Supplement Table S1-Description of 111 complete HEV genome sequences retrieved from Genbank and used for sequence analyses:

(Accession number-Strain-Country-Source-Year)

Genotype-1 (n=19):

M73218-BURMA-Human-1991,D10330-HEVNE8L-Myanmar-Human-1992,AF459438-YAM-North_India-Human-2001,AF051830-TK15/92-Nepal-1998,AF076239-Hyderabad-India-Human-1998,AF185822-Abb-2B-Pak-Human-1988,X99441-Madras-India-Human-1993,DQ459342-Western_India-Human-2000,FJ457024-HEV_H-India-Human-FHF-2005,D11093-Uigh179-Japan-Human-1992,D11092-Xinjiang-china-Human-1986,M94177-HeBei-China-Human-1993,L08816-Hetian-China-Human-1986-88,L25595-K52-87-China-Human-1987,X98292-hev037-India-Human-FHF-1997,FJ998008-BB02-Germany-Wild_Boar-2007,M80581-SAR-55-Pak-Human-1992,AY204877-Chad-Feces-Human-1984, AY230202-Morocco-Human-2003.

Genotype-2 (n=1): M74506-MEXICO-Human, 1992,

Genotype-3 (n=50):

AB291954-JSS-Oka04L-Japan-Human-2004,AB236320-JMNG-Oki02C-Japan-wild_mongoose-2002,AB291957-JYU-Oki04L-Japan-human-2004,FJ906895-GDC9-China-Rabbit-2009,AB443623-JIO-swJ19-1-Japan-swine-2002,AB222183-wbJTS1-Japan-wild_boar-2004,AB248520-HE-JA04-1911-Japan-Human-2004,EU375463-Thai-swHEV07-Thailand-Pig-2006,AB443624-JIO-swJ19-2-Japan-Swine-2002,AB591733JMNG26-Oki08-Japan-Mongoose-2008,AB443626-JIO-swJ19-7-japan-swine-2002,AB291961-JMH-Osa04C-japan-human-2004,AB291960-JTK-Kag06C-japan-human-2006,AB091394-JJT-Kan-Japan-Human-2002,EU723514-SWP6-Spain-Swine-2007,AB291952-JIY-Tot05L-Japan-Human-2005, AB291962-JHK-Toy04C-japan-Human-2004,AB369687-E116-YKH98C-Japan-Human-1998,AB591734-JMNG36-Oki08-Japan-Mongoose-2008,FJ705359-wbGER27-Germany-Wild_Boar-2006,AB291953-JSO-Oki05L-Japan-human-2005,AB291951-JIO-Sai97L-Japan-Human-1997,FJ653660-CU001-Thailand-Human-2008,AB291955-JSW-Kyo-FH06L-Japan-Human-2006,AB369691-E097-OSA05C-Japan-human-2005,AB630971-JRC-HE3-Japan-human-2003,AB222182-wbJSG1-japan-wildboar-2005,AB291956-JYM-Tot04L-Japan-human-2004,AB291958-Type-III-Japan-Human-2004,EU723515-Type-III-Spain-Swine-2008,AP003430-Japan-Human-2001,AB443625-Type-III-Japan-Swine-2002, AB443627-Type-III-Japan-Swine-2002,AB437317-JE03-1760F-Human-Japan-2003,AF060669-HEV-US2-Human-1998,AB074920-JMY-Haw-Japan-Human-2001, AB074918-JKN-Sap-Japan-human-2001,AF082843-Meng-US-Swine-1998, AB073912-swJ570-Japan-Swine-2001,AB089824-HE-JA10-Japan-Human-1993,AY115488-Arkell-Swine-Canada-2001,EU360977-swX07-E1-Sweden-Swine,FJ426403-swKOR-1-S.Korea-2007,AF455784-Osh_205-Kyrgyzstan-Swine-1987,AB369687-E116-YKH98C-Japan-Human-1998,AB222184-wbJYG1-Japan-wild_Boar-2005,AB301710-JE03-1760F-Japan-Human-2003,AB369689-E088-STM04C-Japan-Human-2004,AF060668-HEV-US1-USA-Human-1997, AB290312-Mongolia-Swine-2006.

Genotype-4 (n=40):

AB097812-HE-JA1-Japan-Human-1997, AB080575-HE-JI4-Japan-Human-2000, AB220971-HE-JF3-Japan-Human-FHF-2005, GU206559-bjsw1-China-Swine-2008, AB099347-HE-JK4-Japan-Human-2002,AB193177-JYN-Sap01C-Japan-Human-2001,AB481227-swJB-H7-Japan-swine-1989,AB220974-HE-JA2-Human-Japan-2005,AB220976-HE-JA28-Japan-Human-2005,AB220979-HE-JA41-Japan-Human-Serum-2005,HM152568-bisw5-China-Swine-2008,AB200239-JSN-Sap-FH02C-Japan-Human-FHF-2002,AB091395-JSN-Sap-FH-Japan-Human-FHF-2000,AJ272108-T1-China-2000,AB074915-JAK-Sai-Japan-Human-2001,AB108537-CCC220-China-Human-2000,DQ279091-swDQ-China-Swine-2005,EU366959-swGX32-China-2007,AY723745-IND-SW-00-01-India-Swine-2004,EU676172-swGX40-China-Swine-2008,GU119961-CHN-XJ-SW13-China-Swine-2009,AB193176-JSF-Tot03C-Japan-Human-FHF-2003,AB097811-swJ13-1-Japan-Pig-2002, AB220975-HE-JA19-Japan-Human-2005,GU188851-WH09-China-Swine-2009,FJ610232-swCH189-China-Swine-2008,AB193178-JYN-Nii02L-japan-Human-2002,AY594199-swCH25-China-Swine-2004,AB291968-JMM-Aba06C-Japan-human-2006,AB291967-JKO-Aba-FH06C-Japan-human-2006,AB220973-Type-IV-Japan-Human-2005,AB521806-JYN-Shiz08L-Japan-Human-2008,AB602440-wbJGF_08-1-Japan-Boar-2008,AB220972-HE-JF4-Japan-Hokkaido-Human-FHF-2005,AB220978-HE-JA37-Japan-Hokkaido-Human-2005,AB220976--HE-JA28-Human-Japan-2005,AB074917-JKK-Sap-Human-Japan-soporro-2001,GU119960-CHN-XJ-SW33-Swine-Xinxiang-China-2009, AB197673-JKO-ChiSai98C-Human-Japan-1998,AB220977-HE-JA36-Human-Japan-2005, and 1 novel genotype from rodent, GU345042.