Curriculum Vitae David J. Grdina
CURRICULUM VITAE
NAME: DAVID J. GRDINA
EDUCATION:
University of Houston M.B.A.
Houston, Texas (Finance) 1980
University of Kansas Ph.D.
Lawrence, Kansas (Radiation Biophysics) 1971
University of Kansas M.S.
Lawrence, Kansas (Radiation Biophysics) 1969
St. Mary's College B.A.
Winona, Minnesota (Biology) 1966
Section of Experimental Biology Postdoctoral Fellow March 1971 -
The University of Texas System in Biology May 1972
Cancer Center, M.D. Anderson
Hospital and Tumor Institute,
Houston, Texas
PROFESSIONAL EXPERIENCE:
Department of Radiation and Cellular Professor of Radiation July 1987-
Oncology, The University of Chicago and Cellular Oncology Present
Chicago, Illinois
Associate Professor of Jan. 1985 -
Radiation and Cellular June 1987
Oncology
University of Chicago Co-Program Leader Oct. 1994 -
Cancer Research Center Chemoprevention July 2000
Center for Mechanistic Biology Head, Section of Nov. 1991 -
and Biotechnology Radiation Biology Sept. 1996
(formerly, Biological and Medical
Research Division) Senior Scientist, June 1987 -
Argonne National Laboratory, Group Leader, Sept. 1996
Argonne, Illinois Radiation Carcinogenesis
(Joint Appt. U. of C.)
Scientist, Group Leader, Sept. 1983 -
Radiation Carcinogenesis June 1987
Department of Therapeutic Radiology, Adjunct Associate April 1984 -
Rush Medical College, Rush- Professor March 1985
Presbyterian-St. Luke's Medical Center,
Chicago, Illinois
Department of Experimental Associate Biologist and Sept. 1978 -
Radiotherapy, The University Associate Professor of Sept. 1983
of Texas System Cancer Center, Radiotherapy (Biology)
M.D. Anderson Hospital and
Tumor Institute, Houston, Texas Assistant Biologist and Sept. 1975 -
Assistant Professor of Aug. 1978
Radiotherapy (Biology)
Research Associate June 1972 -
Aug. 1975
Baylor College of Medicine and Visiting Lecturer June-Aug. 1976
St. Luke's Episcopal Hospital Biological Effects Sept. 1983
Houston, Texas, in conjunction of Nuclear Medicine
with University of Houston
School of Nuclear Medicine
Technology
PROFESSIONAL CONSULTANTSHIPS:
National Institutes of Health Consultant
Bethesda, MD Radiation Study Section 1990-1994
Reviewers Reserve 1994-present
National Cancer Institute NCI Discovery and 2007-present
Development P01
HollisEden Consultant 2004-2007
Pinnacle Biologics Consultant 2009-present
Congressional Pharmaceuticals Founding Scientist 2001-2004
Corporation
PrevOnc (Prevention of Oncogenesis) Founding Scientist 1999-2001
Radiation Oncology Modifiers Founding Scientist 1997-1998
Corporation (ROMCOR)
Odyssey Therapeutics Member: Scientific 1993-1996
3461 Route 22 East and Medical Advisory
Somerville, NJ 08876 Board
U.S. Bioscience Member: Basic 1993-1994
One Tower Bridge Science Advisory
100 Front Street, P.O. Box 851 Board
West Conshohocken, PA 19428 Consultant 1999-2000
Microfocus Imaging Consultant 1992-1995
225 Larkin Drive Product Development
Wheeling, IL 60090
Schering-Plough International Speaker 1996-2001
Ethyol Speaker Bureau
ALZA Pharmaceuticals Ethyol
Speakers Bureau Speaker 1996-2001
MedImmune Speakers Bureau Speaker 2001-2004
NIH STUDY SECTIONS:
NIH Special Study Section Member 1989
NIH Radiation Study Section Ad Hoc Member 1990
NIH Radiation Study Section Member 1990 - 1994
NIH Reviewers Reserve Member 1994 - present
NCI Initial Review Group Member 1996 - 2000
Committee-Subcommittee C -
Basic and Preclinical Sciences
NCI Initial Review Group Ad Hoc Member 1998 -
Committee-Subcommittees A,
D, and E
NCI Special Emphasis Panel Ad Hoc Member 2007-present
GRANT REVIEWER:
Department of Energy Ad Hoc Member 1983 - 1995
Veterans Administration Ad Hoc Member 1987 - present
American Cancer Society Member 1991 - 1992
(Illinois Division, Inc.)
Koningin Wilhelmina Fonds Ad Hoc Member 1985 - present
Netherlands Cancer Foundation
MEMBERSHIP ON COMMITTEES:
National
NASA Space Radiation Standing Review Member 2009-present
Panel, Human Research Program
AERAS Global TB Vaccine Foundation
Institutional BioSafety Committee Member 2006-present
NIH/NCI Radiation Carcinogenesis Chairperson and 2006
Workshop Organizer
Blue Ribbon Panel for NIH Strategic Member 2004
Plan and Research Agenda for Medical
Countermeasures Against Radiological
And Nuclear Threats.
Radiation Research Society Member 1997 - 1998
Fundraising Committee
Radiation Research Society Member 1993-1996
Policies and Procedures Committee
Radiation Research Society Member 1993 - 1994
Program Committee
42nd Annual Meeting
BEVALAC Biomedical Program Member 1991 - 1992
Advisory Committee,
Lawrence Berkeley Laboratory
Radiation Research Society Member 1989 - 1993
Executive Committee
Radiation Research Society Chairman 1982 - 1985
Finance Committee
Radiation Research Society Member 1985 - 1987
Management Support Contract
Committee
Radiation Research Society Member 1982 - 1987
Ad Hoc Subcommittee on
Society Journal
The Cell Kinetics Society Member 1982 - 1984
Finance Committee
Local
Nuclear Incident and Radiation Member 2003-2006
Dispersal Device Committee; Subcommittee
Of the ITTF Science and Technology Committee
For The State of Illinois
University of Chicago Cancer Research Member 1994 - 2004
Center Executive Committee
University of Chicago Committee on Member 2000 – 2004 Appointments and Promotions (COAP) 2009-present
University of Chicago Committee on Member 2000 - 2006
Radioactive Use
University of Chicago Committee on Member 1994 - Present
Cancer Biology
Argonne National Laboratory Member 1984 - 1991
BIM Division, Library Committee
Argonne National Laboratory Member 1985 - 1987
BIM Division, Animal Use Committee
Argonne National Laboratory Member 1988 - 1995
BIM Division, Human Use Committee
Argonne National Laboratory Member 1989 - 1992
BIM Division, Promotions Committee
Argonne National Laboratory Chairman 1989 - 1996
BIM Division, Enrico Fermi
Fellowship Committee
Argonne National Laboratory Chairman 1990 - 1991
BIM Division, Seminar Committee
Argonne National Laboratory Member 1992 - 1994
EEST Personnel Oversight Committee
on Hiring and Promotions
Argonne National Laboratory Member 1993 - 1996
Performance Appraisal Task Force,
Scientific/Engineering
Performance Appraisal Task Force
Argonne National Laboratory Member 1993 - 1995
Working Group to Explore Scientific
Relationship between The University
of Chicago and Argonne National
Laboratory in Medical Sciences.
The University of Texas Graduate Member of committees 1975 - 1983
School of Biomedical Sciences, for six students
Houston, Texas,
Advisory, Supervisory, and/or
Candidacy Examining Committees
The University of Texas Member Jan. 1977 - 1980
System Cancer Center
Academic Standards Committee
M.D. Anderson Hospital and Member 1981 - 1982
Tumor Institute,
Ad Hoc Task Force on Extramural
Impact in FY 82 Academic Plan
The University of Texas Member at Large 1981 - 1983
M.D. Anderson Hospital,
Research Committee
EDITORIAL BOARD:
Associate Editor representing Biology; 1986 – 1990
Radiation Research Journal
Advisory Board Member; CRC Critical 1988 - 1989
Reviews in Sulfhydryl Biochemistry
Advisory Board Member; Libri Oncologici 1992 - present
(Cancer Journal published in English and Croatian)
Member of the Overseas Editorial Board, Journal 2000-2005
of Radiation Research (Japanese Journal)
MEMBERSHIP IN SCIENTIFIC SOCIETIES:
Radiation Research Society
American Association for Cancer Research
University of Texas M. D. Anderson Associates (founding member)
ELECTED OFFICE:
Secretary/Treasurer, 1989 - 1993
Radiation Research Society
VISITING SCIENTISTS/POSTDOCTORALS TRAINED:
Dr. Curt Sigdestad University of Louisville
Dr. Biba Nagy Science Advisor to the President
of the Republic of Croatia
Zagreb, Croatia
Dr. Paul Meechan Northern Illinois University
Dr. Ivan Basic University of Zagreb
Zagreb, Croatia
Dr. Andrew Vaughan University of Birmingham
Birmingham, England
Dr. Yasushi Kataoka National Institute of Radiological Sciences
Chiba, Japan
Dr. Naoyuki Shigematsu Keio University
Tokyo, Japan
Dr. Barton Bergquist University of Northern Iowa
Dr. Coral Quiet University of Chicago
Dr. Jeff Murley Northern Illinois University
Dr. Shie-Chau Liu Illinois Institute of Technology
Dr. William Epperly Argonne National Laboratory
HONORS:
Atomic Energy Commission Special Health Physics Fellowship,
University of Kansas, Sept. 1966 - Aug. 1967.
United States Public Health Service Traineeship in Health Physics,
University of Kansas, Sept. 1968 - Feb. 1971.
AWARDS:
6th International Congress for Radiation Research (ICRR) Travel Award,
1979; 7th ICRR Travel Award, 1983; 8th ICRR Travel Award, 1987; 10th ICRR Travel
Award, 1995
Japanese Government Research Award for Foreign Specialists, 1988.
John Yuhas Award for Excellence in Research,
University of Pennsylvania, 1993.
PROFESSIONAL LISTINGS:
Marquis Who's Who in Cancer Professionals and Facilities, 1st Ed., 1985.
American Men and Women of Science, Physical and Biological Sciences,
16th Ed., 1986.
Marquis Who's Who in the Midwest, 23rd Ed., 1991.
PATENTS
U.S. Patents: “Method for Protection Against Genotoxic Mutagenesis,” 5,488,042, issued January 30, 1996.U.S. Patent 5,567,686, issued October 22, 1996. U.S. Patent 5,869,338, issued February 9, 1999. U.S. Patent 5,891,856, issued April 6, 1999.
“Method for Protection Against Tumor Metastasis Formation. U.S. Patent 6,984,619, 2006.
I. PEER REVIEWED JOURNAL ARTICLES
Grdina, D.J., P. Lohman, and R.R. Hewitt. A Fluorometric Method for the Detection of Endodeoxyribonuclease on DNA-Polyacrylamide Gels. Analytical Biochemistry, 51:255-264, #1, January, 1973.
Grdina, D.J., L. Milas, R.R. Hewitt, and H.R. Withers. Buoyant Density Separation of Human Blood Cells in Renografin Gradients. Experimental Cell Research, 81:250-254, 1973.
Grdina, D.J., L. Milas, K. Mason, and H.R. Withers. Separation of Cells from a Fibrosarcoma in Renografin Gradients. Journal of the National Cancer Institute, 52:253-257, #1, January, 1974.
Grdina, D.J., M. Meistrich, and H.R. Withers. Separation of Clonogenic Cells from Stationary Phase Cultures by Density Gradient Centrifugation. Experimental Cell Research, 85:15-22, 1974.
Basic, I., L. Milas, D. Grdina, and H.R. Withers. Destruction of Hamster Ovarian Cell Cultures by Peritoneal Macrophages from Mice Treated with Corynebacterium granulosum. Journal of the National Cancer Institute, 52:1839-1842, June, 1974.
Milas, L., N. Hunter, I. Basic, K. Mason, D.J. Grdina, and H.R. Withers. Nonspecific Immunotherapy of Murine Solid Tumors with C. granulosum. Journal of the National Cancer Institute, 54:895-902, 1975.
Basic, I., L. Milas, D.J. Grdina, and H.R. Withers. In vitro Destruction of Tumor Cells by Macrophages from Mice Treated with C. granulosum. Journal of the National Cancer Institute, 55:589-596, 1975.
Grdina, D.J., I. Basic, K. Mason, and H.R. Withers. Radiation Response of Clonogenic Cell Populations Separated from a Fibrosarcoma. Radiation Research, 63:483-493, 1975.
Grdina, D.J., I. Basic, S. Guzzino, and K.A. Mason. Radiation Response of Cell Populations Irradiated in situ and Separated from a Fibrosarcoma. Radiation Research, 66:634-643, 1976.
Grdina, D.J., W.H. Hittleman, A. White, and M.L. Meistrich. The Formation of Lung Colonies. An Analysis Based on Cellular Parameters of Density, Size, and DNA Content. British Journal of Cancer, 36:659-669, 1977.
Suzuki, N., M. Frapart, D.J. Grdina, M.L. Meistrich, and H.R. Withers. Cell Cycle Dependency of Metastatic Lung Colony Formation. Cancer Research, 37:3690-3693, October, 1977.
Meistrich, M.L., D.J. Grdina, R.E. Meyn, and B. Barlogie. Separation of Cells from Mouse Solid Tumors by Centrifugal Elutriation. Cancer Research, 37:4291-4296, December, 1977.
Grdina, D.J., S. Linde, and K. Mason. Response of Selected Tumor Populations Separated from a Fibrosarcoma Following Irradiation in situ with Fast Neutrons. British Journal of Radiology, 51:291- 301, March, 1978.
Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. I. Relationship Between Cell Size and Age as Modified by Growth in vivo or in vitro. Journal of the National Cancer Institute, 61:209-214, July, 1978.
Grdina, D.J., L.J. Peters, S. Jones, and E. Chan. Separation of Cells from a Murine Fibrosarcoma on the Basis of Size. II. Differential Effects of Cell Size and Age on Lung Retention and Colony Formation in Normal and Pre-Conditioned Mice. Journal of the National Cancer Institute, 61:215- 220, July 1978.
Grdina, D.J., C.P. Sigdestad, and L.J. Peters. Phase Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Cells Synchronized by Centrifugal Elutriation. British Journal of Cancer, 39:152-159, February, 1979.
Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. Cytotoxic Effect of Adriamycin in vivo on Synchronized Murine Fibrosarcoma Cells. International Journal of Radiation Oncology, Biology, Physics, 5:1305-1308, 1979.
Sigdestad, C.P., D.J. Grdina, and K. Ando. Density Gradient Centrifugation of Cells Separated from Multicellular Tumor Spheroids. Experentia, 35/6:815-817, 1979.
Hunter, N., L.J. Peters, D.J. Grdina, R.A. White, and A. Bartel. Radiation Sensitivity of Murine Fibrosarcoma Cells Separated by Centrifugal Elutriation. Radiation Research, 80:389-397, 1979.
Grdina, D.J., C.P. Sigdestad, and J.A. Jovonovich. The Effect of Misonidazole in situ on the Radiation Response of Selected Tumor Cell Subpopulations. Clinical Cancer Trials, 3:149-154, 1980.
Sigdestad, C.P., and D.J. Grdina. Velocity Sedimentation of Tumor Cells: A Comparison of Methods. Experentia, 37:501-502, 1981.
Sigdestad, C.P., and D.J. Grdina. In vivo Cell Cycle Phase Preferential Killing of Murine Fibrosarcoma Cells by Cis-Dichlorodiammine Platinum II. Cancer Treatment Reports, 65:845-851, 1981.
Sigdestad, C.P., and D.J. Grdina. Density Centrifugation of Murine Fibrosarcoma Cells Following in situ Labeling with Tritiated Thymidine. Cell Tissue Kinetics, 14:589-600, 1981.
Grdina, D.J. Phase-Specific Cytotoxicity in vivo of Hydroxyurea on Murine Fibrosarcoma Pulmonary Nodules. British Journal of Cancer, 45:438-446, 1982.
Grdina, D.J., and N. Hunter. Cyclic-Radiation Response of Murine Fibrosarcoma Cells Grown as Pulmonary Nodules. International Journal of Radiation Oncology, Biology, Physics, 8:1727-1734, 1982.
Brock, W.A., D.E. Swartzendruber, and D.J. Grdina. Studies of the Kinetic Heterogeneity in Density Separated Tumor Subpopulations. Cancer Research, 42:4999-5003, 1982.
Mian, T.A., J.C. Theiss, and D.J. Grdina. Lung Tumorigenic Response of Strain A Mice Exposed to Hypoxic Cell Sensitizers Alone and in Combination with Gamma Radiation. Cancer Research, 43:146-149, 1983.
Thames, H.D., D.J. Grdina, and L. Milas. Response of a Fibrosarcoma Cell Population to Small Doses of Radiation Delivered in situ. International Journal of Radiation Oncology, Biology, Physics, 9:217-220, 1983.
Grdina, D.J., and R.A. White. Treatment of Artificially-Induced Pulmonary Metastases with Fractionated Doses of Vincristine and/or Radiation Therapy. Clinical and Experimental Metastasis, 1:71-81, 1983.
Grdina, D.J., R.A. White, and J.J. Stragand. Cytotoxic Effects of Vincristine on Tumor Subpopulations Separated from Pulmonary Nodules. British Journal of Cancer, 48:279-287, 1983.
Grdina, D.J., and G. Zin. Density Gradient Centrifugation of Tumor Cells from Needle Biopsies and Their Respective Source Tumors: A Comparison of Density Distributions. Experentia, 39:916-917, 1983.
Grdina, D.J., M.L. Meistrich, R.E. Meyn, T.S. Johnson, and R.A. White. Cell Synchrony Techniques. I. A Comparison of Methods. Cell and Tissue Kinetics, 17:223-236, 1984.
White, R.A., D.J. Grdina, M.L. Meistrich, R.E. Meyn, and T.S. Johnson. Comparison of Cell Synchrony Techniques. II. Cell Progression Data. Cell and Tissue Kinetics, 17:237-245, 1984.
Grdina, D.J., H.D. Thames, and L. Milas. Tumor Sensitizing Effect by Misonidazole in a Clinically Relevant Radiation Dose Range. International Journal of Radiation Oncology Biology, Physics, 10:379-383, 1984.
Grdina, D.J., S. Jones, and N. Hunter. Effectiveness of AMSA Alone or in Combination with Radiation on Murine Fibrosarcoma Pulmonary Nodules. Clinical and Experimental Metastasis, 2:223-233, 1984.
Grdina, D.J., B. Nagy, C.K. Hill, R.L. Wells, and C. Peraino. The Radioprotector WR1065 Reduces Radiation-Induced Mutations at the HGPRT Locus in V79 Cells. Carcinogenesis, 6:929-931, 1985.
Grdina, D.J., C. Peraino, B.A. Carnes, and C.K. Hill. Protective Effect of [S‑2‑(3‑aminopropylamino) ethyl phosphorothioic acid] Against Induction of Altered Hepatocyte Foci in Rats Treated Once with Gamma Radiation Within One Day After Birth. Cancer Research, 45:5379-5381, 1985.
Thames, H.D., D.J. Grdina, and L. Milas. On the / Ratio and OER for Clonogenic Tumors Cells. International Journal of Radiation Oncology, Biology, Physics, Correspondence, 11:1572-1573, 1985.