Lecture 13 - Genetic mapping

I. Genetic mapping

A. genetic map

B. map unit –

1. map unit = 1/2(# crossovers between markers)

2. 1 map unit = 1% recombination

expressed as map units or centiMorgans

C. frequency proportional to distance between genes

II. Two-factor mapping

A. example 1

w+ = red eyes wm+/wm+ female X w+m/Y male

w = white eyes ¯

m+ = normal wings wm+/w+m & wm+/Y

m = mini wings ¯

226 wm+/Y

202 w+m/Y

102 wm/Y

114 w+m+/Y

B. example 2

y = yellow body y+w/y+w female X yw+/Y male

y+ = dark body ¯

w causes white eyes y+w/yw+ & y+w/Y

w+ = red eyes ¯

4292 y+w/Y

4605 yw+/Y

86 y+w+/Y

44 yw/Y

III. Double crossovers

A. As distance between genes increases, probability of double crossovers increases

P{double} = P{single} X P{single}

B. Double crossovers between markers only detected if third gene is involved

C. as distance between markers increases, recombination frequency provides ever increasing underestimate of genetic distance

- fairly accurate for genes relatively close together


- solution is to consider genes close together:

IV. Using recombination frequencies to order genes on chromosome

A. What is relative position of each gene?

1.

2.

3.

consider 3 X-linked genes in Drosophila

y = yellow body

rb = ruby eye color

cv = shortened wing crossvein

find recombination frequencies of:

7.5% between y & rb

6.2% between rb & cv

13.3% between y & cv

V. Three-factor mapping

A. example 1 – given gene order and genotype of parents

y = yellow body

w = white eyes

ec = echinus eye shape

y w ec/+ + + female X y w ec/Y male

¯

4685 y w ec/y w ec & y w ec/Y (yellow, white, echinus)

4759 + + +/y w ec & + + +/Y (wild type)

80 y + +/y w ec & y + +/Y (yellow)

70 + w ec/y w ec & y+ w ec/Y (white, echinus)

193 y w +/y w ec & y w +/Y (yellow, white)

207 + + ec/y w ec & + + ec/Y (echinus)

3 y + ec/y w ec & y + ec/Y (yellow, echinus)

3 + w +/y w ec & + w +/Y (white)

10000

B. example 2 – don’t know whether heterozygote has all mutations in cis or trans

lz = lazy, or prostrate growth

gl = glossy leaf

su = sugary endosperm

triple heterozygote X lz gl su/lz gl su

¯

wild type 286

lazy 33

glossy 59

sugary 4

lazy, glossy 2

lazy, sugary 44

glossy, sugary 40

lazy, glossy, sugary 272

740

C. Example 3: order and cis/trans unknown

cross triple heterozygote X homozygous recessive

wild type 5

black, waxy, cinnabar 6

waxy, cinnabar 69

black 67

cinnabar 382

black, waxy 379

waxy 48

black, cinnabar 44

1000

D. Points to remember about 3-factor cross

1. can be used to determine gene order and distances

2. 3-factor cross allows us to see doubles

3. double crossover switches the middle gene relative to others

4. gamete genotypes must be apparent from phenotypes of progeny

5. general strategy:

a. cross 2 true breeding parents to create triple heterozygote

b. cross triple heterozygote X homozygous recessive

c. observe F2 progeny phenotypes

d. look for parentals

e. look for products of double crossover

f. determine order from doubles

g. calculate recombination frequencies

VI. Chi-square to test linkage – a statistical test for linkage

- eg. 1: Test cross het parent and find:

- To test, we need to test the null hypothesis (that they are not linked)

- c2 = S(observed – expected)2/expected

Need to look in table to see whether null hypothesis can be rejected

- eg. 2: Test cross het parent and find?

- Test the null hypothesis (that they are not linked)

− χ2 = Σ(observed – expected)2/expected

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