Role of Radiology in the Pretreatment Evaluation of Invasive Cervical Cancer
Principal Investigators: Hedvig Hricak, MD, PhD (ACRIN)
Dennis Chi, M.D. (GOG)
Protocol Statistician: Constantine Gatsonis, Ph.D.
Lead Biostatistician: Bradley S. Snyder, M.S.
Lead Data Manager: Robert Sole, R.T. (R)(CT)
Abstract:
This protocol addresses the diagnostic work-up of invasive cervical cancer. The recommendations for diagnostic evaluation of tumor staging still follow the clinical FIGO staging guidelines which are based on findings from physical examination, colposcopy, lesion biopsy, chest radiography, cystoscopy, sigmoidoscopy, intravenous urography and barium enema. In spite of recognizable inaccuracies in FIGO staging and the need for large numbers of conventional and invasive procedures, modern cross-sectional imaging has not been incorporated in routine diagnostic evaluation. This study will compare clinical FIGO staging to pretreatment evaluation by CT and MRI in order to establish the most accurate pretreatment staging, the most accurate pretreatment assessment of morphologic tumor prognostic factors, a pathway to decreased utilization of invasive tests and, lastly, to design diagnostic test algorithms, which consider both benefits and costs of pretreatment evaluation of cervical cancer. The standard of reference for each test performance will be surgical pathology with lymph node sampling or dissection.
For full protocol text and data forms, click here