3rd International Fetal Immunology and Transplantation Society (iFeTIS)
March 23-24, 2017
Children’s Hospital of Philadelphia
Program
March 23rd, 2017
8:30 am Registration and Continental Breakfast
9 am Welcome and Introduction
Session 1: Prenatal Gene Therapy
9:05 am Invited Plenary: Prof. Charles Coutelle –
Prenatal Gene Therapy - A Look Back and Towards the Future
9:50 amInvited plenary: Graca Almeida-Porada, MD, PhD –
Development of Prenatal Gene Therapy for Hemophilia A.
10:30 am Break
10:45 am Oral Abstracts
High Incidence of Vector Integration Near Cancer-Related Genes within Primitive HSC After Fetal Gene Transfer with γ-Retroviral Vectors. Tellez J, Wood JA, Almeida Porada G, Porada CD. Institute of Regenerative Medicine, Wake Forest University
In Utero Deletional Gene Editing in the mTmG Mouse Model. Hartman HA, Alapati D, Zacharias W, Stratigis JD, Li H, Jain R, Chadwick A, Musunuru K, Morrisey EM, Peranteau WH. Center for Fetal Research, Children's Hosptial of Philadelphia
11:30 pmLunch
Session 2: Developmental Immunology and Fetal Tolerance
12:30 pmInvited Plenary: Sing Sing Way, MD, PhD-
Immune Pathogenesis of Prenatal Infection
1:15 pm Invited Plenary: Aimen F. Shaaban, MD-
Development of Innate Immunity, aBarrier toIn utero Transplantation?
2:00pmBreak
2:15 am Oral Abstracts
The Uteroplacental Interface Immune System In Late Vs. Very Early Pregnancy: Uterine Nk Cells (Cd56hicd16-) Are Outnumbered By Cd56locd16+ Nk Cells. Andrea Loewendorf, PhD1 Huntington Medical Research Institute, Pasadena, CA
A Simple Model to Study the Regulation of Allospecific NK Cell Education within the Bone Marrow.Jones J, Lee A, Turner L, Strong B, Shaaban A. Cincinnati Children’s Hospital Medical Center
Human Fetal Dendritic Cells Promote Pre-Natal T Cell Immune-Suppression Through Arginase-2 Activity. Jerry Chan, MD, PhD,Florent Ginhoux, PhD, Naomi McGovern, PhD. National University Singapore, Singapore
Donor-Reactive Maternal Igg Can Cause Prenatal Graft Rejection In The Mouse Model Of In Utero Hematopoietic Cell Transplantation. John Riley, Lauren McClain, MD, Haiying Li, John Stratigis, MD, Alan Flake, MD, William Peranteau, MD Center for Fetal Research, Children’s Hospital of Philadelphia.
4:00 pm Closing Remarks
6:00 pm Social Event
Program
March 24th, 2017
8 am Continental Breakfast and Society Business Meeting
Session 3. Maternal-Fetal Tolerance and Cellular Therapy
9 amInvited Plenary: Tippi C. Mackenzie, MD–
Fetal T cell Development and Fetal Immune Responses againstMaternal Antigens in Health and Disease
9:45 amAlan W. Flake:Tolerance in the Context of In utero Hematopoietic Cell Transplantation – What is Required?
10:30 amBreak
10:45 amOral Abstracts
Unraveling The Mechanism Of Tolerance Induction Following In Utero Transplantation. Stratigis J, MD*, Ahn N, MD*, Li H, Fachin C, MD, Dias A, Kim A, Peranteau WH, Loukogeorgakis S, Flake AW. Center for Fetal Research, Children’s Hospital of Philadelphia.
Intra-Chorionic Villi Injection At Early Gestational Stage Can Induce Immune Tolerance Towards Allogeneic Cells In A Murine Model. Endo M, Shimazu Y, Okada A. Osaka University, Japan
Prenatal Transplantation of Human Amniotic Fluid Stem Cells Could Improve the Clinical Outcome of Type III Spinal Muscular Atrophy. Steven Shaw, Chang Gung Memorial Hospital, Taipei, Taiwan
Human Amniotic Stem Cells have Hematopoietic Potential in vivo, Ramachandra DL, Loukogeorgakis SP, Antoniadou E, Subramaniam S, Shangaris P, Tedeschi A, Manson A, Carmo M, Blundell M, Howe S, David AL, Di Coppi P. Great Ormand St, University College London, London. UK
12:00 amLunch
Session 4. New Technologies and Prenatal Gene and Cell Therapy
12:45 pmInvited Plenary:Kiran Musunuru, MD, PhD, MPH and
William H. Peranteau, MD –
Prenatal Gene Editing: Scientific Basis and Clinical Considerations.
1:30 pmInvited Plenary: Simon N. Waddington–
Gene Therapy: Are We Out of the Woods Yet?
2:15pm Break
2:30 pm Oral Abstracts
Leukocyte-Specific Conditioning After Tolerance Induction Via Intra-Uterine Hematopoietic Stem Cell Transplantation. Patrick McGovern, MD1, Agnieszka Czechowicz, MD, PhD2, John Stratigis, MD3, Haiying Li4. Philip Zoltick, MD5, John Riley6, Alan Flake, MD7, William Peranteau, MD8Center for Fetal Research, Children’s Hospital of Philadelphia.
Protection And Maintenance Of Normal Neurologic Development In Extreme Prematurity. Patrick McGovern, MD, Marcus Davey, PhD, Ali Mejaddam, MD, Hornick Matthew, MD, William Peranteau, MD, Alan Flake, MDCenter for Fetal Research, Children’s Hospital of Philadelphia.
The Effect of Hypoxia on Human Amniotic Fluid Stem Cell Culture: Developing a GMP Grade Stem Cell Source. Antoniadou E, Ramachandra DL, Subramaniam S, Lowdell M, David AL, De Coppi P. Great Ormand St, University College London, London. UK
Session 5. Clinical Translation and Trials
3:15 pmProf. Anna David –
Progress in the Placental Gene Therapy for IUGR Trial
3:45 pm Cecilia Götherström –
The BOOSTB4 Trial for Osteogenesis Imperfecta
4:15 pm Tippi C. Mackenzie, MD –
IUHCT for Alpha-Thalassemia
4: 45 pm Alan W. Flake, MD –
IUHCT for Hyper IgM, Update on Hemoglobinopathy IND
5:15 pmAdjourn
Course Director
Alan W. Flake, MD
Professor of Surgery
University of Pennsylvania Perelman School of Medicine
Ruth and Tristram C. Colket, Jr. Chair in Pediatric Surgery
Vice Chair of Research, Department of Surgery
Director, Children's Center for Fetal Research
Children's Hospital of Philadelphia
Course Faculty
Graca Almeida-Porada, MD, PhD
Professor, Institute for Regenerative Medicine
Wake Forest University
Prof. Charles Coutelle
Emeritus Professor of Gene Therapy
National Heart and Lung Insitute,
Imperial College London
Prof. Anna David
Consultant and Professor in Obstetrics and Maternal Fetal Medicine
Head of the Research Department of Maternal Fetal Medicine, Institute of Women’s Health
University College London
Cecilia Götherström
Associate Professor
Karolinska Institutet | CLINTEC
Center for Hematology and Regenerative Medicine
Tippi C. Mackenzie, MD
Associate Professor of Surgery
Eli and Edythe Broad Institute for Regenerative Medicine
UCSF School of Medicine
Kiran Musunuru, MD, PhD, MPH
Associate Professor of Cardiovascular Medicine and Genetics
University of Pennsylvania Perelman School of Medicine
William H. Peranteau, MD
Assistant Professor of Surgery
Department of General, Thoracic, and Fetal Surgery
Center for Fetal Research
Children’s Hospital of Philadelphia
University of Pennsylvania Perelman School of Medicine
Aimen F. Shaaban, MD
Professor, University of Cincinnati Department of Surgery
Director, Center for Fetal Cellular and Molecular Therapy
Cincinnati Children’s Hospital Medical Center
Sing Sing Way, MD, PhD
Associate Professor of Pediatrics
Pauline and Lawson Reed Chair, Division of Infectious Disease
Cincinnati Children’s Hospital Medical Center
University of Cincinnati
Simon N. Waddington, PhD
Reader in Gene Transfer Technology
Institute for Women’s Health | University College London
Cecilia Götherström
Associate Professor
Karolinska Institutet | CLINTEC
Center for Hematology and Regenerative Medicine