Article: “Potentially inappropriate medication at hospital admission in patients with palliative care needs”

Journal: “International Journal of Clinical Pharmacy”

Authors: Sevilla-Sánchez D, Molist-Brunet N, Amblàs-Novellas J, Espaulella-Panicot J, Codina-Jané C.

Corresponding author: Daniel Sevilla-Sánchez; Pharmacy Department. Hospital Universitari de Vic, Hospital de la Santa Creu de Vic. Barcelona. E-mail:

Electronic Supplementary Material 2: Determinants not associated with potentially inappropriate medications according to STOPP criteria version 2.

Variable / PIM – STOPP Group 1: having 1 or more
vs not having STOPP criteria / PIM – STOPP Group 2: having 2 or more
vs having 1 or less STOPP criteria / PIM – STOPP Group 3: having 3 or more
vs having 2 or less STOPP criteria
0 Criteria / ≥ 1 criteria / OR (CI 95 %); p value / ≤ 1 Criteria / ≥ 2 criteria / OR (CI 95 %); p value / ≤ 2 Criteria / ≥ 3 criteria / OR (CI 95 %); p value
N / 27 / 208 / 85 / 150 / 140 / 95
Provenance
Home
Nursing homes / 13
(48.1 %)
14
(51.9 %) / 140
(67.3 %)
68
(32.7 %) / Reference
OR 0.45 (0.20 – 1.01)
p = 0.054 / 94
(62.7 %)
56
(37.3 %) / Reference
OR 1.35 (0.76 – 2.38)
p = 0.29 / 61
(64.2 %)
34
(35.8 %) / Reference
OR 1.06 (0.61 – 1.84)
p = 0.81
Previous hospitalizations1 / 1.0
(0 – 2) / 1.0
(0 – 2) / p = 0.642 / 1.0
(0 – 2) / 1.0
(0 – 2) / p = 0.802 / 1.0
(0 – 2) / 1.0
(0 – 2) / p = 0.102
Geriatric Syndromes
Dysphagia / 13
(48.1 %) / 95
(45.7 %) / OR 0.90 (0.40 – 2.02)
p = 0.80 / 37
(43.5%) / 71
(47.3 %) / OR 1.16 (0.68 – 1.99)
p = 0.57 / 62
(44.3%) / 46
(48.4 %) / OR 1.18 (0.70 – 1.99
p = 0.53
Ulcers / 7
(25.9 %) / 48
(23.1 %) / OR 0.85 (0.34 – 2.14)
p = 0.74 / 20
(23.5%) / 35
(23.3 %) / OR 0.98 (0.52 – 1.85)
p = 0.97 / 31
(22.1%) / 24
(25.3 %) / OR 1.18 (0.64 – 2.19)
p = 0.58
Dyspnea / 11
(40.7 %) / 83
(39.9 %) / OR 0.96 (0.42 – 2.18)
p = 0.93 / 35
(41.2%) / 59
(39.3 %) / OR 0.92 (0.53 – 1.59)
p = 0.78 / 56
(40.0%) / 38
(40.0 %) / OR 1.00 (0.58 – 1.70)
p = 1.00
Hearing loss / 11
(40.7 %) / 68
(32.7 %) / OR 0.70 (0.31 – 1.60)
p = 0.40 / 32
(37.6%) / 47
(31.3 %) / OR 0.75 (0.43 – 1.32)
p = 0.32 / 54
(38.6%) / 25
(26.3 %) / OR 0.56 (0.32 – 1.01)
p = 0.052
Constipation / 16
(59.3 %) / 130
(62.5 %) / OR 1.14 (0.50 – 2.59)
p = 0.74 / 51
(60.0%) / 95
(63.3 %) / OR 1.15 (0.66 – 1.98)
p = 0.61 / 83
(59.3%) / 63
(66.3 %) / OR 1.35 (0.78 – 2.32)
p = 0.27
Visual Impairment / 7
(25.9 %) / 52
(25.0 %) / OR 0.95 (0.38 – 2.38)
p = 0.95 / 23
(27.1%) / 36
(24.0 %) / OR 0.85 (0.46 – 1.56)
p = 0.60 / 33
(23.6%) / 26
(27.4 %) / OR 1.22 (0.67 – 2.21)
p = 0.51
Urinary incontinence / 20
(74.1 %) / 159
(76.4 %) / OR 1.13 (0.45 – 2.84)
p = 0.78 / 63
(74.1%) / 116
(77.3 %) / OR 1.19 (0.64 – 2.21)
p = 0.57 / 108
(77.1%) / 71
(74.7 %) / OR 0.87 (0.47 – 1.61)
p = 0.67
Cognitive impairment / 21
(77.8 %) / 145
(69.7 %) / OR 0.65 (0.25 – 1.70)
p = 0.38 / 62
(72.9%) / 104
(69.3 %) / OR 0.83 (0.46 – 1.51)
p = 0.56 / 103
(73.6%) / 63
(66.3 %) / OR 0.70 (0.40 – 1.24)
p = 0.23
Functional dependence
Independent (BI3 ≥ 80)
Dependent (BI3 < 80) / 5
(18.5 %)
22
(81.5 %) / 30
(14.4 %)
178
(85.6 %) / Reference
OR 1.34 (0.47 – 3.83)
p = 0.57 / 17
(20.0 %)
68
(80.0 %) / 18
(12.0 %)
132
(88.0 %) / Reference
OR 1.83 (0.88 – 3.78)
p = 0.10 / 23
(16.4 %)
117
(83.6 %) / 12
(12.6 %)
83
(87.4 %) / Reference
OR 1.36 (0.64 – 2.88)
p = 0.42
Variable
(continuation) / PIM – STOPP Group 1: having 1 or more
vs not having STOPP criteria / PIM – STOPP Group 2: having 2 or more
vs having 1 or less STOPP criteria / PIM – STOPP Group 3: having 3 or more
vs having 2 or less STOPP criteria
0 Criteria / ≥ 1 criteria / OR (CI 95 %); p value / ≤ 1 Criteria / ≥ 2 criteria / OR (CI 95 %); p value / ≤ 2 Criteria / ≥ 3 criteria / OR (CI 95 %); p value
Clinical characteristics – Advanced Chronic Disease
Severe dementia / 17
(63.0 %) / 107
(51.4 %) / Reference / 45
(52.9 %) / 79
(52.7 %) / Reference / 74
(52.9 %) / 50
(52.6 %) / Reference
Advanced Organ disease / 7
(25.9 %) / 72
(34.6 %) / OR 1.53 (0.42 – 5.60)
p = 0.51 / 29
(34.1 %) / 50
(33.3 %) / OR 1.08 (0.48 – 2.46)
p = 0.84 / 48
(34.3 %) / 31
(32.6 %) / OR 1.15 (0.52 – 2.52)
p = 0.72
Oncologic / hematologic / 3
(11.1 %) / 29
(13.9 %) / OR 1.63 (0.64 – 4.14)
p = 0.30 / 11
(12.9 %) / 21
(14.0 %) / OR 0.98 (0.54 – 1.76)
p = 0.95 / 18
(12.9 %) / 14
(14.7 %) / OR 0.95 (0.53 – 1.70)
p = 0.87

1. median (IQR); 2. Comparison between groups by U-Mann-Whitney analysis; 3. BI (Barthel Index).