Additional data file 4. Responsive genes known to be modulated by T3. Outliers (2.0r) previously reported as T3-modulated at the mRNA or protein level or known to interact with components of thyroid hormone signaling are listed. Ratios >1.0 (red) indicate induced expression in T3-injected (iT3) animals. Ratios <1.0 (green) reflect mRNA repression in iT3 animals. IMAGE clone ID numbers and UniGene Cluster ID names are shown for all genes unless probe was derived from a private clone set (indicated by asterisk [*]).

Clone ID and UniGene name

/ Cerebellum (iT3) / Heart (iT3) /

White Adipose

(iT3)
mRNA expression
419146 cyclin-dependent kinase inhibitor 1A (P21) / 1.70 / 4.61 /

1.71

576881 fatty acid synthase / 0.16 /

0.34

570675 glycerol-3-phosphate dehydrogenase 1 (soluble) / 0.30 /

0.43

482270 peptidylglycine alpha-amidating monooxygenase / 0.27 /

1.53

571819 hemoglobin alpha, adult chain 1 / 0.19 / 1.52
313981 [hemoglobin, beta adult major chain] / 0.39
352146 ATP citrate lyase / 0.36 / 0.24
446036 growth arrest and DNA-damage-inducible 45 alpha / 2.50
481408 cytochrome c oxidase, subunit VIIIa / 0.36
482847 uncoupling protein 3, mitochondrial / 3.69
protein expression
579349 epoxide hydrolase 2, cytoplasmic / 1.69 / 2.87
677499 heme oxygenase (decycling) 1 / 5.67
406447 procollagen, type III, alpha 1 / 0.50 / 0.47 / 0.45
618431 carbonic anhydrase 3 / 0.42
476246 somatostatin / 2.61
effector
335319 transthyretin / 3.81
*MP:7B11 retinoid X receptor, alpha / 3.20 / 0.75 / 0.60