Additional File 1. Genes Up-Regulated in Tg(HQK) Muscle Following Induction of Prp

Additional File 1. Genes up-regulated in Tg(HQK) muscle following induction of PrP over-expression

Name / Description / GenBank / Fold Change
SEPT5 / septin 5 / NM_213614 / 3.702
SEPT9 / septin 9 / NM_017380 / 3.522
SEPT11 / septin 11 / AI836723 / *
2310043N10RIK / RIKEN cDNA 2310043N10 gene / AK028745 / 3.292
A2BP1 / ataxin 2-binding protein 1 / AI835398 / *
ABHD2 / abhydrolase domain containing 2 / NM_018811 / 11.883
ABI2 / abl interactor 2 / NM_198127 / 3.075
ABL1 / v-abl Abelson murine leukemia viral oncogene homolog 1 / AI325092 / *
ACBD3 / acyl-Coenzyme A binding domain containing 3 / AI450805 / *
ACCN3 / amiloride-sensitive cation channel 3 / NM_183000 / 3.276
ACHE / acetylcholinesterase (Yt blood group) / NM_009599 / 3.274
ACOT9 / acyl-CoA thioesterase 9 / AI427919 / *
ACTR3B / ARP3 actin-related protein 3 homolog B (yeast) / BC053106 / 8.554
ADAM8 / ADAM metallopeptidase domain 8 / NM_007403 / 11.279
ADCY7 / adenylate cyclase 7 / AK012436 / 5.258
ADIPOR2 / adiponectin receptor 2 / AI854179 / *
ADPGK / ADP-dependent glucokinase / NM_028121 / 4.142
ADPRHL2 / ADP-ribosylhydrolase like 2 / AI836109 / *
ADSSL1 / adenylosuccinate synthase like 1 / AI848125 / *
AFAP1 / actin filament associated protein 1 / AI848729 / *
AFMID / arylformamidase / AI837760 / *
AGPAT2 / 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) / AI835177 / *
AGPAT3 / 1-acylglycerol-3-phosphate O-acyltransferase 3 / AI449684 / *
AGXT2 / alanine-glyoxylate aminotransferase 2 / AI464452 / *
AIF1 / allograft inflammatory factor 1 / NM_019467 / 3.632
AK2 / adenylate kinase 2 / AI854898 / *
AK3 / adenylate kinase 3 / AI854743 / *
AKR1C2 / aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) / AI323755 / *
AKT1S1 / AKT1 substrate 1 (proline-rich) / AI838420 / *
ALS2CR2 / amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 / AI853959 / *
AMFR / autocrine motility factor receptor / AI847084 / *
ANAPC1 / anaphase promoting complex subunit 1 / AK053383 / 3.24
ANKRD1 / ankyrin repeat domain 1 (cardiac muscle) / NM_013468 / 4.331
ANKRD10 / ankyrin repeat domain 10 / NM_133971 / 4.108
ANLN / anillin, actin binding protein / AI429324 / *
ANXA2 / annexin A2 / AK087259 / 6.952
ANXA4 / annexin A4 / NM_013471 / 3.719
ANXA5 / annexin A5 / AI893564 / *
ANXA6 / annexin A6 / AK077843 / 5.107
ANXA7 / annexin A7 / AK032013 / 6.168
AP1G1 / adaptor-related protein complex 1, gamma 1 subunit / AK037086 / 3.589
AP1G2 / adaptor-related protein complex 1, gamma 2 subunit / NM_007455 / 3.292
AP1M1 / adaptor-related protein complex 1, mu 1 subunit / AI854661 / *
AP2B1 / adaptor-related protein complex 2, beta 1 subunit / AI845018 / *
APLP2 / amyloid beta (A4) precursor-like protein 2 / AI849502 / *
APOBEC1 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 / NM_031159 / 3.164
APOC1 / apolipoprotein C-I / AI893652 / *
APP / amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) / AK030583 / 4.203
AQP7 / aquaporin 7 / AI429089 / *
ARF6 / ADP-ribosylation factor 6 / AI854231 / *
ARFGAP3 / ADP-ribosylation factor GTPase activating protein 3 / NM_025445 / 4.216
ARHGAP12 / Rho GTPase activating protein 12 / AI465207 / *
ARHGAP22 / Rho GTPase activating protein 22 / NM_153800 / 3.792
ARHGAP5 / Rho GTPase activating protein 5 / AK080589 / 3.407
ARHGDIB / Rho GDP dissociation inhibitor (GDI) beta / AI323807 / *
ARHGDIG / Rho GDP dissociation inhibitor (GDI) gamma / NM_008113 / 3.675
ARHGEF12 / Rho guanine nucleotide exchange factor (GEF) 12 / BC052785 / 3.265
ARID1B / AT rich interactive domain 1B (SWI1-like) / AI853672 / *
ARID3A / AT rich interactive domain 3A (BRIGHT-like) / AI528789 / *
ARL4C / ADP-ribosylation factor-like 4C / NM_177305 / 3.365
ARL6IP4 / ADP-ribosylation-like factor 6 interacting protein 4 / AI464443 / *
ARPC4 / actin related protein 2/3 complex, subunit 4, 20kDa / AI327076 / *
ASB2 / ankyrin repeat and SOCS box-containing 2 / AI842575 / *
ASGR1 / asialoglycoprotein receptor 1 / AI845829 / *
ATG4B / ATG4 autophagy related 4 homolog B (S. cerevisiae) / AI464444 / *
ATIC / 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase / AI835570 / *
ATOX1 / ATX1 antioxidant protein 1 homolog (yeast) / AI464567 / *
ATP13A5 / ATPase type 13A5 / NM_175650 / 7.679
ATP2A2 / ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 / AI854716 / *
ATP6V0A1 / ATPase, H+ transporting, lysosomal V0 subunit a1 / AK045877 / 3.283
ATP6V0D1 / ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 / AI849250 / *
ATXN2 / ataxin 2 / AK036209 / 4.376
AYTL2 / acyltransferase like 2 / AI847713 / *
B4GALNT1 / beta-1,4-N-acetyl-galactosaminyl transferase 1 / NM_008080 / 4.663
BAIAP2 / BAI1-associated protein 2 / NM_130862 / 4.238
BAK1 / BCL2-antagonist/killer 1 / NM_007523 / 3.049
BBC3 / BCL2 binding component 3 / NM_133234 / 3.001
BAZ1A / bromodomain adjacent to zinc finger domain, 1A / XM_885873 / 4.364
BCL2A1 / BCL2-related protein A1 / NM_007534 / 6.716
BCL2L13 / BCL2-like 13 (apoptosis facilitator) / AI853789 / *
BDP1 / B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB / AI450927 / *
BIN1 / bridging integrator 1 / NM_009668 / 3.071
BIRC5 / baculoviral IAP repeat-containing 5 (survivin) / NM_009689 / 3.408
BLZF1 / basic leucine zipper nuclear factor 1 (JEM-1) / AI428215 / *
BMPR1B / bone morphogenetic protein receptor, type IB / AI464533 / *
BMPR2 / bone morphogenetic protein receptor, type II (serine/threonine kinase) / AK083553 / 3.433
BNIP1 / BCL2/adenovirus E1B 19kDa interacting protein 1 / AK170908 / 3.271
BOK / BCL2-related ovarian killer / NM_016778 / 3.218
BPTF / bromodomain PHD finger transcription factor / AI851639 / *
BRAF / v-raf murine sarcoma viral oncogene homolog B1 / AI426984 / *
C13ORF24 / chromosome 13 open reading frame 24 / AK045133 / 3.185
C14ORF130 / chromosome 14 open reading frame 130 / AI851583 / *
C1ORF57 / chromosome 1 open reading frame 57 / AI449709 / *
C1QBP / complement component 1, q subcomponent binding protein / AI464355 / *
C9ORF52 / chromosome 9 open reading frame 52 / AI450603 / *
C9ORF72 / chromosome 9 open reading frame 72 / AI835604 / *
CABIN1 / calcineurin binding protein 1 / AI427692 / *
CACNA2D4 / calcium channel, voltage-dependent, alpha 2/delta subunit 4 / AK030723 / 4.497
CAMK1D / calcium/calmodulin-dependent protein kinase ID / AK141415 / 3.666
CAMK2N2 / calcium/calmodulin-dependent protein kinase II inhibitor 2 / AK013788 / 3.172
CAPRIN1 / cell cycle associated protein 1 / AK051363 / 3.329
CARD10 / caspase recruitment domain family, member 10 / AI449026 / *
CARD11 / caspase recruitment domain family, member 11 / NM_175362 / 3.961
CARHSP1 / calcium regulated heat stable protein 1, 24kDa / AI449676 / *
CASD1 / CAS1 domain containing 1 / AK087204 / 3.051
CASP14 / caspase 14, apoptosis-related cysteine peptidase / AI448765 / *
CBX5 / chromobox homolog 5 (HP1 alpha homolog, Drosophila) / AI893653 / *
CBX6 / chromobox homolog 6 / AI847596 / *
CCL7 / chemokine (C-C motif) ligand 7 / NM_013654 / 3.259
CCL8 / chemokine (C-C motif) ligand 8 / NM_021443 / 4.678
CCRK / cell cycle related kinase / AI326314 / *
CD28 / CD28 molecule / AI327367 / *
CD300D / Cd300D antigen / NM_134158 / 4.528
CD44 / CD44 molecule (Indian blood group) / NM_009851 / 3.216
CD52 / CD52 molecule / NM_013706 / 4.952
CD81 / CD81 molecule / AI840865 / *
CD82 / CD82 molecule / NM_007656 / 3.103
CDC14A / CDC14 cell division cycle 14 homolog A (S. cerevisiae) / XM_901214 / 6.529
CDC27 / cell division cycle 27 homolog (S. cerevisiae) / AI452358 / *
CDC34 / cell division cycle 34 homolog (S. cerevisiae) / AI465204 / *
CDK5R1 / cyclin-dependent kinase 5, regulatory subunit 1 (p35) / NM_009871 / 8.378
CDK6 / cyclin-dependent kinase 6 / AK030810 / 5.275
CDKN1A / cyclin-dependent kinase inhibitor 1A (p21, Cip1) / NM_007669 / 3.124
CDS1 / CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 / AI844295 / *
CDS2 / CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 / BC059776 / 6.212
CENPA / centromere protein A / AI449898 / *
CENPO / centromere protein O / AI448222 / *
CES2 (includes EG:234671) / carboxylesterase 2 / NM_145603 / 4.611
CGREF1 / cell growth regulator with EF-hand domain 1 / BC023116 / 6.022
CHD2 / chromodomain helicase DNA binding protein 2 / AI449389 / *
CHES1 / checkpoint suppressor 1 / AI849096 / *
CHKB / choline kinase beta / AI326292 / *
CHM / choroideremia (Rab escort protein 1) / AI447929 / *
CHP / calcium binding protein P22 / AI845888 / *
CHRNA1 / cholinergic receptor, nicotinic, alpha 1 (muscle) / NM_007389 / 5.735
CHRNB4 / cholinergic receptor, nicotinic, beta 4 / AI845506 / *
CHRNG / cholinergic receptor, nicotinic, gamma / NM_009604 / 17.62
CHST11 / carbohydrate (chondroitin 4) sulfotransferase 11 / NM_021439 / 4.13
CIC / capicua homolog (Drosophila) / AI836798 / *
CIITA / class II, major histocompatibility complex, transactivator / NM_007575 / 3.559
CISH / cytokine inducible SH2-containing protein / NM_009895 / 10.814
CITED2 / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 / U86445 / 4.376
CKAP4 / cytoskeleton-associated protein 4 / NM_175451 / 4.842
CLASP1 / cytoplasmic linker associated protein 1 / AK080782 / 3.099
CLDN8 / claudin 8 / AI450616 / *
CLEC7A / C-type lectin domain family 7, member A / NM_020008 / 3.662
CLINT1 / clathrin interactor 1 / AI427041 / *
CMPK / cytidylate kinase / AI836710 / *
CNDP1 / carnosine dipeptidase 1 (metallopeptidase M20 family) / AI427125 / *
CNN3 / calponin 3, acidic / AI843550 / *
COL19A1 / collagen, type XIX, alpha 1 / NM_007733 / 5.043
COL1A2 / collagen, type I, alpha 2 / AI841886 / *
COL4A2 / collagen, type IV, alpha 2 / AI843282 / *
COL5A3 / collagen, type V, alpha 3 / NM_016919 / 5.685
COL7A1 / collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) / NM_007738 / 7.27
COPS7A / COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) / AI427951 / *
COTL1 / coactosin-like 1 (Dictyostelium) / NM_028071 / 3.837
CPEB1 / cytoplasmic polyadenylation element binding protein 1 / NM_007755 / 3.326
CRKL / v-crk sarcoma virus CT10 oncogene homolog (avian)-like / AI325100 / *
CSF2RA / colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) / NM_009970 / 5.003
CSK / c-src tyrosine kinase / AI324651 / *
CSPG4 / chondroitin sulfate proteoglycan 4 / NM_139001 / 3.443
CST6 / cystatin E/M / AI853055 / *
CTDSPL / CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like / AI464471 / *
CTF1 / cardiotrophin 1 / AI893883 / *
CTSD / cathepsin D / NM_009983 / 3.003
CTSS / cathepsin S / NM_021281 / 4.606
CTSZ / cathepsin Z / NM_022325 / 3.126
CTTN / cortactin / AI853713 / *
CX3CL1 / chemokine (C-X3-C motif) ligand 1 / NM_009142 / 3.377
CXADR / coxsackie virus and adenovirus receptor / AI427058 / *
CXXC4 / CXXC finger 4 / AI845873 / *
CYB5R3 / cytochrome b5 reductase 3 / NM_029787 / 3.371
DAB1 / disabled homolog 1 (Drosophila) / AI427087 / *
DAG1 / dystroglycan 1 (dystrophin-associated glycoprotein 1) / AI325151 / *
DAP3 / death associated protein 3 / AI464536 / *
DCLK3 / doublecortin-like kinase 3 / AI853072 / *
DCX / doublecortex; lissencephaly, X-linked (doublecortin) / AI843371 / *
DDAH1 / dimethylarginine dimethylaminohydrolase 1 / AI661738 / *
DDEF1 / development and differentiation enhancing factor 1 / XM_976949 / 3.326
DDOST (includes EG:1650) / dolichyl-diphosphooligosaccharide-protein glycosyltransferase / AI852284 / *
DDX3Y (includes EG:26900) / DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked / NM_012008 / 276.925
DEDD / death effector domain containing / AI853070 / *
DGKZ / diacylglycerol kinase, zeta 104kDa / NM_138306 / 3.272
DHX16 / DEAH (Asp-Glu-Ala-His) box polypeptide 16 / AI449975 / *
DHX36 / DEAH (Asp-Glu-Ala-His) box polypeptide 36 / AI465406 / *
DIABLO / diablo homolog (Drosophila) / BC024780 / 3.58
DIAPH1 / diaphanous homolog 1 (Drosophila) / BC070412 / 3.902
DLGAP4 / discs, large (Drosophila) homolog-associated protein 4 / NM_146128 / 3.53
DLST / dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) / AK171100 / 3.33
DMP1 / dentin matrix acidic phosphoprotein / NM_016779 / 8.683
DNAJC10 / DnaJ (Hsp40) homolog, subfamily C, member 10 / AI852588 / *
DNAJC3 / DnaJ (Hsp40) homolog, subfamily C, member 3 / NM_008929 / 4.502
DOCK1 / dedicator of cytokinesis 1 / AI854900 / *
DPEP2 / dipeptidase 2 / NM_176913 / 4.871
DPP3 / dipeptidyl-peptidase 3 / AK039975 / 4.533
DTL / denticleless homolog (Drosophila) / NM_029766 / 4.05
DTNB / dystrobrevin, beta / NM_007886 / 3.713
DUSP10 / dual specificity phosphatase 10 / AK080157 / 5.468
DUSP2 / dual specificity phosphatase 2 / NM_010090 / 3.039
DUSP4 / dual specificity phosphatase 4 / NM_176933 / 6.609
DYNC1H1 / dynein, cytoplasmic 1, heavy chain 1 / Z83808 / 3.421
DYNC1LI2 / dynein, cytoplasmic 1, light intermediate chain 2 / AI851670 / *
DYNC2LI1 / dynein, cytoplasmic 2, light intermediate chain 1 / AI464530 / *
DYSF / dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) / NM_021469 / 3.259
E2F1 / E2F transcription factor 1 / NM_007891 / 3.586
E2F2 / E2F transcription factor 2 / NM_177733 / 4.5
E2F3 / E2F transcription factor 3 / NM_010093 / 3.176
E2F8 / E2F transcription factor 8 / NM_001013368 / 3.488
EDA2R / ectodysplasin A2 receptor / AK029268 / 7.405