CHEM 4670/5900 Dr. Sushama A. Dandekar SPRING, 2014
Lecture: T, Th 8:00 - 9:20 a.m. Chemistry, Rm ENV 115
OFFICE: Chemistry, Rm 307D
PHONE: (940) 369-7090 or (940) 565-2713 (Chemistry Dept. Office)
E-MAIL:
OFFICE HOURS: M 12:00 – 12:50 p.m.
T 9:30 – 10:30 a.m.
TEXTBOOK: Required: “Introduction to Medicinal Chemistry”, 5th Ed., by
Graham L. Patrick (Oxford)
DISABILITIES:
The Chemistry Department believes in reasonably accommodating individuals with disabilities and complies with the university policy established under section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act (1990) to provide for equal access and opportunity. Please communicate with me as to your specific needs so that appropriate arrangements can be made through the department and/or the office of Disability Accommodation (ODA, Room 318A, Union, 565-4323).
ATTENDANCE:
Regular attendance at lectures is required and expected. However, if you are unable to attend due to reasons beyond your control, you must inform me as soon as possible. If you are absent from three or more classes without an excuse, you may be dropped from the class.
EXAMS:
You are responsible for learning and understanding the material covered in the course whether or not you attend class. You are also responsible for reading the text-book: some questions on exams may pertain to material in the text that was not discussed explicitly in class.
Two unit-exams will be given during the semester. The lower of the two exam scores will be worth 10% of your semester grade, while the higher score will be worth 20% of your semester grade.
Tentative dates for the exams:
Exam 1: February 13th
Exam 2: March 20th
The Final Exam is comprehensive, covering material from the entire semester.
Date and time: as per the university’s final exam schedule
PROJECT:
One of the objectives of this course is to make you better aware of the chemical world around you and also hone your self-study skills along the way. One of the ways of accomplishing this objective is to read supplementary material (books, magazines, journals, etc.), comprehend it and then present it in an organized way. You are to sign up for a topic: (suggested topics will be discussed in class) during the first week of classes. The final project grade is a composite of grades obtained for the components described below. Since the term project is primarily a team project (for CHEM 4670 students), it is important to have an effective means of working collaboratively team members: PBworks is a very useful wiki tool for this purpose. For CHEM 5900 students, you will be working on the project by yourself, but it will still be helpful for you to use PBworks, so that I can provide feedback as your paper progresses. You must request access to PBworks during the first week of classes.
Paper: (35 %)
Research the topic, then write a review paper (20 pages minimum). Feel free to discuss with me any aspects of the material you are not clear about.
ü Papers must be typed (at least 1.5-spaced, preferably fontsize 12) and include complete bibliographic information at the end of the paper.
ü You must use at least ten sources (other than your textbook!), of which at least five must be from peer-reviewed publications (journals, textbooks, monographs, etc.).
ü Be sure to include figures, tables, reaction schemes, etc., within the main body of the paper to clarify the material presented. (i.e, do not place them at the very end of your paper!)
ü Figures, tables, structures, equations, reaction schemes, references, etc., must be numbered, in chronological order, and accordingly referred to in the text.
ü Figures, tables, reaction schemes, etc., must have a title and must be accordingly referred to in the text.
ü DO NOT simply position figures, tables, structures, equations, reaction schemes where they need to be without referring to them in the paper. You must refer to it in the paper: e.g., “…..as shown in Scheme # below…..”
ü Use the ACS Style Guide for formatting your paper in accordance with currently accepted norms: if you have questions, ASK !!
ü A sample JOC paper and some tips for writing formal papers is placed in the term project folder on Blackboard.
Deadlines: Outline: January 31st, 2014
Rough Draft: February 18th, 2014
Final Paper: Any time before March 25th, 2014
Seminar: (Begin March 27th) (35 %)
Prepare your research material for a seminar-style presentation (~15 minutes): a power-point presentation would be appropriate and professional. Some information may be suitably presented in poster form if you wish, while molecular models (prepared in advance) may be useful for clarifying some structural concepts. Your presentation will be followed by approximately 5 minutes of open discussion.
NOTE: You must be present for ALL the presentations! Non-attendance
during presentations is subject to penalty.
Follow-up Questions: (20 %)
At the end of the presentation, each student (in the audience) will have an opportunity to ask additional questions, in writing, regarding the topic presented. Go through the questions, and provide answers (typed) to ANY FIVE of these questions within one week of your presentation. You must also provide references for these answers. These will then be distributed to the class.
Overall Project Experience: (10 %)
After you have completed all of the above-mentioned items, reflect on the overall project experience: new skills you acquired, glimpses into areas of chemistry that you may have previously been unaware of, better understanding of certain subtle concepts, etc. Also identify what, if anything, you would do differently the next time you have to do a project of this nature. Articulate and organize these thoughts into a 1-2-page summary.
ASSIGNMENTS:
A variety of assignments will be given throughout the semester. This may involve generating “test bank” questions to help prepare for exams, as well as problem-solving and library research regarding further exploration of topics discussed in class.
A valuable self-assigned exercise would be to answer end-of-chapter questions: these are designed to help you grasp some of the subtler details of the concepts presented in the chapter.
GRADING:
Your semester grade will be determined as follows:
Term Project 20 % of final grade
Assignments 20 % of final grade
Unit Exams 30 % of final grade
Final Exam 30 % of final grade
A grading curve may be used, at my discretion, to achieve a fair distribution of grades. Course Grades will be determined in the following way:
90-100% A
78-89% B
68-77% C
54-67% D
I am looking forward to a wonderful and rewarding semester with you !
☺
Tentative Schedule
1 / Jan 13 / Introduction to the course
Ch 1: Drugs and Drug Targets
Ch 2: Proteins / Term Project Topics: Sign-Up for Term Projects:
PBWorks: Request access (wiki tool for creating term paper)
2 / Jan 20 / Ch 3: Enzymes
Ch 4: Receptors
3 / Jan 27 / Ch 5: Signal transduction: Brief overview
Ch 6: Nucleic Acids / Term Project: Outline Due
4 / Feb 3 / Ch 7: Enzymes as drug targets
Ch 8: Receptors as drug Targets
5 / Feb 10 / Ch 9: Nucleic Acids as Drug Targets
Ch 10: Miscellaneous Drug targets / Exam 1
6 / Feb 17 / Ch 11: Pharmacokinetics and related topics / Term Project: Rough Draft Due
7 / Feb 24 / Ch 19: Antibacterial agents
8 / Mar 3 / Ch 12: Drug Discovery: Finding a lead
9 / Mar 10 / Spring Break: No classes / No classes
10 / Mar 17 / Ch 13,14: Selected topics / Exam 2
11 / Mar 24 / Ch 15: Getting the drug to market Term Project Presentations begin / Term Paper: Final Paper Due
12 / Apr 2 / Term Project Presentations
13 / Apr 9 / Term Project Presentations
14 / Apr 16 / Term Project Presentations
15 / Apr 23 / Term Project Presentations
16 / Apr 30 / Selected topics
17 / May 7 / Selected topics
18 / May 14 / Final Exams / Final Exam:
UNT schedule
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