Clarence Ernest Schutt
DEPARTMENT OF CHEMISTRY
PRINCETON UNIVERSITY
(609) 258-4435 (O)/ (617) 866-0024(c)
;
Education
The University of Michigan, 1967, BS (Physics) Honors Program,
Michigan State University, 1969, MS (Physics)
Harvard University, 1976, Ph.D. (Applied Mathematics)
Thesis: The Structure of Tomato Bushy Stunt Virus to 5.5 Å Resolution
Research Advisor: Prof. Stephen C. Harrison
Employment History
Director and Chief Scientific Officer, Nancy Lurie Marks Family Foundation (2008 - present)
Professor of Chemistry, Princeton University (1995 – 2012)
Associate Professor of Chemistry, Princeton University (1985 - 1995)
Post-doctoral Fellow, Medical Research Council Laboratory of Molecular Biology, Cambridge, England (1977-1985), Research Advisors: Sir Aaron Klug and Dr. Hugh Huxley
Graduate Research Fellow, Department of Biochemistry & Molecular Biology, Harvard University, Cambridge, Massachusetts (1972-1976)
Administration Manager, Aerospace America, Inc., Bay City, Michigan (1970-1971)
Physicist, Bendix Aerospace Systems Division, Ann Arbor, Michigan (1969-1970)
Fellowships and Honors
Honorary Professorship, University of San Marcos (Lima) (2009)
Visiting Fellow Commoner, Trinity College, Cambridge University (2004-2005)
Member, Physiological Chemistry Study Section of the NIH (1998 – 2001)
Past Chairman of the Board, National Alliance for Autism Research (1999 - June 2001)
J & J Focused Giving Award (1989 - 1991)
Ph.D. honoris causa, Stockholm University, 1988
Established Investigatorship, American Heart Association (1982 - 1987)
Muscular Dystrophy Association Fellowship (1980 - 1982)
Helen Hay Whitney Fellowship (1977 - 1979)
General Motors College Scholarship (1963-1967)
Special Advisory Capacity
Scientific Advisor, Nancy Lurie Marks Family Foundation (2002-2007)
Member, Neurodiscovery Advisory Council, Harvard Medical School (2010-2012)
Member, Vice-Chancellor’s Advisory Council, Oxford University (2010-2012)
Advisory Boards
Member, Advisory Council, Department of Neuroscience, Harvard Medical School (2010)
Editorial Board, Phil. Trans. Roy. Soc. B (2007-2010)
Board Member, Center for Jewish Life, Princeton University, (September 2006 -2009)
Founder and Co-Chair, Princeton-Eden Lecture Series (1994 - present)
Member, External Review Committee, St. Jude Children’s Research Hospital (October 2001) Chairman, Scientific Advisory Board, NitroSystems, Inc., GA (1998- 2003)
Member, NIH-Physiological Chemistry Study Section, (1997- 2000)
Chairman, Scientific Advisory Board, DGI Technologies Inc, Upper Montclair, NJ (1994 -2003)
Founding Trustee & Chairman, National Alliance for Autism Research, Princeton, NJ (1995 –2001)
Member, Scientific Advisory Board, 3-D Pharmaceuticals, Inc., Exton, PA (1993 -2003)
Advisory Committee for Brookhaven National Light Source for Protein Crystallography, (1991 - 1998)
Research Group
POSTDOCTORAL FELLOWS:
Nancy Vogelaar (1990-1996)
Michael Rozycki (1987-1996)
Daniel Bollag (1990-1991)
Anne Stock (1988-1990)
GRADUATE STUDENTS:
Alex Plakonatonakis, writing thesis
Volodymyr Gelfand. “Quantitative Modeling of Muscle Contraction”, June 2003
Kartik Narayan. “Towards an Atomic-Resolution Structure of Filamentous Actin”, January 2003
Constantine Kreatsoulas. “A Catalytic Polymerization Model for Actin-Based Motility” November 2002
Raj Chakrabarti. “PCR Enhancement by Organic Solvents”, June 2002.
Ilana M. Nodelman. “Structural Analyses of Human Profilin IIB and Rotavirus NSP4” June 2001
Gregory D. Bowman. “A Structural Investigation of Actin Depolymerizing Factor 1 from Arabidopsis Thaliana” June 2001
Rebecca Page. “Domain Motions in Actin & their Implications for F-actin Modelling” (Department
of Chemistry). December 1999
Donald Preston Huddler, Jr. “Structural Studies of Plant Profilins” (Department of Molecular
Biology). June 1999
Ron Shigeta, Ph.D. 1996, “Structural Analyses of Pertussis Toxin and Profilin I from
Arabidopsis Thaliana.”
John Chik, Ph.D. 1996, “Solid-State Transformations of Crystalline Bovine Profilin:b-Actin
Complex at Atomic Resolution.”
Nalin Goonesekere, Ph.D. 1994, "The Crystal Structure of Profilin."
Katrina Forest, Ph.D. 1993, "X-Ray and Electron Crystallography Applied
to Pertussis Toxin."
James Myslik, Ph.D. 1992, "The Structure of Actin in the Crystalline
Profilin:Actin Complex."
Roberta Susnow, Ph.D. 1991, "Quantitative Biomolecular Structural Sensitivity
Analysis," (Advisors: C. E. Schutt and H. Rabitz)
Joanna Krueger, Ph.D. 1991, "Structure/Function Studies of the Methylesterase
Involved in Bacterial Chemotaxis."
Vidya Raghunathan, Ph.D. 1991, "Study of Profilin Conformation: Effects of
Phosphatidylinositol."
Malini Raghavan, Ph.D.1991, "The Use of Alternative Substrates in the
Characterization of Actin and CarnosineMethylating Enzymes."
Nicholas Strauss, Ph.D. 1987, "X-ray Crystallographic Studies on the Structure
and Interactions of the Profilin:Actin Complex." (Cambridge University)
Courses Taught
Chemistry 981 Junior Independent Study Seminar (Fall,2011, 2012)
Chemistry 543 Structural Biology of Neurodevelopmental Disorders (Spring 2009, 2010)
Chemistry 215 Honors Freshman Chemistry (Fall 2009, 2010)
Chemistry 231-232 Integrated Science Course (Spring 2006, 2007, 2008; Fall 2006, 2007))
Chemistry 306 Thermodynamics & Kinetics (Spring 2003, 2004, 2008)
Woodrow Wilson School 474 Special Topics in Public Affairs: Pharmaceutical Research,
Drug Approval, and Health Policy (Fall 2002-2006) – re-numbered WWS327 Chemistry 543 Structural Biology of the Human Nervous System (Spring 1999) Senior Seminar: Consilience: Case Studies in Complex Adaptive Systems (Fall 1998) Chemistry 508 Biophysical Chemistry (Fall 1997)
Freshman Seminar (FRS119) Symmetry and Chance in Biology (Fall 1996)
Chemistry 542 Principles of Macromolecular Structure (Spring 1996) Freshman Seminar (FRS118) Architectonics of Nature (Spring 1996)
Chemistry 543 Structural Biology of Human Disease (Spring 1994, 1997; Fall 1994; Fall 1995)
Senior Seminar: Complex Adaptive Systems (1993)
Chemistry 543 Advanced Crystallography (1993)
Freshman Seminar: Change and Transformation in the Material World (1991, 1992)
Chemistry 201 Introductory Chemistry (1989 – 1993, 1997-2001) Chemistry 205 Honors Freshman Chemistry (1987 - 1988)
Chemistry 542 Principles of Macromolecular Structure (1987 - 1990)
Conferences Organized
Wenner-Gren Symposium, “Force Transduction in Biological Systems”, Stockholm, Sweden, August 2004
Princeton Class of 1943, "The Amazing Human Mind" Reunion Symposium, Princeton University, May 29, 1998
Princeton 250th Anniversary Symposium “The Architectonics of Nature”, Princeton University,
November 1996
The Eden Institute Foundation Princeton Lecture Series on Autism, “Affecting the Research and Service Agenda,” Princeton, NJ. Annually May 1995-June 2009
Frontiers in Structural Biology: in honor of D. L. D. Caspar’s 60th birthday, Princeton University, May 1986
NSF/NIH Scientific Reviews (selected)
Member, N.I.H., Physiological Chemistry Study Section, (1996-2000)
Committees
Associated Faculty of Molecular Biology Department, Princeton University
Director, Graduate Program in Molecular Biophysics, Princeton University (1992 -2002)
Member, Program in Materials Science, Princeton University
Executive Committee, Program in Neuroscience, Princeton University
Director, Graduate Program of Chemistry Department, Princeton University (1995 - 1997)
Member, Summer Scholars Institute, Princeton University (1995 - 1998)
University Radiation Safety Committee (1987 – 1990, 1998 -2002)
University Committee on Standings and Evaluations (1990 - 1991)
Faculty Fellow, Forbes College
Undergraduate Class Advisor (1990 - 1991)
University Committee, Public Lectures (1993)
Director, Graduate Program of Chemistry Department, Princeton University (1995 - 1997)
Member, Council of the Princeton University Community (2000 – 2002)
Member, Faculty Advisory Committee on Policy (2001-2002)
Member, Faculty Advisory Committee, Program in Neuroscience (2006-2012)
Undergraduate Thesis Directed
2011 Stephanie Noble, Modeling Filamentous Actin. Department of Chemical Engineering
2007 Lauren D. Pflepsen, Personalized Psychopharmacotherapy: A Model for Biomarker- Based Diagnosis and Optimized Treament of Schisophrenia.
.
Tara L. Lloyd, Proton NMR Metabonomic Analysis of Blood Serum from Pregnant Mares Grazing Endophyte-Infected Fescue.
Catherine E. Cushenberry, Redistributing Pharmacovigilance: Physicians and the Industry in U.S. Post-Market Drug Surveillance
2006 Sarah Murphy, Regulation of Molecular Interactions: Implications for Synaptogenesis &
Neurodevelopment.
Lauren F. Chaparro, Generation RX: The Science, Ethics, and Politics of Antidepressants in Pediatrics.
Andrew Goldstein, Public Scientific Literacy: A New Rationale Rooted in Individual Agency.
2003 Michael Bennett, Structural Studies on Tropomyosin Isoforms
2002 Jamie Chaft, Structural Studies on Rotaviral NSP4
1999 Natalie Audage. “Photoperiodic Effects on Brain GnRH and Area X Volume in Male
Canaries (Serinus canaria). Department of Chemistry.
Sulene Liu Chi. “Partial Construction of a Single-Chain Linked Actin Trimer”. Department
Of Chemistry.
Neal A. Desai. “Human Consciousness: A Philosophico-Scientific Theory”. Department
of Molecular Biology.
Sepander David Kamvar. “Muscle Contraction as a Markov Process”. Department of
Chemistry.
1997 Matthew Hassan, “Serotonin and the Synaptic Cytoskeleton.”
1996 Daniel Klebanov, "Analysis of Muscle Contraction through Computer Modeling.”
Kurt Thorn, "The Crystal Structure of Arabidopsis Profilin I at 1.6Å Phased by MAD
Analysis of the Selenomethionyl Protein."
1994 Jennifer Jones, "Purification and Preliminary Characterization of B. Verrucosa
Profilin."
Robert Smith, "Pertussis Toxin a Purification and Crystallization Study
Augmented by ATPgS Precession Photography."
Senaka A. Peter, "Influence of sn-2 Chain Unsaturation on the 2H-NMR Order
Parameter Profiles and the Bilayer Thickness of Stearic Acid sn-1 Chains in Phosphatidylcholines."
1992 Stephen Miller, "Computer Simulation of the Actin Power Stroke
Model of Muscle Contraction."
Kristin Anderson, "A Preliminary Analysis of Tubulin Stability and
pH Dependence of the Tubulin Lattice." (Eng. Biol.)
Patrick Ying, "Basic Fibroblast Growth Factor and Sulfated Polysaccharides:
Development of A Binding Assay."
1991 Kevin Leong, "The Expression of Mammalian Profilin in Escherichia Coli:
Toward an NMR Structural Determination." (Eng. Biol.)
Thomas Cappola, "Investigating the Structure of ADP.Pi-Actin."
Alyssa Kuhn, "Purification, Crystallization and Preliminary X-ray Analysis
of Porcine Growth Hormone." (Eng. Biol.)
Daniel Elkes, "Evidence for Thymosin Beta-4 in Triton-Based Homogenate of
Calf Thymus." (Mol. Biol.)
1990 Thu Huong Le Trinh, "Purification and Crystallization of Gc."
1989 Leo Kwok-Yueh Shin, "Alchemy in Elizabethan England and Late Ming China."
Catherine Smith, "Post-Translational Modification of Actin."
Chinyu Su, "Induction and Partial Purification of Yeast Tubulin."
1988 Mona Gabbay, "Creativity in Science: Visual Perception of the Actin/Profilin
Electron Density Map."
Elizabeth Hilton, "Actin Database: A Tool for Structural and Mechanistic Studies."
1987 Donna Czerniakowski,"Purification and Interaction of Gelsolin and Actin."
Thomas Hawn, "Refinement of the Electron Density Map of the Actin:
Profilin Complex."
Scott Garman, "Progress Toward the Determination of the Structure of
Profilin:actin Crystals."
Stephen Kimatian, "Molecular Dynamics of the Lipid Micelle."
1986 Howard Chen "Molecular Graphics and Biology." (Chem Eng)
Invited Seminars and Lectures
2012
“Implications of Autism Research for Global Health Policy”, 20 November, WWS
“Distinguished Lectureship”, Children’s Hospital, 17 December, Univ. Pennsylvania
2010
“Autism: Advancing Research, Diagnosis and Treatment, Massachusetts General Hospital, 9 April
“Eppley Lecture: Architectonics of Autism”, University of Nebraska Medical School, 22 April 2010
“Plenary Lecture: Why Now is the Time to Fund Adult Programs in Autism”, Interdisciplinary
Council on Development & Learning, Washington DC, 7 November 2010
2009
“Acceptance Lecture: Honorary Professorship”, University of San Marcos, Lima, Peru, 30 March
2008
“An Architectonic Perspective on Autism”, St. Peter’s College, 8 March 2008
“Because of Alex – Cancer Biology & Autism”, Princeton-Eden Lecture
Series, 6 June, 2008
“The Structural Biology of Autism”, Brandeis University, 5 September 2008
2007
“The Origins of Life: An Architectonic Perspective”, 28 March 2007, Nobel Forum: What is Life?, Karolinska Institute, Stockholm, Sweden
“An Architectonic Perspective on Autism: New Directions in Autism Research”, 25 September 2007, Brandeis University
“A Policy Perspective on the Pharmaceutical Industry”, 4 October 2007, The Wharton School, University of Pennsylvania
2006
“Because of Alex – Implications of Genomics for Autism Research”, Princeton-Eden Lecture
Series, June, 2006
“The Lima Lectures on Molecular Evolution: Origins of Life”, 1 August 2006, University of San
Marcos, Lima, Peru.
“The Lima Lectures on Molecular Evolution: Origins of Eukaryotic Cells”, 2 August 2006,
University of San Marcos, Lima, Peru.
“The Lima Lectures on Molecular Evolution: Origins of Multi-Cellularity”, 3 August 2006,
University of San Marcos, Lima, Peru
“The Lima Lectures on Molecular Evolution: Evolution of the Brain and Communication by
Speech, 4 August 2006, University of San Marcos, Lima, Peru
2005
“Actin Filament Modeling: Interpretation of Recent Results from Crystallography”, 26 Sept. 2005,
Medical Research Council Laboratory of Molecular Biology, Cambridge, England
“The Path Forward for Autism Research & Philanthropy”, 26 Sept. 2005, Masters Lodge, Trinity College, Cambridge, England (after dinner speech)
2004
“Architectonics of Molecules”, 17 March 2004, University of San Marcos, Lima Peru
“How Molecules Create Thought”, 18 March 2004, University of San Marcos, Lima, Peru
“Art & Science”, 19 March 2003, University of San Marcos, Lima, Peru
“Beyond the Genome: Evolution of Special Physical Abilities”, 16 June 2004, Arts & Ideas Festival, New Haven, Conn.
“Structural Biology of Actin Filament Assembly: a new model for filament severing and capping by gelsolin”, Wenner-Gren Symposium, 18 August 2004, Stockholm, Sweden
2002
“The Tango of Art & Science”, 19 Feb. 2002, The Newark Museum, Newark, NJ
“Structural Biology and Human Disease”, 12 Feb. 2002, Uppsala, Sweden
“Structural Biology of Actin-Based Motility”, 25 Mar. 2002, Nano Architectonics International Symposium II, Los Angeles, CA
“Personalized Medicine and Structure of Protein Families”, 4 Dec. 2002, Genaissance Pharmaceuticals, New Haven, CT
2001
“Because of Alex…scenarios for future without autism”, 8 June 2001
Keynote Address: “Teaching to Make a Difference”, Harold W. McGraw Jr. Center for Teaching and Learning, Princeton, NJ
“Structural Biology of Autism”, National Institutes of Health/ACC, 8 September 2001, Bethesda, MD
“Genes, Genii and the Architectonics of Autism” FECA Conference, 6 November 2001, Westchester County, NY
2000
MACC Lecture, "Gold in the Details", 18 September 2000
1999
Fox-Chase Cancer Center, Philadelphia, PA “The Architectonics of Actin”, 18 March 1999
New York University Medical School, “The Architectonics of Actin”, 27 April 1999
Stockholm University, “Who does he think he is?” – Symposium on Actin and Chromatin
Remodeling in honor of Uno Lindberg’s 60th Birthday. 19 May 1999
Gordon Conference on Muscle Contraction, Session Chair and Speaker, “Actin Dynamics”,
Colby College, Andover, VT, 8 June 1999
Wyeth-Ayerst Lederle Vaccines Division, Rochester, NY “What Protein Crystallography Teaches us
About Protein Dynamics”. 25 August 1999
Eastern College (St. Davids, PA), “The Architectonics of Nature”, Inaugural Lecture, Templeton
Honors College, 17 September 1999
University of California, Santa Barbara, “Because of Alex… Scenarios for a Future without
Autism”, Plenary Lecturer. Symposium on “Autism 2000: Focus on Solutions”, 24 September 1999
University of Toledo, Annual Distinguished Lecturer of Department of Chemistry, “The Nature of
Actin” – 17 November 1999. Special Public Lecture in Honor of the Installation of Dr. Vic
Kapoor as President of Toledo University – “Architectonics” – 18 November 1999
1998
The Princeton Section of the American Chemical Society, “Protein Architectonics,” Princeton, NJ, January 15
Autism Society of America, Oakland County Chapter, “Because of Alex... My Odyssey from Denial
to NAAR,” West Bloomfield, MI, January 25
Vanderbilt University, “Architectonics of Actin”, Nashville, TN, February 10
Chapel Hill Autism Group, Chapel Hill, NC, February 23