Ludvigsson, Neovius & Hammarström

IgA deficiency & infections

SUPPLEMENTARY APPENDIX

Risk of infections among 2100 individuals with IgA deficiency:a nationwide cohort study

Ludvigsson, Neovius & Hammarström

eTable 1 ICD-10 codes used for definition of outcome Page 18

eTable 2 ICD-10 codes used for definition of outcome Page 19

eFigure 1 Flow chart describing the identification of individuals with Page 20

IgA deficiency for this and a previous study

eFigure 2 Prevalence of selected infections in individuals with IgA deficiency and Page 21
matched general population controls

eTable 1 ICD-10 codes used for definition of outcome

Infection Type / ICD-10
Certain infectious and parasitic diseases / A00-B99
Meningitis / G00-G02
G04.2
G06
G07
Mastoiditis + otitis / H66
H70.0
H70.1
Respiratory tract infections / J00-J22
Gastrointestinal infections / A00-A09
Skin infections / L00-L08
L30.3
Joint infections / M00
M01
Sepsis / A39.2
A40
A41
Urinary tract infections / N10
N11
N30
N39.0
Any infection / Defined as any of the above

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Ludvigsson, Neovius & Hammarström

IgA deficiency & infections

eTable 2 Prevalence ratios in the base case analysis and the sensitivity analysis adjusting for country of birth

Infection type / Analysis / Prevalence ratio / 95%LCI / 95%UCI / P / DIFFERENCE IN PREVALENCE RATIO
Gastrointestinal infections / Base case / 3.49 / 2.83 / 4.31 / <.0001 / -0.03
Country-of-birth-adjusted / 3.52 / 2.85 / 4.34 / <.0001
Sepsis / Base case / 3.42 / 2.27 / 5.15 / <.0001 / -0.01
Country-of-birth-adjusted / 3.43 / 2.28 / 5.18 / <.0001
Meningitis / Base case / 3.24 / 1.44 / 7.28 / 0.0045 / 0.11
Country-of-birth-adjusted / 3.13 / 1.39 / 7.04 / 0.0059
Respiratory tract infections / Base case / 3.19 / 2.81 / 3.62 / <.0001 / -0.02
Country-of-birth-adjusted / 3.21 / 2.83 / 3.64 / <.0001
ICD10 chapter 1 / Base case / 2.44 / 2.22 / 2.69 / <.0001 / 0.07
Country-of-birth-adjusted / 2.37 / 2.10 / 2.68 / <.0001
Mastoiditis or otitis / Base case / 2.02 / 1.45 / 2.80 / <.0001 / 0.01
Country-of-birth-adjusted / 2.00 / 1.44 / 2.79 / <.0001
Joint infections / Base case / 1.98 / 0.996 / 3.93 / 0.052 / -0.10
Country-of-birth-adjusted / 2.08 / 1.04 / 4.14 / 0.038
Skin infections / Base case / 1.94 / 1.53 / 2.45 / <.0001 / 0.00
Country-of-birth-adjusted / 1.94 / 1.53 / 2.46 / <.0001
Urinary tract infections / Base case / 1.85 / 1.52 / 2.25 / <.0001 / -0.05
Country-of-birth-adjusted / 1.89 / 1.56 / 2.30 / <.0001

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Ludvigsson, Neovius & Hammarström

IgA deficiency & infections

eFigure 1 Flow chart describing the identification of individuals with IgA deficiency
for this and a previous study

eFigure 2 Prevalence of selected infections in individuals with IgA deficiency and
matched general population controls

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