CHE499 TRANSPORT MODELING Spring 2004
GRADE:
No late homework. No make-up quizzes or tests
A : 93-100%, A- : 90-93% , B+ : 87-90% , B : 83-87% , B- : 80-83%
C+ : 77-80% , C : 73-77% , C- : 70-73%
D+ : 67-70% , D : 60-67% , F : 0-60%
GRADING SCALE 1
Homework (best 9 of 10 assignments) 15%
Best 4 of 5 biweekly quizzes 45%, closed books and closed notes
Final 40 %
Case Study (Optional) 5%
OPTIONAL GRADING SCALE 2
Homework (best 9 of 10 assignments) 15%
Best 4 of 5 biweekly quizzes 45%, closed books and closed notes
Case Study 40 %
Please sign and return this form by April 12 2004 to be considered for the optional grading scale 2
Your name ___________________________
Your signature __________________________ Date ________________
CHE 499 CASE STUDY ASSIGNMENT (Spring 04)
Due: Friday May 28 2004 at 9:00 AM
Transport Phenomena in Biomedical Engineering
This is a case study that you must select based on any topics related to Transport Phenomena in Biomedical Engineering. A list of acceptable topic is available so you can pick a topic from the list, the first person signing the name next to the topic will be responsible for it. You must read at least 5 references and turn in a copy of your main reference excluding the text materials. You can start with the text materials and the references listed in the text, page 289. Your case study must be quantitative. There must be an equation or set of equations presented to describe the transport phenomena. The solutions to the equation(s) must also be presented and discussed. You can work alone or in a group of 2 and turn in one report. Group of 2 must give an oral presentation for the full credit. Oral presentation is optional for 1 person. Oral presentation is about 20 minutes per group.
Grading criteria:
Presentation of relevant information (20%)
- You must present your case study with a typed-written title page and an executive summary. The format for the title page is given in the opposite page. You need to assign a title to your case study.
- You must write an introduction (backgrounds materials) for the topic before you describe the transport model, its significances and applications. You must provide all the necessary information toward the solution of the model. You should include picture(s) to illustrate the description.
Model development (20%)
- Make a sketch of the system
- List all the assumptions, physical properties, and parameters.
- Derive the equations for your system in details.
Solution (20%)
- Solve the transport model analytically or by using any software package (You can use POLYMATH, MATLAB, MATCAD...).
- Verify and present the results in graphical form. You should plot the dependent variable(s) versus the independent variable(s) with a realistic set of parameters. You are to plot the effect of perturbations (+/- 50%) of these parameters on the dependent variable(s).
Discussion of results (20%)
- Discuss the assumptions and the solutions and possible applications of the solution.
Computer disk (10%)
- A computer disk that contains your report, your Powerpoint presentation and any relevant materials.
General completeness and neatness (10%)
- Your report should contain: (A sample report is available)
1. Title page.
2. Executive summary: This should succinctly summarize your problem, your results, and your conclusions. This summary should not exceed two typed written pages.
3. Transport Model: This should contain an introduction and detailed description of the model.
4. Model Solution: This should contain solution, and results in graphical form.
5. Discussion. This should contain your analysis of the results and the application.
6. Appendices: This should contain any relevant materials (EX: Derivation of equation(s), your computer program, computer output, reference literature, disk, ...)
California State Polytechnic University, Pomona
Chemical&Materials Engineering Department
CHE 499 : TRANSPORT MODELING
CASE STUDY
The Performance of a Bioartificial Pancreas
Date: May 28 2004
by
Last name, first
Last name, first
This case study is given under the Honor System and by signing here
__________________________ , ________________________
We have agreed that the work submitted is our work alone and that we neither sought nor received help from others.
Presentation 20% ________
Model development 20% ________
Solution 20% ________
Discussion 20% ________
Computer disk (CD) 10% ________
Completeness and Neatness 10% ________
Report must have comb binding with CD attached to the back cover.
Lists of acceptable topics: Name
(1) Numerical solution for the oxygen concentrations
within the blood and tissue regions ________________________
(2) Diffusion of urea in both stagnant and flowing
blood (Colton and Lowrie 1981) ________________________
(3) The sieving coefficient for the case of concentration
polarization (Mochizuki and Zydney 1992) ________________________
(4) Hindered transport of large molecules in
liquid-filled pores (Deen 1987) ________________________
(5) Modeling of oxygen uptake in perfluorocarbon
emulsions (Shah 1996) ________________________
(6) First-Order Drug Absorption and Elimination ________________________
(7) A Two-Compartment Model for an Intravenous
Injection ________________________
(8) A A Two-Compartment Model for First Order
Absorption ________________________
(9) Analysis of a Membrane Oxygenator, Oxygen
Transfer ________________________
(10) Analysis of a Membrane Oxygenator, Carbon
Dioxide Transfer ________________________
(11) Reactor Design Equation: Packed-Bed Reactor,
Well-Mixed Reactor ________________________
(12) Pharmacokinetic Modeling of Inulin Transport
in a Polymeric Support Structure ________________________
(13) Islet Insulin Release Model ________________________
(14) Pharmacokinetic Modeling of Glucose and
Insulin Interactions ________________________
(15) Using the Pharmacokinetic Model to Evaluate
the Performance of a Bioartificial Pancreas ________________________
(16)* Oscillating Flow in a Cylindrical Tube ________________________
(17)* Model of Diffusion of a Solute into a Sphere ________________________
(18)* Transport Effects Upon Enzymatic Reactions ________________________
(19)* Transport Effects Upon Enzymatic Reactions ________________________
(20)* Receptor-Ligand Binding Kinetics ________________________
(21)* A Kinetic Model for LDL Receptor-Mediated
Endocytosis ________________________
(22)* Receptor Regulation during Receptor-Mediated
Endocytosis ________________________
(23)* Simplified Model for Gene Induction and Expression ________________________
(24)* Biophysics of Leukocyte Rolling and Adhesion ________________________
(25)* Stochastic Effects on Chemical Interactions ________________________
(26)* Dynamics of Oxygenation of Blood in Lung Capillaries ________________________
(27)* Nitric Oxide Production and Transport in Tissues ________________________
(28)* Unidirectional Transport in a Solid Tumor ________________________
(29)* Pharmacokinetic Analysis of Methotrexate ________________________
(30)* Allometric Scaling Law in Pharmacokinetic Analysis ________________________
* Transport Phenomena in Biological Systems by Truskey, Yuan, and Katz, Prentice Hall, 2004