Supplemental Digital Content 1. Neuropsychological test battery and normative data used for published norms-based cognitive impairment classification

Cognitive Domain / Test / Normative Data Source and Demographic Adjustments
Memory / WMS-III Logical Memory (story A, delayed recall) (1) / Education(2)
Rey Auditory Verbal Learning Test (3) / Age(4, 5)
RAVLT total learning; trials 1-5
RAVLT short-term delayed recall: trial 6
RAVLT long-term delayed recall: trial 7
Benton Visual Retention Test recognition(6) / Age and education(7)
Attention/processing speed / WAIS-III Digit Symbol-Coding(8) / Age(8)
Trail Making Test A(9) / Age and education(10)
Language / Boston Naming Test – 30 items(11) / Age(12)
Semantic Fluency (Animals)(13) / Age and education(14)
Executive function / Controlled Oral Word Association Test (FAS)(15) / Age and education(10)
Trail Making Test B(9) / Age and education(10)
Visuospatial / WAIS-R Block Design(16) / Age (17)

Note. The measure of visuospatial ability (Block Design) was not included in the analyses because it could not be incorporated in all classification methods.

References

1.Wechsler D: Wechsler Memory Scale - III, 3rd edition. San Antonio, The Psychological Corporation, 1997

2.Grundman M, Petersen RC, Ferris SH, et al: Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. Arch Neurol 2004; 61:59-66

3.Strauss E, Sherman EMS,Spreen O: A compendium of neuropsychological tests: Administration, norms, and commentary, 3rd edition. New York, NY, US, Oxford University Press, 2006

4.Ivnik RJ, Malec JF, Smith GE, et al: Mayo's Older Americans Normative Studies: Updated AVLT norms for ages 56 to 97 Clinical Neuropsychologist 1992; 6:S83-104

5.Ivnik RJ, Malec JF, Tangalos EG, et al: The Auditory-Verbal Learning Test (AVLT): Norms for ages 55 years and older. Psychological Assessment 1990; 2:304-312

6.Benton AL, Sivan AB,Spreen O: Der Benton Test 7th edition. Bern, Huber, 1996

7.Lechevallier-Michel N, Fabrigoule C, Lafont S, et al: Normes por le MMSE, le Test de Retention Visuelle de Benton, le Set Test d’Isaacs (15s. et 60s), le sous-test des Codes de la WAIS et le Test Barrage de Zazzo, en function de l’age, du sexe et du niveau d’etudes, chez des sujets ages de 70 ans et plus: donnees de la chorte PAQUID. Revue Neurologique 2004; 160:1059-1070.

8.Wechsler D: Wechsler Adult Intelligence Scale - III, San Antonio, The Psychological Corporation, 1997

9.Reitan RM,Wolfson D: The Halstead-Reitan Neuropsychological Test Battery: theory and clinical interpretation, 2nd ed. Tucson,AZ, Neuropsychology Press, 1993

10.Tombaugh TN: Trail Making Test A and B: Normative data stratified by age and education. Archives of Clinical Neuropsychology 2004; 19:203-214

11.Kaplan E: The Boston Naming Test, Philadelphia, Lippincott Williams Wilkins., 2001

12.Fastenau PS, Denburg NL,Mauer BA: Parallel short forms for the Boston Naming Test: psychometric properties and norms for older adults. J Clin Exp Neuropsychol 1998; 20:828-834

13.Spreen O,Benton AL: Neurosensory Center Comprehensive Examination for Aphasia Manual (NCCEA), Victoria, University of Victoria, 1969

14.Tombaugh TN, Kozak J,Rees L: Normative data stratified by age and education for two measures of verbal fluency: FAS and Animal Naming. Archives of Clinical Neuropsychology 1999; 14:167-177

15.Benton AL: Problems of test construction in the field of aphasia. Cortex 1967; 3:32-58

16.Wechsler D: Wechsler Adult Intelligence Scale - Revised, New York, The Psychological Corporation, 1981

17.Ivnik RJ, Malec JF, Smith GE, et al: Mayo's Older Americans Normative Studies: WAIS-R norms for ages 56 to 97 Clinical Neuropsychologist 1992; 6:S1-30