khalil Pourkhalili, Mahnaz Kesmati, Samad Akbarzadeh, Zahra Akbari. Effects of exercise and supraphysiological dose of nandrolonedecanoate on the rat plasma opioid level: a brief report. Tehran University Medical Journal, June 2014; 72(3):199-206.(Article in Persian).
16. Samad Akbarzadeh, Mohammad Reza Kalantar Hormozi, Soghra Ghasemi, ElahehShabankareh, Niyayesh Keshvari, Niloofar Motamed, Seyed Mojtaba Jafari, Ali Movahed, Parviz Bazzy,Khalil Poorkhalili, Zahra Akbari, Najmeh Hajian, Faezeh Jahanpour, Narges Obeidi. Plasma progranulin and relaxin levels in PCOS women with normal BMI compared to control healthy subjects. ISMJ 2013; 16(3): 181-8.
17. Khalil Pourkhalili, Euikyung Kim, Navid Reza Mashayekhy, Mostafa Kamyab, Seyed Mehdi Hoseiny, Reihane Evazy, Abbas Zare Mirakabadi, Ramin Seyedian. Cardiotoxic and arrhythmogenic effects of hemiscorpius lepturus scorpion venom in rats. J Arthropod Borne Dis2015; 2015, 9(2): 215–225.
18. Zahra Akbari, Zahra Sedaghat, Mansour Esmaili-Dehaj, Esmat Karamean, Narjes Zarei, Abbas Keshavarzi, Khalil Pourkhalili*. Effects of remote limb ischemic preconditioning on pulmonary function tests and maximal oxygen uptake. Physiol Pharmacol 2014; 18 (3), 315-326.(Article in Persian).
19. Khalil Pourkhalili, Mehdi Mohebbi, Mahnaz Kesmati, G. Hossein Mohebbi, SamadAkbarzadeh and Zahra Akbari. The effect of anabolic steroid nandrolone decanoate on exercise-inducedhypoalgesia: Role of opioid peptides. Journal of Chemical and Pharmaceutical Research 2015; 7(1):671-677.
20. S. Akbarzadeh, A. Barghahi, AR. Rahbar, A. Daneshi, S. Najafpour Bushehri, K. Pourkhalili, SM. Jafari, N. Hajian, B. Naeimi, P. Farzadinia. The effects of aqueous extract of stevia plant (Stevia rebaudiana) on serum concentration of vaspin and Angiopoietin-like Protein-3 in streptozotocin induced diabetic rats. ISMJ 2015; 18(2): 239-249. (Article in Persian).
21. GH. Mohebbi, SS. Arshadi, I. Nabipour, KH. Pourkhalili. Marine Tunicate, the Electuary of Mithridates. ISMJ 2015; 18(4): 845-897. (Article in Persian).
22. Hossein Babaei, Raheleh Rahbanian, Fatemeh Malchi, Gholamhossein Mohebbi,Parviz Farzadinia, Afshar Bargahi, Adel Daneshi, Khalil Pourkhaliliand Samad Akbarzadeh. Comparing the effects of metformin with silymarin in biochemical parameters related todiabetes and pancreatic tissue in streptozotocin- induced diabetic rats. Entomology and Applied ScienceLetters, 2016, 3, 1:21-25.
23. Mehrzad Bahtouee, Hossein Fatemikia, Khalil Pourkhalili, Euikyung Kim, Hamidreza Rahimi, Zahra Tavoosy, Abdolhamid Ismaily, Abdolah Hajivandi, Yaghoob Hassan, Ramin Seyedian.Saffron protection against bleomycin induced pulmonary fibrosis in rats. Iranian Journal of Toxicology, 2017 (accepted).
Research projects
1- Effects of the nandrolone decanoate (an anabolic steroid drug) on ischemic preconditioning phenomena (IPC) in isolated rat heart (finished).
2- Investigation of the effects of remote ischemic preconditioning (RIPC) on maximal exercise performance and pulmonary function (Finished).
3- Effect of nandrolone decanoate on exercise induced analgesia and role of endogenous opioids (Finished).
4- Investigation of the delayed effects of remote ischemic preconditioning (RIPC) on maximal exercise performance and pulmonary function (finished).
5- Evaluating the effects of Remote Ischemic Preconditioning on rat renal function and blood flow following ischemia and reperfusion injury (finished).
6- Evaluation of the role of lactate transporters in mediating the protective effects of ischemic preconditioning against ischemia-reperfusion injury in isolated rat heart.
7- Evaluating the alpha-1 adrenergic receptor blockade in prevention of Hemiscropius lepturus venom induced renal toxicity.
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