ORF IDa
Gene / Putative Product / Fold Change 30 min
(LL37- / LL37+)
5 uM: 0uM
Upregulated genes
NMB1404 / hypothetical protein / 3.86
0 / intergenic region 1591805-1591950 / 0.687273525
NMB0660 / hypothetical protein / 3.76
NMB1955 / cadmium resistance protein / 3.59
NMB1746 / hypothetical protein / 3.28
0 / intergenic region 1132389-1132512 / 0.718254496
0 / intergenic region 1260557-1260709 / 0.737547191
0 / intergenic region 151107-151247 / 0.738764829
0 / intergenic region 2170633-2170723 / 0.754577837
NMB1011 / hypothetical protein / 3.10
NMB2110 / hypothetical protein / 3.01
0 / intergenic region 2201339-2201513 / 0.774426374
0 / intergenic region 563913-564080 / 0.775661028
NMB1180 / hypothetical protein / 2.99
NMB1629 / hypothetical protein / 2.92
NMB0233 / hypothetical protein / 2.92
NMB0644 / hypothetical protein / 2.90
NMB0938 / hypothetical protein / 2.89
NMB0112 / 16S RNA methyltransferase / 2.89
0 / intergenic region 796948-797132 / 0.822032032
NMB0501 / hypothetical protein / 2.82
0 / intergenic region 1837259-1837440 / 0.830226842
NMB1142 / hypothetical protein / 2.73
NMB0491 / hypothetical protein / 2.72
NMB0646 / ribonuclease inhibitor barstar / 2.69
0 / intergenic region 221043-221437 / 0.839222488
NMB0200 / hypothetical protein / 2.69
0 / intergenic region 1005456-1005588 / 0.843994284
NMB0495 / replication protein / 2.68
NMB1980 / hypothetical protein / 2.60
NMB1450 / ferredoxin--NADP reductase / 2.59
NMB0068 / polysialic acid capsule biosynthesis protein SiaC / 2.57
NMB0707 / putative rare lipoprotein B / 2.57
0 / intergenic region 1669535-1669637 / 0.855249391
NMB0419 / hypothetical protein / 2.55
NMB0852 / GTP-binding protein EngA / 2.54
NMB1670 / PqiA family protein / 2.50
0 / intergenic region 1986059-1986171 / 0.86394806
NMB1532 / hypothetical protein / 2.46
NMB0755 / hypothetical protein / 2.46
NMB0230 / hypothetical protein / 2.45
NMB1599 / hypothetical protein / 2.44
0 / intergenic region 1912995-1913126 / 0.877848602
0 / intergenic region 2012988-2013122 / 0.880149448
NMB0473 / hypothetical protein / 2.43
NMB0291 / hypothetical protein / 2.43
NMB0508 / hypothetical protein / 2.40
0 / intergenic region 1224176-1224371 / 0.882943915
NMB2108 / hypothetical protein / 2.40
NMB1758 / hypothetical protein / 2.38
0 / intergenic region 41371-41471 / 0.894746638
0 / intergenic region 2089233-2089365 / 0.895312142
0 / intergenic region 901874-902124 / 0.899457637
0 / intergenic region 753496-753641 / 0.900350709
NMB0228 / hypothetical protein / 2.33
0 / intergenic region 558894-559021 / 0.906490486
NMB0502 / hypothetical protein / 2.32
NMB1502 / hypothetical protein / 2.32
NMB0794 / hypothetical protein / 2.32
NMB1517 / hypothetical protein / 2.31
0 / intergenic region 2078392-2078536 / 0.910221553
NMB0447 / DNA repair protein RecO / 2.30
NMB0362 / hypothetical protein / 2.28
NMB0560 / serine acetyltransferase / 2.26
NMB1763 / putative toxin-activating protein / 2.24
0 / intergenic region 552484-552684 / 0.91845822
0 / intergenic region 1137356-1137519 / 0.919453786
NMB1967 / transcriptional regulator, AraC family / 2.24
NMB0654 / hypothetical protein / 2.23
NMB0474 / putative biotin synthesis protein BioC / 2.22
NMB0363 / hypothetical protein / 2.22
NMB1858 / hypothetical protein / 2.21
NMB0331 / putative kinase / 2.21
NMB1558 / diacylglycerol kinase / 2.20
NMB1665 / hypothetical protein / 2.20
NMB0067 / polysialic acid capsule biosynthesis protein SiaD, truncation; disrupted by foreign ermC (NMB0066) cassette / 2.20
0 / intergenic region 800636-800735 / 0.931730781
NMB2118 / hypothetical protein / 2.19
NMB1289 / putative type II restriction enzyme / 2.19
NMB0856 / hypothetical protein / 2.19
NMB2125 / hypothetical protein / 2.18
NMB1646 / putative hemolysin / 2.18
0 / intergenic region 711157-711322 / 0.935946788
NMB1234 / ABC transporter, ATP-binding protein / 2.16
NMB1482 / acyl CoA thioester hydrolase family protein / 2.16
NMB1637 / hypothetical protein / 2.16
NMB1862 / ribosomal protein L11 methyltransferase / 2.15
0 / intergenic region 929613-930007 / 0.94139476
0 / intergenic region 682113-682234 / 0.941974021
NMB1084 / hypothetical protein / 2.15
NMB1628 / putative tspB protein / 2.14
0 / intergenic region 398275-398425 / 0.94550699
NMB0593 / hypothetical protein / 2.14
0 / intergenic region 1955128-1955462 / 0.94611864
NMB1965 / hypothetical protein / 2.13
0 / intergenic region 1565924-1566273 / 0.947782809
0 / intergenic region 1025399-1025488 / 0.949282045
0 / intergenic region 1867538-1867645 / 0.94936306
NMB1343 / hypothetical protein / 2.13
0 / intergenic region 1789049-1789433 / 0.951127805
0 / intergenic region 605127-605401 / 0.952500242
NMB1672 / hypothetical protein / 2.13
0 / intergenic region 1835221-1835365 / 0.95333664
NMB1051 / ABC transporter, ATP-binding protein / 2.13
NMB1715 / multiple transferable resistance system protein MtrD / 2.12
NMB1390 / glucokinase / 2.12
NMB1203 / protein-PII uridylyltransferase / 2.12
NMB0619 / hypothetical protein / 2.11
0 / intergenic region 566659-566906 / 0.957309299
NMB0247 / hypothetical protein / 2.11
NMB0492 / hypothetical protein / 2.10
0 / intergenic region 1131163-1131597 / 0.959500514
0 / intergenic region 60515-60970 / 0.959595389
NMB2008 / ABC transporter, ATP-binding protein-related protein / 2.09
NMB1767 / hypothetical protein / 2.09
NMB2006 / chloride channel protein-related protein / 2.08
NMB1524 / putative oxidoreductase / 2.07
NMB1562 / hypothetical protein / 2.07
0 / intergenic region 1318396-1318550 / 0.964382586
0 / intergenic region 1769558-1769696 / 0.964389129
0 / intergenic region 66069-66161 / 0.964398095
NMB0252 / hypothetical protein / 2.06
0 / intergenic region 2069091-2069785 / 0.967213724
NMB0267 / hypothetical protein / 2.06
NMB2121 / hypothetical protein / 2.05
0 / intergenic region 1896028-1896147 / 0.968279434
0 / intergenic region 307594-307720 / 0.968577287
0 / intergenic region 1169392-1169555 / 0.970499223
NMB1850 / hypothetical protein / 2.05
0 / intergenic region 275294-275434 / 0.97357697
NMB1129 / hypothetical protein / 2.04
NMB0125 / preprotein translocase SecE subunit / 2.04
0 / intergenic region 1429185-1429440 / 0.975173596
NMB0612 / spermidine putrescine ABC transporter, permease protein / 2.04
NMB0917 / death-on-curing protein / 2.03
NMB0889 / hypothetical protein / 2.02
NMB0360 / AmpG-related protein / 2.02
NMB1597 / hypothetical protein / 2.02
NMB1689 / putative dedA protein / 2.02
NMB0687 / GTP-binding protein Era / 2.01
NMB0779 / hypothetical protein / 2.01
NMB1406 / hypothetical protein / 2.01
NMB2120 / hypothetical protein / 2.00
NMB0548 / AcrA AcrE family protein / 1.99
NMB1200 / ribonuclease II family protein / 1.99
NMB0710 / hypothetical protein / 1.99
NMB2116 / hypothetical protein / 1.99
0 / intergenic region 379525-379814 / 0.986596858
0 / intergenic region 399539-399739 / 0.9866842
NMB1330 / hypothetical protein / 1.99
NMB0977 / putative modulator of drug activity B / 1.98
NMB0597 / hypothetical protein / 1.98
NMB0481 / hypothetical protein / 1.98
NMB0789 / amino acid ABC transporter, ATP-binding protein / 1.98
NMB1508 / hypothetical protein / 1.98
0 / intergenic region 2195826-2196042 / 0.990134095
NMB0887 / putative type IV pilus assembly protein PilV / 1.97
NMB1688 / L-asparaginase I / 1.97
NMB0350 / hypothetical protein / 1.97
0 / intergenic region 1479741-1479922 / 0.993463197
0 / intergenic region 2213931-2214084 / 0.993840371
NMB1206 / bacterioferritin B / 1.97
NMB1642 / transcription elongation factor NusA / 1.96
0 / intergenic region 2171357-2171562 / 0.995275614
0 / intergenic region 1423348-1423527 / 0.995440537
NMB0824 / orotidine 5 -phosphate decarboxylase / 1.96
0 / intergenic region 1277147-1277270 / 0.996016808
0 / intergenic region 1963150-1963504 / 0.998151746
NMB1334 / hypothetical protein / 1.96
NMB1246 / hypothetical protein / 1.96
NMB0072 / capsule polysaccharide export inner-membrane protein CtrB / 1.96
0 / intergenic region 740766-740885 / 0.998886354
NMB0266 / hypothetical protein / 1.96
0 / intergenic region 2100086-2100382 / 1.000696037
NMB0800 / hypothetical protein / 1.95
NMB1764 / hypothetical protein / 1.95
NMB1287 / putative ferredoxin / 1.95
0 / intergenic region 1756054-1756199 / 1.003533287
NMB0282 / ribonuclease II-related protein / 1.93
0 / intergenic region 2105995-2106088 / 1.004192548
NMB0588 / ABC transporter, ATP-binding protein / 1.93
NMB0977 / putative modulator of drug activity B / 1.92
NMB1714 / multidrug efflux pump channel protein / 1.92
NMB1512 / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 1.92
NMB1804 / putative cytochrome c-type biogenesis protein / 1.92
NMB0580 / putative protein disulfide isomerase NosL / 1.92
NMB0731 / hypothetical protein / 1.92
0 / intergenic region 2214385-2214621 / 1.010095759
0 / intergenic region 2111457-2111687 / 1.010097164
0 / intergenic region 1078762-1078903 / 1.01135876
0 / intergenic region 777572-777696 / 1.011360209
NMB1917 / hypothetical protein / 1.92
NMB2119 / MafB-related protein / 1.91
0 / intergenic region 584969-585155 / 1.012418064
0 / intergenic region 1689129-1689252 / 1.012519532
NMB0370 / hypothetical protein / 1.91
NMB0520 / hypothetical protein / 1.91
NMB0979 / hypothetical protein / 1.90
NMB1666 / hypothetical protein / 1.90
0 / intergenic region 124832-124921 / 1.01608402
0 / intergenic region 1039582-1039673 / 1.016382825
NMB0655 / hypothetical protein / 1.90
NMB1039 / hypothetical protein / 1.90
NMB0235 / hypothetical protein / 1.90
NMB0239 / hypothetical protein / 1.90
NMB1277 / transporter, BCCT family / 1.89
0 / intergenic region 2214997-2215183 / 1.017910823
NMB1531 / hypothetical protein / 1.88
NMB1537 / DNA primase / 1.88
NMB0958 / hypothetical protein / 1.87
#N/A / #N/A / 1.019953633
NMB0941 / 50S ribosomal protein L36 / 1.87
0 / intergenic region 324896-325095 / 1.020352026
NMB0826 / C-5 cytosine-specific DNA methylase / 1.87
NMB0674 / hypothetical protein / 1.86
NMB1849 / carbamoyl-phosphate synthase small subunit / 1.86
NMB2136 / peptide transporter / 1.86
NMB0890 / type IV pilin-related protein / 1.86
NMB0822 / heat shock protein HtpX / 1.86
0 / intergenic region 685966-686059 / 1.023947451
0 / intergenic region 669032-669317 / 1.024366485
0 / intergenic region 1959695-1959918 / 1.024723829
NMB1397 / hypothetical protein / 1.86
0 / intergenic region 959738-959839 / 1.025056901
NMB1320 / 50S ribosomal protein L9 / 1.86
0 / intergenic region 101178-101491 / 1.02597018
NMB0568 / Na(+)-translocating NADH-quinone reductase subunit B / 1.86
NMB1410 / hypothetical protein / 1.85
0 / intergenic region 2057628-2057799 / 1.026529439
NMB0073 / capsule polysaccharide export inner-membrane protein CtrC / 1.85
NMB2153 / hypothetical protein / 1.85
0 / intergenic region 1881835-1882533 / 1.027490973
0 / intergenic region 312819-312911 / 1.027566296
NMB1675 / hypothetical protein / 1.85
NMB1733 / hypothetical protein / 1.85
NMB0264 / ABC transporter, ATP-binding protein / 1.84
NMB2012 / transcriptional regulator, HTH_3 family / 1.84
NMB1489 / hypothetical protein / 1.84
NMB1833 / isoleucyl-tRNA synthetase / 1.84
0 / intergenic region 830418-830526 / 1.030964021
0 / intergenic region 1527601-1528597 / 1.031572001
NMB0844 / hypothetical protein / 1.84
NMB2001 / hypothetical protein / 1.83
NMB0980 / NAD(P) transhydrogenase subunit alpha / 1.83
0 / intergenic region 1393568-1394055 / 1.032661771
NMB1734 / glutaredoxin / 1.83
NMB0190 / glucose-inhibited division protein B / 1.83
0 / intergenic region 146796-146912 / 1.035194625
NMB0012 / hypothetical protein / 1.83
NMB2139 / hypothetical protein / 1.83
NMB0422 / UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase / 1.82
NMB1357 / hypothetical protein / 1.82
0 / intergenic region 375350-375563 / 1.038119955
NMB0122 / hypothetical protein / 1.82
0 / intergenic region 985872-985962 / 1.038409015
NMB1716 / membrane fusion protein / 1.82
NMB1806 / GTP-binding protein / 1.81
NMB1470 / hypothetical protein / 1.81
0 / intergenic region 1416539-1416658 / 1.041580538
NMB1865 / hypothetical protein / 1.80
NMB1028 / hypothetical protein / 1.80
0 / intergenic region 1079879-1080123 / 1.042093141
NMB1020 / hypothetical protein / 1.80
NMB0273 / hypothetical protein / 1.80
0 / intergenic region 1884111-1884416 / 1.044727216
0 / intergenic region 252422-252732 / 1.044903274
0 / intergenic region 57899-58017 / 1.045519045
0 / intergenic region 2313-2516 / 1.045580349
0 / intergenic region 1665028-1665174 / 1.045583857
0 / intergenic region 873944-874099 / 1.045692298
0 / intergenic region 2251706-2251862 / 1.046356809
NMB2115 / hypothetical protein / 1.80
NMB0702 / competence protein ComA / 1.80
NMB0766 / GTP-binding protein LepA / 1.80
0 / intergenic region 2253963-2254306 / 1.047195121
NMB0310 / hypothetical protein / 1.80
0 / intergenic region 332988-333175 / 1.047764809
NMB0860 / hypothetical protein / 1.79
NMB0610 / spermidine putrescine ABC transporter, ATP-binding protein / 1.79
NMB1852 / hypothetical protein / 1.79
NMB0515 / hypothetical protein / 1.79
NMB0188 / hypothetical protein / 1.79
NMB1832 / signal peptidase II / 1.79
NMB0380 / transcriptional regulator, Crp Fnr family / 1.79
NMB0888 / hypothetical protein / 1.79
NMB0183 / hypothetical protein / 1.78
0 / intergenic region 1681519-1681631 / 1.050875814
NMB1978 / frataxin-like protein / 1.78
NMB1501 / HesA MoeB ThiF family protein / 1.78
NMB0099 / hypothetical protein / 1.78
0 / intergenic region 417792-418069 / 1.052033481
NMB0968 / hypothetical protein / 1.78
NMB1045 / hypothetical protein / 1.78
0 / intergenic region 297978-299359 / 1.053383758
0 / intergenic region 1292126-1292247 / 1.05341312
NMB1771 / hypothetical protein / 1.77
0 / intergenic region 367397-367551 / 1.053911257
NMB1726 / hypothetical protein / 1.77
NMB2022 / hypothetical protein / 1.77
0 / intergenic region 1898545-1898695 / 1.055599663
0 / intergenic region 94826-96814 / 1.056440439
NMB0450 / hypothetical protein / 1.77
NMB1915 / hypothetical protein / 1.77
0 / intergenic region 480554-481823 / 1.057080291
NMB0270 / putative bioH protein / 1.77
NMB2065 / hemK protein / 1.76
0 / intergenic region 301432-301616 / 1.05842684
0 / intergenic region 2194279-2194491 / 1.059785857
NMB0237 / hypothetical protein / 1.76
0 / intergenic region 973985-974082 / 1.060500499
0 / intergenic region 1616879-1617003 / 1.060996992
0 / intergenic region 822185-822447 / 1.061513374
#N/A / #N/A / 1.062150594
NMB1986 / hypothetical protein / 1.75
NMB0872 / hypothetical protein / 1.75
0 / intergenic region 426419-426664 / 1.063523074
NMB1987 / tRNA modification GTPase / 1.75
NMB0111 / methionyl-tRNA formyltransferase / 1.75
NMB0115 / nitrogen assimilation regulatory protein NtrX / 1.75
0 / intergenic region 55181-55465 / 1.066181676
NMB0542 / hypothetical protein / 1.75
NMB2033 / hypothetical protein / 1.75
NMB0177 / putative sodium alanine symporter / 1.75
0 / intergenic region 2161522-2161862 / 1.067719323
NMB2154 / electron transfer flavoprotein, alpha subunit / 1.75
0 / intergenic region 1212627-1212779 / 1.0683657
NMB2109 / hypothetical protein / 1.75
NMB0821 / hypothetical protein / 1.74
NMB0579 / copper ABC transporter, ATP-binding protein / 1.74
0 / intergenic region 207050-207301 / 1.069560915
NMB0261 / geranyltranstransferase / 1.74
NMB1281 / transcription-repair coupling factor / 1.74
0 / intergenic region 188566-188663 / 1.070747168
NMB0943 / 5,10-methylenetetrahydrofolate reductase / 1.74
NMB0226 / hypothetical protein / 1.74
NMB2131 / hypothetical protein / 1.74
NMB1274 / hypothetical protein / 1.74
0 / intergenic region 1537792-1537951 / 1.072263174
0 / intergenic region 1293358-1293558 / 1.072601705
NMB0738 / hypothetical protein / 1.73
0 / intergenic region 691188-691406 / 1.072723447
NMB0254 / NADH dehydrogenase kappa subunit / 1.73
NMB1927 / lacto-N-neotetraose biosynthesis glycosyl transferase-related protein / 1.73
NMB1985 / adhesion and penetration protein / 1.73
0 / intergenic region 796103-796245 / 1.074170733
0 / intergenic region 996912-997055 / 1.074705348
NMB1777 / hypothetical protein / 1.73
0 / intergenic region 1506437-1506584 / 1.075518234
NMB0811 / UDP-N-acetylpyruvoylglucosamine reductase / 1.73
NMB1389 / RpiR YebK YfhH family protein / 1.73
NMB0951 / succinate dehydrogenase catalytic subunit / 1.72
0 / intergenic region 21171-21469 / 1.076045014
0 / intergenic region 1939657-1939770 / 1.076275307
NMB1550 / hypothetical protein / 1.72
0 / intergenic region 145551-145841 / 1.076335242
NMB2144 / RNA polymerase sigma-70 factor / 1.72
NMB0344 / BolA YrbA family protein / 1.72
NMB0214 / oligopeptidase A / 1.72
0 / intergenic region 62772-63177 / 1.07844959
0 / intergenic region 359975-360070 / 1.078632098
0 / intergenic region 571604-571885 / 1.078769222
0 / intergenic region 1980691-1980890 / 1.079013252
0 / intergenic region 2096479-2096641 / 1.080035641
NMB2152 / hypothetical protein / 1.71
NMB1218 / hypothetical protein / 1.71
NMB0118 / DNA topoisomerase I / 1.71
NMB1426 / hypothetical protein / 1.71
NMB1353 / aldehyde dehydrogenase family protein / 1.71
0 / intergenic region 494015-494236 / 1.081821253
NMB2042 / spermidine putrescine ABC transporter, ATP-binding protein / 1.71
NMB2143 / hypothetical protein / 1.71
NMB0402 / sodium proline symporter / 1.71
NMB0886 / fimbrial protein FimT / 1.71
NMB0633 / iron(III) ABC transporter, permease protein / 1.70
0 / intergenic region 561418-561820 / 1.083573521
NMB1176 / hypothetical protein / 1.70
NMB1527 / ADP-heptose--LPS heptosyltransferase II / 1.70
NMB0780 / hypothetical protein / 1.70
0 / intergenic region 1646455-1646548 / 1.084687366
0 / intergenic region 2220615-2220830 / 1.084965961
NMB0348 / hypothetical protein / 1.70
NMB0408 / bacitracin resistance protein / 1.70
NMB1711 / transcriptional regulator, GntR family / 1.70
NMB0767 / 5-methylthioadenosine nucleosidase S-adenosylhomocysteine nucleosidase / 1.70
0 / intergenic region 1934436-1934962 / 1.086483458
NMB0840 / hypothetical protein / 1.70
0 / intergenic region 2219632-2219759 / 1.088151537
0 / intergenic region 1044580-1045039 / 1.088217869
0 / intergenic region 1003687-1003896 / 1.088434539
NMB0465 / hypothetical protein / 1.70
NMB1026 / hypothetical protein / 1.70
0 / intergenic region 2144089-2144426 / 1.089891154
NMB1651 / alanine racemase / 1.70
0 / intergenic region 976151-976709 / 1.090082908
NMB1730 / TonB protein / 1.70
0 / intergenic region 1589690-1589875 / 1.090917241
NMB0677 / hypothetical protein / 1.70
0 / intergenic region 1538384-1538733 / 1.092272769
0 / intergenic region 1952321-1952629 / 1.092456241
NMB1526 / SsrA-binding protein / 1.69
NMB1731 / hypothetical protein / 1.69
NMB1909 / Maf-like protein / 1.69
NMB0543 / putative L-lactate permease / 1.69
NMB1412 / FrpC operon protein / 1.69
NMB0497 / hemagglutinin hemolysin-related protein / 1.69
0 / intergenic region 309522-309927 / 1.094605066
NMB1236 / hypothetical protein / 1.69
0 / intergenic region 1757301-1757391 / 1.096123628
0 / intergenic region 471054-472100 / 1.096262353
NMB2072 / hypothetical protein / 1.69
NMB1381 / HesB YadR YfhF family protein / 1.69
0 / intergenic region 2119311-2119499 / 1.096963921
0 / intergenic region 1031833-1032556 / 1.097811074
0 / intergenic region 1563984-1564138 / 1.097907099
NMB1338 / putative isomerase / 1.69
NMB1706 / hypothetical protein / 1.69
NMB0053 / hypothetical protein / 1.69
NMB0326 / octaprenyl-diphosphate synthase / 1.69
NMB1718 / hypothetical protein / 1.69
0 / intergenic region 1558626-1559635 / 1.100089131
0 / intergenic region 1551726-1551862 / 1.100138668
NMB0561 / grpE protein / 1.68
NMB0816 / hypothetical protein / 1.68
0 / intergenic region 2046989-2047186 / 1.100750531
NMB1506 / arginyl-tRNA synthetase / 1.68
0 / intergenic region 1303119-1303362 / 1.101054935
0 / intergenic region 349617-349787 / 1.101693158
NMB0957 / dihydrolipoamide dehydrogenase / 1.68
0 / intergenic region 686784-686964 / 1.102045652
0 / intergenic region 233254-233554 / 1.102079095
NMB1895 / DNA adenine methylase, truncation / 1.68
NMB0196 / ribonuclease E / 1.68
NMB1442 / DNA mismatch repair protein / 1.68
NMB1760 / hypothetical protein / 1.68
NMB0170 / septum formation inhibitor / 1.67
0 / intergenic region 1344861-1345082 / 1.10377888
NMB1069 / gamma-glutamyl kinase / 1.67
0 / intergenic region 27737-27851 / 1.105017003
NMB0439 / hypothetical protein / 1.67
NMB1460 / single-strand binding protein / 1.67
NMB2142 / hypothetical protein / 1.67
NMB1510 / thermonuclease family protein / 1.66
NMB0656 / hypothetical protein / 1.66
NMB0947 / dihydrolipoamide dehydrogenase / 1.66
NMB0189 / hypothetical protein / 1.66
NMB1791 / cytoplasmic axial filament protein / 1.66
NMB1043 / hypothetical protein / 1.66
NMB1918 / acyl-carrier-protein S-malonyltransferase / 1.66
NMB0721 / translation initiation factor 3 / 1.66
NMB0733 / dithiobiotin synthetase / 1.66
NMB0169 / 50S ribosomal protein L17 / 1.66
NMB1034 / isopropylmalate isomerase small subunit / 1.66
NMB0590 / tRNA (guanine-N1)-methyltransferase / 1.66
NMB0833 / type I restriction enzyme-related protein / 1.66
0 / intergenic region 1647419-1647695 / 1.111520347
0 / intergenic region 1640447-1640722 / 1.111546691
NMB0640 / hypothetical protein / 1.66
0 / intergenic region 1294987-1295170 / 1.112009615
0 / intergenic region 911986-912410 / 1.113374373
NMB0528 / hypothetical protein / 1.66
NMB0876 / 50S ribosomal protein L25 / 1.65
NMB0728 / phenylalanyl-tRNA synthetase beta subunit / 1.65
NMB0584 / FrpC operon protein / 1.65
0 / intergenic region 1531538-1531792 / 1.114049089
0 / intergenic region 607741-607878 / 1.11413832
0 / intergenic region 1660920-1661112 / 1.114410251
NMB1801 / lipid A biosynthesis lauroyl acyltransferase / 1.65
NMB1919 / ABC transporter, ATP-binding protein / 1.65
NMB0747 / hypothetical protein / 1.65
0 / intergenic region 746810-747004 / 1.116377729
NMB1336 / hypothetical protein / 1.65
NMB1639 / hypothetical protein / 1.65
NMB0249 / NADH dehydrogenase gamma subunit / 1.65
NMB2099 / hypothetical protein / 1.65
NMB1863 / oligoribonuclease / 1.65
NMB0277 / virulence factor MviN / 1.65
0 / intergenic region 1087422-1087645 / 1.118408451
NMB0121 / hypothetical protein / 1.65
0 / intergenic region 219854-220475 / 1.121308419
0 / intergenic region 998199-998361 / 1.121422723
NMB0726 / type II restriction enzyme HgaI / 1.65
NMB1443 / DNA polymerase III subunits gamma and tau / 1.64
NMB1868 / integrase recombinase XerC / 1.64
0 / intergenic region 473211-475580 / 1.12239495
NMB0407 / thiol:disulfide interchange protein DsbA / 1.64
NMB0536 / Na+ H+ antiporter / 1.64
NMB0043 / hypothetical protein / 1.64
NMB0507 / hypothetical protein / 1.64
NMB0759 / hypothetical protein / 1.64
0 / intergenic region 1976181-1976326 / 1.12415496
0 / intergenic region 283237-283437 / 1.124260244
NMB0103 / putative bacteriocin resistance protein / 1.63
0 / intergenic region 889399-889539 / 1.127844417
NMB1719 / efflux pump component MtrF / 1.63
NMB1233 / exodeoxyribonuclease V, alpha subunit / 1.63
0 / intergenic region 20293-20831 / 1.128435434
NMB1523 / hypothetical protein / 1.63
NMB0205 / ferric uptake regulation protein / 1.63
NMB1857 / modulator of drug activity B / 1.63
NMB0615 / putative ammonium transporter AmtB / 1.63
NMB1927 / lacto-N-neotetraose biosynthesis glycosyl transferase-related protein / 1.63
NMB0386 / phosphatidylglycerophosphatase A / 1.63
NMB1386 / putative transposase / 1.62
NMB0413 / penicillin-binding protein 2 / 1.62
NMB0186 / undecaprenyl pyrophosphate synthetase / 1.62
0 / intergenic region 327435-327936 / 1.133163776
0 / intergenic region 1784053-1784891 / 1.133200664
NMB1586 / hypothetical protein / 1.62
NMB1369 / hypothetical protein / 1.62
NMB0113 / hypothetical protein / 1.62
NMB0114 / putative nitrogen regulation protein NtrY / 1.62
0 / intergenic region 449749-450085 / 1.133769841
0 / intergenic region 1991839-1992526 / 1.133839943
NMB1231 / ATP-dependent protease La / 1.62
NMB0286 / hypothetical protein / 1.62
0 / intergenic region 141219-141374 / 1.135911345
NMB1814 / 3-dehydroquinate synthase / 1.62
NMB0347 / D-tyrosyl-tRNA deacylase / 1.62
0 / intergenic region 2139799-2139954 / 1.136156639
NMB0155 / 30S ribosomal protein S14 / 1.62
NMB0573 / transcriptional regulator, AsnC family / 1.62
0 / intergenic region 1249318-1249539 / 1.137203955
0 / intergenic region 2002041-2003050 / 1.137264887
NMB0531 / hypothetical protein / 1.62
NMB1004 / hypothetical protein / 1.61
NMB1464 / hypothetical protein / 1.61
NMB2075 / BirA protein Bvg accessory factor / 1.61
NMB0354 / hypothetical protein / 1.61
NMB0665 / coproporphyrinogen III oxidase / 1.61
0 / intergenic region 439798-440169 / 1.140126086
0 / intergenic region 1484154-1484247 / 1.140216958
NMB1772 / hypothetical protein / 1.61
0 / intergenic region 540335-540456 / 1.141387767
NMB1788 / ATP-dependent DNA helicase RecG / 1.61
NMB1821 / pilin glycosylation protein PglC / 1.61
NMB1653 / hypothetical protein / 1.60
NMB1490 / hypothetical protein / 1.60
NMB1780 / putative hemolysin activation protein HecB / 1.60
NMB0676 / hypothetical protein / 1.60
0 / intergenic region 1329009-1329162 / 1.143875263
NMB1237 / recombination protein RecR / 1.60
NMB0667 / hypothetical protein / 1.60
NMB0203 / dihydrodipicolinate reductase / 1.60
NMB1507 / hypothetical protein / 1.60
NMB0562 / hypothetical protein / 1.60
NMB0372 / hypothetical protein / 1.60
NMB0384 / hypothetical protein / 1.60
NMB0532 / protease DO / 1.59
0 / intergenic region 1541196-1541408 / 1.145866248
NMB0182 / outer membrane protein Omp85 / 1.59
NMB1961 / VacJ-related protein / 1.59
NMB1288 / ribonucleotide-diphosphate reductase beta subunit / 1.59
0 / intergenic region 1642109-1642211 / 1.146279881
0 / intergenic region 1618154-1618464 / 1.147134591
0 / intergenic region 648874-649092 / 1.147548545
0 / intergenic region 652711-652948 / 1.147850067
NMB0060 / hypothetical protein / 1.59
NMB0092 / hypothetical protein / 1.59
NMB0423 / UDP-N-acetylmuramate--L-alanine ligase / 1.59
NMB0342 / intracellular septation protein A / 1.59
NMB1509 / amino acid ABC transporter, permease protein / 1.59
NMB1354 / hypothetical protein / 1.59
NMB0351 / transaldolase / 1.59
NMB2122 / MafB-related protein / 1.59
NMB1298 / ribosomal small subunit pseudouridine synthase A / 1.59
NMB2081 / hypothetical protein / 1.59
NMB1074 / acetylglutamate kinase / 1.59
NMB0894 / hypothetical protein / 1.59
NMB1419 / Holliday junction resolvase / 1.59
0 / intergenic region 1549259-1549457 / 1.151708651
NMB0550 / thiol:disulfide interchange protein DsbC / 1.58
NMB0078 / UDP-glucose 4-epimerase, truncation / 1.58
0 / intergenic region 156378-156598 / 1.15313545
0 / intergenic region 2184333-2184501 / 1.153410835
0 / intergenic region 639542-639763 / 1.153634649
0 / intergenic region 1113936-1114690 / 1.153792704
NMB0059 / dnaJ protein / 1.58
NMB1907 / putative inner membrane protein translocase component YidC / 1.58
NMB1655 / putative adenine specific methylase / 1.58
NMB2055 / transcriptional regulator, LysR family / 1.58
0 / intergenic region 722407-722578 / 1.155016342
0 / intergenic region 791624-792085 / 1.1554979
#N/A / #N/A / 1.155615899
NMB1756 / hypothetical protein / 1.58
NMB0751 / integrase recombinase XerD / 1.58
NMB0525 / putative aluminum resistance protein / 1.58
NMB1187 / hypothetical protein / 1.58
NMB1728 / biopolymer transport protein ExbD / 1.58
NMB0847 / hypothetical protein / 1.58
0 / intergenic region 2216792-2217186 / 1.156515742
NMB1785 / hypothetical protein / 1.58
NMB0698 / hypothetical protein / 1.58
NMB1088 / hypothetical protein / 1.58
0 / intergenic region 1803124-1803224 / 1.157864557
0 / intergenic region 1498059-1498268 / 1.157996883
NMB1175 / hypothetical protein / 1.58
NMB0618 / phosphoenolpyruvate synthase / 1.58
0 / intergenic region 1452061-1452190 / 1.158400682
NMB0484 / hypothetical protein / 1.57
NMB1284 / hypothetical protein / 1.57
0 / intergenic region 1361869-1362016 / 1.158807638
NMB1324 / thioredoxin reductase / 1.57
0 / intergenic region 266196-266441 / 1.160119638
NMB0810 / transcriptional regulator, TetR family / 1.57
0 / intergenic region 1775443-1775592 / 1.160676618
NMB1981 / S-ribosylhomocysteinase / 1.57
0 / intergenic region 557224-557513 / 1.16132549
NMB1947 / ABC transporter, permease protein / 1.57
NMB0575 / glycine cleavage system protein H / 1.57
0 / intergenic region 591993-592144 / 1.162192657
0 / intergenic region 1383367-1383495 / 1.162398953
NMB0185 / phosphatidate cytidylyltransferase / 1.57
NMB0259 / NADH dehydrogenase subunit N / 1.57
0 / intergenic region 2023643-2024878 / 1.162920742
NMB0863 / hypothetical protein / 1.57
0 / intergenic region 1875238-1876299 / 1.163799906
NMB0445 / putative bicyclomycin resistance protein / 1.57
NMB0843 / polyA polymerase / 1.57
NMB0632 / iron(III) ABC transporter, ATP-binding protein / 1.57
0 / intergenic region 542210-542522 / 1.165034293
0 / intergenic region 2089798-2090081 / 1.165325408
NMB1441 / putative O-methyltransferase / 1.56
NMB1548 / putative tspB protein / 1.56
0 / intergenic region 2153240-2154536 / 1.166434326
0 / intergenic region 1365958-1366317 / 1.167005269
NMB1505 / nicotinate phosphoribosyltransferase / 1.56
NMB2135 / hypothetical protein / 1.56
NMB0727 / N-6 adenine-specific DNA methylase / 1.56
NMB1008 / hypothetical protein / 1.56
NMB1778 / hypothetical protein / 1.56
NMB0176 / D-amino acid dehydrogenase small subunit / 1.56
NMB0820 / hypothetical protein / 1.56
NMB1717 / trancscriptional regulator MtrR / 1.56
NMB1976 / diaminopimelate decarboxylase / 1.56
0 / intergenic region 610795-612019 / 1.169426986
0 / intergenic region 716033-716131 / 1.169874035
0 / intergenic region 674006-674112 / 1.169881687
0 / intergenic region 1492648-1492815 / 1.170001414
NMB0961 / funZ protein / 1.56
0 / intergenic region 866362-866483 / 1.171010924
0 / intergenic region 890332-890453 / 1.171279517
NMB0332 / type IV prepilin peptidase / 1.56
0 / intergenic region 640034-640278 / 1.171572373
#N/A / #N/A / 1.171646353
0 / intergenic region 634486-635033 / 1.171980337
NMB0510 / hypothetical protein / 1.56
NMB0206 / leucyl phenylalanyl-tRNA--protein transferase / 1.56
0 / intergenic region 1698701-1701288 / 1.17253537
NMB0287 / probable ATP-dependent helicase DinG / 1.55
0 / intergenic region 1599520-1600541 / 1.17352576
NMB1594 / spermidine putrescine ABC transporter, periplasmic spermidine putrescine-binding protein / 1.55
NMB2113 / hypothetical protein / 1.55
NMB1371 / bifunctional N-succinyldiaminopimelate-aminotransferase acetylornithine transaminase protein / 1.55
0 / intergenic region 902962-903251 / 1.173861206
NMB1296 / hypothetical protein / 1.55
NMB1387 / hypothetical protein / 1.55
NMB1877 / prolyl oligopeptidase family protein / 1.55
NMB1565 / hypothetical protein / 1.55
NMB2041 / thiamin pyrophosphokinase-related protein / 1.55
NMB2069 / thiamin-phosphate pyrophosphorylase / 1.55
0 / intergenic region 1998580-1998848 / 1.178342445
NMB1313 / trigger factor / 1.55
0 / intergenic region 1333830-1334051 / 1.178646511
NMB1846 / Mrp NBP35 family protein / 1.55
NMB0357 / monofunctional biosynthetic peptidoglycan transglycosylase / 1.55
NMB1268 / hypothetical protein / 1.55
0 / intergenic region 1486778-1488547 / 1.17985494
NMB1567 / macrophage infectivity potentiator / 1.55
NMB0869 / spermidine synthase / 1.55
NMB0772 / hypothetical protein / 1.54
0 / intergenic region 801048-801152 / 1.180929474
0 / intergenic region 776873-777091 / 1.180997441
0 / intergenic region 588483-588838 / 1.181020758
0 / intergenic region 783376-783515 / 1.181234428
NMB0559 / putative ubiquinone biosynthesis protein UbiB / 1.54
NMB1309 / putative fimbrial biogenesis and twitching motility protein / 1.54
NMB0500 / hypothetical protein / 1.54
NMB0116 / DNA processing chain A / 1.54
0 / intergenic region 1635697-1635919 / 1.182574449
0 / intergenic region 918121-918433 / 1.182590972
NMB0015 / 6-phosphogluconate dehydrogenase / 1.54
NMB0329 / type IV pilus assembly protein / 1.54
NMB1928 / lacto-N-neotetraose biosynthesis glycosyl transferase LgtB / 1.54
0 / intergenic region 2058718-2058976 / 1.183278588
NMB2080 / hypothetical protein / 1.54
NMB1621 / glutathione peroxidase / 1.54
NMB2029 / homoserine kinase / 1.54
NMB1383 / chaperone protein HscB / 1.54
NMB2028 / thermoresistant gluconokinase / 1.54
NMB1290 / C-5 cytosine-specific DNA-methylase / 1.54
NMB2137 / hypothetical protein / 1.54
NMB2127 / putative protease / 1.54
NMB1009 / hypothetical protein / 1.54
0 / intergenic region 2011142-2011315 / 1.187975018
NMB2122 / MafB-related protein / 1.54
NMB1957 / hypothetical protein / 1.53
NMB1519 / thiol:disulfide interchange protein precursor / 1.53
NMB0754 / hypothetical protein / 1.53
NMB0065 / hypothetical protein / 1.53
NMB1887 / triosephosphate isomerase / 1.53
NMB0967 / anthranilate phosphoribosyltransferase / 1.53
NMB1483 / putative lipoprotein NlpD / 1.53
NMB1029 / aspartate ammonia-lyase / 1.53
NMB1687 / hypothetical protein / 1.53
NMB1514 / DNA polymerase III, epsilon subunit / 1.53
NMB2017 / ComEA-related protein / 1.53
0 / intergenic region 1489595-1489847 / 1.191043553
NMB1729 / biopolymer transport protein ExbB / 1.53
NMB0323 / hypothetical protein / 1.53
0 / intergenic region 844561-844860 / 1.191474638
NMB1827 / DNA polymerase III, alpha subunit / 1.53
0 / intergenic region 487552-487701 / 1.192031791
0 / intergenic region 196148-197444 / 1.192034903
NMB1617 / putative tellurite resistance protein / 1.52
NMB0718 / ferrochelatase / 1.52
0 / intergenic region 949837-950214 / 1.193086178
NMB1522 / FKBP-type peptidyl-prolyl cis-trans isomerase SlyD / 1.52
NMB1826 / hypothetical protein / 1.52
0 / intergenic region 1670391-1671728 / 1.193967837
0 / intergenic region 18928-19266 / 1.194320916
0 / intergenic region 1967163-1967565 / 1.194944497
NMB1572 / aconitate hydratase / 1.52
NMB1219 / putative transporter / 1.52
0 / intergenic region 1663151-1663326 / 1.195535445
0 / intergenic region 271163-271291 / 1.195770496
NMB1871 / hypothetical protein / 1.52
NMB1753 / VapD-related protein / 1.52
0 / intergenic region 19642-19917 / 1.196494152
0 / intergenic region 404811-405843 / 1.196521788
0 / intergenic region 1742635-1742828 / 1.196993054
NMB0503 / hypothetical protein / 1.52
NMB0942 / 50S ribosomal protein L31 / 1.52
0 / intergenic region 823788-824002 / 1.198073927
NMB1066 / hypothetical protein / 1.52
NMB0387 / ABC transporter, ATP-binding protein / 1.52
0 / intergenic region 1475010-1475120 / 1.198359879
NMB0782 / DNA repair protein RadA / 1.52
0 / intergenic region 104950-105234 / 1.198645594
0 / intergenic region 1796421-1796822 / 1.19895274
0 / intergenic region 373729-373859 / 1.199049573
NMB1702 / 3-ketoacyl-(acyl-carrier-protein) reductase / 1.52
0 / intergenic region 1468248-1470525 / 1.199849977
NMB2037 / hypothetical protein / 1.52
NMB1278 / site-specific recombinase / 1.52
0 / intergenic region 2250971-2251492 / 1.200878321
0 / intergenic region 910697-911745 / 1.201259217
0 / intergenic region 39918-40010 / 1.201346644
0 / intergenic region 165199-165344 / 1.201370449
NMB1587 / putative protease / 1.52
NMB2128 / CinA-related protein / 1.52
NMB1686 / peptide chain release factor 1 / 1.51
NMB1016 / hypothetical protein / 1.51
NMB0498 / hypothetical protein / 1.51
NMB0128 / 50S ribosomal protein L1 / 1.51
0 / intergenic region 681623-681722 / 1.203034069
0 / intergenic region 1018793-1018972 / 1.203295002
0 / intergenic region 1524949-1525292 / 1.203921421
NMB0797 / hypothetical protein / 1.51
0 / intergenic region 381390-381741 / 1.20428522
NMB1378 / hypothetical protein / 1.51
NMB1253 / hypothetical protein / 1.51
NMB1243 / Holliday junction DNA helicase RuvB / 1.51
NMB0126 / transcription antitermination protein NusG / 1.51
0 / intergenic region 1512131-1513087 / 1.205266938
NMB1150 / dihydroxy-acid dehydratase / 1.51
NMB0775 / hypothetical protein / 1.51
NMB1118 / hypothetical protein / 1.51
NMB0389 / aldose 1-epimerase / 1.51
NMB2038 / PemK-related protein / 1.51
NMB1423 / hypothetical protein / 1.51
0 / intergenic region 346130-346372 / 1.207259647
NMB1959 / hypothetical protein / 1.51
0 / intergenic region 1690009-1690732 / 1.207933995
NMB1216 / lipoyl synthase / 1.51
0 / intergenic region 2190314-2190702 / 1.208912625
NMB1241 / tRNA nucleotidyltransferase / 1.50
NMB0594 / sensor histidine kinase / 1.50
NMB0104 / hypothetical protein / 1.50
NMB1036 / isopropylmalate isomerase large subunit / 1.50
0 / intergenic region 458842-459359 / 1.2103162
NMB0222 / hypothetical protein / 1.50
NMB0074 / capsule polysaccharide export ATP-binding protein CtrD / 1.50
NMB1046 / threonine synthase / 1.50
NMB1062 / hypothetical protein / 1.50
NMB1064 / hypothetical protein / 1.50
NMB0578 / copper ABC transporter, periplasmic copper-binding protein / 1.50
NMB0283 / hypothetical protein / 1.50
NMB0476 / hypothetical protein / 1.50
0 / intergenic region 914751-915012 / 1.211938511
0 / intergenic region 784437-784635 / 1.212089885
0 / intergenic region 1788319-1788748 / 1.212114988
NMB0689 / transcription elongation factor GreB / 1.50
NMB1072 / prolipoprotein diacylglyceryl transferase / 1.50
0 / intergenic region 1264858-1265773 / 1.212380172
NMB1703 / 3-oxoacyl-(acyl carrier protein) synthase / 1.50
NMB0156 / 30S ribosomal protein S8 / 1.50
NMB0711 / hypothetical protein / 1.50
0 / intergenic region 1409875-1409971 / 1.213992233
NMB2002 / hypothetical protein / 1.50
0 / intergenic region 2106848-2107160 / 1.214799577
NMB1916 / 3-oxoacyl-(acyl carrier protein) synthase / 1.50
0 / intergenic region 780641-780960 / 1.215306261
0 / intergenic region 1743459-1743743 / 1.215351726
NMB0399 / exodeoxyribonuclease III / 1.50
Downregulated genes
NMB1712 / L-lactate permease-related protein / 0.77
0 / intergenic region 1145284-1145374 / 3.036152844
NMB1819 / hypothetical protein / 0.76
0 / intergenic region 1363625-1363717 / 3.10853264
NMB1667 / hypothetical protein / 0.72
NMB1492 / hypothetical protein / 0.71
NMB0650 / hypothetical protein / 0.70
NMB1102 / hypothetical protein / 0.56

Table S1. Reports the expression ratios of LL-37 induced vs LL-37 null cultures over a period of 30 min. Genes whose expression ratios changed greater than 1.5 fold were considered as up or down regulated.

aopen reading frame (ORF) ID is N. meningitidis Serogroup B genome sequence (27)