Supplementary table 1 for reviewer. The adjusted odds ratios for risk factors of metabolic syndrome in more than 50 years old subjects
Control(n=1,717) / Any adenomas
(n=1,023) / Type of adenomas / Number of adenomas
Advanced adenoma
(n=119) / Low-risk adenoa
(n=904) / 1-2
(n=816) / 3+
(n=207)
No. / No. / OR (95% CI) / No. / OR (95% CI) / No. / OR (95% CI) / No. / OR(95% CI) / No. / OR(95% CI)
BMI (kg/m2)
<25 / 1,217 / 643 / 1.0 / 74 / 1.0 / 569 / 1.0 / 525 / 1.0 / 118 / 1.0
≥25 / 500 / 380 / 1.26 (1.06-1.50) / 45 / 1.26 (0.85-1.87) / 335 / 1.27 (1.06-1.51) / 291 / 1.21 (1.01-1.46) / 89 / 1.52 (1.12-2.07)
Waist circumference (cm)
<90 in male / <80 in female / 796 / 489 / 1.0 / 62 / 1.0 / 427 / 1.0 / 391 / 1.0 / 98 / 1.0
≥90 in male / ≥80 in female / 921 / 534 / 1.37 (1.15-1.64) / 57 / 1.24 (0.83-1.86) / 477 / 1.39 (1.16-1.67) / 425 / 1.28 (1.06-1.55) / 109 / 1.83 (1.33-2.51)
Blood pressure (mmHg)
SBP<130 and DBP<85 / 1,070 / 599 / 1.0 / 63 / 1.0 / 536 / 1.0 / 477 / 1.0 / 122 / 1.0
SBP≥130 or DBP≥85 / 647 / 424 / 1.06 (0.89-1.25) / 56 / 1.33 (0.90-1.96) / 368 / 1.03 (0.86-1.22) / 339 / 1.08 (0.90-1.29) / 85 / 0.97 (0.71-1.32)
Triglyceride (mg/dl)
<150 / 1,374 / 716 / 1.0 / 77 / 1.0 / 639 / 1.0 / 582 / 1.0 / 134 / 1.0
≥150 / 343 / 307 / 1.39 (1.15-1.68) / 42 / 1.60 (1.06-2.41) / 265 / 1.36 (1.12-1.65) / 234 / 1.36 (1.11-1.66) / 73 / 1.52 (1.10-2.11)
Fatty blood glucose (mg/dl)
<110 / 1,536 / 890 / 1.0 / 99 / 1.0 / 791 / 1.0 / 719 / 1.0 / 171 / 1.0
≥110 / 181 / 133 / 1.10 (0.85-1.41) / 20 / 1.43 (0.85-2.41) / 113 / 1.05 (0.81-1.37) / 97 / 1.02 (0.78-1.34) / 36 / 1.40 (0.92-2.11)
HDL cholesterol (mg/dl)
≥40 in male / ≥50 in female / 1,466 / 880 / 1.0 / 104 / 1.0 / 776 / 1.0 / 700 / 1.0 / 180 / 1.0
<40 in male / <50 in female / 251 / 143 / 1.04 (0.82-1.32) / 15 / 0.98 (0.55-1.74) / 128 / 1.05 (0.82-1.34) / 16 / 1.04 (0.81-1.34) / 27 / 1.06 (0.67-1.67)
No. of risk factor for MS *
<3 / 1,463 / 828 / 1.0 / 98 / 1.0 / 730 / 1.0 / 665 / 1.0 / 163 / 1.0
≥3 / 254 / 195 / 1.24 (1.00-1.54) / 21 / 1.09 (0.66-1.81) / 174 / 1.26 (1.01-1.58) / 151 / 1.21 (0.96-1.53) / 44 / 1.37 (0.94-2.00)
Adjusted by sex, age, education, smoking, alcohol and family history of colorectal cancer
Supplementary table 2 for reviewer. The adjusted odds ratios for risk factors of metabolic syndrome in more than 50 years old subjects
(n=1,717) / Location of adenomas
Right colon
(n=464) / Left colon
(n=260) / Rectum
(n=66) / Multiple location
(n=233)
No. / No. / OR (95% CI) / No. / OR (95% CI) / No. / OR (95% CI) / No. / OR (95% CI)
BMI(kg/m2)
<25 / 1,217 / 286 / 1.0 / 167 / 1.0 / 46 / 1.0 / 144 / 1.0
≥25 / 500 / 178 / 1.40 (1.12-1.75) / 93 / 1.17 (0.88-1.55) / 20 / 0.91 (0.53-1.56) / 89 / 1.25 (0.93-1.68)
Waist circumference(cm)
<90 in male / <80 in female / 796 / 215 / 1.0 / 134 / 1.0 / 27 / 1.0 / 113 / 1.0
≥90 in male / ≥80 in female / 921 / 249 / 1.33 (1.05-1.67) / 126 / 1.16 (0.87-1.54) / 39 / 1.88 (1.09-3.24) / 120 / 1.67 (1.23-2.26)
Blood pressure(mmHg)
SBP<130 and DBP<85 / 1,070 / 281 / 1.0 / 148 / 1.0 / 38 / 1.0 / 132 / 1.0
SBP≥130 or DBP≥85 / 647 / 183 / 1.01 (0.81-1.25) / 112 / 1.12 (0.85-1.47) / 28 / 1.13 (0.68-1.89) / 101 / 1.07 (0.80-1.44)
Triglyceride(mg/dl)
<150 / 1,374 / 335 / 1.0 / 182 / 1.0 / 48 / 1.0 / 151 / 1.0
≥150 / 343 / 129 / 1.35 (1.06-1.72) / 78 / 1.37 (1.01-1.85) / 18 / 1.18 (0.67-2.08) / 82 / 1.57 (1.15-2.15)
Fatty blood glucose (mg/dl)
<110 / 1,536 / 413 / 1.0 / 227 / 1.0 / 57 / 1.0 / 193 / 1.0
≥110 / 181 / 51 / 0.93 (0.67-1.31) / 33 / 1.11 (0.74-1.67) / 9 / 1.15 (0.55-2.39) / 40 / 1.42 (0.96-2.11)
HDL cholesterol (mg/dl)
≥40 in male / ≥50 in female / 1,466 / 394 / 1.0 / 225 / 1.0 / 54 / 1.0 / 207 / 1.0
<40 in male / <50 in female / 251 / 70 / 1.08 (0.80-1.45) / 35 / 1.03 (0.70-1.53) / 12 / 1.34 (0.70-2.60) / 26 / 0.87 (0.55-1.37)
No. of risk factor for MS *
<3 / 1,463 / 380 / 1.0 / 212 / 1.0 / 53 / 1.0 / 183 / 1.0
≥3 / 254 / 84 / 1.19 (0.90-1.57) / 48 / 1.20 (0.85-1.71) / 13 / 1.28 (0.68-2.40) / 50 / 1.41 (0.99-2.02)
Adjusted by sex, age, education, smoking, alcohol and family history of colorectal cancer