In Oral Cancercode

In Oral CancerCode / Gene / Function
Cell Metabolism
ABHD5 / Abhydrolase domain containing 5 / Belongs to a large family of proteins defined by an alpha/beta hydrolase fold; functions in phosphatidic acid biosynthesis
ACOX3 / Acyl-CoA oxidase 3, pristanoyl / Involved in desaturation of 2-methyl branched fatty acids in peroxisomes; expressed in low amounts in liver
AHCYL2 / Adenosylhomocysteinase- like 2 / Involved in conversion of S-adenosyl- L- homocysteine to L- homocysteine and adenosine
AKR1B10 / Aldo-ketoreductase family 1, member B10 (aldose reductase) / Reduces aliphatic and aromatic aldehydes; expressed in adrenal gland, small intestine and colon; role in liver carcinogenesis
ALDH2 / Aldehyde dehydrogenase 2 family (mitochondrial) / Second enzyme of the major oxidative pathway of alcohol metabolism
ALDH3A1 / Aldehyde dehydrogenase 3 family, memberA1 / Detoxification of alcohol-derived acetaldehyde; involved in metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation
ALDOC / Aldolase C, fructose – bisphosphate / Glycolytic enzyme that catalyses the reversible aldol cleavage of fructose 1,6 – biphosphate and fructose 1- phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3- phosphate or glyceraldehyde respectively; expressed in hippocampus and Purkinje cells of brain;
ALPP / Alkaline phosphatase (placental) / Membrane bound glycosylated enzyme expressed primarily in placenta
B3GALT4 / UDP- Gal: beta GlcNAc beta 1,3- galactosyltransferase, polypeptide 4 / Encodes type II membrane – bound glycoproteins with diverse enzymatic functions, primarily ganglioseries glycolipid biosynthesis
BCMO1 / Beta-carotene 15,15'-monooxygenase 1 / Retinoic acid biosynthesis
CAPNS2 / Calpain, small subunit 2 / Catalyzes limited proteolysis of substratesinvolved in cytoskeletal remodeling and signal transduction
CDC2L6 / Cyclin dependent kinase 19 / Catalytic activity converting ATP to ADP and forming a phosphoprotein
CDRT1 / CMT1A duplicated region transcript 1 / Protein-ubiquitin ligase; interacts with SKP1 through the F box, and ubiquitination targets through other protein interaction domains
CITED2 / Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 / Inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1;mutations associated with cardiac septal defects
CROT / Carnitine O-octanoyltransferase / Encodes a member of carnitine/choline acetyltransferase family in the peroxisome; necessary for transport of medium- and long- chain acyl-CoA molecules; role in lipid metabolism and fatty acid beta-oxidation
CYB5A / Cytochrome b5 type A (microsomal) / Membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, required for stearyl-CoA-desaturase activity; defects associated with type IV hereditary methemoglobinemia
DUOX1 / Dual oxidase 1 / Glycoprotein; member of the NADPH oxidase family; generates hydrogen peroxide and plays a role in activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces
DQX1 / DEAQ box RNA-dependent ATPase 1 / Catalytic activity to convert ATP to ADP
ELOVL4 / ELOVL fatty acid elongase 4 / Membrane-bound protein member of ELO family proteins which participate in biosynthesis of fatty acids;mutations and small deletions associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration
FAAH2 / Fatty acid amide hydrolase 2 / Catalyzeshydrolysis of a broad range of bioactive lipids, including N-acylethanolamines, fatty acid primary amides and N-acyl amino acids
GATM / Glycine amidinotransferase (L-arginine:glycineamidinotransferase) / Catalyzes biosynthesis of guanidinoacetate, immediate precursor of creatine
GCAT / Glycine C-acetyltransferase / Class II pyridoxal-phosphate-dependent aminotransferase; degradation of L-threonine to glycine
GDPD3 / Glycerophosphodiesterphosphodiesterase domain containing 3 / Glycerol metabolic process
GGT6 / Gamma-glutamyltransferase 6 / Gamma-glutamyltransferase, a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides, and transfers gamma-glutamyl moiety to acceptors
HSD17B4 / Hydroxysteroid (17-beta) dehydrogenase 4 / Bifunctional enzyme involved in the peroxisomal beta-oxidation pathway for fatty acids; acts as a catalyst for formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids
HSDL2 / Hydroxysteroid dehydrogenase like 2 / Oxido-reductase activity
IMPA2 / Inositol(myo)-1(or 4)-monophosphatase 2 / Catalyzesdephosphoylration of inositol monophosphate; role in phosphatidylinositol signaling
JARID1D / Lysine (K)-specific demethylase 5D. Protein interactor (other name: KDM5D) / Histone demethylase; demethylates 'Lys-4' of histone H3
KLK11 / Kallikrein-related peptidase 11 / Cleaves synthetic peptides after arginine residues; implicated in carcinogenesis ; potential as cancer biomarkers
OPLAH / 5-oxoprolinase (ATP-hydrolysing) / Acts as a homodimer, using ATP hydrolysis to catalyze conversion of 5-oxo-L-proline to L-glutamate
OXCT1 / 3-oxoacid CoA transferase 1 / Homodimeric mitochondrial matrix enzyme; role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate
PANK3 / Pantothenate kinase 3 / Regulatory enzyme in biosynthesis of coenzyme A (CoA) inmammalian cells;catalyzes the first committed step in the universal biosynthetic pathway leading to CoA; regulated by CoA through feedback inhibition
PIGN / Phosphatidylinositol glycan anchor biosynthesis, class N / Involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis; expressed in endoplasmic reticulum and transfers phosphoethanolamine (EtNP) to the first mannose of the GPI anchor
PLA2G4F / Phospholipase A2, group IVF / Selectively hydrolysis of glycerophospholipids
PRSS8 / Protease, serine, 8 / Encodes trypsinogen, a member of the trypsin family of serine proteases; expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid
SEC6L1 / Exocyst complex component 3 / Essential for targeting exocytic vesicles to specific docking sites on plasma membrane; essential for biogenesis of epithelial cell surface polarity
SMPD2 / Sphingomyelinphosphodiesterase 2 / Functions as a lysophospholipase
TGM5 / Transglutaminase 5 / Catalyzes formation of protein cross-links between glutamine and lysine residues, resulting in stabilization of protein assemblies
TM7SF2 / Transmembrane 7 superfamily member 2 / Involved in the conversion of lanosterol to cholesterol
TST / Thiosulfate sulfurtransferase (rhodanese) / Catalyzesconversion of thiosulfate and cyanide to thiocyanate and sulphite; localized to the mitochondria; interacts with 5S ribosomal RNA and facilitates its import into mitochondria
UBE4B / Ubiquitination factor E4B / Involved in multiubiquitin chain assembly; candidate asneuroblastomatumor suppressor gene
YOD1 / YOD1 deubiquitinase / Belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain;participates in endoplasmic reticulum-associated degradation (ERAD) ofrmisfoldedlumenal proteins
Xenobiotic metabolising enzymes
CYP4F12 / Cytochrome P450, family 4, subfamily F, polypeptide 12 / Monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
FLJ39501 / Cytochrome P450, family 4, subfamily F, polypeptide 22 / Monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids (other name: CYP4F22)
GSTA4 / Glutathione S-transferase alpha 4 / Involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds
Regulation
APBB3 / Amyloid beta (A4) precursor protein – binding family B, member 3 / Binds to intracellular domain of the Alzheimer’s disease beta- amyloid precursor protein as well as other APP proteins; may modulate internalization of APP
CLOCK / Clock circadian regulator / Regulates circadian rhythm and metabolism; polymorphisms iassociated with behavioral changes, obesity and metabolic syndrome
CRIPAK / Cysteine-rich PAK1 inhibitor / Negative regulator of PAK1;upregulated by estrogen
ENOSF1 / Enolase superfamily member 1 / Naturally occurring antisense transcript to human thymidylate synthase gene; regulated expression of TS locus both via the antisense transcript as well as through the encoded protein
HDAC11 / Histone deacetylase 11 / Localized to the nucleus; regulates expression of interleukin 10
LMO4 / LIM domain only 4 / Transcriptional regulator or as an oncogene
MALL / Mal, T-cell differentiation protein-like / Associated with raft-mediated trafficking in endothelial cells; interacts with caveolin-1
PEX11G / Peroxisomal biogenesis factor 11 gamma / Regulates number and size of peroxisomes in evolutionarily distant organisms;induces clustering of peroxisomes
RMND5B / Required for meiotic nuclear division 5 homolog B / Transcriptional regulation
RUTBC1 / Small G protein signalingmodulator 2 (other name: SGSM2) / Regulates membrane trafficking
TP53INP2 / Tumor protein p53 inducible nuclear protein 2 / Dual regulator of transcription and autophagy; Positively regulates autophagy and required for autophagosome formation and processing
TRAK1 / Trafficking protein, kinesin binding 1 / Regulation of endosome-to-lysosome trafficking
ZNF223 / Zinc finger protein 223 / Transcriptional regulation
ZNF426 / Zinc finger protein 426 / Transcriptional regulation
ZNF431 / Zinc finger protein 431 / Transcriptional regulation
ZNF770 / Zinc finger protein 770 / Transcriptional regulation
ZNF786 / Zinc finger protein 786 / Transcriptional regulation
Signal transduction
ADIPOR2 / Adiponectin receptor 2 / Receptor for globular and full length adiponectin; mediates increased AMPK and PPAR- alpha ligand activities along with fatty acid oxidation and glucose uptake by adiponectin
AP1B1 / Adaptor- related protein complex 1 beta 1 subunit / Localised in coated vesicles at golgi complex; mediates recruitment of clathrin to the membrane and recognition of sorting signals within the cytosolic trails of transmembrane receptors
ARRDC3 / Arrestin domain containing 3 / Tumor suppressor function; negatively regulate integrin β4 signalling by inducing degradation
CGN / Cingulin / Regulation of RhoAsignalling; expressed in adenocarcinomas; down-regulated in squamous carcinomas
CTNNBIP1 / Catenin, beta interacting protein 1 / Negative regulator of Wntsignaling pathway
DENND2C / DENN/MADD domain containing 2C / Guanine nucleotide exchange factor (GEF);may activate RAB9A and RAB9B
DUSP16 / Dual specificity phosphatase 16 / Encodes mitogen-activated protein kinase phosphatase; member of the dual specificity protein phosphatase subfamily;phosphatase inactivates the target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues; regulates c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways
FLJ41603
(ARHGEF37) / Rho guanine nucleotide exchange factor (GEF) 37 / Regulation of Rho protein signal transduction; guanyl-nucleotide exchange factor activity, protein binding, Rho guanyl-nucleotide exchange factor activity
GP1BB / Glycoprotein Ib (platelet), beta polypeptide / Receptor for von Willebrand factor (VWF); mediates platelet adhesion in the arterial circulation;GPIb beta participates in transmembranesignaling through phosphorylation of intracellular domain
HTR3B / 5-hydroxytryptamine (serotonin) receptor 3B / Receptor for Serotonin; a ligand gated ion channel, when activated causes depolarizing responses
IL20RA / Interleukin 20 receptor, alpha / Heterodimeric complex in Type II cytokine receptor family; expressed in skin; upregulated in psoriasis
LMTK2 / Lemur tyrosine kinase 2 / Involved in nerve growth factor (NGF)-TrkA signalling; critical role inendosomal membrane trafficking
LRP10 / Low density lipoprotein receptor-related protein 10 / Probable receptor, involved in internalization of lipophilic molecules and/or signal transduction
MAP3K6 / Mitogen-activated protein kinase kinasekinase 6 / Interacts with MAP3K5/ASK, a protein kinase; activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase
MAP4K5 / Mitogen-activated protein kinase kinasekinasekinase 5 / Activation of Jun kinase in mammalian cells, indicating a role in stress response
RALBP1 / RalA binding protein 1 / Receptor-mediated endocytosis; downstream effector of the small GTP-binding protein
RAPGEFL1 / Rap guanine nucleotide exchange factor (GEF)-like 1 / Probable guanine nucleotide exchange factor
SH3D19 / SH3 domain containing 19 / Suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1 by EBP; regulation of ADAM proteins in signaling of EGFR-ligand shedding
STXBP5 / Syntaxin binding protein 5 (tomosyn) / Docking and fusion of synaptic vesicles with presynaptic plasma membrane
UNC13B / Unc-13 homolog B / Role in vesicle maturation during exocytosis; involved in neurotransmitter release; synaptic vesicle maturation
Transcription factors
DYNLT3 / Dynein, light chain, Tctex-type 3 / Regulates binding dynein to specific cargos including the spindle checkpoint protein BUB3; may function independent of dynein as a transcriptional modulator
ELL2 / Elongation factor, RNA polymerase II, 2 / Increasescatalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiplesites along the DNA
P8 (NUPR1) / Nuclear Protein, Transcriptional Regulator, 1 / Chromatin-binding protein; converts stress signals into a program to combat stress induced by change in microenvironment; binds RELB promoter and activates transcription, leading to the transactivation of IER3; activation of PI3K/AKT signaling pathway; associated with breast cancer, adenocarcinoma, pancreatic cancer,etc
SOX21 / SRY (sex determining region Y)-box 21 / Activator of transcription of OPRM1
TEF / Thyrotrophic embryonic factor / Encodes a member of PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors
Development
C21orf55 / Chromosome 21 open reading frame 55 / Role in protein folding
CNFN / Cornifelin / Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia
EVPL / Envoplakin / Novel precursor of the cornified envelope that has homology to desmoplakin
IRX5 / Iroquois homeobox 5 / Embryonic developmental processes; involved in retinal cone bipolar cell differentiation; negatively regulates potassium channel gene expression and coordinates cardiac repolarization
LGR4 / Leucine-rich repeat containing G protein-coupled receptor 4 / Activatorof Wnt signaling pathway; necessary for the development of various organs
MEIS1 / Meishomeobox 1 / Encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins; transcriptional regulator
Role in hematopoiesis, megakaryocyte lineage development and vascular patterning
OVOL1 / Ovo-like 1 / Role in spermatogenesis
PPFIBP2 / PTPRF interacting protein, binding protein 2 (liprin beta 2) / beta liprin; role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane
PROM2 / Prominin 2 / Localizes to basal epithelial cells; involved in the organization of plasma membrane microdomains
SH3YL1 / SH3 domain containing, Ysc84-like 1 / Regulates dorsal ruffle formation
SPIRE1 / Spire-type actin nucleation factor 1 / Actin nucleation factor; involved in intracellular vesicle transport along actin fibers
TESK2 / Testis-specific kinase 2 / Serine/threonine protein kinase;role in spermiogenesis
TFAP2C / Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) / Sequence-specific DNA-binding transcription factor involved in activation of several developmental genes; involved in development of the eyes, face, body wall, limbs and neural tube
Cell proliferation and cell cycle
C1orf21 / Chromosome 1 open reading frame 21 / Proliferation-Inducing Protein 13; associated with gastric cancer and prostate cancer
FAM84B / Family with sequence similarity 84, member B / Component of the Smc5-6 complex (SUMO ligase); required for the response to DNA damage; associated with esophageal carcinoma, breast cancer, colorectal cancer, leukemia, etc
PTPN13 / Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) / PTPs are signaling molecules; regulate cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation