CURRICULUM VITAE
NAME: Pedro Jorge Macedo de Abreu
PLACE OF BIRTH: Lisbon, Portugal
DATE OF BIRTH: July 17th, 1949
QUALIFICATIONS: Licence Degree in Chemistry, University of Brussels, 1975
PhD in Chemistry, New University of Lisbon, 1987
PRESENT POSITION: Professor at the Chemistry Department of Faculty of Science and Technology, New University of Lisbon.
PROF. MEMBERSHIP: Portuguese Chemical Society; Phytochemical Society of Europe; American Society of Pharmacognosy; RIPROFITO (Iberamerican Network of Phytopharmaceutical Products).
INTERNATIONAL EDITORIAL BOARD
Marine Drugs
URL: http://www.dq.fct.unl.pt/QOA/abreu
RESEARCH INTERESTS
Natural Products Chemistry: isolation and characterization of natural products from sponges, algae, fungi and medicinal plants; biological evaluation. Pharmacognosy. Medicinal Plants.
RELATED WORK EXPERIENCE
- Research Fellow at the Laboratory of Molecular Structural Chemistry, Namur University (1980).
- NATO Research Fellow at the Bio-Organic Chemistry Department, Brussels University (1982).
- Post-doc Research Fellow at the Faculty of Agriculture, University of Tokyo (1987).
RESEARCH PROJECTS UNDER CONTRACT
- "Natural products from algae from the portuguese coast” (1989).
- "Natural products from medicinal plants from Guinea-Bissau” (1992).
- “Detection and isolation of antibiotic and antitumoral compounds from extracts from medicinal plants from Guinea-Bissau” (1997).
- “Bioassay -guided isolation and identification of anti.inflammatory and antioxidant compounds from a medicinal extract of Pedilanthus tithymaloides” (2005-)
PUBLICATIONS
1. "Luminescence Studies in Polymers, part X. Triplet energy migration in copolymers Styrene-vinylbenzophenone. Decay-time and its relation to phosphorescence emission and excitation spectra", C.David, D.Bayens-Volant, P.Macedo de Abreu, G.Gueskens, Europ. Polym. J. 13, 841-846 (1977).
2. "Cavernosine, a novel ichthyotoxic terpenoid lactone from the sponge Fasciospongia cavernosa", J.C.Braekman, D.Daloze, R.Bertau, P.Macedo de Abreu, Bull. Soc. Chim. Belg. 91, 791-796 (1982).
3. "A novel type of bis-quinolizidine alkaloid from the sponge Petrosia seriata", J.C.Braekman, D.Daloze, P.Macedo de Abreu, C.Piccinni-Leopardi, G.Germain, M.Van Meerssche, Tetrahedron Letters, 4277-4280 (1982).
4. "Pisolactone, a novel triterpenoid isolated from the fungus Pisolithus tinctorius", Ana M.Lobo, P.Macedo de Abreu, Sundaresan Prabhakar, Lício S.Godinho, Tetrahedron Letters, 2205-2208 (1983).
5. "Novel triterpenoids from the fungus Pisolithus tinctorius", Ana M.Lobo, P.Macedo de Abreu, Sundaresan Prabhakar, Lício Godinho, Henry S.Rzepa, Richard N.Sheppard, Tetrahedron Letters, 2589-2592 (1985).
6. "Triterpenoids of the fungus Pisolithus tinctorius", Ana. M.Lobo, P.Macedo de Abreu, Sundaresan Prabhakar, Lício Godinho, Ray Jones, Henry S.Rzepa, David J.Williams, Phytochemistry, 27, 3569-3574 (1988).
7. "Brassinosteroids: a new group of phytohormones", Pedro Abreu, Químca Nova, 1, 44-48 (1991).
8. "Revision of C-22,23 configurations of two triterpenoids of the fungus Pisolithus tinctorius, P.Macedo de Abreu, Ana M.Lobo, Sundaresan Prabhakar, Phytochemistry, 30, 3818-3819 (1991).
9. "Chemical constituents of Parkia biglobosa", M.E.M.Araújo, F.M.S.B.Palma, A.T.Moutinho, P.M.Abreu, Fitoterapia, 5, 468 (1995).
10. “Constituents of Tephrosia uniflora”, Pedro M.Abreu and Maria H.Luis, Natural Product Letters, 9, 81-86 (1996).
11. “Polyhalogenated monoterpenes from Plocamium cartilagineum from the Portuguese coast”, Pedro M.Abreu and José M.Galindro, Journal of Natural Products, 59, 1159-1162 (1996).
12. “Volatile constituents of the rhizomes of Aframomum alboviolaceum (Ridley) K.Schum. from Guinea-Bissau, Pedro M.Abreu and Rita G.Noronha, Flavour and Fragrance Journal 12, 79-83 (1997).
13. “Non-terpenoid compounds from Plocamium cartilagineum”, Pedro M.Abreu, José M. Galindro, Angela M. Relva and Ana M. Ramos, Phytochemistry, 45, 1601-1603 (1997).
14. “Chemical composition of Lactarius controversus, a basidiomycetes fungus”, Abreu P, Araújo ME, Fonseca T, dos Santos SP, Pharm. Pharmacol. Letters, 7, 138-140 (1997).
15. “A new indole alkaloid from Sarcocephalus latifolius", Pedro M. Abreu, António Pereira, Heterocycles, 48, 885-891 (1998).
16. "Phytochemical analysis and antimicrobial evaluation of Detarium microcarpum bark extracts", P.M. Abreu, V.S. Rosa, E.M. Araujo, A.B. Canda, O. Kayser, K.-U. Bindseil, K. Siems and A. Seemann, Pharm. Pharmacol. Letters, 8, 107-109 (1998).
17. "A new polyhalogenated epoxymonoterpene from Plocamium cartilagineum", Pedro M. Abreu and José Galindro, Indian J. Chemistry, 37B, 610-611 (1998).
18. "Antimicrobial, Antitumor and Antileishmania Screening of medicinal Plants from Guinea-Bissau", P. M. Abreu, E. S. Martins, O. Kayser, K. -U. Bindseil, K. Siems, A. Seemann and J. Frevert, Phytomedicine, 6, 187 (1999).
19. “New trichothecenes isolated from Holarrhena floribunda stem”, Ali Loukaci, O. Kayser, K.-U. Bindseil, K. Siems, J. Frevert and Pedro Abreu, Journal of Natural Products, 63, 52-56 (2000).
20. “Characterisation of a sugar fraction from Sarcocephalus latifolius stem bark extract”, P. Abreu, A. Relva and A. Pereira, Carbohydrate Polymers, 45, 155-160 (2001).
21. "New indole alkaloids from Sarcocephalus latifolius”, Pedro M. Abreu and António Pereira, Nat. Prod. Letters, 15, 43-48 (2001).
22. "Antileishmanial and immunostimulating activities of two dimeric proanthocyanidins from Khaya senegalensis", O. Kayser and P.M. Abreu, Pharmaceutical Biology, 39, 284-288 (2001).
23. "Carbohydrates from Detarium microcarpum bark extract", Pedro Abreu and Angela Relva, Carbohydrate Research, 337, 1663-1668 (2002).
24. "Étude biologique et chimique de la plante Prasium major poussant en Tunisie. Structure d'un heteroside steroidique et d'un steroide. Identification de constituents de la fraction volatile", M.A. Mahjoub, H. Ben Jannet, P.J.M. Abreu, Z. Mighri, J. Soc. Chim. Tun., 4, 1419-1426 (2002).
25. "Triterpenoids from the fruit barks of Periploca laevigata growing in Tunisia", F. Hichri, O. Hammouda, H. Ben Jannet, Z. Mighri, P.M. Abreu, J. Soc. Chim. Tun., 4, 1565-1569 (2002).
26. "Three New Jatrophane-Type Diterpenes from Euphorbia pubescens", Cláudia Valente, Maria José U. Ferreira, Pedro M. Abreu, Madalena Pedro, Fátima Cerqueira, Maria São José Nascimento, Planta Medica, 69, 361-366 (2003).
27. "Natural product-like combinatorial libraries", Pedro M Abreu and Paula S. Branco, J. Braz. Chem. Soc., 14, 675-712 (2003).
28. "Triterpénes isolés des écorces des fruits de la plante Periploca laevigata poussant en Tunisie", F. Hichri, H. Ben Jannet, P.M. Abreu, Z. Mighri, J. Soc. Alg. Chim., 13, 187-196 (2003).
29. “Rearranged jatrophane-type diterpenes from Euphorbia species. Evaluation of their effects on the reversal of multidrug resistance”, A. M. Madureira, Maria-José U. Ferreira, N. Gyémánt, K. Ugocsai, José R. Ascenso, Pedro M. Abreu, J. Hohmann, J. Molnar, Planta Medica, 70, 45-49 (2004).
30. “Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversal activity on mouse lymphoma cells, C. Valente, Maria-José U. Ferreira, Pedro M. Abreu, N. Gyémánt, K. Ugocsai, J. Hohmann, J. Molnar, Planta Medica, 70, 81-84 (2004).
31. "Euphopubescenol and Euphopubescene, Two New Jatrophane Polyesters, and Lathyrane-type diterpenes from Euphorbia pubescens", Cláudia Valente, Madalena Pedro, José R. Ascenso, Pedro M. Abreu, Maria São José Nascimento and Maria-José U. Ferreira, Planta Medica, 70, 244-249 (2004).
32. “Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells”, A. M. Madureira, G. Spengler, A. Molnar, A. Varga, J. Molnar, Pedro M. Abreu, Maria-José U. Ferreira Anticancer Res., 24 (2B), 859-864 (2004).
33. “Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens, C. Valente, M. Pedro, A, Duarte, M. S. J. Nascimento, Pedro M. Abreu, and Maria-José U. Ferreira, Journal of Natural Products, 67, 902-904 (2004).
34. A new sesquiterpene-coumarin ether and a new abietane diterpene and their effects as inhibitors of P-glycoprotein, Ana M. Madureira, Annamária Molnár, Pedro M. Abreu, Joseph Molnár, Maria-José U. Ferreira, Planta Medica, 70 , 828-833 (2004).
35. “Structure d’un coumarino-lignane isolé de la partie aérienne de la plante Salsola tetrandra”, M. M. Oueslati, H. Ben Jannet. P. J. Abreu and Z. Mighri, J. Soc. Alg. Chim., 14, 181-187 (2004).
36. “Alcools tetrahydropyraniques polyacetyleniques antibacteriens de la plante Rantherium suaveolens poussant dans le sud Tunisien” M. M. Oueslati, H. Ben Jannet. P. J. Abreu, and Z. Mighri, J. Soc. Alg. Chim., 14, 245-258 (2004).
37. “Antioxidant Phenolic Glycosides from Moricandia arvensis”, Hatem Braham, Zine Mighri, Hichem Ben Jannet, Susan Matthew, and Pedro M. Abreu, Journal of Natural Products, 68, 517-522 (2005).
38. “New Ceramides from Rantherium suaveolens”, M. Habib Oueslati, H. Ben Jannet, Zine Mighri, Pedro M. Abreu, Lipids, 40, 1075-1079 (2005).
39. “QSAR analysis of phenolic antioxidant using MOLMAP descriptors of local properties”, Sunil Gupta, Susan Mathew, Pedro Abreu, and João Aires-de-Sousa, Biorg. Med. Chem., 14, 1199-1206 (2006).
40. “Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides”, Pedro Abreu, Susan Matthew,Tania González, David Costa, Marcela A. Segundo, and Eduarda Fernandes, Life Sciences, 78, 1578-1585 (2006).
41. “New Macrocyclic Lathyrane Diterpenes, from Euphorbia lagascae, as Inhibitors of Efflux Pump of Tumour Cells”, Noélia Duarte, Joseph Molnár, Nora Gyémánt, Pedro M. Abreu, Maria José U. Ferreira, Planta Medica, 72, 162-168 (2006).
42. “Long Chain Alkyl and Alkenyl Phenols from the Roots of Ozoroa insignis”, Yonghong Liu and Pedro J.M. Abreu, J. Braz. Chem. Soc., 17, 527-532 (2006).
43. “Effect of extraction parameters on the chemical structure and gel properties of κ/ι-hybrid carrageenans obtained from Mastocarpus stellatus”, L. Hilliou, F.D.S. Laratonda, P. Abreu, A.M. Ramos, A.M. Sereno, M.P. Gonçalves, Biomolecular Engineering, 23, 201-208 (2006).
44. “Euphoportlandols A and B, tetracylic diterpene polyesters from Euphorbia portlandica and their anti-MDR effects in cancer cells”, Ana M. Madureira, Nora Gyémánt, José R. Ascenso, Pedro M. Abreu, Joseph Molnár, and Maria-José U. Ferreira, Journal of Natural Products, 69, 950-953 (2006).
45. “Tirucallane triterpenes from the roots of Ozoroa insignis”, Yonghong Liu and Pedro Abreu, Phytochemistry, 67, 1309-1315 (2006).
46. “Heterocyclic terpenes: Linear furano- and pyrrolo-terpenoids”, Yonghong Liu, Si Zhang, P.J.M. Abreu, Natural Product Reports, 23, 630-651 (2006).
47. “Phytochemical Constituents from Salsola tetrandra”, M. Habib Oueslati, Hichem Ben Jannet, Zine Mighri, J. Chriaa, and Pedro M. Abreu, Journal of Natural Products, 69, 1366-1369 (2006).
48. “Ellagic acid glycosides from Turpinia ternata”, Susan Matthew, Kuo-Ching Kao, Yuan-Shiun Chang, Pedro M. Abreu, Natural Product Research, 21, 83-88 (2007).
49. “Antioxidant compounds from Ebenus pinnata”, Hatem Braham, Hichem Ben Jannet, Zine Mighri, Susan Matthew, Pedro M. Abreu, Fitoterapia, 78, 32-34 (2007).
50. “High-Performance Liquid Chromatographic Determination of Glycoalkaloids in Potatoes from Conventional, Integrated, and Organic Crop Systems” Pedro Abreu, Angela Relva, Susan Matthew, Zulmira Gomes, and Zilda Morais, Food Control, 18, 40-44 (2007).
51. “Ozoroalide, a new orsellinic acid type macrolide from Ozoroa insignis”, Yonghong Liu, Pedro J.M. Abreu, Fitoterapia, 78, 388-389 (2007).
52. “A new C9 nor-isoprenoid glucoside from Rantherium suaveolens”, M. Habib Oueslati, H. Ben Jannet, Zine Mighri, Susan Matthew, and Pedro M. Abreu, Natural Product Research 21, 884-888 (2007).
53. “Antimalarial Flavonol Glycosides from Euphorbia hirta”, Y. Liu, N. Murakami, H. Ji, Pedro Abreu, S. Zhang, Pharmaceutical Biology, 45, 278-281 (2007).
54. “Isolation and Identification of Antioxidants from Pedilanthus tithymaloides”, Pedro M. Abreu, Susan Matthew, Tania González, Lucie Vanickova, David Costa, Ana Gomes, Marcela A. Segundo, Eduarda Fernandes, J. Natural Medicines, 62, 67-70 (2008).
55. “Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds", Noélia Duarte, Oliver Kayser, Pedro Abreu, and Maria José U. Ferreira, Phytotherapy Research, 22, 455-457 (2008).
56. “Saoussanabiloide, a novel antifungal alkaloid from Echiochilon fruticosum Desf. growing in Tunisia”, S. Hammami, N. Migrhi, H. Ben Jannet, N. Boughalleb, A. Zardi-Bergaoui, A. Nefzi, P. M. Abreu, Z. Mighri, Natural Product Research, 23, 1466-1471 (2009).
57. “Effects of strictosamide on mouse brain and kidney Na+,K+-ATPase and Mg2+-ATPase activities”, M.F. Candeias, P. Abreu, A. Pereira, J. Cruz-Morais, Journal of Ethnopharmacology, 121, 117–122 (2009).
58. “Composition and in vitro antioxidant effects of jellyfish Catostylus tagi from Sado estuary (SW Portugal)”, Z. B. Morais, A. M. Pintão, I. M. Costa, M. T. Calejo, N. M. Bandarra, Pedro Abreu, Journal of Aquatic Food Product Technology, 18, 90-107 (2009).
59. “Phenolic constituents of Convolvulus dorycnium L flowers”, Sana Nacef, Hichem Ben Jannet, Pedro Abreu, Zine Mighri, Phytochemistry Letters, 3, 66–69 (2010).
60. “The impact of seaweed life phase and 1 post-harvest storage duration on the chemical and rheological properties of hybrid carrageenans isolated from Portuguese Mastocarpus stellatu.”, Loic Hilliou, Fábio D.S. Larotonda, Pedro Abreu, Maria H. Abreu, Alberto M. Sereno, Maria P. Gonçalves, Carbohydrate Polymers 87, 2655–2663 (2012).
BOOK CHAPTERS
P. M. Abreu; P. Branco; S. Matthew, “Natural product-like combinatorial libraries towards the discovery of lead compounds”, in Combinatorial Synthesis of Natural Product Based Libraries, vol. 2, Ed. A. M Boldi, Combinatorial Chemistry Series, CRC Press, Chapt 11, 257-352, 2006.
P. J. M. Abreu; W. Heggie, “Terpenóides e esteróides”, in Biossíntese dos Produtos Naturais, Eds. A.M. Lobo e A.M. Lourenço, IST Press (2007).
Hendrik Luesch and Pedro Abreu, “A Natural Product Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening”, in Ligand-Macromolecular Interactions in Drug Discovery, Methods in Molecular Biology, vol. 572, Ed. A.C. Roque, The Humana Press Inc., Chapt 17, 261-277 (2010).
COMMUNICATIONS
- "Research in Organic Chemistry at the FCT-UNL", University of Namur, Belgium (1980).
- "Isolation of natural products from Pisolithus tinctorius", Instituto Superior Técnico, Lisbon (1981).
- "Chemical constituents of Pisolithus tinctorius", P.Macedo de Abreu, A.M.Lobo, L.S.Godinho, 7th Meeting of the Portuguese Chemical Society, Lisbon (1984).
- "Novel triterpenoids from the fungus Pisolithus tinctorius", Ana Lobo, P. Macedo de Abreu, S.Prabhakar, L.S.Godinho, H.S.Rzepa, R.N.Sheppard, 8th Meeting of the Portuguese Chemical Society, Braga (1985).
- "Novel triterpenoids from the fungus Pisolithus tinctorius", A.M.Lobo, P.Macedo de Abreu, S.Prabhakar, L.S.Godinho, D.J.Williams, 9th Meeting of the Portuguese Chemical Society, Coimbra (1986).
- "Chemical study of the fungus Pisolithus tictorius", FCT-UNL (1986).
- "Novel triterpenoids from the fungus Pisolithus tinctorius", University of Tokyo (1987).
- "Novel triterpenoids from the fungus Pisolithus tinctorius", Pedro M.Abreu, Ana M.Lobo, Sundaresan Prabhakar, 16th Intenational Symposium on the Chemistry of Natural Products (IUPAC), Kyoto (1988).
- "Brassinosteroids", FCT-UNL (1988).
- "Brassinosteroids: chemistry, physiology and agriculture aplications", LNETI, Lisbon (1988).
- "Halogenated monoterpenos from the algae Plocamium cocciuneum, from the portuguese coast”, Pedro Abreu and José Galindro, National Meeting of Macroalgae, LNETI, Lisbon (1990).
- "Brassinosteróides, a new class of phyto-hormones", CSIC, Madrid (1990).
- "Natural products of the red alga Plocamium coccineum and Porphyra umbilicalis", Pedro Abreu, José Galindro, 12th Meeting of the Portuguese Chemical Society, Coimbra (1991).
- "Isolation and identification of Brassinosteroids", University of Brussels, (1993).
- "Reverse phase LPLC and HPLC isolation of meliacines from Khaya senegalensis LPLC", Pedro Abreu, 14th Meetingº of the Portuguese Chemical Society, Aveiro (1994).
- "Stereochemical elucidation of cyclic halogenated monoterpenes by Nuclear Overhauser Effect”, José M.Galindro and Pedro Abreu, 14th Meetingº of the Portuguese Chemical Society, Aveiro (1994).
- "Characterization of 2-O-b-galactopyranosilglycerol from Gelidium sesquipedale", Maria H.Luís, Angela M. Relva and Pedro Abreu, 14th Meeting of the Portuguese Chemical Society, Aveiro (1994).