Appendix 2- Full text articles excluded = 36 with reasons

1. / Gray P et al. Pregabalin in severe burn injury pain: a double-blind, randomised placebo-controlled trial. Pain. 2011; 152:1279-88. / Population- Non Surgical
2. / Lavand'homme PM et al. Evaluation of pregabalin as an adjuvant to patient-controlled epidural analgesia during late termination of pregnancy. Anesthesiology. 2010; 113:1186-91. / Population- Non Surgical
3. / Olesen, SS et al. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial. Gastroenterology 2011, 141:536-43. / Population- Non Surgical
4. / Olesen SS et al. Randomized clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. Alimentary Pharm & Therap. 2011, 34:878-87. / Population- Non Surgical
5. / Pontari MA et al. Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. Arch Int Med. 2010, 170:1586-93. / Population- Non Surgical
6. / Meuran, F. Sparing analgesic effect using pregabalin in postsurgical trauma patients in the ICU. Crit Care 2006, 10:439. / Population- Non-surgical
7. / Silverman A et al. Pregabalin for the treatment of abdominal adhesion pain: a randomized, double-blind, placebo-controlled trial. Am J Ther 2012; 19:419-28. / Population- Non-surgical
8. / Mishra S, Bhatnagar S, Goyal GN, et al. A comparative efficacy of amitriptyline, gabapentin, and pregabalin in neuropathic cancer pain: a prospective randomized double-blind placebo-controlled study. Am J Hosp Palliat Care 2012; 29:177-82. / Population- Non-surgical
9. / Cardenas D et al. A randomized trial of pregabalin in patients with neuropathic pain due to spinal cord injury. Neurology 2013; 80:533-9. / Population- Non-surgical
10. / Sahu S et al. Evaluation of pregabalin for attenuation of postoperative pain in below umbilical surgeries under spinal anaesthesia. J Anaesth Clin Pharm 2010; 26: 167-71. / Population- non comparable and heterogeneous surgical models
11. / Jo HR et al. Remifentanil-induced pronociceptive effect and its prevention with pregabalin. Korean J Anesth. 2011; 60: 198-204. / Intervention- Remifentanil
12. / Garcia RM et al. A multimodal approach for postoperative pain management after lumbar decompression surgery: A prospective, randomized study. J Spinal Disord Tech 2013; 26:291-7. / Intervention- multimodal analgesia not pregabalin compared to placebo
13. / Ali A, Babar KM. Comparison of preoperative dose of pregabalin with celecoxib for attenuation of postoperative pain after open cholecystectomy. Anaesth Pain Intensive Care 2012; 16:137-41. / Intervention-no placebo
14. / Huseyinoglu U. et al. Effect of pregabalin on post-dural-puncture headache following spinal anesthesia and lumbar puncture. J Clin Neurosc. 2011, 18:1365-68. / Outcome- post-dural puncture headache
15. / Gonano C et al The anxiolytic effect of pregabalin in outpatients undergoing minor orthopaedic surgery. J Psychopharmacol. 2011; 25:249-53. / Outcome- anxiety
16. / Gupta K et al. Oral premedication with pregabalin or clonidine for hemodynamic stability during laryngoscopy and laparoscopic cholecystectomy: A comparative evaluation. Saudi J Anaesth. 2011, 5:179-84. / Outcome- hemodynamic stability
17. / White PF et al. The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. Anesth Analg. 2009, 108:1140-5. / Outcomes- anxiety and sedation
18. / Engelman E at al. Efficacy and safety of perioperative pregabalin for post-operative pain: A meta-analysis of randomized-controlled trials. Acta Anaesth Scand 2011; 55: 927-943. / Study- Systematic Review
19. / Zhang J et al. Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth. 2011; 106:454-62. / Study- Systematic Review
20. / Moore RA et al. Pregabalin for acute and chronic pain in adults. Cochrane Database of Systematic Reviews 2009, (3), 007076. / Study- Systematic Review
21. / Tiippana EM et al. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007; 104:1545-56. / Study- Systematic Review
22. / Clarke H et al. The prevention of chronic postsurgical pain using gabapentin and pregabalin: A combined systematic review and meta-analysis. Anesth Analg 2012; 115:428-42. / Study- Systematic Review
23. / Durkin B et al. Pregabalin for the treatment of postsurgical pain. Expert Opinion on Pharmacotherapy 2010; 11:2751-8. / Study- Narrative Review
24. / Dauri M et al. Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Current Drug Targets 2009; 10: 716-33. / Study- Narrative Review
25. / Baidya DK et al. Pregabalin in acute and chronic pain. Journal of Anaesthesiology Clinical Pharmacology 2011; 27:307-14. / Study- Narrative Review
26. / Gajraj N M. Pregabalin: its pharmacology and use in pain management. Anesth Analg. 2007; 105:1805-15. / Study- Narrative Review
27. / Remerand F et al. [Benefits and safety of perioperative pregabalin: a systematic review]. [French]. Annales Francaises d Anesthesie et de Reanimation 2011; 30:569-77. / Study- Narrative Review
28. / Zaccara G et al. The adverse event profile of pregabalin across different disorders: a meta-analysis. Eur J Clin Pharmacol 2012;68:903-12. / Study- Review
29. / Eipe N, Penning J, Ansari M, et al. A protocol for a systematic review for perioperative pregabalin use. Syst Rev 2012;1:40 / Study- Protocol
30. / Post ZD et al. A prospective evaluation of 2 different pain management protocols for total hip arthroplasty. J Arthroplasty. 2010; 25:410-5. / Study- Prospective observational
31. / Acin M P et al. [Preventive analgesia with pregabalin in mesh hernia repair. Review at 1 year]. Revista de la Sociedad Espanola del Dolor 2009, 16:215-21. / Study- retrospective
32. / Eipe N et al. Postoperative respiratory depression with pregabalin: a case series and a preoperative decision algorithm. Pain Res & Manage. 16:353-6. / Study- Case Series
33. / Trabulsi EJ et al. Preemptive multimodal pain regimen reduces opioid analgesia for patients undergoing robotic-assisted laparoscopic radical prostatectomy. Urology. 2010; 76:1122-4. / Study- Non randomized with historical controls
34. / Akarsu T et al. Comparison of pre-emptive pregabalin with placebo and diclofenac combination for postoperative analgesia and cognitive functions after laparoscopic cholecystectomy. Turk Klinikleri J Med Sci 2012;32:963-70. / Study- single blind
35. / Cheung CW et al. A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia. J Oral Maxillofac Surg. 2012; 70:25- 30. / Study- Cross-over Trial