3rd International Fetal Immunology and Transplantation Society (iFeTIS)

March 23-24, 2017

Children’s Hospital of Philadelphia

Program

March 23rd, 2017

8:30 am Registration and Continental Breakfast

9 am Welcome and Introduction

Session 1: Prenatal Gene Therapy

9:05 am Invited Plenary: Prof. Charles Coutelle –

Prenatal Gene Therapy - A Look Back and Towards the Future

9:50 amInvited plenary: Graca Almeida-Porada, MD, PhD –

Development of Prenatal Gene Therapy for Hemophilia A.

10:30 am Break

10:45 am Oral Abstracts

High Incidence of Vector Integration Near Cancer-Related Genes within Primitive HSC After Fetal Gene Transfer with γ-Retroviral Vectors. Tellez J, Wood JA, Almeida Porada G, Porada CD. Institute of Regenerative Medicine, Wake Forest University

In Utero Deletional Gene Editing in the mTmG Mouse Model. Hartman HA, Alapati D, Zacharias W, Stratigis JD, Li H, Jain R, Chadwick A, Musunuru K, Morrisey EM, Peranteau WH. Center for Fetal Research, Children's Hosptial of Philadelphia

11:30 pmLunch

Session 2: Developmental Immunology and Fetal Tolerance

12:30 pmInvited Plenary: Sing Sing Way, MD, PhD-

Immune Pathogenesis of Prenatal Infection

1:15 pm Invited Plenary: Aimen F. Shaaban, MD-

Development of Innate Immunity, aBarrier toIn utero Transplantation?

2:00pmBreak

2:15 am Oral Abstracts

The Uteroplacental Interface Immune System In Late Vs. Very Early Pregnancy: Uterine Nk Cells (Cd56hicd16-) Are Outnumbered By Cd56locd16+ Nk Cells. Andrea Loewendorf, PhD1 Huntington Medical Research Institute, Pasadena, CA

A Simple Model to Study the Regulation of Allospecific NK Cell Education within the Bone Marrow.Jones J, Lee A, Turner L, Strong B, Shaaban A. Cincinnati Children’s Hospital Medical Center

Human Fetal Dendritic Cells Promote Pre-Natal T Cell Immune-Suppression Through Arginase-2 Activity. Jerry Chan, MD, PhD,Florent Ginhoux, PhD, Naomi McGovern, PhD. National University Singapore, Singapore

Donor-Reactive Maternal Igg Can Cause Prenatal Graft Rejection In The Mouse Model Of In Utero Hematopoietic Cell Transplantation. John Riley, Lauren McClain, MD, Haiying Li, John Stratigis, MD, Alan Flake, MD, William Peranteau, MD Center for Fetal Research, Children’s Hospital of Philadelphia.

4:00 pm Closing Remarks

6:00 pm Social Event

Program

March 24th, 2017

8 am Continental Breakfast and Society Business Meeting

Session 3. Maternal-Fetal Tolerance and Cellular Therapy

9 amInvited Plenary: Tippi C. Mackenzie, MD–

Fetal T cell Development and Fetal Immune Responses againstMaternal Antigens in Health and Disease

9:45 amAlan W. Flake:Tolerance in the Context of In utero Hematopoietic Cell Transplantation – What is Required?

10:30 amBreak

10:45 amOral Abstracts

Unraveling The Mechanism Of Tolerance Induction Following In Utero Transplantation. Stratigis J, MD*, Ahn N, MD*, Li H, Fachin C, MD, Dias A, Kim A, Peranteau WH, Loukogeorgakis S, Flake AW. Center for Fetal Research, Children’s Hospital of Philadelphia.

Intra-Chorionic Villi Injection At Early Gestational Stage Can Induce Immune Tolerance Towards Allogeneic Cells In A Murine Model. Endo M, Shimazu Y, Okada A. Osaka University, Japan

Prenatal Transplantation of Human Amniotic Fluid Stem Cells Could Improve the Clinical Outcome of Type III Spinal Muscular Atrophy. Steven Shaw, Chang Gung Memorial Hospital, Taipei, Taiwan

Human Amniotic Stem Cells have Hematopoietic Potential in vivo, Ramachandra DL, Loukogeorgakis SP, Antoniadou E, Subramaniam S, Shangaris P, Tedeschi A, Manson A, Carmo M, Blundell M, Howe S, David AL, Di Coppi P. Great Ormand St, University College London, London. UK

12:00 amLunch

Session 4. New Technologies and Prenatal Gene and Cell Therapy

12:45 pmInvited Plenary:Kiran Musunuru, MD, PhD, MPH and

William H. Peranteau, MD –

Prenatal Gene Editing: Scientific Basis and Clinical Considerations.

1:30 pmInvited Plenary: Simon N. Waddington–

Gene Therapy: Are We Out of the Woods Yet?

2:15pm Break

2:30 pm Oral Abstracts

Leukocyte-Specific Conditioning After Tolerance Induction Via Intra-Uterine Hematopoietic Stem Cell Transplantation. Patrick McGovern, MD1, Agnieszka Czechowicz, MD, PhD2, John Stratigis, MD3, Haiying Li4. Philip Zoltick, MD5, John Riley6, Alan Flake, MD7, William Peranteau, MD8Center for Fetal Research, Children’s Hospital of Philadelphia.

Protection And Maintenance Of Normal Neurologic Development In Extreme Prematurity. Patrick McGovern, MD, Marcus Davey, PhD, Ali Mejaddam, MD, Hornick Matthew, MD, William Peranteau, MD, Alan Flake, MDCenter for Fetal Research, Children’s Hospital of Philadelphia.

The Effect of Hypoxia on Human Amniotic Fluid Stem Cell Culture: Developing a GMP Grade Stem Cell Source. Antoniadou E, Ramachandra DL, Subramaniam S, Lowdell M, David AL, De Coppi P. Great Ormand St, University College London, London. UK

Session 5. Clinical Translation and Trials

3:15 pmProf. Anna David –

Progress in the Placental Gene Therapy for IUGR Trial

3:45 pm Cecilia Götherström –

The BOOSTB4 Trial for Osteogenesis Imperfecta

4:15 pm Tippi C. Mackenzie, MD –

IUHCT for Alpha-Thalassemia

4: 45 pm Alan W. Flake, MD –

IUHCT for Hyper IgM, Update on Hemoglobinopathy IND

5:15 pmAdjourn

Course Director

Alan W. Flake, MD

Professor of Surgery

University of Pennsylvania Perelman School of Medicine

Ruth and Tristram C. Colket, Jr. Chair in Pediatric Surgery

Vice Chair of Research, Department of Surgery

Director, Children's Center for Fetal Research

Children's Hospital of Philadelphia

Course Faculty

Graca Almeida-Porada, MD, PhD

Professor, Institute for Regenerative Medicine

Wake Forest University

Prof. Charles Coutelle

Emeritus Professor of Gene Therapy

National Heart and Lung Insitute,

Imperial College London

Prof. Anna David

Consultant and Professor in Obstetrics and Maternal Fetal Medicine

Head of the Research Department of Maternal Fetal Medicine, Institute of Women’s Health

University College London

Cecilia Götherström

Associate Professor

Karolinska Institutet | CLINTEC

Center for Hematology and Regenerative Medicine

Tippi C. Mackenzie, MD

Associate Professor of Surgery

Eli and Edythe Broad Institute for Regenerative Medicine

UCSF School of Medicine

Kiran Musunuru, MD, PhD, MPH

Associate Professor of Cardiovascular Medicine and Genetics

University of Pennsylvania Perelman School of Medicine

William H. Peranteau, MD

Assistant Professor of Surgery

Department of General, Thoracic, and Fetal Surgery

Center for Fetal Research

Children’s Hospital of Philadelphia

University of Pennsylvania Perelman School of Medicine

Aimen F. Shaaban, MD

Professor, University of Cincinnati Department of Surgery

Director, Center for Fetal Cellular and Molecular Therapy

Cincinnati Children’s Hospital Medical Center

Sing Sing Way, MD, PhD

Associate Professor of Pediatrics

Pauline and Lawson Reed Chair, Division of Infectious Disease

Cincinnati Children’s Hospital Medical Center

University of Cincinnati

Simon N. Waddington, PhD

Reader in Gene Transfer Technology

Institute for Women’s Health | University College London

Cecilia Götherström

Associate Professor

Karolinska Institutet | CLINTEC

Center for Hematology and Regenerative Medicine