AMERICAN FEDERATION FOR AGING RESEARCH

55 West 39th Street, 16th floor, New York, NY 10018 (212) 703-9977

2013 New Investigator Awards in Alzheimer’s Disease

Supported by The Rosalinde and Arthur Gilbert Foundation and The Diane and Guilford Glazer Foundation in

Partnership with the American Federation for Aging Research

Grant Instruction Sheet

Instruction Sheet: DO NOT INCLUDE with your grant application!

Please carefully read the application guidelines on the AFAR website, http://www.afar.org/research/funding/new-investigator-awards/ before completing this application.

INSTRUCTIONS: The application must be submitted via http://www.afar.org/grants/ no later than December 17, 2012, at 5:00 p.m, EST as a single PDF application, not to exceed 5 MB. Files formatted solely for Macintosh will not be accepted. No late submissions or submissions sent by regular mail or facsimile will be accepted. The application file should be named as follows: “last name, first name”; for example “Smith, John.doc” or “Smith, John.pdf”.

Upon submission, you will receive an automated confirmation of receipt from . If you DO NOT receive a receipt for your application, please contact the AFAR office right away. Please set your spam filter accordingly. All applicants will also receive an email notification in mid-January upon completion of the administrative review.

This application consists of the application form, and must be accompanied by the following sections (1 to 5) and be submitted in this order:

1. Research proposal in eight pages or less, including figures, addressing each of the following (Identify each section by the corresponding letter):

a. Brief (1/4 of a page) description on research plan in lay (non-scientific) terms;

b. List of specific aims of the research plan;

c. Background information needed to understand the importance of the problem;

d. Significance of this research to the field of Alzheimer’s disease and/or healthy brain aging;

e. Preliminary data produced by the Principal Investigator (if any);

f.  Experimental design, with key methodologies; include statistical methods; include pitfalls;

g. Brief discussion of implications for future research in your lab and elsewhere;

h. Relation of this work to current research in your lab;

i.  Reviewer comments (applies only to applicants who are re-applying and received reviewer critiques);

j.  Facilities available; include statement of space committed to your use, and space shared with others.

2. Complete titles of essential references (not to exceed two pages).

3. NIH-style biosketch and bibliography of PI (and collaborators, if applicable), not exceeding four pages each. Include past and current funding.

4. Include only the application and required materials. If absolutely necessary for the review, the applicant may include one manuscript of a paper that has been accepted for publication but has not yet appeared in print. Do not include any reprints or papers that have been submitted but not yet accepted for publication.

Sections 1-4 should be submitted with the application as a single PDF File.


5. Two letters of support (i.e. Supporting Materials). Each letter should be written by a faculty member or senior professional who is well-acquainted with the candidate’s capabilities, activities, and accomplishments. At least one of the letters should come from an individual with expertise in Alzheimer’s disease and who will be willing to provide consultation on these aspects as needed. Letters are NOT to be included in the application, but must be submitted directly to AFAR by the letter writer (NOT the applicant), to http://www.afar.org/grants/ as a Word or PDF file. Letters submitted via regular mail are also accepted.

6. Form confirming institutional commitment to the candidate must be completed by the Dean or Department Chair. The form is NOT to be included in the application, but must be submitted directly to AFAR by the person completing the form (NOT the applicant), to http://afar.org/grants/ as a Word or PDF file. The form submitted via regular mail is also accepted.

Sections 5 and 6 are NOT to be included in the application.

These pages are the Instruction Sheet: DO NOT INCLUDE THEM with your grant application!


2013 New Investigator Awards in Alzheimer’s Disease

Supported by The Rosalinde and Arthur Gilbert Foundation and The Diane and Guilford Glazer Foundation in

Partnership with the American Federation for Aging Research

Grant Application

[Title page: should be the first page of your application]

ONLY ONE APPLICATION PER INDIVIDUAL MAY BE SUBMITTED EACH YEAR

Title of Proposal:
Institution:
Proposed Start Date:
Proposed End Date:
Total Funds Requested:
(not to exceed $100,000 total) / Name, title and address of official authorizing proposal:
E-mail:
Phone:
Signature of Official:
Applicant:
Title:
Degree(s):
Mailing Address:
City, State, Zip:
E-mail:
Phone:
Signature of PI: / Names of two people who will submit letters of support:
1.
2.

ABSTRACT: Provide a summary of your research proposal. Underline key words and species used for the proposed research. Do not exceed space provided.


2013 New Investigator Award in Alzheimer’s Disease Application - Page 2

1. List all current sources of research support using the format shown below. This should include project titles, your role on the project, source of funds, periods of support, and current year direct costs. Do not include amounts for overhead or indirect costs. Briefly summarize the specific aims, and note whether or not the research aims overlap those for which AFAR support is sought. Use additional pages if needed. If you have already received major extramural funding for research on aging (such as an R01 grant) you are not eligible to apply.

Example: "Role of T cells in zebrafish aging." Jane Applicant, PI. Source: NIH/NCI. Period of support: 7/1/2011 - 6/30/2013. Current year direct costs: $50,000. Specific Aims: 1) to develop new assays for assessment of T cell function in aging and calorically restricted zebrafish; 2) to determine the frequencies of T cell receptor mutations in aging and calorically restricted zebrafish. No overlap with AFAR application.

Example: "Claude Pepper Center, Project 3: Zebrafish: Pets or Food?" Center PI: John Professor. Project 3 PI: Jane Applicant. Source: NIH/NIA. Period of support of pilot project: 5/1/2012 - 4/30/2013. Current year direct costs: $56,789. Specific Aims: 1) One year pilot grant to study suitability of excess laboratory zebrafish as commercial pet or food sources. No overlap with AFAR project.

2. List all pending applications for research support using the format shown above. Applications made to other sponsors will not prejudice the application to AFAR. In the event that funding for research with comparable specific aims is secured from another source, AFAR must be notified at once. Use additional pages if needed.


2013 New Investigator Award in Alzheimer’s Disease Application - Page 3

3. BUDGET

Indicate if you are applying for a one- or two-year grant: one-year ____ two-year ____

Year I Year II

a. Personnel

b. Equipment

c. Supplies

d. Travel $ 1,500

e. Other Expenses

f. 8% Overhead/Indirect costs

TOTAL

§  Personnel can be used for P.I., research assistant(s), technician(s), postdoc(s), or graduate student(s)

§  $1,500 is budgeted to cover travel expenses to attend the AFAR Grantee Conference

§  If overhead/indirect costs are requested, the amount may not exceed 8% ($7,407) over one OR two years

§  Total amount requested may not exceed $100,000 over one OR two years

(note: AFAR does not provide funding for the purchase of personal computers or laptops or other costs not directly related to the research project, such as tuition)

4. BUDGET DETAIL AND JUSTIFICATION – Use as much space as needed

5. Does the research plan include use of human subjects? YES NO

Does the research plan include use of animal subjects? YES NO

Applicants should note that IRB certification (for human subjects) and/or Animal Use Committee approval (for animal subjects) must be provided to AFAR before a grant award can be made.

Applicants are suggested to consult the AFAR website at http://www.afar.org/research/funding/animal-use/ for advice on human and animal usage. The website includes a helpful set of guidelines for optimal use of rodents in aging research projects.

6. Month and Year the candidate received the terminal degree (M.D., Ph.D. or equivalent.) _____/_____

7. Does the candidate have independent investigator status at his/her institution?

YES NO

8. Indicate the candidate’s % of time/effort that will be spent on the planned project:

______%

9. a. Have you previously applied for an AFAR Grant? Yes_____ No_____

b. If yes, have you previously received any AFAR Grant? Yes_____ No _____

If yes, indicate year of submission and title of the proposal: ______

2013 New Investigator Award in Alzheimer’s Disease Application, Page 4 Applicant's Name:

[Start text of grant application and additional materials here, in the order as listed on the instructions page. Insert page number and applicant's name at the top of each page, and use Arial font that is not smaller than 12 point with at least 1 inch margins on all sides. Any figures used must be included within the 8 page limit.]