Article title: MDM2 T309G polymorphism is an ethnicity-dependent risk factor for digestive tract cancers

Journal name: Tumor Biology

Author names:Bo Chen, Lei Cao, Kong-Wang Hu, Jia-Wei Zhang, Xiang-Ling Meng and Mao-Ming Xiong

Affiliation of the corresponding author:The First Affiliated Hospital of Anhui Medical University

E-mail address of the corresponding author：

Table S2.Meta-analyses of the association between MDM2T390G polymorphism andDTC risk stratified by country

Meta-analysis models / China / Japan / Korea / European countries / Germany / Italy / United States
OR(95%CI)
p(Modela） / OR(95%CI)
p(Modela） / OR(95%CI)
p(Modela） / OR(95%CI)
p(Modela） / OR(95%CI)
p (Modela） / OR(95%CI)
p(Modela） / OR(95%CI)
p(Modela）
DTC
TT vs. TG / 0.89 [0.80, 0.98]
0.02 R / 0.86 [0.63, 1.19]
0.37 R / 0.91 [0.37, 2.27]
0.84 R / 0.78 [0.59, 1.04]
0.09 R / 0.97 [0.72, 1.31]
0.86 F / 0.61 [0.22, 1.66]
0.33 R / 0.78 [0.61, 1.00]
0.05 F
TG vs. GG / 0.76 [0.66, 0.87]
0.0002 R / 0.87 [0.65, 1.17]
0.35 R / 0.78 [0.59, 1.03]
0.08 F / 1.03 [0.82, 1.29]
0.80 F / 0.93 [0.62, 1.40]
0.74 F / 1.06 [0.59, 1.91]
0.84 F / 1.26 [0.89, 1.79]
0.19 F
TT vs. GG / 0.66 [0.55, 0.78]
< 0.0001 R / 0.75 [0.53, 1.06]
0.11 R / 0.72 [0.20, 2.60]
0.62 R / 0.82 [0.54, 1.25]
0.36 R / 0.90 [0.59, 1.37]
0.61 F / 0.65 [0.13, 3.30]
0.60 R / 0.96 [0.44, 2.10]
0.92 R
T vs.G / 0.81 [0.73, 0.89]
< 0.0001 R / 0.87 [0.74, 1.04]
0.13 R / 0.83 [0.42, 1.63]
0.59 R / 0.88 [0.71, 1.09]
0.24 R / 0.96 [0.78, 1.17]
0.66 F / 0.75 [0.33, 1.70]
0.49 R / 0.96 [0.64, 1.43]
0.83 R
TT + TG vs. GG / 0.71 [0.62, 0.83]
< 0.001 R / 0.84 [0.64, 1.11]
0.21 R / 0.77 [0.39, 1.49]
0.43 R / 0.96 [0.69, 1.34]
0.82 R / 0.92 [0.63, 1.35]
0.67 F / 0.85 [0.49, 1.47]
0.55 F / 1.16 [0.84, 1.61]
0.37 F
TT vs. TG+GG / 0.80 [0.71, 0.90]
0.0002 R / 0.83 [0.61, 1.11]
0.20 R / 0.83 [0.28, 2.42]
0.73 R / 0.79 [0.59, 1.06]
0.11 R / 0.96 [0.72, 1.27]
0.75 F / 0.61 [0.19, 1.93]
0.40 R / 0.87 [0.51, 1.47]
0.60 R
Esophagealcancer
TT vs. TG / 1.06 [0.75, 1.52]
0.73 R / NA / NA / NA / NA / NA / 0.86 [0.63, 1.17]
0.32 F
TG vs. GG / 0.65 [0.44, 0.98]
0.04 R / NA / NA / NA / NA / NA / 1.51 [0.98, 2.32]
0.06 F
TT vs. GG / 0.70 [0.58, 0.84]
0.001 F / NA / NA / NA / NA / NA / 1.29 [0.83, 2.02]
0.26 F
T vs.G / 0.85 [0.78, 0.93]
0.004 F / NA / NA / NA / NA / NA / 1.07 [0.87, 1.32]
0.53 F
TT + TG vs. GG / 0.70 [0.52, 0.94]
0.02 R / NA / NA / NA / NA / NA / 1.41 [0.94, 2.12]
0.10 F
TT vs. TG+GG / 0.89 [0.77, 1.03]
0.12 F / NA / NA / NA / NA / NA / 0.95 [0.70, 1.28]
0.73 F
Gastric cancer
TT vs. TG / 0.90 [0.80, 1.02]
0.11 F / 1.27 [0.90, 1.78]
0.17 F / 1.45 [0.94, 2.22]
0.09 F / NA / NA / NA / NA
TG vs. GG / 0.61 [0.49, 0.77]
< 0.0001 R / 0.62 [0.44, 0.85]
0.004 F / 0.96 [0.64, 1.44]
0.83 F / NA / NA / NA / NA
TT vs. GG / 0.52 [0.45, 0.61]
< 0.00001 F / 0.78 [0.53, 1.15]
0.21 F / 1.39 [0.86, 2.23]
0.18 F / NA / NA / NA / NA
T vs.G / 0.74 [0.69, 0.80]
< 0.00001 F / 0.88 [0.72, 1.06]
0.18 F / 1.17 [0.92, 1.49]
0.20 F / NA / NA / NA / NA
TT + TG vs. GG / 0.58 [0.48, 0.71]
< 0.00001 R / 0.66 [0.49, 0.90]
0.009 F / 1.08 [0.74, 1.58]
0.69 F / NA / NA / NA / NA
TT vs. TG+GG / 0.76 [0.68, 0.86]
< 0.00001 F / 1.08 [0.78, 1.48]
0.65 F / 1.43 [0.96, 2.13]
0.08 F / NA / NA / NA / NA
Hepatic cancer
TT vs. TG / 0.79 [0.60, 1.03]
0.08 R / 0.63 [0.45, 0.90]
0.01 F / 0.57 [0.37, 0.89]
0.01 F / 0.35 [0.17, 0.75]
0.007 F / 0.35 [0.17, 0.75]
0.007 F / NA / NA
TG vs. GG / 0.90 [0.79, 1.03]
0.12 F / 0.78 [0.57, 1.07]
0.12 F / 0.66 [0.45, 0.95]
0.03 F / 0.79 [0.36, 1.76]
0.57 F / 0.79 [0.36, 1.76]
0.57 F / NA / NA
TT vs. GG / 0.67 [0.43, 1.06]
0.08 R / 0.50 [0.34, 0.73]
0.0004 F / 0.38 [0.24, 0.59]
< 0.0001 F / 0.28 [0.11, 0.69]
0.006 F / 0.28 [0.11, 0.69]
0.006 F / NA / NA
T vs.G / 0.77 [0.57, 1.03]
0.08 R / 0.71 [0.59, 0.86]
0.0005 F / 0.59 [0.47, 0.75]
< 0.0001 F / 0.49 [0.32, 0.77]
0.002 F / 0.49 [0.32, 0.77]
0.002 F / NA / NA
TT + TG vs. GG / 0.78 [0.57, 1.07]
0.12 R / 0.69 [0.51, 0.92]
0.01 F / 0.55 [0.39, 0.77]
0.0007 F / 0.52 [0.24, 1.10]
0.09 F / 0.52 [0.24, 1.10]
0.09 F / NA / NA
TT vs. TG+GG / 0.71 [0.49, 1.03]
0.07 R / 0.58 [0.41, 0.81]
0.001 F / 0.48 [0.32, 0.72]
0.0004 F / 0.33 [0.16, 0.67]
0.002 F / 0.33 [0.16, 0.67]
0.002 F / NA / NA
Pancreatic cancer
TT vs. TG / NA / NA / NA / NA / 0.84 [0.52, 1.33]
0.45 F / 0.84 [0.52, 1.33]
0.45 F / 0.54 [0.35, 0.85]
0.008 F
TG vs. GG / NA / NA / NA / NA / 1.21 [0.65, 2.26]
0.55 F / 1.21 [0.65, 2.26]
0.55 F / 0.85 [0.44, 1.65]
0.63 F
TT vs. GG / NA / NA / NA / NA / 1.01 [0.52, 1.95]
0.98 F / 1.01 [0.52, 1.95]
0.98 F / 0.46 [0.23, 0.92]
0.03 F
T vs.G / NA / NA / NA / NA / 0.97 [0.71, 1.31]
0.83 F / 0.97 [0.71, 1.31]
0.83 F / 0.66 [0.49, 0.89]
0.006 F
TT + TG vs. GG / NA / NA / NA / NA / 1.12 [0.62, 2.04]
0.71 F / 1.12 [0.62, 2.04]
0.71 F / 0.65 [0.34, 1.23]
0.19 F
TT vs. TG+GG / NA / NA / NA / NA / 0.87 [0.56, 1.37]
0.55 F / 0.87 [0.56, 1.37]
0.55 F / 0.53 [0.34, 0.81]
0.004 F
CRC cancer
TT vs. TG / 0.84 [0.73, 0.98]
0.02 F / 0.81 [0.63, 1.04]
0.10 F / NA / 0.99 [0.57, 1.71]
0.96 F / 0.97 [0.76, 1.25]
0.82 F / NA / 1.58 [0.66, 3.78]
0.31 F
TG vs. GG / 0.91 [0.59, 1.41]
0.68 R / 1.17 [0.93, 1.46]
0.19 F / NA / 1.50 [0.63, 3.56]
0.36 F / 1.08 [0.77, 1.51]
0.66 F / NA / 1.11 [0.32, 3.88]
0.87 F
TT vs. GG / 0.84 [0.49, 1.44]
0.52 R / 0.95 [0.72, 1.26]
0.73 F / NA / 1.48 [0.62, 3.51]
0.37 F / 1.11 [0.78, 1.59]
0.57 F / NA / 1.75 [0.52, 5.92]
0.37 F
T vs.G / 0.90 [0.70, 1.14]
0.38 R / 0.99 [0.86, 1.13]
0.87 F / NA / 1.13 [0.77, 1.67]
0.53 F / 1.02 [0.86, 1.20]
0.85 F / NA / 1.43 [0.78, 2.61]
0.25 F
TT + TG vs. GG / 0.88 [0.56, 1.40]
0.60 R / 1.10 [0.89, 1.37]
0.38 F / NA / 1.49 [0.66, 3.38]
0.34 F / 1.07 [0.78, 1.48]
0.67 F / NA / 1.41 [0.44, 4.46]
0.56 F
TT vs. TG+GG / 0.78 [0.68, 0.90]
0.0006 F / 0.86 [0.68, 1.09]
0.21 F / NA / 1.07 [0.63, 1.80]
0.80 F / 1.00 [0.79, 1.26]
0.97 F / NA / 1.62 [0.72, 3.63]
0.24 F

Abbreviation:CI, confidence intervals;DTC, digestive tract cancers;F, fixed effects model;NA, not applicable; OR, odds ratios;R, random effects model

a If the results of the studies were heterogeneous, the random effects model was used for meta-analysis; Otherwise, the fixed-effects model was used