Appendix 1. Human Health and Ecological Reference Values Used in This Study

Appendix 1. Human Health and Ecological Reference Values Used in this Study

Human Health Reference Values

The MIAT decision tree requires data on Reference Values (RVs)for human health and ecological effects. The human health effects should be based on the noncarcinogenic endpoints of the compounds. The samples were grab samples; therefore, the most appropriate standards for use in this assessment are acute oral toxicity standards. However, acute oral standards were not available for most of the compounds. In this study chronic standardswere used as a conservative measure of acute RVs. Preference was givento standards or advisory criteria set by the European Union (EU) over those set by individual European countries. Preference was given to enforceable standards rather than guidance criteria and final values over proposed values. When drinking water standardswere considered for use as the basis for the RVs, we excluded standards that are based on economic considerations, analytic considerations, or limitations inwatertreatment technology. Finally, because our analysis focuses on the effects from exposure to the mixture of chemicals from a specific source and not the cumulative risks from all sources of the contaminants, it is inappropriate to include the source-apportionment factor.RVs of four pharmaceuticals (diclofenac, erythromycin, erythromycin+erythromycinH2O, and mefenamic acid) were based on minimum therapeutic dose (MTD), a body weight of 60 kg, and an adjustment factor of 1000 according to Australian guidelines for water recycling[1].A list of the standards and their sources are provided in Tables A-1and A-2.

When human health criteria were not available, the Cramer class portion of the TTC was used to conservatively estimate a safe dose. This was done by assuming anuncertainty factor of 100 and the point of departure is set for each of the three Cramer classes (Price et al, 2007). This approach was applied to 107 chemicals. The approach could not be applied to seven common ions and to four polynuclear aromatic compounds.

Ecological Reference Values

The ecological criteria were based on intermittent standards when they were available. Standards were only acceptedif they are based on acute toxicity values and that were calculated according to the methods outlined in the technical guidance document for deriving environmental quality standards (European Commission 2011) for the MAC-EQS and according to the methods outlined in the technical guidance document of risk assessment ( European Commission 2003) for the PNECintermittent. In cases where such acute data were unavailable chronic standards like the AA-EQS (European Commission 2011) or the PNEC (European Commission 2003)were used. Since the AA-EQS is equal to or lower than the MAC-EQS by definition, this substitution is in line with the precautionary principle.The reason of preferring reference values for intermittent exposure over reference values for chronic exposure is that the exposure datasets, with only one-time measurements do not allow for the calculation of chronic exposures, which would require at least 12 measurements per year. Preference was givento standards or advisory criteria set by the EU over those set by individual European countries. Preference was also given to enforceable standards rather than guidance criteria, and final values rather than proposed values. For some substances (mostly pharmaceuticals), RVs published were not in line with the two above mentioned guidance documents, because higher assessment factors were used, indicating that not all required data were available for the derivation. These values were not considered for the assessment.

In certain cases where the degradation products are missing an RV, the parent compounds RVs were used. A list of criteria and their sources are provided in Tables A-3 and A-4.

References

European Commission (2011). Common Implementation Strategy for the Water Framework Directive (2000/60/EC). Guidance Document No. 27. Technical Guidance for Deriving Environmental Quality Standards. Technical Report - 2011 – 055.

European Commission (2003). Technical Guidance Document on Risk Assessment in support of Commission Directive 93/67/EEC on Risk Assessment for new notified substances Commission Regulation (EC) No 1488/94 on Risk Assessment for existing substances Directive 98/8/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market.

Table A-1.Reference Values (RVs) for the chemicals in human health risk assessment. RVs where no source code is given were derived from based on the Threshold of Toxicological Concern

CAS Number / Chemical / PD (ng/kg/day) / Source Code
128-42-7 / 1,2-Bis-(4,4'-dinitro-2,2'-disulfonic acid)
-phenylethylenoxide / 1500
77538-56-8 / 17α-Ethinylestradiol / 0.043 / 11
50-28-2 / 17β-Estradiol / 50 / 1
13351-73-0 / 1-Methyl-1H-benzotriazole (tolyltr.) / 1500
68631-49-2 / 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE153) / 1500
207122-15-4 / 2,2',4,4',5,6'-Hexabromodiphenyl ether (PBDE154) / 1500
60348-60-9 / 2,2',4,4',5-Pentabromodiphenyl ether (PBDE99) / 1500
189084-64-8 / 2,2',4,4',6-Pentabromodiphenyl ether (PBDE100) / 1500
5436-43-1 / 2,2',4,4'-Tetrabromodiphenyl ether (PBDE47) / 1500
32534-81-9 / 2,4,4'-Tribromodiphenyl ether (PBDE28) / 2000 / 2
94-75-7 / 2,4 Dichlorophenoxyacetic acid / 10000 / 7
51-28-5 / 2,4-Dinitrophenol / 2000 / 2
92-41-1 / 2,7-Naphthalindisulfonic acid / 1500
834-32-7 / 2-Aminobenzimidazole / 1500
120-18-3 / 2-Naphthalinsulfonic acid / 1500
26530-20-1 / 2-n-Octyl-4-isothiazolin-3-one (OIT) / 1500
402-45-9 / 4-(Trifluoromethyl)phenol / 1500
81-11-8 / 4,4'-Diaminostilbene-2,2'-disulfonic acid (DAS) / 1500
64359-81-5 / 4,5-Dichloro-2-n-octyl-isothiazol-3(2H)-one (DCOIT) / 1500
83-15-8 / 4-Acetamidoantipyrine / 1500
83-07-8 / 4-Aminopyrin
(=4-Aminoantipyrine 4-AA) / 1500
58-15-1 / 4-Dimethylaminoantipyrine (Aminopyrin) / 1500
1672-58-8 / 4-Formyl-aminoantipyrine / 1500
136-85-6 / 5-Methyl-Benzotriazole / 1500
55589-62-3 / Acesulfam / 1500
21312-10-7 / Acetylsulfamethoxazole / 1500
7429-90-5 / Aluminium (total) / 1000000 / 15
AMDOPH [1-acetyl-1-methyl-2-dimethyl-oxamoyl-2-phenylhydrazide] / 1500
117-96-4 / Amidotrizoic acid [3,5-Bis(acetamido) -2,4,6-triiodbenzoic acid] / 1500
1066-51-9 / Aminomethylphosphonic acid / 900000 / 7
7664-41-7 / Ammonia / 857142.86 / 6
Ammoniacal Nitrogen (as NH4) / 14285.714 / 12
120-12-7 / Anthracene / 40000 / 14
22839-47-0 / Aspartame / 40000000 / 1
29122-68-7 / Atenolol / 9100
56392-14-4 / Atenolol acid (Metoprolol acid) / 9100
81346-71-6 / Atenolol-desisopropyl / 1500
1912-24-9 / Atrazine / 20000 / 7
6190-65-4 / Atrazine-Desethyl / 20000 / 7
1007-28-9 / Atrazine-Desisopropyl / 20000
2163-68-0 / Atrazine-Hydroxy / 20000 / 7
89305-01-5 / Azithromycin / 11000 / 11
7440-39-3 / Barium / 20000 / 14
25057-89-0 / Bentazone / 30000 / 2
50-32-8 / Benzo(a)pyrene / NA
205-99-2 / Benzo(b)fluoranthene / NA
191-24-2 / Benzo(g,h,i)perylene / 30000 / 14
207-08-9 / Benzo(k)fluoranthene / NA
119-61-9 / Benzophenone / 1500
95-14-7 / Benzotriazole / 1500
41859-67-0 / Bezafibrate / 1500
80-05-7 / Bisphenol A / 10000 / 4
Boron / 170000 / 7
7440-43-9 / Cadmium / 360 / 19
58-08-2 / Caffeine / 25170000 / 8
7440-70-2 / Calcium / NA
298-46-4 / Carbamazepine / 10000 / 5
29331-92-8 / Carbamazepine-10,11-dihydro
-10,11-dihydroxy / 2800 / 11
36507-30-9 / Carbamazepine-10,11-epoxid / 2800 / 11
10605-21-7 / Carbendazim / 20000 / 20
83881-51-0 / Cetirizine / 1500
16887-00-6 / Chloride / NA
Chromium / 5000 / 13
81103-11-9 / Clarithromycin / 7100 / 11
38083-17-9 / Climbazole / 75000 / 8
18323-44-9 / Clindamycin / 8600 / 11
882-09-7 / Clofibric acid / 21400 / 11
76-57-3 / Codeine / 1400 / 11
7440-50-8 / Copper / 140000 / 14
50-18-0 / Cyclophosphamide / 100 / 11
147-94-4 / Cytarabine / 1500
34245-14-2 / D617 [3,4-Dimethoxy-alpha-(3-(methylamino)propyl)-alpha-(1-methylethyl)benzeneacetonitrile] / 1500
30125-63-4 / Desethylterbutylazine / 2300 / 16
50-02-2 / Dexamethasone / 15 / 1
439-14-5 / Diazepam / 71 / 11
333-41-5 / Diazinon / 200 / 6
75-09-2 / Dichloromethane / 60000 / 14
15307-86-5 / Diclofenac / 1250 / 3
117-81-7 / Diethylhexylphthalate / 25000 / 17
4710-17-2 / Dimethylphenylsulfamide / 1500
66840-71-9 / Dimethyltolylsulfamide / 1500
330-54-1 / Diuron / 3000 / 6
60-00-4 / EDTA / 1900000 / 1
133040-01-4 / Eprosartan / 1500
114-07-8 / Erythromycin / 4166 / 24
Erythromycin + ErythromycinH2O / 4166 / 24
53-16-7 / Estrone / 0.86 / 11
74-55-5 / Ethambutol / 1500
31637-97-5 / Etofibrate / 1500
107868-30-4 / Exemestane / 1500
49562-28-9 / Fenofibrate / 1500
42017-89-0 / Fenofibric acid / 1500
31879-05-7 / Fenoprofen / 12900 / 11
86386-73-4 / Fluconazole / 1500
206-44-0 / Fluoranthene / 40000 / 2
54910-89-3 / Fluoxetine / 280 / 11
54-31-9 / Furosemide / 1500
60142-96-3 / Gabapentin / 1500
1222-05-5 / Galaxolidone / 500000 / 11
95058-81-4 / Gemcitabine / 1500
25812-30-0 / Gemfibrozile
Gentamicin / 20000 / 1
1071-83-6 / Glyphosate (N-(phosphonomethyl)glycine) / 300000 / 25
58-93-5 / Hydrochlorothiazide / 1500
15687-27-1 / Ibuprofen / 11428 / 11
3778-73-3 / Ifosfamide / 1500
256-96-2 / Iminostilbene / 1500
193-39-5 / Indeno(1,2,3-cd)pyrene / NA
53-86-1 / Indomethacin / 710 / 11
53-86-1 / Iodipamide / 1500
66108-95-0 / Iohexol / 20600 / 11
78649-41-9 / Iomeprol / 1500
78649-41-9 / Iomeprol + Iopamidol / 1500
62883-00-5 / Iopamidole / 1500
96-83-3 / Iopanoic acid / 1500
73334-07-3 / Iopromide / 21400 / 11
2276-90-6 / Iotalamic acid / 1500
96-83-3 / Ioxaglic acid / 1500
28179-44-4 / Ioxithalamic acid / 1500
138402-11-6 / Irbesartan / 1500
138402-11-6 / Irgarol / 1500
Irgarol-descyclopropyl / 1500
7439-89-6 / Iron / 500000 / 1
34123-59-6 / Isoproturon / 3000 / 7
22071-15-4 / Ketoprofen / 1000 / 11
84057-84-1 / Lamotrigin / 1500
7439-92-1 / Lead / 3600 / 13
102767-28-2 / Levetiracetam / 1500
137-58-6 / Lidocain / 9100
114798-26-4 / Losartan / 1500
93-65-2; 7085-19-0 racemic mixture / Mecoprop / 3300 / 7
61-68-7 / Mefenamic acid / 8333 / 3
7439-97-6 / Mercury / 100 / 13
657-24-9 / Metformin / 7100 / 11
83-43-2 / Methylprednisolon / 1500
7232-21-5 / Metoclopramide / 1500
51384-51-1 / Metoprolol / 710 / 11
443-48-1 / Metronidazole / 1500
71320-77-9 / Moclobemide / 1500
57-27-2 / Morphine / 1500
119-63-1 / N-(4-Aminophenyl)-N-methyle
-acetamide / 1500
N,N-Didesvenlafaxine / 1500
134-62-3 / N,N-diethyl-3-methylbenzamide / 1500
135308-74-6 / N,O-Didesvenlafaxine / 1500
127-74-2 / N4-Acetylsulfadiazine / 1500
N4-Acetyl-Sulfadimethoxine / 1500
N4-Acetyl-Sulfamethazine / 1500
21312-10-7 / N4-Acetyl-Sulfamethoxazole / 1500
N4-Acetyl-Sulfathiazole / 1500
91-20-3 / Naphthalene / 40000 / 14
22204-53-1 / Naproxen / 6300 / 11
149289-30-5 / N-Desvenlafaxine / 1500
7440-02-0 / Nickel / 12000 / 7
Nitrate / 3700000 / 7
Nitrite / 70000 / 7
100-02-7 [4-] / Nitrophenol / 8000 / 6
579-10-2 / N-Methylacetanilide / 1500
104-40-5 / Nonylphenol / 5000 / 4
3115-49-9 / NPE1C / 1500
93413-62-8 / o-Desvenlafaxine (+ Tramadol) / 1500
82419-36-1 / Ofloxacin / 1500
Orthophosphate / NA
196618-13-0 / Oseltamivir / 1500
Oseltamivir-carboxylate / 867 / 18
604-75-1 / Oxazepam / 1500
79-57-2 / Oxytetracycline / 3000 / 1
103-90-2 / Paracetamol / 50000 / 11
1677687 / Pentoxifylline / 1500
335-76-2 / PFDA [Perfluorodecanoic acid] / 1500
375-85-9 / PFHpA [Perfluoroheptanoic acid] / 1500
307-24-4 / PFHxA [Perfluorohexanoic acid] / 1500
375-95-1 / PFNA [Perfluorononanoic acid] / 1500
335-67-1 / PFOA [Perfluorooctanoic acid] / 1500 / 21
3825-26-1 / PFOS [perfluorooctane sulfonate] / 150 / 22
2058-94-8 / PFUnA [Perfluoroundecanoic acid] / 1500
62-44-2 / Phenacetin / 1500
60-60-0 / Phenazone (Antipyrine) / 28400 / 11
108-95-2 / Phenol / 40000 / 14
Polybrominated Diphenyl Ethers / 200 / 2
7440-09-7 / Potassium / NA
50-24-8 / Prednisolone / 1500
125-33-7 / Primidone / 1500
525-66-6 / Propanolol / 1500
60207-90-1 / Propiconazole / 1500
66357-35-5 / Ranitidine / 1500
73857-20-2 / Ranitidine-N-oxide / 1500
73851-70-4 / Ranitidine-S-oxide / 1500
19395-41-6 / Ritalinic acid / 1500
155213-67-5 / Ritonavir / 1500
80214-83-1 / Roxithromycin / 4300 / 11
69-72-7 / Salicylic Acid / 1000000 / 8
7440-22-4 / Silver / 5000 / 2
122-34-9 / Simazine / 520 / 7
82115-62-6 / Sodium / NA
3930-20-9 / Sotalol / 1500
56038-13-2 / Sucralose / 15000000 / 1
99105-77-8 / Sulcotrione / 1500
68-35-9 / Sulfadiazine / 1500
122-11-2 / Sulfadimethoxine / 10000 / 11
57-68-1 / Sulfamethazine / 10000 / 11
723-46-6 / Sulfamethoxazole / 10000 / 11
144-83-2 / Sulfapyridine / 1500
72-14-0 / Sulfathiazole / 1500
122-11-2 / Sulfdimethoxine / 1500
Sulphate / NA
886-50-0 / Terbutryn / 1000 / 2
5915-41-3 / Terbutylazine / 1500
140-66-9 / Tert-OP (4-tert-octylphenol) / 15000 / 11
76-75-5 / Thiopental / 1500
Titanium / 350000000 / 8
27203-92-5 / Tramadol (+ O-Desvenlafaxine) / 9100
36643-28-4 / Tributyltin (TBT) / 270 / 23
79-01-6 / Trichloroethylene / 23800 / 9
3380-34-5 / Triclosan / 300 / 10
738-70-5 / Trimethoprim / 20000 / 11
1401-69-0 / Tylosin / 30000 / 1
Uranium / 1000 / 7
137862-53-4 / Valsartan / 1500
164265-78-5 / Valsartan acid / 1500
93413-69-5 / Venlafaxine / 1500
152-11-4 / Verapamil / 1500
7440-66-6 / Zinc / 300000 / 2
58-89-9 / γ-HCH [Lindane] / 5000 / 7

Table A-2. Sources for the Reference Values for the chemicals in human health risk assessment.

Source Code / Source
1 /
2 /
3 /
4 /
5 /
6 /
7 /
8 /
9 /
10 /
11 /
12 /
13 /
14 /
15 /
16 /
17 /
18 /
19 /
20 /
21 /
22 /
23 /
24 / Alvarez-Elcoro and Enzler, 1999.The macrolides: erythromycin, clarithromycin, and azithromycin. Mayo Clin Proc. 74: 613-34.
25 / European Commission (2002) Report for the Active Substance Glyphosate, Directive 511/VI/99. Jan. 21

Table A-3.Reference Values (RVs) for the chemicals in ecological risk assessment.

CAS number / Chemical / RV (ng/L) / Source Code
128-42-7 / 1,2-Bis-(4,4'-dinitro-2,2'-disulfonic acid)-phenylethylenoxide / NA
57-63-6 / 17α-Ethinylestradiol / 0.035 / 36
50-28-2 / 17β-Estradiol / 0.4 / 36
1-Methyl-1H-benzotriazole (tolyltr.) / NA
68631-49-2 / 2,2',4,4',5,5'-hexabromodiphenyl ether (PBDE153) / 140
for the sum of all these PBDEs / 36
207122-15-4 / 2,2',4,4',5,6'-hexabromodiphenyl ether (PBDE154) / 36
60348-60-9 / 2,2',4,4',5-pentabromodiphenyl ether (PBDE99) / 36
189084-64-8 / 2,2',4,4',6-pentabromodiphenyl ether (PBDE100) / 36
5436-43-1 / 2,2',4,4'-tetrabromodiphenyl ether (PBDE47) / 36
32534-81-9 / 2,4,4'-tribromodiphenyl ether (PBDE28) / 36
94-75-7 / 2,4-Dichlorophenoxyacetic acid / 1300 / 25
51-28-5 / 2,4-Dinitrophenol / 74000 / 20
92-41-1 / 2,7-Naphthalindisulfonic acid / NA
934-32-7 / 2-Aminobenzimidazole / 600
120-18-3 / 2-Naphthalinsulfonic acid / NA
26530-20-1 / 2-n-Octyl-4-isothiazolin-3-one (OIT) / 13 / 2
402-45-9 / 4-(Trifluoromethyl)phenol / 32 / 26
81-11-8 / 4,4'-Diaminostilbene
-2,2'-disulfonic acid (DAS) / NA
64359-81-5 / 4,5-Dichloro-2-n-octyl-isothiazole-3(2H)-one (DCOIT) / 34 / 6
83-15-8 / 4-Acetamidoantipyrine / 20000 / 26
83-07-8 / 4-Aminopyrine
(=4-Aminoantipyrine 4-AA) / NA
57-15-1 / 4-Dimethylaminoantipyrine (Aminopyrine) / NA
1672-58-8 / 4-Formyl-aminoantipyrine / NA
136-85-6 / 5-Methyl-Benzotriazole / 200000 / 21
55589-62-3 / Acesulfame / NA
21312-10-7 / Acetylsulfamethoxazole / 2700
7429-90-5 / Aluminium / 25000 / 34
519-65-3 / AMDOPH / NA
117-96-4 / Amidotrizoic acid / NA
1066-51-9 / Aminomethylphosphonic acid (AMPA) / 79700 / 22
Ammonia / NA
Ammoniacal nitrogen (as NH4) / NA
120-12-7 / Anthracene / 100 / 36
22839-47-0 / Aspartame / NA
29122-68-7 / Atenolol / 330000 / 21
56392-14-4 / Atenolol acid (Metoprolol acid) / 330000
81346-71-6 / Atenolol-desisopropyl / 330000
6190-65-4 / Atrazin-Desethyl / 2000
1007-28-9 / Atrazin-Desisopropyl / 2000
1912-24-9 / Atrazine / 2000 / 10
Atrazin-Hydroxy / 2000
83905-01-5 / Azithromycin / 90 / 21
Barium / 227800 / 4
25057-89-0 / Bentazone / 450000 / 19
50-32-8 / benzo(a)pyrene / 270 / 36
205-99-2 / benzo(b)fluoranthene / 17 / 36
191-24-2 / benzo(g,h,i)perylene / 8.2 / 36
207-08-9 / benzo(k)fluoranthene / 17 / 36
131-57-7 / Benzophenone / NA
95-14-7 / Benzotriazole / 120000 / 21
41859-67-0 / Bezafibrate / 76000 / 21
80-05-7 / Bisphenol-A / 1600 / 8
Boron / 785000 / 3
7440-43-9 / Cadmium / 450 / 33
58-08-2 / Caffeine / NA
Calcium / NA
298-45-4 / Carbamazepine / 2550000 / 21
58955-93-4 / Carbamazepine-10,11-dihydro
-10,11-dihydroxy / 2550000
36507-30-9 / Carbamazepine-10,11-epoxide / 2550000
10605-21-7 / Carbendazim / 600 / 24
83881-52-1 / Cetrizine / NA
Chloride / NA
Chromium / 2000 / 34
81103-11-9 / Clarithromycin / 110 / 21
38083-17-9 / Climbazole / NA
18323-44-9 / Clindamycin / NA
882-09-7 / Clofibric acid / 5000 / 28
76-57-3 / Codein / NA
Copper / 1000 / 25
50-18-0 / Cyclophosphamide / 20000000 / 26
147-94-4 / Cytarabine / NA
34245-14-2 / D617 (3-(3,4-dimethoxyphenyl)-2-methyl-6-methylaminohexane-3-carbonitrile) / 250
30125-63-4 / Desethylterbutylazine / 20
50-02-2 / Dexamethasone / NA
439-14-5 / Diazepam / 2700 / 26
333-41-5 / Diazinon / 20 / 25
75-09-2 / Dichloromethane / 20000 / 10
15307-86-5 / Diclofenac / 100 / 36
117-81-7 / Diethylhexylphthalate / 1300 / 10
- / Dimethylphenylsulfamide / NA
66840-71-9 / Dimethyltolylsulfamide / NA
330-54-1 / Diuron / 1800 / 10
60-00-4 / EDTA / 12100000 / 21
133040-01-4 / Eprosartan / NA
133040-01-4 / Erythromycin / 2300 / 21
114-07-8 / Erythromycin + ErythromycinH2O / 2300
53-16-7 / Estrone / 100 / 21
1070-11-7 / Ethambutol / NA
Etofibrate / NA
107868-30-4 / Exemestan / NA
49562-28-9 / Fenofibrate / 1600 / 26
42017-89-0 / Fenofibric-Acid / 1600
31879-05-7 / Fenoprofen / NA
86386-73-4 / Fluconazole / NA
206-44-0 / Fluoranthene / 1000 / 36
54910-89-3 / Fluoxetine / 32 / 26
54-31-9 / Furosemide / 1600 / 26
60142-96-3 / Gabapentin / NA
256393-37-0 / Galaxolidon / NA
95058-81-4 / Gemcitabine / 5400 / 16
25812-30-0 / Gemfibrozil / NA
1403-66-3 / Gentamicin / 70 / 35
1071-83-6 / glyphosate (N-(phosphonomethyl)glycine) / 65000 / 11
58-93-5 / Hydrochlorothiazide / 100000 / 18
15687-27-1 / Ibuprofen / 23000 / 21
3778-73-2 / Ifosfamide / 2000000 / 26
256-96-2 / Iminostilbene / NA
193-39-5 / indeno(1,2,3-cd)pyrene / 0.17 / 36
53-86-1 / Indomethacin / NA
606-17-7 / Iodipamide / NA
66108-95-0 / Iohexol / 1000000 / 26
78649-41-9 / Iomeprol / 1000000 / 12
78649-41-9/62883-00-5 / Iomeprol + Iopamidol / 1000000
62883-00-5 / Iopamidol / NA
96-83-3 / Iopanoic acid / NA
73334-07-3 / Iopromide / 6800000 / 26
2276-90-6 / Iotalamic acid / NA
Ioxaglic acid / NA
Ioxithalamic acid / NA
138402-11-6 / Irbesartan / 704000 / 13
28159-98-0 / Irgarol (Cybutryn) / 16 / 36
- / Irgarol-descyclopropyl / 16 / 36
Iron / 41000 / 34
34123-59-6 / Isoproturon / 1000 / 10
22071-15-4 / Ketoprofen / NA
84057-84-1 / Lamotrigine / 39700 / 14
7439-92-1 / Lead / 16000 / 30
102767-28-2 / Levetiracetam / NA
137-58-6 / Lidocain / NA
114798-26-4 / Losartan / 1400000 / 26
7085-19-0 / Mecoprop / 24000 / 25
61-68-7 / Mefenamic acid / 40000 / 21
7439-97-6 / Mercury / 70 / 32
657-24-9 / Metformin / 60000 / 26
83-43-2 / Methylprednisolone / NA
7232-21-5 / Metoclopramide / NA
37350-58-6 / Metoprolol / 76000 / 26
443-48-1 / Metronidazole / 36000 / 26
71320-77-9 / Moclobemide / NA
57-27-2 / Morphine / NA
119-63-1 / N-(4-Aminophenyl)-N-methyl
-acetamide / NA
93413-77-5 / N,N-Didesvenlafaxine / 4800
134-62-3 / N,N-Diethyl-3-methylbenzamide (DEET) / 43000 / 5
135308-74-6 / N,O-Didesvenlafaxine / 4800
127-74-2 / N4-Acetylsulfadiazine / 1400
24341-30-8 / N4-Acetyl-Sulfadimethoxine / 8.8
100-90-3 / N4-Acetyl-Sulfamethazine / 1000
21312-10-7 / N4-Acetyl-Sulfamethoxazole / 2700
127-76-4 / N4-Acetyl-Sulfathiazole / 3400
91-20-3 / Naphthalene / 2400 / 9
22204-53-1 / Naproxen / 370000 / 21
149289-30-5 / N-Desvenlafaxine / 4800
7440-02-0 / Nickel / 2000 / 30
Nitrate / NA
Nitrite / NA
88-75-5 / Nitrophenol / 4200 / 27
579-10-2 / N-Methylacetanilide / NA
104-40-5 / Nonylphenol / 2000 / 10
3115-49-9 / NPE1C / NA
93413-62-8 / o-Desvenlafaxine (+ Tramadole) / NA
82419-36-1 / Ofloxacin / 110 / 26
Orthophosphate / NA
196618-13-0 / Oseltamivir / 100000 / 15
187227-45-8 / Oseltamivir-carboxylate / 100000
604-75-1 / Oxazepam / NA
79-57-2 / oxytetracycline / 1100 / 26
103-90-2 / Paracetamol / 1000 / 26
6493-05-6 / Pentoxifyllin / NA
335-76-2 / PFDA / NA
375-85-9 / PFHpA / NA
68259-11-0 / PFHxA / NA
375-95-1 / PFNA / NA
335-67-1 / PFOA / NA
1763-23-1 / PFOS / 36000 / 36
2058-94-8 / PFUnA / NA
62-44-2 / Phenacetin / NA
60-80-0 / Phenazone (Antipyrine) / NA
108-95-2 / Phenol / 46000 / 25
Polybrominated Diphenyl Ethers / 140 / 36
7440-09-7 / Potassium / NA
50-24-8 / Prednisolone / NA
125-33-7 / Primidone / 320 / 26
525-66-6 / Propanolol / 100 / 26
60207-90-1 / Propiconazole / 1600 / 7
66357-35-5 / Ranitidine / NA
738557-20-2 / Ranitidin-N-oxide / 26000
73851-70-4 / Ranitidin-S-oxide / 26000
19395-41-6 / Ritalinic acid / NA
155213-67-5 / Ritonavir / NA
80214-83-1 / Roxithromycin / NA
69-72-7 / Salicylic Acid / 200000 / 26
7440-22-4 / Silver / 100 / 30?
122-34-9 / Simazine / 4000 / 10
82115-62-6 / Sodium / NA
3930-20-9 / Sotalol / NA
56038-13-2 / Sucralose / NA
99105-77-8 / Sulcotrione / NA
68-35-9 / Sulfadiazine / 1400 / 26
122-11-2 / Sulfadimethoxine / 8.8 / 26
57-68-1 / Sulfamethazine / 1000 / 26
723-46-6 / Sulfamethoxazole / 2700 / 21
144-83-2 / Sulfapyridine / NA
72-14-0 / Sulfathiazole / NA
122-11-2 / Sulfdimethoxine / NA
Sulphate / NA
886-50-0 / Terbutryn / 34 / 36
5915-41-3 / Terbutylazine / 20 / 29
140-66-9 / 4-tert-Octylphenol / NA
76-75-5 / Thiopental / NA
Titanium / 15000 / 1
27203-92-5 / Tramadol (+ o-Desvenlafaxine) / 320 / 26
36643-28-4 / Tributyltin (TBT) / 1.5 / 31
79-01-6 / Trichloroethylene / 10000 / 10
3380-34-5 / Triclosan / NA
738-70-5 / Trimethoprim / 1100000 / 21
1401-69-0 / Tylosin / 340 / 26
Uranium / NA
137862-53-4 / Valsartan / NA
164265-78-5 / Valsartan acid / NA
93413-69-5 / Venlafaxine / 4800 / 17
152-11-4 / Verapamil / NA
7440-66-6 / Zinc / 10900 / 30?
58-89-9 / γ-HCH [Lindane] / 40 / 10

Table A-4. Sources for the Reference Values for the chemicals in ecological risk assessment.

Source Code / Source
1 /
_%C3%9Cbersicht_Stoffdaten-_und_Ma%C3%9Fnahmenbl%C3%A4tter#Zugeh.C3.
B6rige_Dokumente_.28aktuelle_Fassung.29
2 / Burkhardt M., Junghans M., Zuleeg S., Schoknecht U., Lamani X., Bester K.,
Vonbank R., Simmler H., Boller M. (2009 Umweltwiss Schadst Forsch 21:36-47)
3 / CSR/ ECHA
4 / ECHA/ IUCLID
5 /
assessment_reportpdf_2/_EN_1.0_&a=d
6 /
ca_reports/wood_preservatives/doc_i_publicpdf/_EN_1.0_&a=d
7 /
AnnexI_AR_60207-90-1_PT08_en.pdf
8 /
bisphenolareport325.pdf
9 /
naphthalenereport020.pdf
10 /
11 /
name,23065,en.html
12 /
DocTypeID=78#IDE4POFGUAYZGVERT1
13 /
DocTypeID=78#IDE4POFGUAYZGVERT2
14 /
DocTypeID=78#IDE4POFGUAYZGVERT3
15 /
DocTypeID=78#IDE4POFGUAYZGVERT4
16 /
DocTypeID=78#IDE4POFGUAYZGVERT5
17 /
DocTypeID=78#IDE4POFGUAYZGVERT6
18 /
DocTypeID=78#IDE4POFGUAYZGVERT7
19 /
Bericht__Nr._164.pdf
20 /
LAWA/Vorhaben_des_Ausschusses_Oberflaechengewaesser_und_Kuestengewaesser_%
28AO%29/O_5.07/Abschlussbericht_LAWA_QN-V_100317.pdf)
21 /
22 /
23 /
24 /
25 / UK Technical Advisory Group on the Water Framework Directive. Proposals for
environmental quality standards for annex VIII substances. SR1-2007. Revised June 2008.
26 / IWW Rheinisch-Westfälisches Institut für Wasser Beratungs- und
Entwicklungsgesellschaft (2011). Zusammenstellung von Monitoringdaten zu
Umweltkonzentrationen von Arzneimitteln - Gutachten zum FKZ 360 14 013.
Auftraggeber Umweltbundesamt.
27 / Jahnel J. et al. (200Entwicklung von Umweltqualitätsnormen zum Schutz aquatischer
Biota in Oberflächengewässer für flussgebietsspezifische Stoffe, Teil 2; cited in

28 / Jahnel J., Neamtu, M., Schudoma, D., Frimmel, F.H. (2006). Bestimmung von
Umweltqualitätsnormen für potentiell gewässerrelevante Stoffe. Acta hydrochim.
Hydrobiol. 34: 389-397
29 /
riktvarden_vaxtskyddsmedel.pdf
30 / Not yet published
31 /
documents/priority_substances/supporting_background/substance_sheets/
eqsdatasheet_150105pdf_7/_EN_1.0_&a=d
32 /
documents/priority_substances/supporting_background/substance_sheets/
eqsdatasheet_150105pdf_6/_EN_1.0_&a=d
33 /
documents/priority_substances/supporting_background/substance_sheets/
eqsdatasheet_310705pdf_6/_EN_1.0_&a=d
34 / TBC -
35 / Straub JO, Gysel D, Kastl U, Klemmer J and Studer M (2011). Environmental Risk
Assessment for Ancillary Substances in Biotechnological Production of Pharmaceuticals.
Roche Poster SETAC Europe 21st Annual Meeting Milan, Italy, May 15th-19th, 2011
36 / European Commission (2012). Proposal for a DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy. Brussels 31.01.2012.

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