January 2011
CURRICULUM VITAE
ALICE MAROUDAS
PERSONAL DATA
Address: 47 Ha’Choresh St, Kiryat Tivon. Tel: 04337315
Business Address: Department of Biomedical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel
Date of Birth: May 8, 1933 (Poland)
Nationality: British/Israeli
Marital Status: Married
School Education:
Primary Education: none, due to war
Secondary Education: 19471949, Paris, France
1950, Johannesburg, South Africa. Matriculated in South Africa in 1950, 4 Distinctions.
ACADEMIC DEGREES:
19511955 Chemical Engineering, University of Witwatersrand, Johannesburg, South Africa.
1961 D.I.C., Ph.D., University of London
PostGraduate Studies
19561957 Research at Ecole Centrale, Paris, on Distillation in Wetted Wall Columns (Heat and Mass Transfer)
1957 Diplome Superieur with distinction, University of Paris.
19571960 Research in the Chemical Engineering Department at Imperial College, on the Flow of Fluid and Particle Deposition in Model Filter Beds.
PROFESSIONAL EXPERIENCE:
19551956 Research Officer at the Chamber of Mines Laboratories, Johannesburg. Comparison between Different Methods of Measuring the Surface Area of Fine Particles; Experimental Study of the Resistance of Wire Mesh Screen to Air Flow; Development of Dust Respirators
1962 Research Fellow in the Chemistry Department, University of Reading. Research on The Heat of Mixing of Hydrocarbons
19631965 Parttime work due to family commitments.
(a) Editing and translating of scientific books and papers.
(b) 19631964: Parttime teaching of Chemistry at Reading
(c) 19641965: Parttime teaching of Heat and Mass Transfer to chemical Engineering Students (2nd and 3rd year) at the Borough Polytechnic, London
19661970 Research Fellow, Biomechanics Unit, Department of Mechanical Engineering, Imperial College, London.
19701976 Lecturer in Biomechanics in the Mechanical Engineering Department, Imperial College. In charge of the Physical Biochemistry Sections of the Biomechanics Unit. Just prior to leaving fulltime employment at Imperial College promoted to Reader Equivalent Research Grade.
19761981 Head of Chemistry Section of the Bone & Joint Research Unit; Arthritis & Rheumatism Council Senior Lecturer, The London Hospital Medical College.
19761981 Consultant, Biomechanics Unit, Imperial College.
19811982 Weizmann Institute, Rehovot, Visiting Scientist supported by Israel Academy Royal Society Fellowship.
19822001 Full Professor, Dept. of Biomedical Engineering, Technion, Haifa, Israel. Head of the Laboratories for Studies of Connective Tissue and Joint Disease.
2001 - Professor Emeritus, Dept. of Biomedical Engineering, Technion, Haifa, Israel
Head of the Laboratories for Studies of Connective Tissue and Joint Disease.
TEACHING EXPERIENCE:
19721978 Teaching undergraduates Engineering Thermodynamics; Supervising Biomechanical Projects; Mechanical Engineering Department, Imperial College.
19751979 Giving lectures in Connective Tissue Physiology as part of “Cours de biomecanique”, Ecole de Médecine, Lyon.
19751981 Taking part in various postgraduate courses on Connective Tissue in England.
19761981 Lecturing to 5th and 6th year Medical Students on Connective Tissue Structure and Function; Teaching in various B.Sc. courses and offering laboratory projects; London Hospital Medical College.
19761981 London University Teacher and Internal Examiner (Engineering Board)
19811984 External Examiner, London University
19811982 Graduate Course on Fluid and Solute Transport in Joints, Bioengineering Programme, University of Tel Aviv.
1982-present Graduate Course on Connective Tissue Biophysics, Dept. of Biomedical Engineering, Technion Israel Institute of Technology.
Supervision of Graduate Research Students see below.
GRADUATE STUDENTS:
L. Almeida 1972, Ph.D. thesis (Portugal)
C. Ficat 19721974, M.D. thesis, British Council Fellow from France.
J.P.G. Urban 19721977 Ph.D. thesis, University of London
N. Tomlinson 19781979 M.Sc. thesis, University of London
Sten Holm 19731980 Ph.D. thesis, University of Gothenburg (joint supervision with Professor Alf Nachemson)
David Keret 19831985 M.Sc. thesis, University of TelAviv
Rosa Schneiderman 19831987 Ph.D. thesis, Technion
Claude Weinberg 19851987 M.Sc. thesis, Technion.
Galina Grushko 19851988 M.Sc. thesis, Technion.
Deborah Tobias 19851988 M.Sc. thesis, Technion
Netta Weisman 19841989 M.Sc. thesis, Technion.
Eric Benaim 19861989 Ph.D. thesis, Technion (joint supervisor with Prof. J. Mizrahi)
Israel Ziv 198390 D.Sc. thesis, Technion (joint supervisor with Prof. Robins, Hebrew University).
Moshe Sayag, 19891994 M.Sc. thesis, Technion (joint supervisor with Prof. J. Mizrahi)
Orna Popper, 19891992 M.Sc. thesis
Sharon Cohen, 19901993 M.Sc. thesis
Einat Snir, 19901993 M.Sc. thesis
Shlomit Cohen 1992-1995 M.Sc. thesis
Natalie Uchitel 1992-1995 M.Sc. thesis
Nimer Emad 1994-1997 M.Sc. thesis
David Rigler 1994-1997 M.Sc. thesis
Naomi Wolf 1995-1999 M.Sc. thesis
Michelle Jiminez 1994-1997 M.Sc. thesis (Recipient of Lady Davis Scholarship)
Dr. Nahum Rosenberg 1995-1997 Basic Science Project
Yael Ben Zaken 1996-1999 M.Sc. thesis
Tamar Eviatar 1997-2000 M.Sc. thesis
Haya Ben-Zaken 1997-2000 M.Sc. thesis
Orit Braun 1997-2000 M.Sc. thesis
Nimmer Emad 2000-2003 D.Sc. thesis
Eva Tsitron 2002- M.Sc. thesis
Yulia Merkher 2002- M.Sc. thesis
MAIN RESEARCH INTERESTS:
Biophysical Chemistry of Connective Tissues with special reference to cartilage and the intervertebral disc;
Relations between functional properties and structure;
Fluid and solute transport and equilibria in joint tissues;
Biomechanics of cartilage and disc;
Nutrition and Metabolism of cartilage and intervertebral disc;
Aetiology of Osteoarthritis and lowback pain.
MAIN GRANTS:
Date Title of Grant Grant Giving Organization.
19721974 Transport of Large Molecules Through Arthritis and Rheumatism
Cartilage Council of Great Britain
19721977 Fluid and Solute Transport in the Arthritis and Rheumatism
Intervertebral Disc Council of Great Britain
19741976 Urate and Pyrophosphate Ions in Arthritis and Rheumatism
Cartilage Council of Great Britain
19771979 Transport and Absorption of Arthritis and Rheumatism
Proteins in Cartilage Council of Great Britain
19781981 Effect of Cyclic Compression on Wellcome Fund
Transport of Large Molecules
19791981 Biophysical Chemistry of Medical Research Council
Cartilaginous Tissues (Programme Grant)
19841985 LoadBearing Capacity of the Human Israel Ministry of Health
Annulus Fibrosus
19841987 Biophysical Studies of Healthy USIsrael Binational
and Degenerative Discs and Joints Science Foundation
19871988 Facet Joints and their Hydration Jacknow Research Fund
1985 Equipment Grant towards New Caroline and Joseph Gruss
Laboratories Fund
1990 Equipment Grant towards New Caroline and Joseph Gruss
Laboratories Fund (Barecha Foundation)
19861989 Molecular Packing of Collagen in The Israel Academy of
in Cartilaginous Tissues: Effect of Sciences and Humanities
the ExtraFibrillar Environment
19881991 Proteoglycan Metabolism in USIsrael Binational
Cartilage: Effects of Cyclic Science Foundation
Compression and Hormones
1991-1994 The Molecular Packing of Collagen in US-Israel Binational
Different Connective Tissues and its Science Foundation
Relationship to Chemical Environment
and Biomechanical Function
1992-1994 Solute Transport in Cartilage: Israel Ministry of Health
Effect of Age and Degeneration
1992-1995 Solute Transport in Cartilage: Israel Academy of Sciences
Effect of Compression and Humanities
1995-1996 Intervertebral disc turnover and Committee for Research and
repair: Effect of Occupational and Safety and Health (Ministry
Prevention in Occupational Loads of Labor and Social Affairs)
And Growth Factors
1996-1999 Functional behaviour of normal and Israel Academy of Sciences
osteoarthritic cartilage: the and Humanities
relation between collagen tension
and swelling pressure
1999-2001 Relationship between non-enzymatic Israeli Ministry of Health
crosslinks in collagen and the bio-
mechanics of cartilage.
2003-2005 Ageing and Degeneration of human European Commission (EC)
Intervertaebral Disc (“Eurodisc”)
2006-2011 Molecular origin of lubrication in the McCutchen Foundation
Synovial Joints
2008-2011 Disc-degeneration linked pathologies: European Commission (EC)
Novel Biomarkers and Diagnostics for
Targeting Treatment, Prevention and
Repair (‘Genodisc’)
MEMBERSHIP OF SOCIETIES
British Society of Rheumatology;
Orthopaedic Research Society of Great Britain;
Biochemical Society of Great Britain;
European Connective Tissue Society;
American Orthopaedic Research Society;
International Society of Biorheology;
PROFESSIONAL ACTIVITIES
Grant Refereeing for:
Medical Research Council of Gt. Britain
Wellcome Fund of Gt. Britain
Arthritis and Rheumatism Council of Great Britain;
I.N.S.E.R.M. (France);
British Columbia Health Care Research Foundation (Canada);
Israeli Academy of Sciences;
USIsrael Binational Science Foundation.
Refereeing for Journals:
Connective Tissue Research;
J. Bone and Joint Surgery;
Biochem. J.;
Biochim. Biophys. Acta;
J. Biomechanical Engineering;
Spine;
American Journal of Orthopaedic Research;
Annals of Rheumatic Diseases;
J. Musculoskeletal Research;
Arthritis and Rheumatism.
Editorial Work:
Guest Editor, Annals of Rheumatic Diseases
Editor of "Studies in Joint Disease", Pitman Medical London
Editor "Methods in Cartilage Research, Academic Press
On the Editorial Board of "Clinical and Experimental Rheumatology"
On the Editorial Board of "Biorheology"
On the Editorial Board of "Osteoarthritis and Cartilage"
Organization of International Meetings:
International Conference on Articular Cartilage, Imperial College, London, 1974.
International Symposium on Joint Disease, London Hospital Medical College, 1977
Arthritis Workshop: Hypothesizing about joints, London, 1978.
Symposium on Articular Cartilage, Ecole Polytechnique de Lyon Institut Pasteur de Lyon, Lyon 1978 (Honorary Chairman)
International Workshop: Hypotheses in Osteoarthritis. The Institute of Orthopaedics, London, 1987.
Bat Sheva International Seminar on "Methods Used in Research on Cartilaginous Tissues, Israel 1989.
Collagen Workshop under the auspices of the Israel Science Foundation, 1999.
OTHER ACTIVITIES
1970-1980 Fundraising and lecturing on behalf of the British Arthritis and Rheumatism Council
1998 Special guest of the American Technion Women’s Society, lecture tour in US.
SPECIAL AWARDS
Pearl Milch Chair in Biomedical Engineering Sciences, Department of Biomedical Engineering, Technion (until 2001).
Carol Nachman Prize for Research in Rheumatology, 1988.
Lee Silver Friedman Award in Biomedical Engineering, 1991
OARSI International Award for Research in Cartilage and Arthritis, 1999.
Fellowship of the American Institute for Medical and Biological Engineering, 2000.
Honorary Fellowship of the Israel Orthopaedic Society, 2001.
The Elizabeth Winston Lanier Award Winner, Kappa Delta, 2007
Lifetime Achievement Award, Osteoarthritis Research Society International's (OARSI’s), for outstanding scientific creativity and contributions to the understanding of the biophysical properties of cartilage and joint tissues, 2009.
SELECTION OF INVITED LECTURES
AND PAPERS PRESENTED AT SCIENTIFIC MEETINGS
Professor A. Maroudas
Maroudas, A.: Permeability of Articular Cartilage. Annual Meeting of the British Orthopaedic Association, Edinburgh, 1966.
Maroudas, A.: Hyaluronic Acid Films. Symposium on Joint Lubrication, Institute of Mechanical Engineers, London, 1967.
Maroudas, A.: Fixed Charge Density in Articular Cartilage. 7th International Conference on Medical and Biological Engineering, Stockholm, 1967.
Maroudas, A.: Further Studies on Hyaluronic Acid Films. 35th Scientific Meeting of Biological Engineering Society, Leeds, 1969
Maroudas, A.: Effect of Fixed Charge Density on the Distribution and Diffusion Coefficients of Solutes in Cartilage. NATO Advanced Study Institute on the Chemistry and Biology of the Intercellular Matrix, Santa Margherita, Italy, 1969.
Maroudas, A. and Muir, H.: The Effect of Collagen and Glycosaminoglycans in Human Articular Cartilage on Hydraulic Permeability. Intercellular Matrix, Santa Margherita, Italy, 1969.
Maroudas, A.: Formation of Hyaluronic Acid Films. Symposium on Lubrication and Wear in Joints, Royal College of Physicians, London, 1970.
Maroudas, A.: Electron Probe Studies of Articular Cartilage. Meeting of Royal Microscopical Society ('Micro 70'), London, 1970.
Maroudas, A.: Electron Probe Studies of Articular Cartilage. Bone and Tooth Society, London, 1971.
Maroudas A.: Distribution of Ionic Solutes in Connective Tissue. Symposium 'Metals in the Body', organized by Atomic Weapons Research Establishment, London, 1971.
Maroudas, A.: Physical Chemistry and Structure of Cartilage. Meetings of Physiological Society, London, 1972.
Maroudas, A.: Variation in the PhysicoChemical Properties of Human Articular Cartilage. Symposium of Bioengineering Society, Glasgow, 1972.
Maroudas, A.: Lubrication of Synovial Joints. Symposium on Some Aspects of Lubrication, Society of Applied Chemistry, Bristol, 1972
Maroudas, A., Nachemson, A. and Stockwell, R.: Nutrition of the intervertebral Disc. Meeting of the American Orthopaedic Research Society, Las Vegas, USA, 1973.
Maroudas, A. and Evens, J.: Turnover of Proteoglycans in Articular Cartilage: An InVitro Study. VIIth International Congress of Biochemistry, Stockholm, 1973.
Maroudas, A.: Transport in Articular Cartilage and its Physiological Implications (invited Lecture). Symposium on 'Normal and Osteoarthritic Cartilage', Royal National Orthopaedic Hospital, Stanmore, England, 1973.
Maroudas, A. and Snowden, J.: Permeability of Cartilage to Large Globular Proteins. Meeting of the American Orthopaedic Research Society, Dallas, U.S.A., 1974.
Maroudas, A. Cartilage Matrix Turnover (invited Lecture). Discussion Meeting on the Pericellular Environment, The Royal Society, London, 1974.
Maroudas, A.: Charged Group Behaviour in Connective Tissue as a Function of pH. Symposium on Articular Cartilage, Imperial College, London, 1974.
Maroudas, A.: Transport of Solutes and Fluid through Articular Cartilage (invited Lecture). Meeting of Anatomical Society of Great Britain, Symposium on Cartilage, 1974.
Maroudas, A.: Biophysical Properties of Cartilaginous Tissues (invited Lecture). 2nd International Symposium on Biorheology, Weizmann Institute of Science, Rehovot, Israel, 1975
Maroudas, A.: Cartilage Deformation and Recovery as a Function of Fluid Flow and Osmotic Pressure. Meeting of the American Research Society, San Francisco, U.S.A., 1975.
Maroudas, A. Properties PhysicoChemical du Cartilage Articulaire (Invited Lecture). Mecanique et Lubrification Articulaires, University of Paris, 1975.
Maroudas, A.: Turnover Studies in Normal and Osteoarthritic Cartilage (By invitation). Round Table Conference on Pathogenesis of Osteoarthritis, Massachusetts General Hospital, Boston, USA, 1975.
Maroudas, A.: Methodology in Studies on Glycosaminoglycan Turnover. VIIth European Congress of Rheumatology, Helsinki, Finland, 1975.
Maroudas, A.: PhysicoChemical Properties of Articular Cartilage and the Intervertebral Disc: Similarities and Differences (Invited Lecture). Sahlgren Hospital, Gothenburg, Sweden, 1975.
Maroudas, A., Urban, J. and Holm, S.: In Vivo Studies of the Nutrition of the Intervertebral Disc. British Orthopaedic Research Society Meeting, Glasgow, Scotland, 1975.
Maroudas, A. and Urban, J.: Transport of Solutes into Articular Cartilage and the Intervertebral Disc. Mathematics of Diffusion in Biology and Medicine. Meeting organized by the Institute of Mathematical Application, Midhurst, Surrey, England, 1975
Maroudas, A.: Fluid Flow and Swelling Pressure in Connective Tissue (invited Lecture). University of New York, Stony Brook, U.S.A., 1976
Maroudas, A.: Nutrition of the Intervertebral Disc. Annual Meeting of the American Orthopaedic Research Society, New Orleans, 1976
Maroudas, A.: Sulphate Metabolism in Normal and Osteoarthritic Human Cartilage. British Orthopaedic Research Society Meeting, Nottingham, England, 1976
Maroudas, A.: Solute and Fluid Transport in Articular Cartilage (invited lecture). Royal Infirmary, Department of Orthopaedics, Sheffield, England, 1976
Maroudas, A.: Effect of Different Tissue Constituents on Solute and Fluid Transport in Cartilage and the Intervertebral Disc (invited Lecture). International Symposium of the Microcirculation Society, Antwerp, Belgium, 1976
Maroudas, A., Byers, P., Stockwell, R. and Venn, M.: Biochemical and Metabolic Studies of Normal and Osteoarthritic Cartilage. Symposium of the European Society of Connective Tissue, Liege, Belgium, 1976